1,721,198 research outputs found
Insulin-Like Growth Factor-1 Receptor Identifies a Pool of Human Cardiac Stem Cells With Superior Therapeutic Potential for Myocardial Regeneration (vol 108, pg 1467, 2011)
No full textSex Differences in Heart Failure
No full textHeart failure (HF) represents a global pandemic health problem with a high impact on health-care costs, affecting about 26 million adults worldwide. The overall HF prevalence and incidence are ~2% and ~0.2% per year, respectively, in Western countries, with half of the HF population with reduced ejection fraction (HFpEF) and half with preserved (HFpEF) or mid-range ejection fraction (HFmrEF). Sex differences may exist in HF. More males have HFrEF or HFmrEF and an ischemic etiology, whereas more females have HFpEF and hypertension, diastolic dysfunction, and valvular pathologies as HF etiologies. Females are generally older, have a higher EF, higher frequency of HF-related symptoms, and lower NYHA functional status. Generally, it is observed that female HF patients tend to have more comorbidities such as atrial fibrillation, diabetes, hypertension, anemia, iron deficiency, renal disease, arthritis, frailty, depression, and thyroid abnormalities. However, overall, females have better prognosis in terms of mortality and hospitalization risk compared with men, regardless of EF. Potential sex differences in HF characteristics may be underestimated because of the underrepresentation of females in cardiovascular research and, in particular, the sex imbalance in clinical trial enrollment may avoid to identify sex-specific differences in treatments’ benefit
Combining balloon-assisted tracking and sheathless guiding catheter: unloosening the Gordian knot
No full textIn a patient with a small-calibre radial artery and a 360 degrees radio-ulnar loop, we combined the balloon-assisted tracking (BAT) technique (used to track a catheter trough the loop) with the use of a 6.5 F PB sheathless guiding catheter, in order to allow the extensive catheter manipulations needed for PCI despite the ongoing artery spasm. (C) 2015 Elsevier Inc. All rights reserved
The ongoing search for simplifying fractional flow reserve assessment: the role of contrast medium
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Predicting the future after acute myocardial infarction: A gaze into the crystal ball of gene expression profile
No full textNeoatherosclerosis and Late Thrombosis After Percutaneous Coronary Intervention: Translational Cardiology and Comparative Medicine from Bench to Bedside
No full textNeoatherosclerosis is a form of accelerated atherosclerosis that occurs within stented segments of the coronary vessel late or very late after drug-eluting stent (DES+) implantation via percutaneous coronary intervention (PCI). This proliferation of neointima with a formation of new atheromatous plaque within stent struts lacking re-endothelialization can provoke thrombotic occlusion and lead to catastrophic acute coronary events. Knowing that coronary artery disease is the leading single cause of mortality worldwide and that there is a constant trend of increase in PCI procedures, it is reasonable to conclude that late thrombotic events and neoatherosclerosis post-PCI remain an important therapeutic challenge. For these reasons, early identification of patients at risk through the means of advanced imaging methods or preventive solutions available through novel technological solutions in DES design that target proinflammatory pathways and enable optimized arterial healing are central strategies in prevention and treatment of in-stent neoatherosclerosis and thrombosis. Due to this, pre-clinical studies performed on animal models are crucial building blocks that enable the objective and scientific assessment of innovative technological and therapeutic solutions before they are introduced to early stages of human clinical trials. A comparative medicine approach allows designing and executing experiments in animal models with a high degree of similarity with human coronary anatomy possibly promising the translation of encouraging findings to human clinical studies. The aim of this review is to provide contemporary insights on the pathophysiology of neoatherosclerosis and in-stent thrombosis and emergence of novel biomedical and technological solutions used to counter them
Coronary microvascular dysfunction in heart failure with preserved ejection fraction: not the end but the end of the beginning
No full textThis article refers to 'Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction' by A. Ahmad et al., published in this issue on page
Colchicine and risk of non-cardiovascular death in patients with coronary artery disease: A pooled analysis underling possible safety concerns
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Dynamic thrombosis associated with bare-metal stent malapposition in a patient with hyperhomocysteinemia
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