112,578 research outputs found
Colonna and Petrarch in the Rime of Lucia Colao
No full textThis paper focuses on the lyric production of the Friulian writer Lucia Colao (b. 1578), which survives in two manuscripts, in the state libraries of Treviso and Vittorio Veneto. Colao’s Rime represent a rare contribution by a woman to the tradition of spiritual rewritings of Petrarch’s Fragmenta, which began in the 1530s with Girolamo Malipiero’s Petrarca spirituale. Colao recasts in a spiritual form 121 Petrarchan texts (sonnets and canzoni), all deriving from the first part of the RVF and mainly following the sequence of the original. The paper analyzes the complexities of the relationship between hypotext and hypertext in Colao’s Petrarchan reworkings, and the dialectic between conservation, substitution, and resemantization of the lexis and content of the originals. At the same time, it considers the way in which Colao’s texts construct a feminine subject within lyric discourse, in a manner which reflects the lessons of Vittoria Colonna’s earlier creative appropriation of Petrarch in her spiritual lyrics
Role of the lipid rafts in the life cycle of canine coronavirus
No full textCoronaviruses are enveloped RNA viruses that have evolved complex relationships with their host cells, and modulate their lipid composition, lipid synthesis and signalling. Lipid rafts, enriched in sphingolipids, cholesterol and associated proteins, are special plasma membrane microdomains involved in several processes in viral infections. The extraction of cholesterol leads to disorganization of lipid microdomains and to dissociation of proteins bound to lipid rafts. Because cholesterol-rich microdomains appear to be a general feature of the entry mechanism of non-eneveloped viruses and of several coronaviruses, the purpose of this study was to analyse the contribution of lipids to the infectivity of canine coronavirus (CCoV). The CCoV life cycle is closely connected to plasma membrane cholesterol, from cell entry to viral particle production. The methyl-β-cyclodextrin (MβCD) was employed to remove cholesterol and to disrupt the lipid rafts. Cholesterol depletion from the cell membrane resulted in a dose-dependent reduction, but not abolishment, of virus infectivity, and at a concentration of 15 mM, the reduction in the infection rate was about 68 %. MβCD treatment was used to verify if cholesterol in the envelope was required for CCoV infection. This resulted in a dose-dependent inhibitory effect, and at a concentration of 9 mM MβCD, infectivity was reduced by about 73 %. Since viral entry would constitute a target for antiviral strategies, inhibitory molecules interacting with viral and/or cell membranes, or interfering with lipid metabolism, may have strong antiviral potential. It will be interesting in the future to analyse the membrane microdomains in the CCoV envelope
Characterization and discrimination of plastic materials using laser-induced fluorescence
No full textThe most meaningful spectral components in laser-induced fluorescence (LIF) spectra for several different commercial plastics have been individuated and used to automatically discriminate among different plastic materials and between plastics and complex organic materials, such as woods. Starting from LIF measurements on known samples, a number of significant wavelengths have been identified by principal component analysis (PCA). These have been used to produce intensity ratios functional to the discrimination. Threshold values for such ratios have been individuated in order to obtain an automatic recognition of plastics. The work done has been preparatory to the design and development of a multispectral imaging LIF system for fast detection of plastic debris in a post-blast scene. © The Author(s) 2016
Biomechanical overload of the arm:experience with risk prevention in the Fabrian metal-mechanical industy.
No full textIn the year 2000, the S.P.S.A.L. of Fabriano territorial zone, after a high number of reported cases of CTS in the Orthopedic Unit of the local hospital, started an informative and preventive study program on the risk of biomechanical overloading of the upper extremities. The study was divided in four main steps: 1. Epidemiological study I. A questionnaire assessing professional and pathological anamnesis, musculoskeletal disorders of the upper extremities as well as the professional and non professional risk factors was administered to 448 assembly line workers in seven metal mechanic factories (2000-2001). 2. Lecture for the proposed institution to communicate the results of study I (2001). 3. Evaluation of the trend on professional diseases reported by medical doctors and verified by INAL during the years 1999-2005. 4. Epidemiological study II. The same questionnaire from the first study has been administered to 448 assembly line workers in the same industries selected for the previous investigation (2005). The first study results, presented in the December 2001 lecture from the supervising institution, indicated the departments at risk and showed the necessity of collaboration between specific departments and specialized medical doctors to achieve a rapid diagnosis of work-related diseases. Following our data, the companies have adopted preventative measures, scientific methods of specific risk evaluation as well specific protocols of health survey. Both the reported and the verified diseases showed an increment starting from 2002. The comparison between the two studies demonstrated that the second group had a reduction in the CTS prevalence and in the other work-related upper extremities disorders; a reduction in the repetitive movements, in the use of vibrating instruments and work force; an increment in the number of working pauses and rotation exercises; an increment in the position switch following the appearance of the disorders. However, the results obtained show a fundamental discrepancy: a better trend has been observed in the big companies, but it is still not sufficient in the smaller companies
Application of molecular biology of differentiated thyroid cancer for clinical prognostication
No full textAlthough cancer outcome results from the interplay between genetics and environment, researchers are making a great effort for applying molecular biology in the prognostication of differentiated thyroid cancer (DTC). Nevertheless, role of molecular characterisation in the prognostic setting of DTC is still nebulous. Among the most common and well-characterised genetic alterations related to DTC, including mutations of BRAF and RAS and RET rearrangements, BRAF(V600E) is the only mutation showing unequivocal association with clinical outcome. Unfortunately, its accuracy is strongly limited by low specificity. Recently, the introduction of next-generation sequencing techniques led to the identification of TERT promoter and TP53 mutations in DTC. These genetic abnormalities may identify a small subgroup of tumours with highly aggressive behaviour, thus improving specificity of molecular prognostication. Although knowledge of prognostic significance of TP53 mutations is still anecdotal, mutations of the TERT promoter have showed clear association with clinical outcome. Nevertheless, this genetic marker needs to be analysed according to a multigenetic model, as its prognostic effect becomes negligible when present in isolation. Given that any genetic alteration has demonstrated, taken alone, enough specificity, the co-occurrence of driving mutations is emerging as an independent genetic signature of aggressiveness, with possible future application in clinical practice. DTC prognostication may be empowered in the near future by non-tissue molecular prognosticators, including circulating BRAF(V600E) and miRNAs. Although promising, use of these markers needs to be refined by the technical sight, and the actual prognostic value is still yet to be validated
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Complete disappearance of liver metastases in a patient with iodine-refractory differentiated thyroid cancer subjected to sorafenib re-challenge
No full textThe tyrosine-kinase inhibitor (TKI) sorafenib is the most studied targeted agent for the treatment of radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). Its specificity for this clinical setting was suggested by the inhibition of the RAF kinases, which are
strikingly involved in the development and progression of thyroid cancer. Nevertheless, sorafenib has a multifunctional activity, and is also active on TK-angiogenic receptors, thus inhibiting neoangiogenesis, which is considered crucial for progression of the disease. The phase III
trial DECISION has definitively proved efficacy of sorafenib in RAI-refractory DTC, leading to the approval by the Food and Drug Administration. Given that the study cohort included only TKIs naive patients, sorafenib can be fully considered the first-line systemic therapy for this clinical setting. Nevertheless, such treatment is never curative and has a temporally limited effect. To date, clear indications about the management of RAI-refractory DTC patients after the failure of first-line sorafenib are lacking
DE LATERI=||BVS ET ANGVLIS TRI-||angulorum, tum planorum rectilineorum,|| tum Sphaericorum, libellus eruditissimus || & utilissimus ... || scriptus à Clarissimo & || doctissimo uiro D.Ni-||colao Copernico || Toronensi.|| Additus est Canon semissium subten=||sarum rectarum linearum || in Circulo.||
No full textDE LATERI=||BVS ET ANGVLIS TRI-||ANGULORUM, TUM PLANORUM RECTILINEORUM,|| TUM SPHAERICORUM, LIBELLUS ERUDITISSIMUS || & UTILISSIMUS ... || SCRIPTUS À CLARISSIMO & || DOCTISSIMO UIRO D.NI-||COLAO COPERNICO || TORONENSI.|| ADDITUS EST CANON SEMISSIUM SUBTEN=||SARUM RECTARUM LINEARUM || IN CIRCULO.||
DE LATERI=||BVS ET ANGVLIS TRI-||angulorum, tum planorum rectilineorum,|| tum Sphaericorum, libellus eruditissimus || & utilissimus ... || scriptus à Clarissimo & || doctissimo uiro D.Ni-||colao Copernico || Toronensi.|| Additus est Canon semissium subten=||sarum rectarum linearum || in Circulo.|| ([1]r)
Titelseite ([1]r)
Doctrina Et Virtvte Praestanti Georgio Hartmano Noribergensi, Ioachimus Rheticus S. D. ([2]r)
De Lateribvs Et Angvlis Triangvlorum planorum rectilineorum. ([4]r)
De Triangvlis Sphaericis ([6]r)
Canon Svbtensarvm ([12]v
Thyroid diseases in elderly.
No full textThyroid diseases are the commonest endocrine disorders in the general population. In most of the cases, they are consistent with benign conditions which may be asymptomatic or affect people at a variable extent. Since they often represent chronic conditions their prevalence increases by age and reaches in elderly the highest rates. Thyroid nodules are a common clinical finding. Most subjects with thyroid nodules have few or no symptoms. Thyroid nodules are more commonly non-functioning. However, in elderly, toxic multinodular goiter is the most frequent cause of spontaneous hyperthyroidism and often, it emerges insidiously from nontoxic multinodular goiter. Although autoimmune thyroiditis is the most common cause of hypothyroidism in elderly subjects, other causes, such as drugs, neck radiotherapy, thyroidectomy or radioiodine therapy, are frequently observed among these subjects. A small subset of medications including dopamine agonists, glucocorticoids and somatostatin analogs affect thyroid function through suppression of TSH. Other medications that may affect TSH levels are metformin, antiepileptic medications, lithium carbonate and iodine-containing medications. Other drugs can alter T4 absorption, T4 and T3 transport in serum and metabolism of T4 and T3, such as proton-pump inhibitors and antacids, estrogens, mitotane and fluorouracil, phenobarbital and rifampin. Amiodarone administration is associated with thyrotoxicosis or hypothyroidism. Thyroid cancer has similar characteristics in elderly as in general population, however the rate of aggressive forms such as the anaplastic histotype, is higher in older than younger subjects. Diagnosis of thyroid diseases includes a comprehensive medical history and physical examination and appropriate laboratory tests. A correct diagnosis of thyroid diseases in the elderly is crucial for proper treatment, which consists in the removal of medications that may alter thyroid function, in the use of levo-thyroxine in case of hypothyroidism, anti-thyroid drugs in case of hyperthyroidism and use of surgery, radioiodine therapy and percutaneous ablative procedures in selected cases. In conclusion, thyroid diseases in patients older than 60 years deserve attention from different points of view: the prevalence is different from the young adult; symptoms are more nuanced and makes difficult the diagnosis; age and comorbidity often force therapeutic choices and may limit safety and efficacy of therapy. Finally, in elderly patients for whom specific therapy is necessary, more gradual and careful therapeutic approach and close follow-up are recommended in order to minimize the alterations of thyroid function which are induced by many drugs commonly used in clinical practice
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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