407 research outputs found
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
No full textWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Efficient preservation of young terrestrial organic carbon in sandy turbidity-current deposits
No full text© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hage, S., Galy, V. V., Cartigny, M. J. B., Acikalin, S., Clare, M. A., Grocke, D. R., Hilton, R. G., Hunt, J. E., Lintern, D. G., McGhee, C. A., Parsons, D. R., Stacey, C. D., Sumner, E. J., & Talling, P. J. Efficient preservation of young terrestrial organic carbon in sandy turbidity-current deposits. Geology, 48(9), (2020): 882-887, doi:10.1130/G47320.1.Burial of terrestrial biospheric particulate organic carbon in marine sediments removes CO2 from the atmosphere, regulating climate over geologic time scales. Rivers deliver terrestrial organic carbon to the sea, while turbidity currents transport river sediment further offshore. Previous studies have suggested that most organic carbon resides in muddy marine sediment. However, turbidity currents can carry a significant component of coarser sediment, which is commonly assumed to be organic carbon poor. Here, using data from a Canadian fjord, we show that young woody debris can be rapidly buried in sandy layers of turbidity current deposits (turbidites). These layers have organic carbon contents 10× higher than the overlying mud layer, and overall, woody debris makes up >70% of the organic carbon preserved in the deposits. Burial of woody debris in sands overlain by mud caps reduces their exposure to oxygen, increasing organic carbon burial efficiency. Sandy turbidity current channels are common in fjords and the deep sea; hence we suggest that previous global organic carbon burial budgets may have been underestimated.We thank C. Johnson, M. Lardie, A. Gagnon, A. McNichol, and the NOSAMS (National Ocean Sciences Accelerator Mass Spectrometry) team (Woods Hole Oceanographic Institution [WHOI], Massachusetts, USA) for their help with ramped oxidation system and isotopes. We thank the captain and crew of CCGS Vector. Support was provided by UK Natural Environment Research Council (NERC) grants NE/M007138/1 (to Cartigny) and NE/L013142/1 (to Talling), NE/P005780/1 and NE/P009190/1 (to Clare); a Royal Society Research Fellowship (to Cartigny); an International Association of Sedimentologists Postgraduate Grant and National Oceanography Centre Southampton–WHOI exchange program funds (to Hage); an independent study award from WHOI (to Galy); the Climate Linked Atlantic Sector Science (CLASS) program (NERC grant NE/R015953/1); and the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant 725955, to Parsons). We thank François Baudin, Xingqian Cui, editor James Schmitt, and three anonymous reviewers
Perceptions of wildland fire smoke : literature synthesis
No full textAutumn Ellison, Heidi Huber-Stearns, Stacey Sargent Frederick, Michael R. Coughlan, Sarah McCaffrey, and Christine S. Olsen.Title from PDF cover (viewed on July 22, 2021).This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 23-25).This synthesis was made possible with funds from the Joint Fire Science Program and the University of Oregon. It is a Northwest Fire Science Consortium product that was created over several years with initial input from scholars involved in JFSP Project #10-1-03-7.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Why black children can't grow up: the construction of racial childhood in American Llfe, 1896-1954
No full textThis dissertation explores how black childhood was constructed as a racial ideology during the Jim Crow era. I discuss how the extension of white childhood and the construction of the white child’s innocence depended upon the curtailment and demonization of the black child. Using oral narratives, medical studies, visual imagery, literature, sociological data, intelligence
tests, court records and news articles, the individual chapters reveal how the racialization of the black child unfolded at each developmental milestone of life – birth, adolescence, and puberty. The insidious consequences, past and present, was foundational to the formation of a post-Emancipation racial hierarchy and to various regimes of social control in American society. Unlike their parents and grandparents, the Jim Crow era’s black children grew up as free citizens and free laborers with no memory of slavery. And so a new ideology of repression emerged to contain them, to cast doubt upon their capabilities for citizenship and intellect, to exempt them from the powerful category of innocence, and to demean the value of their labor. Without the racialization of black children, without controlling their minds and their bodies, they would have grown to be full and equal citizens. My agenda expands beyond victimization to hope, telling how African-American parents, both leaders and ordinary folk along with their white allies, created a rich counter narrative to defend and protect black children. In
hopes of inspiring institutional reform and positive change in the age of Obama, this historical
investigation seeks to help contemporary Americans understand how racism shaped cultural stereotypes and social welfare policies so damaging to black children.Ph.D.Includes bibliographical referencesIncludes vitaby Stacey Pamela Patto
This (traumatized, kinky, queer) body holds a story
No full textThe chapter, "This (traumatized, kinky, queer) body holds a story" was written by Amber Dawn (Douglas College Faculty). Personal stories of surviving after the trauma of sexual assault. In the era of #MeToo, we’ve become better at talking about sexual assault. But sexual assault isn’t limited to a single, terrible moment of violence: it stays with survivors, following them wherever they go. Through the voices of twelve diverse writers, Whatever Gets You Through offers a powerful look at the narrative of sexual assault not covered by the headlines—the weeks, months, and years of survival and adaptation that people live through in its aftermath. With a foreword by Jessica Valenti, an extensive introduction by editors Stacey May Fowles and Jen Sookfong Lee, and contributions from acclaimed literary voices such as Alicia Elliott, Elisabeth de Mariaffi, Heather O’Neill, and Juliane Okot Bitek, the collection explores some of the many different forms that survival can take. From ice hockey to kink, boxing to tapestry-making, these striking personal essays address experiences as varied as the writers who have lived them. With candor and insight, each writer shares their own unique account of enduring: the everyday emotional pain and trauma, but also the incredible resilience and strength that can emerge in the aftermath of sexual assault. --From publisher description.Published
Patient perspectives on switching disease-modifying therapies in the NARCOMS registry
No full textAmber R Salter,1 Ruth Ann Marrie,2,3 Neetu Agashivala,4 Daniel A Belletti,4 Edward Kim,4 Gary R Cutter,1 Stacey S Cofield,1 Tuula Tyry51Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Internal Medicine, 3Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada; 4Novartis Pharmaceutical Corporation, East Hanover, NJ, USA; 5Division of Neurology, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USAIntroduction: The evolving landscape of disease-modifying therapies (DMTs) for multiple sclerosis raises important questions about why patients change DMTs. Physicians and patients could benefit from a better understanding of the reasons for switching therapy. Purpose: To investigate the reasons patients switch DMTs and identify characteristics associated with the decision to switch.Method: The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry conducted a supplemental survey among registry participants responding to the 2011 update survey. The supplemental survey investigated reasons for switching DMT, origin of the discussion of DMT change, and which factors influenced the decision. Chi-square tests, Fisher’s exact tests, and logistic regression were used for the analyses. Results: Of the 691 eligible candidates, 308 responded and met the inclusion criteria (relapsing disease course, switched DMT after September 2010). The responders were 83.4% female, on average 52 years old, with a median (interquartile range) Patient-Determined Disease Steps score of 4 (2–5). The most recent prior therapy included first-line injectables (74.5%), infusions (18.1%), an oral DMT (3.4%), and other DMTs (4.0%). The discussion to switch DMT was initiated almost equally by physicians and participants. The primary reason for choosing the new DMT was based most frequently on physician’s recommendation (24.5%) and patient perception of efficacy (13.7%). Conclusion: Participants frequently initiated the discussion regarding changing DMT, although physician recommendations regarding the specific therapy were still weighed highly. Long-term follow-up of these participants will provide valuable information on their disease trajectory, satisfaction with, and effectiveness of their new medication. Keywords: multiple sclerosis, health communicatio
Zelda Fitzgerald: The Unreachable Female Artist and American Dream
No full textThis poster presents a dissertation which will explore Zelda Fitzgerald’s dual personality, both as a flapper and a writer, whilst analysing the failed female artists in her only novel and short stories. This will be done by examining how Zelda’s novel, Save Me the Waltz, reflects the socio-historical context in which it was produced, and more specifically the status and role of women in society in nineteen-twenties America. This dissertation will demonstrate how Zelda’s writings suggest that despite social advancements for women and new experimentation in aesthetic and form, there was still communal notions of domesticity that remained inescapable for the independent modernist woman and artist. By being split into three sections, this dissertation will follow a who, what and why framework. Chapter one will explore how Zelda enable’s narrative through autobiography, displaying herself, and her female protagonists as artists. This chapter will demonstrate how both Zelda and her protagonists are dreams, aspirers and hard-workers whilst demonstrating how arbitrarily close to their dreams they came. Chapter two is concerned with the failure of these dreams and will analyse closely what happened to these female artists following a mathematical asymptotic framework and using the American Dream as a both a theory and an idea in nineteen-twenties America. Finally, chapter three focuses on why these dreams were unattainable for female artists by exploring ideas of the patriarchy and a gendered American dream, supported by modernist and feminist theories
Gender and the politics of the gaze in Bronte's Wuthering Heights
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2009.O objetivo deste estudo é apresentar uma análise de como a imagem de Catherine é moldada pelo olhar masculino, como ela enfrenta os três tipos de olhar - o olhar dos personagens, o olhar do leitor, e o olhar do autor - e finalmente, se o olhar masculino é interrompido. O parâmetro teórico desta análise, o conceito do olhar masculino, é teorizado por Laura Mulvey no artigo "Prazer Visual e Cinema Narrativo" (1975) o qual critica a relação entre o olhar masculino e a imagem feminina do prazer visual moldado pela sociedade patriarcal. Através da crítica de Mulvey do prazer visual generizado em filmes, que pertence ao contexto do cinema clássico de Hollywood, articulo sua teoria em relação ao romance Wuthering Heights de Emily Brontë para examinar a dinâmica do olhar masculino em relação à personagem feminina Catherine. Este estudo teve também por objetivo analisar o quanto o paradigma teórico de Mulvey produzido para cinema poderia ser aplicado especificamente em um texto literário escrito no século XIX.The objective of this thesis is to present an analysis of whether Catherine's image has been shaped by the male gaze, how she contends with the three looks of the male gaze - the look of the characters, the look of the reader, and the look of the author - and finally, how the male gaze is broken. The theoretical parameter of this analysis, the concept of the male gaze, is theorized by Laura Mulvey in the article "Visual Pleasure and Narrative Cinema" (1975) which critiques the relation between the male gaze and the female image within the patriarchal molding of visual pleasure. Borrowing Mulvey's critique of the gendering of visual pleasure in films, which pertains to the context of classical Hollywood cinema, I have articulated her theory in relation to Emily Brontë's Wuthering Heights, to examine the dynamics of the male gaze regarding the female character, Catherine. This study also aimed at examing the extent to which Mulvey's theoretical paradigm produced for cinema could be articulated specifically in relation to a literary text written in the nineteenth century
Contemporary Counterpoint: Theory & Application
No full textLibrarian, Judy Pinnolis, talks with author Dr. Beth Denisch, Professor of Composition, about her book, Contemporary Counterpoint. This presentation was part of Berklee Teachers on Teaching, 2022.
Video editing by Stacey Snyder.https://remix.berklee.edu/library-books-at-berklee/1007/thumbnail.jp
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