4,931 research outputs found
Interação do zinco com antidepressivos no teste de suspensão da cauda e no teste do campo aberto
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O efeito tipo-antidepressivo do zinco vem sendo demonstrado em alguns modelos animais de depressão. No presente estudo, cloreto de zinco (ZnCl2) foi administrado, sozinho ou em combinação com diferentes antidepressivos, por via oral (p.o.), em camundongos, e a resposta comportamental no teste de suspensão da cauda (TSC), teste preditivo de atividade antidepressiva, e no teste do campo aberto foi investigada. ZnCl2 administrado nas doses de 10 e 30 mg/kg, p.o., 60 minutos antes dos testes comportamentais, reduziu o tempo de imobilidade no TSC, sem afetar a atividade locomotora no teste do campo aberto. Além disso, ZnCl2 (30 mg/kg, p.o.) apresentou efeito tipo-antidepressivo quando foi administrado 30' antes do TSC. Os antidepressivos fluoxetina, paroxetina, imipramina, desipramina e bupropiona produziram uma significativa redução no tempo de imobilidade no TSC nas doses de 10; 1; 1;1;10 mg/kg, p.o., respectivamente. O tratamento combinado de doses sub-efetivas de ZnCl2 (1 mg/kg) com doses sub-efetivas de fluoxetina (5 mg/kg), paroxetina (0,1 mg/kg), desipramina (0,1 mg/kg), imipramina (0,1 mg/kg), ou bupropiona (1 mg/kg) gerou uma significativa redução no tempo de imobilidade no TSC, quando comparado com grupos tratados com o veículo, ZnCl2 ou antidepressivos sozinhos. O tratamento com ZnCl2 e antidepressivos sozinhos ou em combinação não afetou a locomoção dos animais submetidos ao teste do campo aberto, exceto a desipramina que administrada sozinha reduziu a locomoção dos animais. O tratamento com desipramina (0,1 mg/kg) ou paroxetina (0,1 mg/kg) sozinhos reduziu o número de respostas de levantamento vertical ("rearings") no teste do campo aberto. O tratamento com bupropiona (1 mg/kg) ou desipramina (0,1 mg/kg) sozinhos reduziu o número de respostas de auto-limpeza dos animais submetidos ao teste do campo aberto. Ainda, a administração combinada de ZnCl2 com bupropiona também diminuiu o número de respostas de auto-limpeza, condizente com um efeito semelhante a de benzodiazepínicos (ansiolíticos). Os resultados indicam, inicialmente, que o ZnCl2 administrado por via oral produz um efeito tipo-antidepressivo no TSC. Além disso, efeitos sinérgicos da administração de ZnCl2 com antidepressivos em diferentes classes foi mostrado no TSC, sugerindo que uma melhora na terapia antidepressiva clássica ocorra quando o zinco é acrescentado ao tratamento realizado com antidepressivos. Ainda, a combinação de ZnCl2 com o inibidor da recaptação de dopamina bupropiona diminuiu o número de auto-limpeza de animais submetidos ao teste do campo aberto, sugerindo que esta combinação seja efetiva no tratamento de pacientes aonde a depressão coexista com a ansiedade
In-vitro evaluation of bioactive and biodegradation properties of mesoporous ZnO architectures
No full textCurrently there is strong interest in the development of smart piezoelectric biomaterials for tissue engineering, where piezoelectricity may actively promote the growth, proliferation and differentiation of cells. [1] Piezoelectric Zinc Oxide (ZnO) materials may be easily prepared in high-surface area structures by several techniques, and captured considerable attention due to their biocompatibility and antibacterial properties. [2] Despite being widely investigated for sensors and energy harvesting applications, [3] the study of ZnO-based materials for tissue engineering is still in its infancy. Herein, we propose a preliminary investigation on the in-vitro bioactive and biodegradation behavior of high-surface area mesoporous ZnO layers, after soaking in Simulated Body Fluid (SBF) solution for different times. The ZnO samples were obtained by thermal oxidation of Zn layers sputtered on silicon substrates. The morphology, crystal structure, and chemical composition of the ZnO samples were studied before and after in-vitro tests. Our results show the rapid formation of CaP structures after soaking in SBF for few hours, then resulting into the formation of a CaP-rich layer onto the whole ZnO surface for prolonged soaking times. The mesoporous ZnO architecture was preserved during the overall in-vitro experimental analyses, with negligible release of biodegradation products from the ZnO structure. [1] C. Ribeiro, V. Sencadas, D.M. Correia, and S. Lanceros-Méndez, Colloids. Surf. B, 136 (2015) 46-55. [2] Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, Curr. Mol. Med. 13 (2013) 1633-1645. [3] M. Laurenti, G. Canavese, A. Sacco, M. Fontana, K. Bejtka, M. Castellino, C.F. Pirri, and V. Cauda, Adv. Mater. 27 (2015) 4218-4223
Franco (Albert M.) interview, 2000
No full textRhodes, GreeceAlbert was born November 10, 1914 to immigrant parents Rosa Boullissa and Marco Franco of the Island of Rhodes. He attended Leschi Elementary, Garfield High School and graduated from the University of Washington and University of Washington Law School Class of 1939. He served in the US Army Intelligence Corps. Returning to Seattle, he became a founding partner of the law firm Franco, Asia, Bensussen and Coe, and practiced immigration and business law, also serving as the representative of the Mexican Embassy in the Northwest. Albert was an early civil rights advocate, and helped author King County's Civil Rights Ordinance. He also served on the King County Human Rights Commission. A strong philanthropic supporter of the Jewish Community and United Way, Albert was past president of the Jewish Federation of Greater Seattle and was active in the Anti-Defamation League, the American Civil Liberties Union and the American Jewish Committee. In this interview Mr. Franco discusses the lawsuit of Eugene Levy vs. Jewish Family and Child Service (JFCS) of 1948. This accession is part of the Washington State Jewish Archives.To request a high resolution or uncompressed reproduction, or to obtain permission to use any portion of this item, contact the University of Washington Libraries, Special Collections. Email: [email protected]. Please reference the Digital ID Number
Comparison of expression vectors in Lactobacillus reuteri strains
No full textSynthesis of heterologous proteins in lactobacilli is strongly influenced by the promoter selected for the
expression. In addition, the activity of the promoters themselves may vary among different bacterial
hosts. Three different promoters were investigated for their capability to drive EGFP expression in L.
lactis spp. cremoris MG1363, in Lactobacillus reuteri DSM 20016T and in five Lactobacillus reuteri
strains isolated from chicken crops. The promoters of L. acidophilus Surface Layer Protein gene (slp),
L. acidophilus lactate dehydrogenase gene (ldhL) and enterococcal rRNA adenine N-6-methyltransferase gene (ermB) were fused to the coding sequence of EGFP and inserted into the
backbone of pTRKH3 shuttle vector (pTRKH3-slpGFP, pTRKH3-ldhGFP, pTRKH3-ermGFP).
Besides conventional analytical methods, a new quick fluorimetric approach was set up to quantify the
EGFP fluorescence in transformed clones using the QubitTM fluorometer. ermB proved to be the most
effective promoter in L. reuteri isolates producing 3.90 x 10-7 g of fluorescent EGFP (ml x ODstationary
culture)-1. In the same conditions ldhL promoter produced 2.66 x 10-7 g of fluorescent EGFP (ml x
ODstationary culture)-1. Even though the slp promoter was efficient in L. lactis spp. cremoris MG1363, it was nearly inactive both in L. reuteri DSM 20016T and in L. reuteri isolates
Cauda equina ependymomas: surgical treatment and long-term outcomes in a series of 125 patients
No full textCauda equina ependymoma (CEE) is a rare tumor for which little information is available on the oncological and clinical outcomes of patients. In this study the authors aimed to address functional, oncological, and quality-of-life (QOL) outcomes in a large series of consecutive patients operated on at their institution during the past 20 years
Adoption and diffusion of no tillage practices in Southern Spain olive groves
No full textThis paper analyses the process of adoption of no tillage in South-eastern Spain’s olive groves. Olive tree groves in South-eastern Spain’s mountainous areas are subject to a high risk of soil erosion, which is the main environmental problem for this crop, and have to incur in high costs of soil conservation. This results in a greater difficulty to comply with the practices required to benefit from both the single payment and agri-environmental schemes. In many high-steeped areas, farmers have opted for non-tillage practices as an alternative to other conservation practices. Using our own data from a survey carried out in 2006 among 215 olive tree farmers from the Granada Province in Southern Spain regarding the adoption of soil conservation and management practices, we model the diffusion process of no tillage practices using several specifications (logistic, Gompertz and exponential). We also estimate an ordered probit model to analyse which socio-economic and institutional factors determine the adoption of no tillage. Our results show that 90% of farmers in the area of study perform no tillage with either localized (21%) or no localized (69%) application of weedicides. The diffusion process of no tillage has been very intense since the middle nineties, and has been based on the interactions among farmers in the area of study rather than in external factors such as EU policies or extension services. Among other relevant factors that positively affect the adoption of no tillage practices in general, such as farm size and irrigation, the probability of a farmer adopting no tillage with non-localized application of weedicides increases when there is a relative that will continue with the farming activity, what causes the farmer to incorporate long term effects in his farming decisions, when the farmer is only a manager or when he bought the farm rather than inherited it (i.e. on more professionalized farms), and with his educational level. These results confirm some findings from previous studies in other nearby areas.Spanish olive groves, soil erosion, no tillage, Crop Production/Industries, Land Economics/Use,
Franco (Albert M.) interview, 1978
No full textRhodes, GreeceAlbert was born November 10, 1914 to immigrant parents Rosa Boullissa and Marco Franco of the Island of Rhodes. He attended Leschi Elementary, Garfield High School and graduated from the University of Washington and University of Washington Law School Class of 1939. He served in the US Army Intelligence Corps. Returning to Seattle, he became a founding partner of the law firm Franco, Asia, Bensussen and Coe, and practiced immigration and business law, also serving as the representative of the Mexican Embassy in the Northwest. Albert was an early civil rights advocate, and helped author King County's Civil Rights Ordinance. He also served on the King County Human Rights Commission. A strong philanthropic supporter of the Jewish Community and United Way, Albert was past president of the Jewish Federation of Greater Seattle and was active in the Anti-Defamation League, the American Civil Liberties Union and the American Jewish Committee.
Albert Franco tells of his family's life on the Isle of Rhodes; why they left; how they came to Seattle. He tells of his father, Marco Franco's, achievements in business and of his father's extensive participation in community affairs, in the Sephardic community and in the community in general. He tells of his own education, his career as a lawyer, his war service in the Army Intelligence, and of his work in the community. He experienced discrimination by his fellow Jews when no Sephardic student could join a Jewish fraternity or sorority. This interview gives illuminating insights concerning the history of an early day Sephardic family and how a child who grew up in that era reacted as shown in his community work as as adult. His account of his father, Marco Franco, as a liaison between the various segments in the community is interesting.
This accession is part of the Washington State Jewish Archives.To request a high resolution or uncompressed reproduction, or to obtain permission to use any portion of this item, contact the University of Washington Libraries, Special Collections. Email: [email protected]. Please reference the Digital ID Number
The political instrumentalization of professional football in Francoist Spain 1939-1975
No full textPhDThe objective of this thesis is to be the first systematic study of the
political instrumentalization of football in Francoist Spain from 1939
to 1975.
Seven separate and contrasting aspects of this political
instrumentalization may be isolated, and, accordingly, this thesis will
consist of a chapter examining each one of these seven aspects in turn.
After a first introductory chapter, Chapter Two will examine the
application of Fascist concepts to Spanish football. In the third
chapter, the questions of whether and to what extent football was used
by the Franco regime as a political soporific will be discussed. The
theme of Chapter Four is the lack of democracy within the structures of
the game, a situation that is alleged to have been deliberately imposed
by the regime in order to not create an uncomfortable comparison for
itself with the lack of national and local political democracy. The
poor working conditions of the footballers, which mirrored those of the
great majority of Spanish workers during the Franco period, are the
subject of Chapter Five. In the sixth Chapter, the political
significance of the presence in Francoist Spain of a group of refugee
players and coaches from Europe will be examined. The diplomatic
and ambassadorial significance of football, in particular of the
spectacular international triumphs of the Real Madrid club, will be
discussed in Chapter Seven. The political significance of football as a
focus for Basque and Catalan nationalist sentiment, in opposition to the
centralist Madrid regime, is the subject of Chapter Eight
Uno zaino di ricordi invisibili. Vita e opere di Carl Sandburg
No full textLife and works of Carl Sandburg (1878-1967), American poet, author of "Chicago Poems" (1916)
[Neurinomas and ependymomas of the cauda equina. A review of the clinical characteristics].
No full textA retrospective review of 603 cases of intradural benign tumors of the cauda equina are presented (283 schwannomas and 320 ependymomas). For each tumor, the clinical course and long-term postoperative results were analyzed: it emerged that differential diagnosis between neurinomas and non tumoral lesions is not possible if based on clinical findings alone and that neuroradiological diagnosis is more accurate when MRI is employed. Long-term prognosis of neurinomas was always favourable, while in the ependymomas, early diagnosis gives excellent results because prognosis is apparently directly correlated to the length of preoperative clinical history
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