117,586 research outputs found
In-Batch and In-Flow Synthesis of Thermo-responsive Polymeric Inorganic Nanoparticle Platforms for Cancer Therapy
No full textInorganic nanoparticles (INPs) possess unique optical, magnetic, and electronic features accounting for their wide applicability in fields ranging from opto-electronics to medicine to catalysis. When their hydrophobic surfaces are coated with polymers engineered to become responsive to stimuli like heat, pH, light etc., the resulting polymeric-INPs could be used as platforms to simultaneously mediate the diagnosis and treatment of tumors. To this end, using an in-batch Photo-induced Copper mediated atom transfer radical polymerization technique, the synthesis of a PEG-based thermo-responsive polymer (TR-polymer) grafted onto the surface of chalcopyrite NPs was pursued. On the resulting polymeric-inorganic nanoparticle platform (TR-CuFeS2) Doxorubicin, a chemotherapeutic drug, was loaded in the TR-polymer shell for a heat-mediated drug release while the CuFeS2 NP displayed high heating and tunable reactive oxygen species (ROS) generation upon irradiation with 808nm-NIR laser. Using this platform the multi-therapeutic effect was proven. Similarly, a multi-catechol polymer having PEG stabilizing side chains and furfuryl moieties was synthesized and grafted to the surface of Iron Oxide NPs. To the furfuryl groups, thermal labile fluorescein dyes were tagged as a model drug by Diels-Alder chemistry. The obtained platform under alternating magnetic field (AMF) of clinical use and at very low nanocube dose ([Fe] of 0.5 g/L) were leading to local hot spots which drives the release of the dye without macroscopic temperature change of the solution. Lastly, a novel protocol was developed to produce TR-polymer coated iron oxide nanocubes (TR-Cube) using in-flow processing technique. In comparison with the previous in-batch TR-Cube synthesis, the optimize in-flow synthesis conditions features a much shorter reaction time, easy post polymerization cleanup, and higher % yield of TR-cubes. Thus, the in-flow method is more feasible for large scale clinical production of TR-Cubes than the batch process
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
Lillian L. Lambert, Author, Speaker, and Entrepreneur
No full textLillian L. Lambert, Author, Speaker, and Entrepreneu
Economic Report for the WHO Technical Expert Group Meeting on Intermittent Preventive Treatment of Malaria in Children
No full textFor Intermittent Preventive Treatment of Malaria in Children (IPTc) to be accepted and sustainable as a malaria control strategy it must be affordable and cost effective as well as safe and acceptable. Thus, several of the IPTc studies have included an economic component. These studies range from randomised controlled trials to operational research studies. In addition, modelling was used to supplement the information available from the trials and to provide predictions where the trials could not, for practical reasons, provide estimates. Both financial and economic costs associated with IPTc delivery have been investigated to help forecast how introducing the intervention may impact health budgets, and to help determine the cost effectiveness of IPTc compared to other malaria interventions.
In this report we present the costs and cost-effective of IPTc using three different drug regimens and various delivery strategies. Across all studies, the financial cost per IPTc course range from US3.44 and the economic cost per course from US3.44. These costs are within the range of the costs associated with delivering existing malaria control interventions. The cost effectiveness of the intervention was comparable, but marginally higher than other prevention strategies, however possibilities exist for reducing the costs of IPTc by scaling up and by incorporating delivery of IPTc with the delivery of other interventions such as the distribution of Vitamin A or Community and Home Management of Malaria. Supervision, training and remuneration of CHWs and IPTc drug delivery have been identified as the main cost components and key determinants to the success of the delivery strategy. There is scope for the costs associated with supervision and training to be reduced if IPTc is integrated into existing routine activities. Alternatively, in settings where supervision and training of CHWs is weak, IPTc may offer an opportunity to strengthen both these important aspects of service delivery which will offer benefits beyond reducing malaria morbidity and mortality
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