1,354,388 research outputs found
Phase II trial of 5-fluorouracil and the natural l isomer of folinic acid in the treatment of advanced colorectal carcinoma.
No full textBetween February 1991 and July 1992, 79 previously untreated patients with metastatic colorectal carcinoma were enrolled in a phase II study of combined 5-fluorouracil (5-FU) and l-folinic acid (FA). 5-FU 370 mg/m2/day was administered for 5 consecutive days as an intravenous (i.v.) bolus injection preceded by l-FA 100 mg/m2/day with the same administration modality. Treatment was given every 4 weeks until progression. 79 patients were evaluable for toxicity and 64 for response. 2 patients (3\%) achieved a complete remission and 8 (12.5\%) a partial remission, 33 (52\%) had stable disease and 21 patients (33\%) had progressive disease. Median duration of remission was 32.5 weeks and median survival for all evaluable patients was 64.5 weeks. Substantial to severe side-effects occurred in 39\% of patients. Dose-limiting toxicity (grade 3-4) was mainly diarrhoea (18\%) and mucositis (15\%). Nausea/vomiting, cutaneous toxicity, leucopenia, alopecia and conjunctivitis of grade 3-4 occurred respectively in 6, 4, 2.5, 1 and 1\% of cases. Toxicity appeared to be substantially similar to that characteristic of combined 5-FU and the chiral mixture of d,l-FA. Efficacy was within the range of that observed with the 5-FU/d,l-FA combination, although at the lower level
KV CBCT-Guided Frameless SRS in a patient with a solitary brain metastasis treated on a Varian Linear Accelerator
No full textRegulament privind organizarea şi funcţionarea departamentelor la Universitatea Tehnică a Moldovei
No full textActivitatea didactico-ştiinţifică a cadrelor didactice în Universitatea Tehnică a Moldovei se organizează în cadrul departamentelor academice. Departamentul în cadrul Universităţii Tehnice a Moldovei este o subdiviziune structurală fundamentală a Universității, care funcţionează conform legislației în vigoare, în baza prevederilor Codului Educației al RM, Cartei Universitare și ale altor acte normative interne
Bilateral sensorineural hearing loss after adjuvant treatment with cyclophosphamide, methotrexate, Fluorouracil and alternative oral medications in a male with breast cancer.
No full textabstract not availabl
Danno glomerulare progressivo in cancerosi trattati con dd-platino (DDP); ulteriori osservazioni.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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