5,412 research outputs found
Local Author Book Talk: Meet D.M. Pulley author of The Dead Key
No full textLocal Author D.M. Pulley, author of The Dead Key.
2014 Winner — Amazon Breakthrough Novel Award — Grand Prize and Mystery & Thriller Fiction Winner. It’s 1998, and for years the old First Bank of Cleveland has sat abandoned, perfectly preserved, its secrets only speculated on by the outside world.--Source Amazon.com
These books and all Friends of the Library 2021/2022 book selections are on sale at Viking Outfitters, located in the CSU Student Center
Poke and Posey War, 1915 P.3
No full textGeneral Scott and guide. Moab, March 1915. Gift of Mrs. Elaine Garrity. D.M. Cooper , photog
Canceled: Local Author Book Talk: Meet D.M. Pulley author of The Dead Key
No full textThis event has been canceled due to the Coronavirus.
Meet Local Author D.M. Pulley, author of The Dead Key.
2014 Winner — Amazon Breakthrough Novel Award — Grand Prize and Mystery & Thriller Fiction Winner. It’s 1998, and for years the old First Bank of Cleveland has sat abandoned, perfectly preserved, its secrets only speculated on by the outside world.--Source Amazon.com
The books titled The Dead Key, No one’s Home, Unclaimed Victim, and The Buried Book will be available for sale by Viking Outfitters at the event. These books and all Friends of the Library 2019/2020 book selections are on sale at Viking Outfitters, located in the CSU Student Center
field photographs, diagrams and notes of a privately owned, complete lepisosteiform specimen from the Turonian of Asfla, Morocco (Asfla Member): Supplementary data for Cooper et al., 2020 .
No full textData consists of field photographs, notes and annotated diagrams of a complete marine gar fish from the Turonian Akrabou Formation (Asfla Member) of Asfla Morocco. This data is entered as unofficial supplementary data for "A large marine gar fish (Ginglymodi, Lepisosteiformes) from the Turonian Akrabou Formation of Asfla, Morocco" by S.L.A. Cooper, D.M. Martill and T. Beevor. This specimen is privatively owned with its current whereabouts presently unknown. Therefore it is not figured or described in the original manuscript in order to abide by the journal's policies. Data is stored as a PDF and contains 18 figures of this private specimen
Meglumine Eicosapentaenoic acid (MeEPA) a new soluble omega-3 fatty acid formulation: in vitro bladder cancer cytotoxicity tests in combination with epirubicin and mitomycin
No full textOBJECTIVE: To determine if Meglumine-Eicosapentaenoic Acid (MeEPA) acts synergistically with epirubicin and mitomycin to enhance cytotoxicity towards bladder cancer cell lines in vitro.MATERIALS AND METHODS: Bladder cancer cells were exposed to MeEPA in combination with epirubicin or mitomycin. Residual viable cell biomass was estimated with the methyl-thiazoldiphenyl tetrazolium (MTT) assay following drug exposure. Drug interaction was analysed using median effect analysis to determine levels of synergism.RESULTS: Most combinations of MeEPA with both epirubicin and mitomycin showed a high-level of synergism. At high doses, drug precipitation adversely affected MTT assay analysis suggesting antagonism of action. However, the predominant pattern was of synergism for most dose combinations tested.CONCLUSION: Bladder cancer treated by endoscopic resection alone is subject to high recurrence rates. Post-operative intravesical instillation of epirubicin and mitomycin can halve recurrence rates, but there is no evidence that disease progression to invasive bladder cancer is altered. Thus, optimisation of current treatment strategies is required. The anti-tumour activity of fatty acids is well established and MeEPA is a new, soluble formulation with the potential to enhance intravesical drug efficacy
field photographs, diagrams and notes of a privately owned, complete lepisosteiform specimen from the Turonian of Asfla, Morocco (Asfla Member): Supplementary data for Cooper et al., 2020 .
No full textData consists of field photographs, notes and annotated diagrams of a complete marine gar fish from the Turonian Akrabou Formation (Asfla Member) of Asfla Morocco. This data is entered as unofficial supplementary data for "A large marine gar fish (Ginglymodi, Lepisosteiformes) from the Turonian Akrabou Formation of Asfla, Morocco" by S.L.A. Cooper, D.M. Martill and T. Beevor. This specimen is privatively owned with its current whereabouts presently unknown. Therefore it is not figured or described in the original manuscript in order to abide by the journal's policies. Data is stored as a PDF and contains 18 figures of this private specimen
Poke and Posey War, 1915 P.7
No full textPosey; Elaine Cooper (Garrity) child; Mrs. D.M. Cooper, Polk. Taken March, 1915 in Moab
Gender differences in self-reported late effects, quality of life and satisfaction with clinic in survivors of lymphoma
No full textObjectives: gender differences in perceived vulnerability to late effects and views about follow-up among cancer survivors have received little attention. As lymphoma affects both genders similarly, we compared the consequences of cancer (late effects, perceived vulnerability and quality of life (health-related quality of life (HRQoL)), and satisfaction with clinic visits between genders.Methods: a cohort of 115 younger adults (18–45 years, >5 years disease-free survival), who had been treated for lymphoma participated. Questionnaires (n = 91) were completed before and after (n = 62) routine consultant-led appointments. Survivors (n = 24) without appointments were recruited by post. Questionnaires included HRQoL, late effects, perceived vulnerability, issues survivors wanted to discuss and reported discussing in clinic, time waiting in clinic and consultation satisfaction.Results: there were no gender differences in number of self-reported late effects or perceived vulnerability. Men with more late effects reported worse psychological HRQoL (r = 0.50, p<0.001). While men wanted to discuss more topics than they did, women were able to discuss the topics they wanted (ANOVA, p = 0.01). Multiple regression analyses showed a shorter wait in clinic (r = ?0.46, p = 0.009) and discussing more topics (r = 0.34, p = 0.06) explained 30.6% of the variance in consultation satisfaction for men.Conclusions: issues surrounding follow-up provision are increasingly important given the length of survival in young adults following treatment for lymphoma. Men may experience poor psychological well-being due to distress about unanswered concerns. Consideration of their concerns should be prioritised, given that satisfaction and ultimately continued attendance at clinic and HRQoL may be dependent on the extent to which follow-up meets survivors' expectation
Na-ca Exchange And Ca Fluxes During Contraction And Relaxation In Mammalian Ventricular Muscle
No full textThere are four cellular Ca transport systems which compete to remove Ca from the myoplasm in mammalian ventricular myocytes. These are 1) the SR Ca-ATPase, 2) the sarcolemmal Na-Ca exchange, 3) the sarcolemmal Ca-ATPase and 4) the mitochondrial Ca uniporter. Using multiple experimental approaches we have evaluated the dynamic interaction of these systems during the normal cardiac contraction-relaxation cycle. The SR Ca-ATPase and Na-Ca exchange are clearly the most important, quantitatively; however, the relative roles vary in a species-dependent manner. In particular, the SR is much more strongly dominant in rat ventricular myocytes, where ~ 92% of Ca removal is via SR Ca-ATPase and only 7% via Na-Ca exchange during a twitch. In other species (rabbit, ferret, cat, and guinea pig) the balance is more in the range of 70% SR Ca-ATPase and 25-30% Na-Ca exchange. Ferret ventricular myocytes also exhibit an unusually strong sarcolemmal Ca-ATPase. During the steady state the same amount of Ca must leave the cell as enters over a cardiac cycle. This implies that 25-30% of the Ca required to activate contraction must enter the cell, and experiments demonstrate that this amount of Ca may be supplied by the L-type Ca current.779430442Bers, D.M., (1991) Excitation-Contraction Coupling and Cardiac Contractile Force, pp. 1-258. , (Single author monograph.) Kluwer Academic Press. Dordrecht, NetherlandsSutko, J.L., Willerson, J.T., Ryanodine alteration of the contractile state of rat ventricular myocardium. Comparison with dog, cat and rabbit ventricular tissues (1980) Circ. Res., 46, pp. 332-343Bers, D.M., Ca influx and SR Ca release in cardiac muscle activation during postrest recovery (1985) Am. J. Physiol., 248, pp. H366-H381Bers, D.M., Mechanisms contributing to the cardiac inotropic effect of Na-pump inhibition and reduction of extracellular Na (1987) J. Gen. Physiol., 90, pp. 479-504Bers, D.M., Christensen, D.M., Nguyen, T.X., Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction? (1988) J. Mol. Cell. Cardiol., 20, pp. 405-414Beuckelmann, D.J., Wier, W.G., Mechanism of release of calcium from sarcoplasmic reticulum of guinea pig cardiac cells (1988) J. Physiol., 405, pp. 233-255Fabiato, A., Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell (1985) J. Gen. Physiol., 85, pp. 247-290Leblanc, N., Hume, J.R., Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum (1990) Science, 248, pp. 372-376Levi, A.J., Spitzer, K.W., Kohmoto, O., Bridge, J.H.B., Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes (1994) Am. J. Physiol., 266, pp. H1422-H1433Kohmoto, O., Levi, A.J., Bridge, J.H.B., Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells (1994) Circ. Res., 74, pp. 550-554Bassani, R.A., Bassani, J.W.M., Bers, D.M., Mitochondrial and sarcolemmal Ca transport can reduce [Ca]i during caffeine contractures in rabbit cardiac myocytes (1992) J. Physiol., 453, pp. 591-608Bassani, J.W.M., Bassani, R.A., Bers, D.M., Relaxation in rabbit and rat cardiac cells: Species-dependent differences in cellular mechanisms (1994) J. Physiol., 476, pp. 279-293Bassani, R.A., Bassani, J.W.M., Bers, D.M., Relaxation in ferret ventricular myocytes: Unusual interplay among calcium transport systems (1994) J. Physiol., 476, pp. 295-308Bers, D.M., Bridge, J.H.B., Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum Ca-pump: Ryanodine and voltage sensitivity (1989) Circ. Res., 65, pp. 334-342Bridge, J.H.B., Relationships between the sarcoplasmic reticulum and transarcolemmal Ca transport revealed by rapidly cooling rabbit ventricular muscle (1986) J. Gen. Physiol., 88, pp. 437-473Bers, D.M., Bridge, J.H.B., Spitzer, K.W., Intracellular Ca transients during rapid cooling contractures in guinea-pig ventricular myocytes (1989) J. Physiol., 417, pp. 537-553Bers, D.M., Lederer, W.J., Berlin, J.R., Intracellular Ca transients in rat cardiac myocytes: Role of Na/Ca exchange in excitation-contraction coupling (1990) Am. J. Physiol., 258, pp. C944-C954Hryshko, L.V., Stiffel, V.M., Bers, D.M., Rapid cooling contractures as an index of SR Ca content in rabbit ventricular myocyte (1989) Am. J. Physiol., 257, pp. H1369-H1377Hove-Madsen, L., Bers, D.M., SR Ca uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes (1993) Cir. Res., 73, pp. 820-828Bassani, J.W.M., Bassani, R.A., Bers, D.M., Twitch-dependent SR Ca accumulation and release in rabbit ventricular myocytes (1993) Am. J. Physiol., 265, pp. C533-C540Bassani, R.A., Bers, D.M., Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes (1995) Biophys. J., 68, pp. 2015-2022Bassani, J.W.M., Yuan, W., Bers, D.M., Fractional SR Ca release is altered by trigger Ca and SR Ca content in cardiac myocytes (1995) Am. J. Physiol., 268, pp. 1313-1319Gatto, C., Milanick, M.A., Inhibition of the red blood cell calcium pump by eosin and other fluorescein analogues (1993) Am. J. Physiol., 264, pp. C1577-C1586Gatto, C., Hale, C.C., Milanick, M.A., Eosin, a potent inhibitor of the plasma membrane Ca pump, does not inhibit the cardiac Na-Ca exchanger (1995) Biochemistry, 34, pp. 965-972Bassani, R.A., Bassani, J.W.M., Bers, D.M., Relaxation in ferret ventricular myocytes: Role of the sarcolemmal Ca ATPase (1995) Pflüg. Arch., 430, pp. 573-579Hove-Madsen, L., Bers, D.M., Passive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes (1993) Am. J. Physiol., 264, pp. C677-C686Negretti, N., O'Neill, S.C., Eisner, D.A., The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes (1993) Cardiovasc. Res., 27, pp. 1826-1830Crespo, L.M., Grantham, C.J., Cannell, M.B., Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes (1990) Nature, 345, pp. 618-621Puglisi, J.L., Bassani, R.A., Bassani, J.W.M., Amin, J.N., Bers, D.M., Temperature and the relative contributions of Ca transport systems in cardiac myocyte relaxation (1996) Am. J. Physiol., , In pressDelbridge, L.M., Bassani, J.W.M., Bers, D.M., Steady-state twitch Ca fluxes and cytosolic Ca buffering in rabbit ventricular myocytes (1996) Am. J. 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Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013
No full textSince the launch in 2008 by the National Osteoporosis Guideline Group (NOGG), of guidance for the diagnosis and management of osteoporosis in postmenopausal women and older men in the UK there have been significant advances in risk assessment and treatment. These have been incorporated into an updated version of the guideline, with an additional focus on the management of glucocorticoid-induced osteoporosis, the role of calcium and vitamin D therapy and the benefits and risks of long-term bisphosphonate therapy. The updated guideline is summarised below. The recommendations in the guideline are intended to aid management decisions but do not replace the need for clinical judgement in the care of individuals in clinical practice
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