15 research outputs found
Carmichael, Jr., Halbert R., June 4, 2019 [Interview]
No full textHalbert R. Carmichael, Jr. was interviewed on June 4, 2019, by Devin McKinney about his youth and his education at Gettysburg College.Hyman, James; Glover, Buddy; Cooper, Jr., Donald L.; Lee, Michael; King, Jr., Martin Luther; Malcolm X; Cato, Oliver W.; Beatty, Murel; Clark, Perry; Ciolini, Salvatore; Jones, W. Ramsey; Hanson, C. Arnold; Jones, Lorenzo; Mudd, Samuel A.; Smoke, Kenneth L.; Shand, John D.; Pittman, Thane S.Carl Arnold Hanson Year
Interview with Halbert R. Carmichael, Jr., June 4, 2019
No full textHalbert R. Carmichael, Jr. was interviewed on June 4, 2019, by Devin McKinney about his youth and his education at Gettysburg College.
Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit https://gettysburg.contentdm.oclc.org/digital/collection/p16274coll2/search
Whitfield, Wendelin Watts, November 15, 2021 [Interview]
No full textWendelin Watts Whitfield was interviewed on November 15, 2021, by Devin McKinney about her childhood in Washington D.C., her education at Gettysburg College, and her work as a student with the children of Gettysburg's Third Ward.Martin Luther King, Jr.; Glover, Buddy; Hanson, C. Arnold; Hyman, James; Lee, Michael; Cooper, Jr., Donald L.; Carmichael, Jr., Halbert R.; Johnson, Suzie; Johnson, Suzanne; Johnson, Claudietta; Reese, Carol; Capron, Mary; Hartman, David W.; Hartman, Cheryl; Waters, Shirley; Augustine, Ann Karen; Augustine, Paul; Taylor, Myra-Anita; Adams, VaNessa Patten; Odom, Jean; Nutter, Cassie; Nutter, Jane; Vannorsdall, John W.Carl Arnold Hanson Year
Domain-independent programming by demonstration in existing applications
No full textThis paper describes Familiar, a domain- independent programming by demonstration system for automating iterative tasks in existing, unmodified applications on a popular commercial platform. Familiar is domain- independent in an immediate and practical sense: it requires no domain knowledge from the developer and works immediately with new applications as soon as they are installed. Based on the AppleScript language, the system demonstrates that commercial operating systems are mature enough to support practical, domain- independent programming by demonstration – but only just, for the work exposes many deficiencies
Authorship, Incentives for Creation, and Copyright in the Digital 21st Century
No full textCopyright in the United States is under enormous stress in the digital age. The cause of this stress is often described in technological terms, yet there are deeper systemic policy and legal factors at play. Specifically, there is an ever-increasing, and increasingly obvious, disconnect between the constitutionally based justification for copyright, and copyright's lived out implementation. That is particularly true regarding two key justifications for the expansions of copyright protection that have occurred since 1790: the concept of the author, and the necessity of providing a high level of control and financial incentives to authors to encourage the production of socially valuable works. This paper examines both of these justifications for expanded copyright protection and finds them unproven and, in fact, significantly lacking force under both philosophical and empirical analysis. We suggest that the U.S. abandon those justifications for copyright in today's digital world. We offer eight principles upon which a more integrated and relevant copyright system could be based, one in which policy, law, and practice could be brought into coherence so that today's stresses on copyright would be minimized, and the Constitutional charge to promote
"the Progress of Science and useful Arts" would be maximized for society as a whole
Transportation and Infrastructure, Retail Clustering, and Local Public Finance: Evidence from Wal-Mart's Expansion
No full textThe author examines the role highway infrastructure and local property tax rate variability play in retail agglomeration in Indiana from 1988 through 2003. To account for data errors and the potential endogeneity of taxes and infrastructure on retail agglomeration, he introduces a unique identification strategy that exploits the entrance timing and location of Wal-Mart stores in Indiana. Using a time-series cross-sectional model of Indiana’s 92 counties from 1988 through 2003, he estimates the impact highway infrastructure, property taxes, and big-box competition have in creating regional agglomerations. Among two separate specifications and a full and rural-only set of the data, the author finds considerable agreement in the results. In the full sample, he finds no relationship between property tax rates or highway infrastructure and retail agglomeration. Within the non-metropolitan statistical area (MSA) counties, this relationship is very modest, though it possesses considerable statistical certainty. Highway impacts within the non-MSA counties are significant and positively related to retail agglomeration, with the presence of highways explaining about 10 percent of total agglomeration variability. (JEL R11, R53)Infrastructure; endogeneity; taxation; Wal-Mart
Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology
No full textSpinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons. No effective treatment is currently available for SMA however it may be possible to treat the disease using gene therapy. The aim of this project is to develop potential therapies for SMA by investigating different viral and non-viral gene therapy vectors and assessing the effect of potential disease modifying genes. The data collected are described under four chapters as follows:
1: The aim here was to develop a novel approach based on polymer nanoparticles (polymersomes) for gene delivery. Encapsulation of DNA by polymersomes was optimised and polymersomes were used to restore SMN levels into a fibroblast cell line isolated from a child with severe SMA. 2: The ability of adeno-associated virus serotype 5 (AAV5) vectors expressing GFP to transduce the central nervous system (CNS) following intravenous injection was tested in neonatal wild-type mice. Overall transduction efficiency of AAV5-GFP in the brain was low and very few lumbar spinal cord neurons were found to be transduced, suggesting that AAV5 is not an appropriate vector to treat diseases such as SMA. 3: AAV6 was used to overexpress hnRNP R in an in vivo model of SMA. hnRNP R is a candidate disease modifying gene for SMA due to its interaction with SMN and β-actin. However this strategy had only a very marginal effect on the phenotype and life-span of this SMA mouse model. 4: Finally AAV9 was used to silence phosphatase and tensin homolog (PTEN) in an in vivo model of SMA. PTEN is a negative regulator of growth which acts on the PI3K/Akt pathway. AAV9-mediated PTEN silencing resulted in a significant increase in the lifespan of a SMA mouse model coupled with an improved phenotype.
In conclusion this work highlights two major findings: i) polymersomes can be used to deliver SMN plasmid DNA to restore SMN mRNA and protein levels in an in vitro model of SMA; ii) AAV9-mediated silencing of PTEN can improve the phenotype and increase lifespan of a SMA mouse model
Open Access Bibliography: Liberating Scholarly Literature with E-Prints and Open Access Journals
No full textThe Open Access Bibliography: Liberating Scholarly Literature with E-Prints and Open Access Journals provides an overview of open access concepts, and it presents over 1,300 selected English-language books, conference papers (including some digital video presentations), debates, editorials, e-prints, journal and magazine articles, news articles, technical reports, and other printed and electronic sources that are useful in understanding the open access movement's efforts to provide free access to and unfettered use of scholarly literature. Most sources have been published between 1999 and August 31, 2004; however, a limited number of key sources published prior to 1999 are also included. Where possible, links are provided to sources that are freely available on the Internet (approximately 78 percent of the bibliography's references have such links). The 129-page bibliography has been published in print and PDF formats by the Association of Research Libraries (ARL). The print version is available from ARL. The book is licensed under the Creative Commons Attribution-NonCommercial License
Sintomas depressivos e ansiosos em pacientes com doença isquêmica do coração e variáveis associadas
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2013.OBJETIVOS: Estimar a prevalência de sintomas psicológicos em pacientes com coronariopatia isquêmica e testar sua associação com variáveis clínicas, sócio-demográficas e hábitos de vida. PACIENTES E MÉTODOS: Estudo observacional, transversal, realizado entre outubro de 2012 e fevereiro de 2013, no ambulatório de cardiologia de um hospital público de referência regional. A coleta de dados foi realizada pela aplicação de um questionário de investigação sócio-demográfico, clínico e de hábitos de vida, e da Escala HADS - Hospital Anxiety and Depression. O projeto obteve a aprovação dos Comitês de Ética em Pesquisa com Seres Humanos da Universidade Federal de Santa Catarina e do Instituto de Cardiologia de Santa Catarina. Todas as variáveis foram categorizadas dicotomicamente e sua associação com o desfecho ?sintomas depressivos e/ou ansiosos? (escore ao HADS > 11 ou uso de medicações psicotrópicas) foi testada à análise bivariada. As variáveis que apresentaram significância p Abstract : OBJECTIVES: To estimate the prevalence of depressive and anxious symptoms in patients with ischemic heart disease and to test its association with clinical, socio-demographic variables and life habits. PATIENTS AND METHODS: It was an observational, cross-section, held between October 2012 and February 2013, in a cardiology ambulatory of a regional reference public hospital. The data were collected by a questionnaire with socio-demographic, clinical and life habits variables, and the application of the scale HADS - Hospital Anxiety and Depression. Local Committees of ethics in research with Human Beings approved the project. All variables were dichotomously categorized and their association with the endpoint depressive and/or anxious symptoms (HADS score above 11 or the use of psychotropic drugs) were tested by bivariate analysis, and variables with associations with p < 0.2 were tested by forward logistic regression, non-conditional, by likelihood method. RESULTS: The sample was composed by 204 individuals, 110 men and 94 women, aged between 26 and 88 years, with ischemic heart disease. There were statistically significant association among psychological symptoms and female sex (PR:1.61;CI95%:1.46-1.79), NYHA Functional Classes III or IV (PR:1.60;CI95%:1.43-1.79), beta blocker use (PR:1.31;IC95%:1.09-1.58), and presence of grandchildren (PR:0.88;CI95%:0.78-0.99). Also contributed to the adjustment of the model age above 60 years. CONCLUSION: At the studied sample female sex, worse physical limitation, the use of beta blockers and the absenceof grandchildren were statistically significant associated with higher prevalence of psychological symptoms during their treatment of ischemic heart disease
Stock market development and long-run growth
No full textThe authors empirically evaluate the relationship between stock market development and long-term growth. The data suggest that stock market development is positively associated with economic growth. Moreover, instrumental variables procedures indicate a strong connection between the predetermined component in the long run. While cross-country regressions imply a strong link between stock market development and economic growth, the results should be viewed as suggestive partial correlations that stimulate additional research rather than as conclusive findings. Careful case studies might help identify causal relationships and further research could bedone on the time-series property of such relationships.Economic Theory&Research,Financial Intermediation,Health Economics&Finance,Environmental Economics&Policies,Labor Policies,Economic Theory&Research,Financial Intermediation,Achieving Shared Growth,Governance Indicators,Health Economics&Finance
