702 research outputs found
Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers
No full textSubstantial evidence suggests that soluble oligomers of Aβ are the neurotoxic form resulting in progression of Alzheimer's disease (AD). Tyrosine-10 has been identified as a pivotal residue in the neurotoxicity of Aβ and dityrosine cross-linked Aβ dimers have been proposed as the physiologically relevant Aβ species linked to the progression of AD. We describe the synthesis and characterization of dityrosine-linked Aβ dimers and demonstrate that, in contrast to other covalently linked Aβ dimers, dityrosine-linked Aβ dimers form discrete, stable, soluble aggregates. Furthermore, dityrosine-linked Aβ dimers display increased toxicity in a neuronal cell-line assay compared with the corresponding monomer, consistent with the hypothesis that dityrosine-linked Aβ dimers are implicated in the progression of AD.W. Mei Kok, Jade M. Cottam, Giuseppe D. Ciccotosto, Luke A. Miles, John A. Karas, Denis B. Scanlon, Blaine R. Roberts, Michael W. Parker, Roberto Cappai, Kevin J. Barnham and Craig A. Hutto
An old threat in a new setting: High prevalence of silicosis among jewelry workers
No full textBACKGROUND:
Silicosis is caused by inhaling free crystalline silica. Few case reports have addressed the risk of silicosis in the jewelry trade where chalk molds containing a high percentage of silica are used in gold and silver casting. We conducted a cross-sectional study involving 100 goldsmiths exposed to silica.
METHODS:
All workers replied to a respiratory questionnaire and underwent a full clinical examination, pulmonary function tests wit a study of flow, volumes and diffusion capacity, a chest X-ray and a high-resolution CT scan.
RESULTS:
High-resolution CT scan visualized signs of silicosis in 23 workers involved in gold and silver casting, confirmed by standard chest X-rays in 10 cases. In the 23 workers with CT evidence of silicosis Total Lung Capacity, FEV1 and the Lung Diffusing Capacity did not differ from the workers without the disease. Pulmonary function tests, including diffusing capacity did not correlate with silica exposure, measured as refractory material used to make the molds.
CONCLUSION:
In this study we demonstrate that use of chalk molds in casting in jewelry causes high prevalence of silicosis. Lung function test were not able to discriminate between workers with and without silicosis. The composition of the dust could be responsible of the high prevalence observed
L’actio in factum come surrogato dell’azione di ripetizione? A proposito di Iul. 60 dig. D. 39.6.18.1 e Iav. 13 epist. D. 19.5.10
No full textThe study touches upon the theme of the relationship between condictio and actio in factum in the matter of innominate contracts. More precisely, the question arises whether the atio in factum could have performed a merely repetitive function, rather than lead to the protection of the negative interest. In this regard the author deals with Iul. 60 dig. D. 39.6.18.1 and Iav. 13 epist. D. 19.5.10, on the subject of donatio mortis causa and (quasi-)usufruct respectively. What the two texts have in common is the fact that in both cases the use of an actio in factum pretoria (pursuant to Gai 4.46) is envisaged in a purely repetitive function and that for both cases a relationship with the issue of the protection of nova negotia has been hypothesized, in particular for Iav. 13 epist. D. 19.5.10. The author’s conclusions go in the direction of excluding such a connection
D.1.1.2 e la sua portata nel contesto del liber singularis enchiridii
No full textThe Author conjectures that the text preserved in Pomp. l. sing. ench. D. 1.1.2: Veluti erga deum religio: ut parentibus et patriae pareamus is a residue of a contraposition between ius gentium (or ius naturale?) and ius civile, enunciated among the initial passages of Pomponius’ didactic discourse and preceded, probably, by a review of the meanings of the term ‘ius’; and that after this contraposition, a specific teaching on ius civile = ius civitatis would begin: first with an articulate historical introduction (the well-known excursus of D. 1.2.2) and then with an illustration of concrete institutes and disciplines of private law
Tra patti dotali e spese di viaggio: a proposito dell’actio utilis in factum di Pap. 4 resp. D. 23.4.26.3
No full textThis study deals with Pap. 4 resp. D. 23.4.26.3, interesting text of Papinian in which an actio utilis in
factum is granted against the husband who, in violation of what was agreed, had not reimbursed his wife
for the travel expenses incurred to reach him. The author excludes it was a contractual action (a. praescriptis
verbis, a.c.i.), believing rather that it was an a. de dolo in factum, in application of the principle that prohibited
the exercise of infaming actions between spouses (C. 5.12.1.2; Ulp. 11 ad ed. D. 4.3.11.1)
Effect of Canal Length and Curvature on Working Length Alteration with WaveOne Reciprocating Files
No full textThe article “Effect of Canal Length and Curvature on Working Length Alteration with WaveOne Reciprocating Files” by Elio Berutti, Giorgio Chiandussi, Davide Salvatore Paolino, Nicola Scotti, Giuseppe Cantatore, Arnaldo Castellucci and Damiano Pasqualini (J Endod 37[12]:1687–90; 2011] should have included this statement in the author information section: “Giuseppe Cantatore, Arnaldo Castellucci, and Elio Berutti declare that they have financial involvement (patent licensing arrangements) with Dentsply Maillefer with direct financial interest in the materials discussed in this article.” In addition, Dentsply provided some of the instruments used in this study." The authors regret this omission
La rilevanza ecclesiasticistica della riforma del Terzo settore. Il cinque per mille
No full textIl contributo tematizza gli effetti ecclesiasticistici della riforma del Terzo settore, soffermandosi in particolare sul meccanismo di finanziamento noto come "cinque per mille", come disciplinato dal D. Lg.vo n. 111/2017. Gli aspetti positivi e le criticità che emergono dall'analisi del Decreto sono ricollocate nella più ampia prospettiva dell'apporto che le realtà religiose e confessionali sono in grado di assicurare, anche attraverso il principio della collaborazione, al miglior conseguimento degli obiettivi perseguiti dal legislatore della riforma.The article deals with the effects of the Italian Reform of the Third Sector on the Ecclesiastical law of the State and focuses on the peculiar measure of financial aid called “cinque per mille”, as governed by the legislative decree n. 111/2017. The author analyzes some problematic issues involved by this decree and underlines its importance in achieving the goal of a more amply and extended awareness of the today meaning of religious freedom as well as of the relationships between the State and the Church
Uma leitura do afresco "A árvore de Jessé", de Giuseppe Arcimboldo: articulações simbólicas numa perspectiva interdisciplinar
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-graduação em Ciências Humanas, Florianópolis, 2013.Esta pesquisa consiste numa análise dos simbolismos presentes no afresco de Giuseppe Arcimboldo intitulado "A Árvore de Jessé", artista milanês do século XVI, famoso por suas obras compostas. Nesta investigação será apresentada uma hipótese que permite ampliar o olhar sobre essa obra a partir da percepção de uma cabeça composta. A problemática investigada consiste na significação da obra a partir das escolhas feitas pelo artista em termos de linguagem pictórica e simbólica, na articulação de conceitos e ideias, visando responder à pergunta: o que essa obra que abrange duas imagens e seus símbolos inter-relacionados pode significar? A perspectiva teórica utilizada concebe os símbolos como parte do mundo imaginário , com suas raízes no inconsciente coletivo. O objetivo principal visa realizar uma interpretação possível da referida obra, analisando os símbolos presentes que faziam parte do imaginário da sociedade européia daquele período. E como objetivos específicos: aprofundar o conhecimento sobre a significação na pintura com relação à interpretação de simbolismos; e contribuir no campo de estudos sobre a criação pictórica de Arcimboldo. Foram incluídos elementos extra-pictóricos abrangendo o seu contexto de surgimento, numa perspectiva metodológica que se aproxima da de Panofsky, mas à qual foi acrescentada a identificação de formas perceptíveis e uma análise dos símbolos. Os procedimentos utilizados foram: pesquisa bibliográfica sobre o artista, seu contexto e os significados de mitos e símbolos segundo o método comparativo; pesquisa e trabalho com imagens; e observações à obra em uma reprodução e in loco na Catedral de Monza. A obra é abordada de diferentes ângulos, buscando o desenvolvimento de um olhar multifocal com contribuições de diversas disciplinas das ciências humanas. A imagem da árvore veicula significados que lhe foram atribuídos por diferentes tradições, agrupados neste trabalho em 10 categorias de análise e mais uma abrangendo as demais. Para a leitura desta imagem dupla propõe-se aqui o conceito de âncora da imagem. Os diversos símbolos direcionam para significados coincidentes, cuja recorrência condiz com o pensamento mágico da época voltado para a busca de correspondências entre os elementos da natureza e o homem visando encontrar uma unidade harmônica Abstract: The present research is an analysis of symbolisms in the fresco entitled Tree of Jesse painted by G. Arcimboldo, a XVI century artist from Milan, famous for his composite works. This thesis presents a hypothesis that allows for the broadening look at this fresco from the perception of a composite head. The investigated problem consists in the meaning of the work from the choices made by the artist in terms of pictoric and symbolic language, in the articulation of concepts and ideas, aiming at answering the following question: What can this work (which comprises two images and their interrelated symbols) mean? From the theoretical perspective drawn upon, the symbols are part of the imaginary world, with its roots in the collective unconsciousness. The main purpose aims at a possible interpretation of this fresco, analyzing its symbols which were part of the European society of that time. The specific objectives are to further the understanding of the painting in terms of interpretation of its symbolisms and of Arcimboldo´s pictoric creation. Extra-pictoric elements were included such as the context where the fresco was produced, in a methodological perspective resembling that of Panofsky, but also adding the identification of perceptible forms and an analysis of the symbols. The procedures were: bibliographic search about the author, his context and the meanings of myths and symbols as proposed in the comparative method; research and work with images; and observation of a copy of the work and of the original fresco at the Monza Cathedral. The fresco is studied from different angles, with an attempted multifocal look drawing on several disciplines from the Human Sciences. The image of the tree conveys meanings attributed to it by different traditions, grouped in this thesis under 10 categories of analysis and an additional one comprising all the others. For the reading of the double image the concept of anchor image is proposed. The diverse symbols are directed towards coincidental meanings whose occurrence is aligned with the magic thought of that time, with the search for congruity between elements of nature and man aiming at finding a harmonious unity
Contrahere e animus contrahendi in Salvio Giuliano
No full textThe paper deals with the category of negotium in Salvius Iulianus. The author rejects the thesis according
to which the jurist would have developed a concept of negotium as an objective relationship between two
distinct assets. From the examination of Iul. 15 dig. D. 18.5.5 and Iul. 18 dig. D. 12.1.20 has rather
taken shape the image of a jurist attentive to the will of the contracting parties, in the determination of id
quod actum est
- …
