10,508 research outputs found
Roles of dFmr1, the Drosophila homolog of the human gene responsible for the Fragile X syndrome, in the genome stability
No full textDrosophila melanogaster as a model to study the role of FMRP protein, involved in the Fragile-X syndrome, in the piRNA-mediated genome stability
No full textFragile-X Syndrome represents the most common form of hereditary mental retardation. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and FXR2, constitute a well-conserved family of RNA-binding proteins. The dFmr1 gene is the Drosophila ortholog of the human gene (Fmr1) involved in the syndrome (1). Drosophila melanogaster is considered a good model for the study of the molecular mechanism at the bases of the different phenotypes exhibited by patients. Drosophila has a unique fragile X-related gene, the dFmr1 gene, whose mutants exhibit defects in neuronal structure and function, behavior, and germline development, resembling those observed in patients (2,3).
During the first part of the project, we identified and validated a new role for the dFmr1 gene in the silencing of transposable elements and repetitive sequences mediated by the piRNA pathway in the gonads (2,4-6). The starting point was the observation that the crystal-Stellate interaction (2), depending on a correct function of the piRNA pathway, was deregulated in dFmr1 mutants. We also demonstrated that dFmr1 interacts genetically and co-localizes with Aubergine and Vasa, two key components of the pathway. We also investigated in detail the genetic and physical interaction of dFmr1 in gonads, looking at the rescue of the “crystal phenotype” in testes and at the fertility of dFmr1 mutants in a genetic background overexpressing genes with a role in the piRNA pathway. These results will be useful for clarifying the role of dFmr1 in gonads and even in the nervous system (6-8). During the last part of the project we analyzed the possible role of the piRNA pathway in the nervous system, gaining information on its presence in this tissue and on the function of dFmr1 in the pathway. In addition, we started studying a possible physiological role of transposable elements during the brain development.
Our research intends to clarify if a common molecular base is involved in the majority of the phenotypes exhibited by dFmr1 mutants due to genome instability
Les Évêques dans l’histoire de la France des origines à nos jours. [Reseña]
No full textReseña de: Jean JULG, Les Évêques dans l’histoire de la
France des origines à nos jours, préface de
Mgr. Jean-Pierre Cattenoz, Pierre Téqui éditeur,
París 2004, 581 pp
“Enquête sur l’auteur. Entretien avec Pierre Bayard”
No full textInternational audience05/04/2019 “Enquête sur l’auteur. Entretien avec Pierre Bayard” [“Investigation into the Author. Interview with Pierre Bayard”], event for bachelor’s and master’s students in French and comparative literature, Lorraine University
Is There Market Power in the French Comte Cheese Market?
No full textAn NEIO approach is used to measure seller market power in the French Comté cheese market, characterised by government-approved supply control. The estimation is performed on quarterly data at the wholesale stage over the period 1985-2005. Three different elasticity shifters are included in the demand specification, and the supply equation accounts for the existence of the European dairy quota policy. The market power estimate is small and statistically insignificant. Monopoly is rejected, as well as weak forms of Cournot oligopoly. Results appear to be robust to the choice of functional form, and suggest little effect of the supply control scheme on consumer prices.Supply control, NEIO, protected designation of origin, Marketing,
The aesthetics of Pierre Boulez
No full textTo enable the reader to find references as quickly and easily as possible, I have grouped all references together in the bibliography in alphabetical order. Texts by the same author are distinguished first by year and second, if there are several texts from the same year, by letter. Interviews and writing collaborations (including published correspondence) involving Boulez are also ordered alphabetically. The year given at the beginning of each bibliographical entry is, in the majority of cases, the year in which the text was first published (not necessarily the year of the edition cited). For all writings written by Boulez, I have provided the original title under which the text in question was first published (usually in French). Many articles have subsequently been translated into English and therefore I have decided to provide page references for both versions. For all texts by writers other than Boulez, I have cited the version of the text I have used. Wherever possible, I have cited the existing English translations of texts originally written in French. However, on many occasions I have considered it necessary to make alterations to the published translations. This is particularly applicable to Boulez on Music Today (1971) and Orientations (1986), both of which display an often heavy-handed and rather inaccurate approach to the task of translating specific concepts employed by Boulez. In contrast. Stocktakings of an Apprenticeship (1991) has required only occasional minor amendments. All changes to the published English translations are acknowledged in the corresponding footnote. None of the material m this thesis has previously been submitted for a degree in this or any other University. The copyright of this thesis rests with the author. No quotation from it should be published without prior written consent and information from it should be acknowledged. I have received permission to exceed the word limit from the Graduate School Committee at the University of Durham
Etnografia e fotografia: reflexões sobre as fotografias etnográficas de Pierre Fatumbi Verger
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-graduação em Antropologia Social, Florianópolis, 2009A relação entre a fotografia e a etnografia nos estudos da Antropologia, apesar de antiga e densa, é incerta e complexa. Se por um lado a fotografia é a cada dia mais utilizada nos trabalhos antropológicos, por outro sua potencialidade como algo além da ilustração e de uma técnica de interação com o Outro é pouco explorada. A partir do exemplo, do legado, da trajetória de vida e, principalmente, da obra de Pierre Fatumbi Verger, esta pesquisa se dedica a analisar essa relação. Francês radicado na Bahia na década de 1940, Verger é conhecido mundialmente tanto por seu trabalho como fotógrafo quanto pelas suas pesquisa etnográficas. Há, entretanto, uma indefinição quanto à razão desse reconhecimento, e examinar as suas razões oferece um profícuo campo de reflexão sobre a pesquisa etnográfica, especialmente quando relacionada ao universo das imagens fotográficas. A Fundação Pierre Verger é a instituição que atualmente abriga o acervo do fotógrafo-etnógrafo e onde foi realizada a pesquisa de campo através da qual, aliada à leitura de fotografias relacionadas ao candomblé em suas manifestações na África e na Bahia, foi criada uma metodologia de análise das fotografias que privilegia as interações e os diálogos como espaço de construção de definições sobre a etnografia. Pelo contato com a Fundação, seus freqüentadores e o acervo fotográfico ali disponibilizado, esta pesquisa pretende refletir sobre a etnografia e a construção de um olhar etnográfico em relação direta com o exercício da fotografia.The relationship between photography and ethnography in anthropological studies, albeit ancient and deep, is uncertain and complex. Photography has been increasingly used in anthropological researches but it´s potencial as something beyond illustration and it´s interaction with the Other as a technique is very little explored. This research is dedicated to the analysis of this relationship by taking the work of Pierre Fatumbi Verger, his life and legacy. A French man, rooted in Bahia, Brasil, in the decade of 1940, Verger is known worldwide for his work as a photographer as well as for his etnographic studies. However, the reason of this recognition is undefined and examining the reason for these indefinitions can be a fruitful field of reflection concerning ethnographic researches, especially when related to the photographic universe. The Pierre Verger Foundation is the institution that hosts his photographic and ethnographic collection and it´s also where the field research of this work took place. Through the field research combined with the readings of photographs related to candomblé and it´s manifestations in Africa and Bahia, a photographic analysis methodology was created that privilege interaction and dialogue as a way to build definitions about ethnography. By the contact with the Foundation, it´s users and it´s available photographic collection, this research intends to reflect about the ethnography and the creation of an ethnographic view in direct relation to the exercise of photography
A Emergência Do Autor Pierre Rivièrethe Emergence Of The Pierre Rivière Author
No full textNesse artigo apresento uma análise do caso de parricídio / fraticídio cometido por um jovem camponês francês, nascido na comuna de Courvaudon, Pierre Rivière que em 3 de junho de 1835, aos vinte anos, assassinou a golpes de foice sua mãe grávida de sete meses, sua irmã de 18 anos, e seu irmão de sete anos. O livro intitulado Eu, Pierre Rivière, que degolei minha mãe, minha irmã e meu irmão produzido pelo trabalho de uma equipe de pesquisadores, no Collège de France, sob a coordenação de Michel Foucault em 1973, apresenta em seu conjunto notícias de jornais, testemunhos, interrogatórios, laudos médicos e uma gama de diferentes discursos. Para empreender a análise do nó entre a escrita e o assassinato, utilizo a relação entre a escrita e o autor demarcando o personagem Rivière no desdobramento, na ordem do corpo e da linguagem. Palavras-chave Função autor; Corpo; Linguagem; Pierre Rivière; Michel Foucault Abstract This paper has as aim to present an analysis of the case of patricide / fratricide cometed by a French Countryman, Pierre Rivière, who was born in the commune of Courvaudon, who, on July 3rd, 1835, at age of 20, killed his mother, his brother and sister with a sickle. His mother was in the seventh month of pregnancy, his sister was 18 and his brother was 7 years old. The book, whose name was “I, Pierre Riviere, Having Slaughtered My Mother, My Sister, and My Brother ...: A Case of Parricide in the Nineteenth Century” was produced by a group of researchers at the Collège de France, under the coordination of Michel Foucault in 1973, has a set of newspaper news, witnesses, inquiring, forensic medical reports and a variety of different texts. To understand and analyze the writings and the homicide, the relationship between writing and the author is used, marking the character Rivière unfolding body and language. Keywords Function author; Body; Language; Pierre Rivière; Michel Foucault80227-24
A emergência do autor Pierre RivièreThe emergence of the Pierre Rivière author
No full textNesse artigo apresento uma análise do caso de parricídio / fraticídio cometido por um jovem camponês francês, nascido na comuna de Courvaudon, Pierre Rivière que em 3 de junho de 1835, aos vinte anos, assassinou a golpes de foice sua mãe grávida de sete meses, sua irmã de 18 anos, e seu irmão de sete anos. O livro intitulado Eu, Pierre Rivière, que degolei minha mãe, minha irmã e meu irmão produzido pelo trabalho de uma equipe de pesquisadores, no Collège de France, sob a coordenação de Michel Foucault em 1973, apresenta em seu conjunto notícias de jornais, testemunhos, interrogatórios, laudos médicos e uma gama de diferentes discursos. Para empreender a análise do nó entre a escrita e o assassinato, utilizo a relação entre a escrita e o autor demarcando o personagem Rivière no desdobramento, na ordem do corpo e da linguagem.
Palavras-chave
Função autor; Corpo; Linguagem; Pierre Rivière; Michel Foucault
Abstract
This paper has as aim to present an analysis of the case of patricide / fratricide cometed by a French Countryman, Pierre Rivière, who was born in the commune of Courvaudon, who, on July 3rd, 1835, at age of 20, killed his mother, his brother and sister with a sickle. His mother was in the seventh month of pregnancy, his sister was 18 and his brother was 7 years old. The book, whose name was “I, Pierre Riviere, Having Slaughtered My Mother, My Sister, and My Brother ...: A Case of Parricide in the Nineteenth Century” was produced by a group of researchers at the Collège de France, under the coordination of Michel Foucault in 1973, has a set of newspaper news, witnesses, inquiring, forensic medical reports and a variety of different texts. To understand and analyze the writings and the homicide, the relationship between writing and the author is used, marking the character Rivière unfolding body and language.
Keywords
Function author; Body; Language; Pierre Rivière; Michel Foucaul
Pierre Ryckmans (1935-2014)
No full textAprès le décès de Pierre Ryckmans, alias Simon Leys, de très nombreux hommages lui ont été rendus dans la presse ou sur les réseaux sociaux. Callick, Rowan. Chairman’s New Clothes author Pierre Ryckmans dies aged 78. The Australian, 11 August 2014. En ligne : Chairman’s New Clothes author Pierre Ryckmans dies aged 78 http://www.theaustralian.com.au/arts/books/chairmans-new-clothes-author-pierre-ryckmans-dies-aged-78/story-e6frg8nf-1227020219798 ONE of the world’s most eminent sinologists and ..
- …
