33,135 research outputs found
Xinjiang (China), folk dancing of Uyghurs
No full textFolk-dance of UighursImage is part of research conducted by Chang Chih-Yi for the article: Land Utilization and Settlement Possibilities in Sinkiang
Author(s): Chang Chih-Yi
Source: Geographical Review, Vol. 39, No. 1 (Jan., 1949), pp. 57-75
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/211157http://www.jstor.org/stable/211157Grayscal
Negative Transcriptional Modulation and Silencing of the Bi-exonic Rnf35 Gene in the Preimplantation Embryo
No full textPrevious works have indicated promiscuous transcription from the zygotic genome immediately after fertilization. The mouse Rnf35 gene is bi-exonic in structure and is transcribed in the preimplantation embryo until it is permanently silenced at the blastocyst stage of development. We have previously shown that Rnf35 transcription is positively regulated by the nuclear factor Y. Using the uniquely permissive Chinese hamster ovary-K1 cell line in transient transfection assays, we demonstrate in this work that the Rnf35 promoter was negatively modulated by a cis-cognate repressor element, designated as the downstream exon 1 repressor, or DER, residing between 72 and 95 in the untranslated exon 1 of the Rnf35 gene. Simultaneous mutagenesis of the two half-sections, DER1 and DER2, of the DER sequence was required for derepression suggesting participation of multiple proteins in the DER-dependent transcriptional repression. Electrophoretic mobility shift assays demonstrated that the 3-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux. Chromatin immunoprecipitation experiments further demonstrated in vivo CDP-DER association in the blastocyst and the 8.5- day embryo. Furthermore, the DER-dependent repression was partially relieved in vivo in co-transfection with an antisense CDP construct. Transcription of the Cdp gene was shown to first occur between the eight-cell and the blastocyst stages, correlating and possibly explaining the onset of Rnf35 silencing at the blastocyst stage. Taken together, our results suggest that the evolutionarily acquired exon 1 of Rnf35, and possibly exon 1 of other similarly structured bi-exonic early embryonic genes, contributes to transcriptional modulation and silencing in the developing mouse embryo
plink2 (21 Jan 2022)
No full text21 Jan release of plink2 as used in prspipe (https://github.com/intervene-EU-H2020/prspipe). Christopher Chang is the author of the plink2 software. Plink2 is made available on the GPLv3+ license. The binary is made available here for reproducibility reasons.Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, s13742-015 (2015).</p
Positive Association of Ankylosing Spondylitis with Homozygous HLA-B27, but Protection with B2705 in Taiwan Chinese
No full text僵直性脊椎炎(Ankylosing spondylitis, AS)是常見的慢性病之一，有超過90%以上的病人為人類白血球抗原 (Human lymphocyte antigen, HLA) HLA-B27抗原陽性。我們利用Polymerase chain reaction-restrictive fragment length polymorphism, PCR-RFLP的方法分析HLA-B27的亞型與僵直性脊椎炎的關係。我們發現在738位年紀超過65歲的正常人中，有42位(5.69%)為HLA-B27抗原陽性；其中6位(14.3%)為B2704的同合子；18位(42.9%)為B2704的異配子；2位(4.8%)同時有B2704及B2705, 1位(2.3%)同時有B2704及B2706；2位(4.8%)為B2705的同合子；11位(26.1%)為B2705的異配子及2位(4.8%)為B2706的異配子。而在62位罹患僵直性脊椎炎的病人中，37位(59.6%)為B2704的同配子；而25位(40.3%)則為B2704的異配子。由此可知，HLA-B27的帶原率在台灣地區約為5.69%左右，而同合子的B2704與僵直性脊椎炎的發病有關，但在本研究中發現B2705可能具有保護作用。The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese. A polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated as 5.69%. Susceptibility to AS is determined by homozygosity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese.中文摘要……………………………………………………… I
英文摘要……………………………………………………… II
目次…………………………………………………………… III
圖次…………………………………………………………… IV
表次…………………………………………………………… V
壹、緒言……………………………………………………… 1
貳、文獻探討………………………………………………… 3
一、致病機轉…………………………………………… 4
二、臨床症狀…………………………………………… 6
三、臨床診斷…………………………………………… 9
四、治療與諮詢………………………………………… 12
參、材料與方法……………………………………………… 15
一、材料………………………………………………… 15
二、方法………………………………………………… 16
1. DNA萃取步驟…………………………………… 16
2.PCR條件設定…………………………………… 18
3.PCR偵測B27及B7301………………………… 19
4.PCR-RFLP analysis of HLA-B27 subtypes……… 20
5.DNA片段的定序分析…………………………… 23
6.統計分析………………………………………… 24
肆、結果……………………………………………………… 25
伍、討論……………………………………………………… 28
陸、參考文獻………………………………………………… 31
附錄一：聚合酶鏈鎖反應原理（Polymerase chain
reaction, PCR）……………………………………… 43
附錄二：本論文所使用之所有限制酶……………………… 4
Can reforming global institutions help developing countries share more in the benefits from globalization?
Get PDFGlobalization could significantly expand trade, international investment, and technological advances, but the gains from global integration have been unevenly distributed across and within nations. Greater global interdependence has also brought greater macroeconomic volatility, resulting in several serious financial crises in the second half of the 1990s. The global matrix of Bretton Woods and United Nations institutions that developed starting in the 1940s, formed under a different balance of power, in a world of fixed exchange rates and limited capital mobility. Since the 1960s regional financial institutions have emerged because of the greater autonomy of different regions and the greater financial needs of development. The author reviews different proposals for reform of the international financial institutions and changes in the roles of the International Monetary Fund (IMF) and the World Bank. He highlights the implications for developing countries of (1) Policy conditionality. (2) The countercyclical role of multilaterals'lending. (3) Greater lending to middle-income than to low-income developing countries. (3) Access to liquidity at times of crisis. (4) Mechanisms for giving low-income countries a greater voice in IMF and World Bank decisionmaking. The author streses the overlapping responsibilities of the Bretton Woods and regional financial institutions and the need to reassess the allocation of responsibilities and to develop better coordination mechanisms between these institutions. Those designing institutional reform must consider the corporate capabilities of each type of institution. The corporate cultures of global and regional institutions differ. So does the kind of knowledge they generate and disseminate, and so do patterns of interactions with, and mechanisms for representation of, client countries.Finally, the author calls attention to the need to harmonize national and global growth-oriented policies in a way that reduces volatility and promotes social equity.Environmental Economics&Policies,Governance Indicators,Financial Intermediation,Economic Theory&Research,Banks&Banking Reform
Molecular characterization of G6PD deficiency by natural and Amplification created restriction sites - Five mutations account for most Glucose-6- phosphate Dehydrogenase (G6PD) deficiency cases in Taiwan
No full textJan Kapr's contribution to contemporary music : an essay about a composer and teacher
No full textThis creative project is a treatise on a leading personality of Czechoslovakian musical life, the composer, Jan Kapr. The author discusses the following:1. The complicated development of Kapr's career and work, 2. Kapr's method of organization of musical material in a composition, as described in his book Constants,3. His former and current style which is demonstrated in two of his compositions, Concert Variations, for flute and string orchestra and Testimonies for four solo instruments,4. Two of his recent works, Exercises for Gydli and the Symphony No. 7, Country of Childhood.Thesis (M.A.
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ELEVEN FACES OF JAN GOGOL, JR.
No full textAuthor Jan Rendl in his thesis attempts to look at the world of ideas and educator Jan
Gogola ml. through the eleven chapters in which each chapter somehow characterizes itself by Jan Gogola ml. and each of them somehow determines its creative ideas of it through the metaphor of a football match when Jan Gogola, with its characters, movies himself a teammate, as well as defensively. It gives goals with their situations as well as occasionally digging his opponents ankles.
Jan Gogola ml. thus embodies one stage of the Department of Documentary Film at FAMU, which often stands at the intersection between teaching activities and Karel Vachek among students who applied by them during their seminars psychological methods that work must be peculiarly associated with the author of the film
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