76 research outputs found
Management of hot flashes in patients who have breast cancer with Venlafaxine and Clonidine: a randomized, double-blind, placebo-controlled trial
No full textPurpose: Therapies for breast cancer may induce hot flashes that can affect quality of life. We undertook a double-blind, placebo-controlled trial with the primary objective of comparing the average daily hot flash scores in the twelfth week among patients treated with venlafaxine, clonidine, and placebo. Additional analyses of the hot flash score over the full 12 weeks of treatment were performed. Patients and Methods: In all, 102 patients with a history of breast cancer were randomly assigned (2:2:1) to venlafaxine 75 mg, clonidine 0.1 mg, or placebo daily for 12 weeks. Questionnaires at baseline and during treatment assessed daily hot flash scores, sexual function, sleep quality, anxiety, and depression. Results: After 12 weeks, a total of 80 patients were evaluable for the primary end point. During week 12, hot flash scores were significantly lower in the clonidine group versus placebo (P = .03); for venlafaxine versus placebo, the difference was borderline not significant (P = .07). However, hot flash scores were equal in the clonidine and venlafaxine groups. Over the course of 12 weeks, the differences between both treatments and placebo were significant (P <.001 for venlafaxine v placebo; P = .045 for clonidine v placebo). Frequencies of treatment-related adverse effects of nausea (P = .02), constipation (P = .04), and severe appetite loss were higher in the venlafaxine group. Conclusion: Venlafaxine and clonidine are effective treatments in the management of hot flashes in patients with breast cancer. Venlafaxine resulted in a more immediate reduction of hot flash scores when compared with clonidine; however, hot flash scores at week 12 were lower in the clonidine group than in the venlafaxine group.Annelies H. Boekhout, Andrew D. Vincent, Otilia B. Dalesio, Joan van den Bosch, Joke H. Foekema-Töns, Sandra Adriaansz, Sylvia Sprangers, Bastiaan Nuijen, Jos H. Beijnen, and Jan H.M. Schellen
Recommended from our members
High Availability On-line Relational Databases for Accelerator Control and Operation
No full textThe role that relational database (RDB) technology plays in accelerator control and operation continues to grow in such areas as electronic logbooks, machine parameter definitions, and facility infrastructure management. RDBs are increasingly relied upon to provide the official 'master' copy of these data. Whereas the services provided by the RDB have traditionally not been 'mission critical', the availability of modern RDB management systems is now equivalent to that of standard computer file-systems. RDBs can be relied on to supply pseudo real-time response to operator and machine physicist requests. This paper describes recent developments in the IRMIS RDB project. Generic lattice support has been added, serving as the driver for model-based machine control. Abstract physics name service and process variable introspection has been added. Specific emphasis has been placed both on providing fast response time to accelerator operators and modeling code requests, as well as high (24/7) availability of the RDB service
A Proposal for Introspection in EPICS
No full textIntrospection provides some mapping of function to process variables. To implement this in EPICS, a service is required to define these relationships that may be accomplished external to the control system as an extension to the directory service. This paper outlines the functionality and design to implement this functionalit
CSF levels of neurotransmitters in Alzheimer-type dementia. Effects of ergoloid mesylate
No full textRecommended from our members
A virtual control panel configuration tool for the X-window system
No full textComputer Graphics Workstations are becoming increasingly popular for use as virtual process control and read back panels. The workstations's CRT, keyboard, and pointing device are used in concert to produce a display that is in essence a control panel, even if actual switches and gauges are not present. The code behind these displays is most often specific to one display and not reusable for any other display. Recently, programs have been written allowing many of these virtual control panel displays to be configured without writing additional code. This approach allows the initial programming effort to be reapplied to many different display instances with minimal effort. These programs often incorporate many of the features of a graphics editor, allowing a pictorial model of the process under control to be incorporated into the control panel. We have just finished writing a second generation software system of this type for use with the X-window system and the Experimental Physics and Industrial Control System (EPICS). This paper describes the primary features of our software, the framework of our design, and our observations after initial installation
L Polarization in Unpolarized Hadron Reactions.
No full textThe transverse polarization observed in the inclusive production of {Lambda} hyperons in the high energy collisions of unpolarized hadrons is tackled by considering a new set of spin and {kappa}{perpendicular} dependent quark fragmentation functions. Simple phenomenological expressions for these new ''polarizing fragmentation functions'' are obtained by a fit of the data on {Lambda}'s and {bar {Lambda}}'s produced in p - N processes
Recommended from our members
The Experimental Physics and Industrial Control System architecture: Past, present, and future
No full textThe Experimental Physics and Industrial Control System (EPICS), has been used at a number of sites for performing data acquisition, supervisory control, closed-loop control, sequential control, and operational optimization. The EPICS architecture was originally developed by a group with diverse backgrounds in physics and industrial control. The current architecture represents one instance of the ``standard model.`` It provides distributed processing and communication from any LAN device to the front end controllers. This paper will present the genealogy, current architecture, performance envelope, current installations, and planned extensions for requirements not met by the current architecture
The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment
No full textThe international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz instantaneous muon rate, with a neglible pion contamination in the beam
- …
