52 research outputs found
National Institutes of Health classification for chronic graft-versus-host disease predicts outcome of allo-hematopoietic stem cell transplant after fludarabine-busulfan-antithymocyte globulin conditioning regimen
No full textAbstract In 2005, the National Institutes of Health (NIH) proposed standard criteria for diagnosis, organ scoring and global assessment of chronic graft-versus-host disease (cGvHD) severity. We retrospectively reclassified cGvHD with NIH criteria in a monocentric cohort of 130 consecutive adult patients with hematological malignancies presenting cGvHD after receiving allo-hematopoietic stem cell transplant (HSCT) with a fludarabine-busulfan-antithymocyte globulin (ATG) conditioning regimen, among 313 consecutive HSCT recipients. We compared NIH and Seattle classifications to correlate severity and outcome. The follow up range was effectively 2-120 months. Forty-four percent developed Seattle-defined cGvHD (22% limited, 78% extensive forms). Using NIH criteria, there were 23%, 40% and 37% mild, moderate and severe forms, respectively, and 58%, 32% and 8% classic cGvHD, late acute GvHD and overlap syndrome. Five-year overall survival was 55% (49-61), and cumulative incidences of non-relapse mortality (NRM) and relapse/progression at 2 years were 19% (14-23) and 19% (14-24). NIH mild and moderate forms were associated with better survival compared to severe cGvHD (hazard ratio [HR] = 3.28, 95% confidence interval [CI]: 1.38-7.82, p = 0.007), due to higher NRM among patients with severe cGvHD (HR = 3.04, 95% CI: 1.05-8.78, p = 0.04) but comparable relapse risk (p = NS). In conclusion, the NIH classification appears to be more accurate in predicting outcome mostly by the reclassification of old-defined extensive forms into NIH-defined moderate or severe
The accounted human capital of stock listed companies and their firm performances : the search for an association.
No full textSammanfattning Titel: Börsnoterade företags redovisade humankapital och deras företagsprestationer – sökandet efter ett samband Nivå: D-nivå Författare: Joachim Saillard Handledare: Lars Ekstrand Datum: 2013-06-24 Bakgrund: Humankapital är en viktig resurs för samhället och företagen, vilket lett till överväganden huruvida den ska tas med i redovisningen. Divergerande uppfattningar om humankapitalets samband med prestationen i företag leder till ett behov av vidare forskning, i synnerhet utifrån fördjupningsområdet redovisning. Ett klargörande av kunskapsläget vad gäller humankapitalredovisning och företagsprestation kan möjligen bidra med att minska diskrepansen mellan humankapitalredovisning i teorin och praktiken samt tjäna som utgångspunkt för fortsatt forskning. Syfte: Syftet med studien är att göra en beskrivning och kritisk analys av aktuell forskning om sambandet mellan börsnoterade företags redovisade humankapital och deras företagsprestationer. Teori: Den teoretiska referensramen består huvudsakligen av tre sambandsmodeller som beskriver sambandet mellan börsföretags redovisade humankapital och deras företagsprestationer, men även av begreppen: humankapitalredovisning, intellektuellt kapital, humankapitalmått, finansiella prestationsmått och kunskapsföretag. Metod: Uppsatsen är en litteraturanalys/forskningsöversikt baserad på vetenskapliga artiklar. Empirin består av tidigare empirisk forskning som har analyserats genom sekundäranalys. Resultat och slutsatser: Den empiriska forskningen har hittills givit blandade resultat och sambandet mellan börsnoterade företags redovisade humankapital och deras företagsprestationer har inte verifierats i tillräckligt hög utsträckning, vilket försvårar tolkningen av resultaten. Forskningsresultaten hittills tycks likväl tyda på ett positivt samband mellan börsnoterade företags redovisade humankapital och deras företagsprestationer samt att detta samband gäller humankapitalkategorierna: anställda, kunskap och produktivitet; finansiella prestationsmått; industriella marknader och kunskapsföretag. Den granskade forskningen tyder också på att det finns flera redovisningsdimensioner av sambandet mellan börsnoterade företags redovisade humankapital och deras företagsprestationer. Dimensionerna är: humankapitalredovisning, redovisning av intellektuellt kapital, frivillig redovisning och kvaliteten och omfattningen av redovisningen. Förslag till fortsatt forskning: En idé till fortsatt forskning är att undersöka potentiella kausala samband mellan humankapitalredovisning och prestation i svenska företag, genom företagsanalyser, för att på detta sätt söka skapa empirisk falsifiering av sambandsmodellerna. En annan idé kan vara att undersöka någon av de dimensioner som fenomenet – börsnoterade företags redovisade humankapital och deras företagsprestationer – innefattar. Dimensionerna framgår av föregående stycke och är viktiga för att i forskningen täcka in sambandets komplexitet. Uppsatsens bidrag: Uppsatsens bidrag är en genomgång av aktuell forskning om sambandet mellan börsföretags redovisade humankapital och deras företagsprestationer och kan därmed användas som utgångspunkt för fortsatt forskning inom området humankapitalredovisning. Nyckelord: Humankapital, humankapitalredovisning, börsnoterade företag, humankapitalmått, finansiella prestationsmått, samband mellan redovisat humankapital och företagsprestationer, kunskapsföretag.Abstract Title: The accounted human capital of stock listed companies and their firm performances – the search for an association. Level: D-level Author: Joachim Saillard Supervisor: Lars Ekstrand Date: 2013-06-24 Background: Human capital is an important resource for companies and society, which has lead to considerations, whether it should be accounted for, or not. Divergent views on human capital and the connection to firm performance, leads to a need for further research, especially from the accounting point of view. A demonstration of the known research on human capital accounting and company performance, can possibly contribute to reducing the discrepancy concerning human capital accounting, in theory and practice, and serve as a starting point for further research. Aim: The study’s aim is to give a description and a critical analysis of the current research on the association between stock listed companies’ accounted human capital and their firm performances. Theory: The theoretical reference frame mainly consists of three association models on the accounted human capital of stock listed companies and their firm performances, as well as the concepts of: human capital accounting, intellectual capital, human capital- and financial performance measures and knowledge companies. Method: The thesis is a literature review, based on research papers. The empirical material consists of past empirical research which has been analyzed through secondary analysis. Results and conclusions: The empirical research, has until now, given mixed results and the verification of the association between the accounted human capital of stock listed companies and their firm performances is modest, which complicates the interpretation of the results. The known research, however seems to show a positive relationship between stock listed companies’ accounted human capital and their firm performances and that this relationship concerns the human capital measures: employees, knowledge and productivity; financial performance measures; industrial markets and knowledge companies. The examined research also seems to point out that there are several accounting dimensions of the association between stock listed companies’ accounted human capital and their firm performances. These dimensions are: human capital accounting, accounting for intellectual capital, voluntary disclosure and the quality and comprehensiveness of accounting. Suggestions for future research: An idea for future research is to examine potential causal relationships between human capital accounting and performance in Swedish companies, through company analyzes – in order to try to establish an empirical falsification of the association models. An other idea could be to examine the dimensions of the phenomenon – stock listed companies’ accounted human capital and their firm performances. These dimensions were made clear in the previous paragraph, and are important to study in order to capture the complexity of the association, in the research field. Contribution of thesis: The contribution of the thesis is a review of current research on the association between stock listed companies’ accounted human capital and their firm performances and can thus be used as a starting point for further research within the area of human capital accounting. Key words: Human capital, human capital accounting, stock listed companies, human capital measures, financial performance measures, connections between accounted human capital and firm performances, knowledge companies
Swot-modellen : modellen, dess användning och användbarhet för framgångsrika företag i regionen
No full textSammanfattning Titel: Swot-modellen – Modellen, dess användning och användbarhet för framgångsrika företag i regionen Nivå: C-uppsats i ämnet företagsekonomi Författare: Joachim Saillard Handledare: Lars Torsten Eriksson Datum: 2012-07-16 Bakgrund: Swot-modellen ger en struktur för beskrivning och analys av en organisations starka samt svaga sidor, dess externa hot och möjligheter. Modellen har funnits i cirka 50 år och nått stor spridning. Vad har forskningen om swot-modellen hittills kommit fram till? Hur ser små- och medelstora företag i Gävleregionen på modellen i sina praktiker? Syfte: Syftet med uppsatsen är att göra en state-of-the-art genomgång av forskningen om swot-modellen samt visa hur en grupp regionala små- och medelstora företag använder modellen samt kritiskt testa Framför-databasens potential som empiriskt material. Avsikten är att lägga en grund samt skapa en utgångspunkt för fortsatt forskning om modellen som verktyg för företagsutveckling i den regionala miljön. Metod: Studien bygger på en genomgång av ett stort antal forskningsartiklar om swot-modellen. De flesta artiklar analyserar enskilda aspekter av modellen, medan några visar sig ge en översikt över olika modellstudier. Eftersom det visar sig att ytterst få studier redovisar empiriska data om modellens användning och fortsatta empiriska studier behövs, har en genomgång också gjorts av swot-kommentarer i en databas för regionala företag – det så kallade Framför-projektet som drivs av bland annat Svenskt Näringsliv, Aktiv Revision och kommunerna i Gästrikland. I databasen finns registrerade data för små- och medelstora företag, åren 2002-2012. Databasen bygger på standardiserade intervjuer där svar registrerats om swot-data. Baserade på dessa har en sekundäranalys gjorts och den empiriska genomgången har behandlats som en pilotstudie om företags beskrivning av interna faktorer. Resultat & slutsatser: Studien ger en analys av forskningen om swot-modellen. Den visar att antalet teoretiska studier om swot-modellen ökat, medan få empiriska studier gjorts. Den empiriska delen visar att företagen i regel är väl förtrogna med modellen, men inte alltid har aktuella värden för dess huvudkategorier. Den aktuella databasen behöver förstärkas och modellen ges en bättre koppling till aktiv implementering. Förslag till fortsatt forskning: Fortsatta studier behövs om företagens strategiska beslutssituationer utifrån swot-modellen som utvärderingsverktyg, och möjligen andra kompletterande teorier/modeller. Uppsatsens bidrag: Studien ger en överblick över den hittillsvarande forskningen om swot-modellen, dess användning och användbarhet för olika organisationer. Eftersom förvånansvärt få empiriska studier hittills gjorts kan uppsatsens empiriska studie ses som ett särskilt forskningsbidrag. Nyckelord: Swot, företag, interna faktorer det vill säga starka och svaga sidor, strategisk planering, Framför-databasen, swot-modellens dualperspektiv.Abstract Title: The swot model – the model, its usage and usefulness for successful firms in the region Level: Final assignment for Bachelor Degree in Business Administration Author: Joachim Saillard Supervisor: Lars Torsten Eriksson Date: 2012-07-16 Background: The swot-model provides a structure for description and analysis of an organizations strong and weak sides, its opportunities and threats. The model has existed approximately 50 years and has attained a big spread. What has the present research on swot concluded? How do small- and medium sized firms in the region of Gävle treat the model in their practices? Aim: The aim of the thesis is to do a state-of-the-art review on the research concerning the swot-model, and to show how a group of regional small- and medium sized firms use the model as well as to conduct a critical examination of the Framför-databases potential as empirical substance. The intention is to form a basis and starting point for future research, regarding to the model as a tool for business development in the regional environment. Method: The study is founded on a review of a big number of research papers about the swot-model. Most of them analyze certain aspects of the model, while others seem to give a summary over different model studies. Since there has been shown to be exceedingly few studies who account for empirical data about the models use and further empirical studies is needed, a review of a database containing swot-comments – the so called Framför-project which is run by the Federation of Swedish Enterprise, Aktiv Revision and the municipalities in Gästrikland, has also been carried out. In the database there are registered data for small- and medium sized firms between the years 2002-2012. The database builds on standardized interviews of which swot-data have been registered. Based on this, secondary analysis has been carried out and the empirical review has been attended as a pilot study about firms’ descriptions of their internal factors. Result & Conclusions: The study provides an analyze on research concering the swot-model. It shows that the number of theoretical studies about the swot-model has increased, while few empirical studies have been carried out. The empirical part of the study shows that the firms generally are well familiar with the model, but that they don’t always have current values for its main categories. The current database needs to be strengthened and the model given a better connection to active realization. Suggestions for future research: Future research is needed about the firms strategic decision situations with the swot-model as an evaluation tool as starting point, and possibly other complementing theories/models. Contribution of the thesis: The thesis provides an overview over the research up until now concerning the swot-model, its use and usefulness for different organizations. Since surprisingly few present empirical studies have been carried out, the empirical study that the thesis provides can be seen as a particular research contribution. Key words: Swot, firms, internal factors i.e. strong and weak sides, strategic planning, the Framför-database, swot-model dual perspective
A Book Exhibit at the Musée Pompidou
No full textIn her poetic introduction to the exhibit of her books, which she also curated for the Musée Pompidou, the author goes beneath the surface of the genre of artist’s book—beyond the materials and the aesthetics into their meanings replete with uncertainty and enigma. Four projects from this exhibit are presented; each demonstrates a divergent approach and intention
Export Price Stability and Compatibility of Euro under the Export- Biased Productivity Growth in Turkey: A Criticism against the Maastricht Inflation Criterion
No full textIn this work, we analyzed the export- biased productivity, wage growth and the ULCP in Turkey. Then, by using input- output methods , we could show that Turkey has an economy which is able to be a part of the Euro system and Euro is compatible under the export- biased productivity growth in Turkey though its relatively high inflation. That means Maastricht inflation criterion should be revised in terms of countries’ economic performance
Non-invasive ventilation indication for critically ill cancer patients admitted to the intensive care unit for acute respiratory failure (ARF) with associated cardiac dysfunction: Results from an observational study.
No full textBackgroundAcute respiratory failure (ARF) is a life-threatening complication in onco-hematology patients. Optimal ventilation strategy in immunocompromised patients has been highly controversial over the last decade. Data are lacking on patients presenting with ARF associating isolated cardiac dysfunction or in combination with another etiology. The aim of this study was to assess prognostic impact of initial ventilation strategy in onco-hematology patients presenting ARF with associated cardiac dysfunction.MethodsWe conducted an observational retrospective study in Institut Paoli-Calmettes, a cancer-referral center, assessing all critically ill cancer patients admitted to the ICU for a ARF with cardiac dysfunction.ResultsBetween 2010-2017, 127 patients were admitted. ICU and hospital mortality were 29% and 57%. Initial ventilation strategy was invasive mechanical ventilation (MV) in 21%. Others ventilation strategies were noninvasive ventilation (NIV) in 50%, associated with oxygen in 21% and high flow nasal oxygen (HFNO) in 29%, HFNO alone in 6% and standard oxygen in 23%. During ICU stay, 48% of patients required intubation. Multivariate analysis identified 3 independent factors associated with ICU mortality: SAPSII at admission (OR = 1.07/point, 95%CI = 1.03-1.11, pConclusionIn onco-hematology patients admitted for ARF with associated cardiac dysfunction, severity at ICU admission, invasive fungal infections and initial ventilation strategy were independently associated with ICU mortality. NIV was a protective factor on ICU mortality
Venetoclax in Acute Myeloid Leukemia: Molecular Basis, Evidences for Preclinical and Clinical Efficacy and Strategies to Target Resistance
No full textVenetoclax is a BH3-mimetics agent specifically interacting with the antiapoptotic protein BCL-2, facilitating cytochrome c release from mitochondria, subsequent caspases activation, and cell death. Utilization of venetoclax has profoundly changed the landscape of treatment for the poor-prognosis category of AML patients unfit for intensive chemotherapy. In the phase III VIALE-A study, Venetoclax, in combination with the hypomethylating agent azacitidine, showed a 65% overall response rate and 14.7-month overall survival, in comparison with 22% and 8 months in the control arm. These results led to the widespread use of venetoclax in this indication. Other combination regimens, consisting of low-intensity, intensive, or targeted therapies are currently under evaluation. Despite promising results, preventing relapses or resistance to venetoclax is still an unmet clinical need. Numerous studies have been conducted to identify and overcome venetoclax resistance in preclinical models or in clinical trials, including the inhibition of other antiapoptotic proteins, the induction of proapoptotic BH3-only proteins, and/or the targeting of the mitochondrial metabolism and machinery
Devenir des patients âgés de plus de 60 ans admis en réanimation à la phase initiale d’une leucémie aiguë
No full textIntroduction : les leucémies aiguës sont les hémopathies malignes les plus consommatrices de séjour en service de réanimation. Concernant majoritairement les sujets âgés de plus de 60 ans, elles sont associées à un ensemble de situations pouvant mettre en jeu le pronostic vital, inhérentes à la fois à l’agressivité de ces pathologies et aux toxicités des thérapeutiques utilisées. Peu de données existent actuellement quant au devenir des sujets âgés atteints de leucémie aiguë et admis en réanimation. Les protocoles thérapeutiques actuels permettent pourtant d’espérer des survies prolongées pour cette population à la prise en charge complexe. Dans cette étude, nous nous sommes intéressés au devenir des sujets âgés de plus de 60 ans, et admis en réanimation au diagnostic d’une leucémie aiguë. Méthodologie : cette étude de cohorte monocentrique rétrospective a porté sur 164 patients admis en réanimation à l’Institut Paoli-Calmettes entre Avril 2010 et Octobre 2020, à la phase initiale de prise en charge d’une leucémie aigüe. 139 patients étaient atteints de leucémie aigüe myéloblastique, 10 de leucémie aigüe promyélocytaire et 15 de leucémie aiguë lymphoblastique. 3 groupes de patients ont été distingués selon la présence de critères biologiques institutionnels de « haut risque » de défaillances d’organes/complications (thrombopénie 50G/L) et le moment d’apparition d’une défaillance d’organe. Des modèles de régression logistique multiple ont été utilisés pour déterminer les facteurs prédictifs de mortalité intra-hospitalière, à J90 et 1an du diagnostic. Résultats : pour les patients atteints de LAM, les taux de mortalité intra-hospitalière, à J90 et à 1 an étaient de 37%, 42% et 60% respectivement. Les facteurs associés à la mortalité intra-hospitalière étaient l’index de comorbidités de Charlson, la nécessité d’un recours à la ventilation mécanique invasive et la défaillance multi-viscérale. Les patients présentant des critères biologiques de haut risque avaient une mortalité intra-hospitalière similaire à ceux présentant une défaillance d’organe immédiate. Les caractéristiques cytogénétiques et moléculaires de la pathologie onco-hématologique n’impactaient pas la mortalité précoce des patients. A 1 an toutefois, le risque ELN 2017 devenait significativement associé à la mortalité. Le sexe masculin, l’âge au diagnostic et le recours à une ventilation mécanique invasive étaient eux-aussi prédictifs d’une surmortalité (Figure 3). Conclusion : notre étude démontre la faisabilité d’une prise en charge en réanimation des sujets âgés de plus de 60 ans à l’induction d’une leucémie aigüe. Elle affirme l’implication des caractéristiques du patient (âge, comorbidités) et de la sévérité des défaillances d’organes sur la mortalité à court terme. Elle met en évidence l’impact des caractéristiques cytogénétiques et moléculaires de l’hémopathie maligne sur la mortalité à long terme et son absence sur la mortalité précoce. Elle confirme l'intérêt de critères biologiques particuliers quant à la possibilité d’une admission préemptive en soins critiques de malades non défaillants mais à haut risque de développer précocement des complications à la phase initiale
Simulation of microwave scattering from wind-driven ocean surfaces
No full textAn efficient approach for fast analysis of vector wave scattering from random rough surtaces is described in this paper. Numerical examples are provided to demonstrate the merits of the scheme. The underlying methodology lies on using a single integral equation formulation combined with a multilevel sparse-matrix canonical-grid method. Triangular patches are employed to tightly model the surfaces. A localized approximation method is employed for the highly conductive seawater medium. A beam decomposition technique is incorporated to cope with an extremely large surface. Monte-Carlo simulation results are presented as bistatic scattering coefficients for wind-driven ocean surfaces illuminated by microwave beams at L-band. A special attention is paid to low grazing incidences due to its practical importance.Engineering, Electrical & ElectronicRemote SensingTelecommunicationsCPCI-S(ISTP)
Acute respiratory failure in immunocompromised patients : outcome and clinical features according to neutropenia status
No full textAbstract
Background
The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF according to neutropenia.
Methods
We performed a post hoc analysis of a prospective multicenter multinational study from 23 ICUs belonging to the Nine-I network. Between November 2015 and July 2016, all adult immunocompromised patients with ARF admitted to the ICU were included in the study. Adjusted analyses included: (1) a hierarchical model with center as random effect; (2) propensity score (PS) matched cohort; and (3) adjusted analysis in the matched cohort.
Results
Overall, 1481 patients were included in this study of which 165 had neutropenia at ICU admission (11%). ARF etiologies distribution was significantly different between neutropenic and non-neutropenic patients, main etiologies being bacterial pneumonia (48% vs 27% in neutropenic and non-neutropenic patients, respectively). Initial oxygenation strategy was standard supplemental oxygen in 755 patients (51%), high-flow nasal oxygen in 165 (11%), non-invasive ventilation in 202 (14%) and invasive mechanical ventilation in 359 (24%). Before adjustment, hospital mortality was significantly higher in neutropenic patients (54% vs 42%; p = 0.006). After adjustment for confounder and center effect, neutropenia was no longer associated with outcome (OR 1.40, 95% CI 0.93–2.11). Similar results were observed after matching (52% vs 46%, respectively; p = 0.35) and after adjustment in the matched cohort (OR 1.04; 95% CI 0.63–1.72).
Conclusion
Neutropenia at ICU admission is not associated with hospital mortality in this cohort of critically ill immunocompromised patients admitted for ARF. In neutropenic patients, main ARF etiologies are bacterial and fungal infections
- …
