324,569 research outputs found
Signaling Pathways in Inflammation and Its Resolution: New Insights and Therapeutic Challenges
No full text: Tissue inflammation is a dynamic process that develops step by step, in response to an injury, to preserve tissue integrity [...]
Hypertension in Cushing's Syndrome: from Pathogenesis to treatment
No full textHypertension is one of the most distinguishing features of endogenous Cushing’s syndrome (CS), as it is present in about 80% of adult patients whereas in children its prevalence is about 47%. Hypertension in CS is significantly correlated with the duration of hypercortisolism and results from the interplay between several pathophysiological mechanisms regulating plasma volume, peripheral vascular resistance and cardiac output, all of which are increased in this state. Glucocorticoids cause hypertension through several mechanisms: their intrinsic mineralocorticoid activity; through activation of the renin-angiotensin system; by enhancement of vasoactive substances, and by causing suppression of the vasodilatory systems. In addition, glucocorticoids may exert some hypertensive effects on cardiovascular regulation through the CNS via both glucocorticoid and mineralocorticoid receptors. Hypertension in CS usually resolves with surgical removal of the tumor, but some patients require pharmacological antihypertensive treatment both pre- and postoperatively. Thiazides and furosemide should be avoided, while adrenergic blockade and calcium channel antagonists are usually ineffective. Mineralocorticoid receptor antagonists, Ang II blockers and ACE inhibitors are good anti-hypertensive options; PPAR-γ agonists may help in many aspects of the insulin resistance syndrome. The relatively selective glucocorticoid receptor antagonist Mifepristone (RU 486) could reduce blood pressure in patients with CS. Neuromodulatory agents such as the serotonin inhibitors cyproheptadine and ritanserin, valproid acid, dopamine agonists, somatostatin analogs may occasionally be effective, as well as drugs acting directly at the adrenal levels, such as Ketoconazole and aminoglutetimide or even opDDD. Treating hypertension in CS remains a difficult task and a big challenge, in order to decrease the morbidity and mortality associated with the disease.</jats:p
Archaeometric approach to identifying the provenance of white marbles from the shipwreck of Cala Cicala (Crotone, Calabria, Italy)
No full textThis paper presents the results of an archaeometric study performed on white marbles from the shipwreck of Cala Cicala (Crotone, Calabria, Italy). The stone materials, especially the white marbles, are an excellent tool for reconstructing the trade routes of the past and studying the relationships between ancient populations. The purposes of this study were to establish the provenance of the white marbles of the shipwreck of Cala Cicala (Crotone, Calabria, Southern Italy) and to use analysis of their composition to acquire more knowledge about trade routes in the Roman imperial age. The 35 samples of white marble were studied by X-ray diffraction (XRPD), optical microscopy (OM), and isotopic analysis (δ13C and δ18O). All of the archaeometric data collected indicate that the marble blocks in the cargos are from the Greek island of Thasos, in the northern Aegean Sea
Navi graffite dalle fortificazioni medioevali di Velia
No full textLe fortificazioni medioevali dell’Acropoli di Velia hanno restituito alcuni graffiti visibili sui rivestimenti parietali nella torre circolare, posta ai margini del Terrazzo superiore, raffiguranti navi ed imbarcazioni, ricordati solo da Oreste Dito, nella sua monografia su Velia del XIX secolo.
Lo studio è stato condotto, innanzitutto, sull’edificio, attraverso l’analisi delle stratigrafie murarie, che ha consentito di recuperare una serie di dati sulle diverse fasi costruttive della torre, restata inedita dopo gli scavi degli anni Cinquanta del Novecento.
Per quanto riguarda i graffiti, considerata la loro peculiarità ed il buono stato di conservazione, si è tentato di proporre un inquadramento della tipologia delle diverse imbarcazioni rappresentate, tenendo conto di alcune caratteristiche tecniche e costruttive, utili anche sul piano cronologico.
L’insieme delle navi sembra riferibile ad un’unica scena di carattere portuale, che offre anche qualche elemento per valutare la continuità d’uso della Torre e dei possibili attracchi lungo il litorale di Velia sul finire dell’età medioevale
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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