195,619 research outputs found
Jacob D. Cox portrait
No full textCarte de visite portrait of Jacob Dolson Cox (1828-1900) in military uniform, taken by Warner & Elliott of Columbus, Ohio. Originally from Montreal, Canada, Cox emigrated to the United States, and attended Oberlin College. After several pre-war political positions in Ohio, he joined the Ohio Volunteer Infantry. Cox fought at Antietam, South Mountain, and Atlanta, and eventually became military supervisor for the District of Ohio and the District of Michigan. He went on to become the 28th governor of Ohio from 1866 to 1868, and served as Secretary of the Interior from 1869 through 1870 in the presidential cabinet of fellow Ohioan Ulysses S. Grant
The Geary Journal
No full textWeekly newspaper from Geary, Oklahoma that includes local, state, and national news along with advertising
The Geary Journal
No full textWeekly newspaper from Geary, Oklahoma that includes local, state, and national news along with advertising
D-calibration comparison with elastic-net Cox model.
No full texta) D-calibration of survival predictions for the DJIN model. Estimated survival probabilities are expected to be uniformly distributed (dashed black line). We use Pearson’s χ2 test to assess the distribution of survival probabilities finding χ2 = 1.3 and p = 1.0 and an elastic net Cox model. (Higher p-values and smaller χ2 statistics are better). b) D-calibration of survival predictions for the elastic-net Cox model. Estimated survival probabilities are expected to be uniformly distributed (dashed black line). We use Pearson’s χ2 test to assess the distribution of survival probabilities finding χ2 = 2.1 and p = 1.0. Error bars show the standard deviation. (TIF)</p
Concentration in Knowledge Output: A case of Economics Journals
Get PDFThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
Selective COX-2 inhibitors and risk of myocardial infarction
Get PDFSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
Berry Cox, Cliff Table, Custer County, Nebraska.
No full textNote: 'An old bach in sod house; Mr. Cox now has an elegant house on same land.
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