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Douglas G. Baird, Group 2
No full textDouglas G. Baird (right), the Harry A. Bigelow Professor of Law and dean of the Law School at the University of Chicago. He is pictured with Scott Turow, lawyer and author.
University of Chicago Photographic Archive, [apf1-11871], Hanna Holborn Gray Special Collections Research Center, University of Chicago Library.
View information about rights and permissions.https://chicagounbound.uchicago.edu/douglas_baird_images/1002/thumbnail.jp
Douglas G. Baird, Group 2
No full textDouglas G. Baird (right), the Harry A. Bigelow Professor of Law and dean of the Law School at the University of Chicago. He is pictured with Scott Turow, lawyer and author.
University of Chicago Photographic Archive, [apf1-11871], Hanna Holborn Gray Special Collections Research Center, University of Chicago Library.
View information about rights and permissions.https://chicagounbound.uchicago.edu/douglas_baird_images/1002/thumbnail.jp
Precipitated withdrawal following codeine administration is dependent on CYP genotype
No full textCopyright © 2001 Elsevier Science B.V. All rights reserved.The role of metabolic polymorphism in the development of physical dependence to codeine was assessed in cytochrome P450 2D2 (CYP2D2) deficient Dark Agouti and CYP2D2 intact Sprague-Dawley rats by assessment of the severity of naloxone precipitated withdrawal after codeine and morphine administration. Plasma morphine concentrations after codeine were significantly higher (P<0.01) in Sprague-Dawley than in Dark Agouti rats with metabolic ratios of 0.71±0.27 and 0.07±0.04, respectively. Withdrawal after codeine resulted in significantly greater hypothermia (3.5–4 °C, P<0.0001) in Sprague-Dawley animals compared to the other groups. Body weight loss was similar for all groups ranging from 6.2±0.4 to 8.2±0.6 g. When strain and treatment data were combined, a relationship between body temperature and plasma morphine concentration could be described by the inverse Hill equation (r2=0.76, EC50=556±121 ng/ml, n=2.9±1.5). These data indicate that dependence and withdrawal after codeine administration are dependent on its bioconversion to morphine.May Chew, Jason M. White, Andrew A. Somogyi, Felix Bochner and Rodney J. Irvinehttp://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description#descriptio
COVID-19 and the Internet: Lessons Learned
No full textThe COVID-19 pandemic has disrupted the ‘real’ world and substantially impacted the virtual world and thus the Internet ecosystem. It has caused a significant exogenous shock that offers a wealth of natural experiments and produced new data about broadband, clouds, and the Internet in times of crisis. In this chapter, we characterise and evaluate the evolving impact of the global COVID-19 crisis on traffic patterns and loads and the impact of those on Internet performance from multiple perspectives. While we place a particular focus on deriving insights into how we can better respond to crises and better plan for the post-COVID-19 ‘new normal’, we analyse the impact on and the responses by different actors of the Internet ecosystem across different jurisdictions. With a focus on the USA and Europe, we examine the responses of both public and private actors, with the latter including content and cloud providers, content delivery networks, and Internet service providers (ISPs). This chapter makes two contributions: first, we derive lessons learned for a future post-COVID-19 world to inform non-networking spheres and policy-making; second, the insights gained assist the networking community in better planning for the future.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume
No full textBiomechanical studies of the thoracic spine often scan cadaveric segments by dual energy X-ray absorptiometry (DXA) to obtain measures of bone mass. Only one study has reported the accuracy of lateral scans of thoracic vertebral bodies. The accuracy of DXA scans of thoracic spine segments and of anterior-posterior (AP) thoracic scans has not been investigated. We have examined the accuracy of AP and lateral thoracic DXA scans by comparison with ash weight, the gold-standard for measuring bone mineral content (BMC). We have also compared three methods of estimating volumetric bone mineral density (vBMD) with a novel standard–ash weight (g)/bone volume (cm3) as measured by computed tomography (CT). Twelve T5–T8 spine segments were scanned with DXA (AP and lateral) and CT. The T6 vertebrae were excised, the posterior elements removed and then the vertebral bodies were ashed in a muffle furnace. We proposed a new method of estimating vBMD and compared it with two previously published methods. BMC values from lateral DXA scans displayed the strongest correlation with ash weight (r=0.99) and were on average 12.8% higher (p<0.001). As expected, BMC (AP or lateral) was more strongly correlated with ash weight than areal bone mineral density (aBMD; AP: r=0.54, or lateral: r=0.71) or estimated vBMD. Estimates of vBMD with either of the three methods were strongly and similarly correlated with volumetric BMD calculated by dividing ash weight by CT-derived volume. These data suggest that readily available DXA scanning is an appropriate surrogate measure for thoracic spine bone mineral and that the lateral scan might be the scan method of choice.Peer reviewedDXA Accuracy Thoracic spine Ash weight Bone volum
Synthesis and structural characterization of m-terphenyl Schiff base ligands and their aluminum complexes
No full text2,4,6-Triphenylbenzaldehyde 1 undergoes a condensation reaction with 2-aminophenol to give N-(2′,4′,6′-triphenylbenzylidene)-2-iminophenol (TPIP) 2. The imine 2 can be reduced with NaBH4 in ethanol to form N-(2′,4′,6′-triphenylbenzyl)-2-aminophenol (TPAP) 3. Addition of trimethylaluminum to 2 or 3 results in the formation of the complexes TPIP-AlMe2·AlMe3 (4) or TPAP-AlMe2 (5). Compounds 2, 3, and 4 have been crystallographically characterized. [ABSTRACT FROM AUTHOR]Peer reviewedFinal article publishedSchiff basesN,O ligandsaluminumm-terphenylX-ray crystallograph
Serial femtosecond crystallography datasets from G protein-coupled receptors
No full textabstract: We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH[subscript 2], the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.The final version of this article, as published in Scientific Data, can be viewed online at: https://www.nature.com/articles/sdata20165
Nomada lepida Cresson 1863
No full textNomada lepida Cresson 1863 (ruficornis group: bidentate mandible) County records: Lake, Livingston, Manistee, St. Clair, Van Buren, Washtenaw, Wexford. Notes. Scott et al. (2011) noted that type material of this species from Colorado and Illinois may not be conspecific and could not confirm presence in Colorado of material matching N. lepida from the eastern United States as described by Mitchell (1962) and identified by that author. They therefore removed this species from the fully confirmed Colorado state list. However, the male lectotype in the ANSP designated by Cresson (1916) was collected in Pike’s Peak, Colorado, making that occurrence correct by definition. The type series of lepida may prove to have been composite, and this would explain failure by Scott et al. (2011) to confirm non-type lepida from Colorado that match this species sensu Mitchell (1962) and as identified by subsequent bee specialists working on the eastern fauna. If lepida sensu Mitchell (1962) do diverge from the Colorado lectotype, then populations from the eastern United States, including Michigan, may require description as a new species unless another name is found to be applicable.Published as part of Gibbs, Jason, Ascher, John S., Rightmyer, Molly G. & Isaacs, Rufus, 2017, The bees of Michigan (Hymenoptera: Apoidea: Anthophila), with notes on distribution, taxonomy, pollination, and natural history, pp. 1-160 in Zootaxa 4352 (1) on page 60, DOI: 10.11646/zootaxa.4352.1.1, http://zenodo.org/record/106385
Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G
No full textSummaryEndonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C. elegans through an EndoG-mediated cell-death pathway. In response to high reactive oxygen species (ROS) levels, homodimeric CPS-6—the C. elegans homolog of EndoG—is dissociated into monomers with diminished nuclease activity. Conversely, the nuclease activity of CPS-6 is enhanced, and its dimeric structure is stabilized by its interaction with the worm AIF homolog, WAH-1, which shifts to disulfide cross-linked dimers under high ROS levels. CPS-6 thus acts as a ROS sensor to regulate the life and death of cells. Modulation of the EndoG dimer conformation could present an avenue for prevention and treatment of diseases resulting from oxidative stress
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