101,918 research outputs found
CAPE and CAPPE each induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest in CRC cells.
No full text<p>Human CRC cells were synchronized in RPMI-1640 medium with 0.05% FBS in tissue culture dishes overnight. To measure the distribution of the cell cycle, cell were cultured in the presence or absence of CAPE and CAPPE (0, 10, 50 and 100 µM) cultured in 10% FBS RPMI-1640 medium for another 24 h. (A) The measurement of the cell population at different cell cycle phases was performed using flow cytometry analysis, as described under <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099631#s2" target="_blank">Materials and Methods</a>. The data indicate the (B) HCT-116 cell (C) SW-480 cell population percentage at different cell phases under the treatment of CAPE or CAPPE in human CRC cells. Human CRC (D) HCT-116 cells (E) SW-480 cells were treated with either CAPE or CAPPE (at concentrations of 0, 5, 10, 20, 50 and 100 µM) in 10% FBS RPMI-1640 for 24 h. Nuclear proteins were prepared for Western blotting analysis using monoclonal antibodies against cyclin D1, Cdk4, PCNA, and lamin A antibodies, as described under <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099631#s2" target="_blank">Materials and Methods</a>. The levels of detection represent the amounts of cyclin D1, Cdk4 and PCNA in the nuclei of human CRC cells. The results (mean ± SD) represent the folds change of control group and are representative of three different experiments. The immunoreactive bands are noted with an arrow. The mean integrated densities of these proteins adjusted with the internal control lamin A protein are shown in bottom row. The standard deviation (SD) of each measured protein was indicated in the parenthesis. A single asterisk indicates a significant difference compared to the CAPE- or CAPPE-untreated control group, respectively (<i>P</i><0.05).</p
Fatica oligociclica su cappe e rotori di turboalternatori
No full textDopo un’introduzione sulle principali caratteristiche delle cappe e dei rotori, sui materiali, sul ciclo di carico affaticante, viene illustrata la pianificazione sperimentale, per caratterizzare a fini progettuali due diversi tipi di acciai, tenendo conto anche della loro anisotropia. Particolare cura è dedicata al progetto concettuale e alla costruzione dell’attrezzatura di carico, appositamente studiata per ridurre al minimo i disassamenti dei provini nelle prove a trazione e compressione. La campagna sperimentale è stata divisa in due fasi. Nella prima ci si è accertati dell’effettiva corrispondenza dell’attrezzatura ai requisiti: per via estensimetrica si sono rilevate le entità dei disassamenti (dell’ordine del centesimo di mm) ed il rapporto fra contributi deformativi flessionali e dovuti a trazione e compressione (5-7%). Nella seconda si è intrapresa la caratterizzazione dei materiali del rotore e della cappa (direzione tangenziale di formatura), determinando le curve statica e ciclica e la curva di fatica in condizioni di ampiezza di deformazione imposta
Impact of malnutrition on the performance of the APACHE II severity-of-illness scoring system in acute renal failure
No full textBibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The Contributions of Sensory Dominance and Attentional Bias to Cross-modal Enhancement of Visual Cortex Excitability
No full textAbstract
Approaching or looming sounds (L-sounds) have been shown to selectively increase visual cortex excitability [Romei, V., Murray, M. M., Cappe, C., & Thut, G. Preperceptual and stimulus-selective enhancement of low-level human visual cortex excitability by sounds. Current Biology, 19, 1799–1805, 2009]. These cross-modal effects start at an early, preperceptual stage of sound processing and persist with increasing sound duration. Here, we identified individual factors contributing to cross-modal effects on visual cortex excitability and studied the persistence of effects after sound offset. To this end, we probed the impact of different L-sound velocities on phosphene perception postsound as a function of individual auditory versus visual preference/dominance using single-pulse TMS over the occipital pole. We found that the boosting of phosphene perception by L-sounds continued for several tens of milliseconds after the end of the L-sound and was temporally sensitive to different L-sound profiles (velocities). In addition, we found that this depended on an individual's preferred sensory modality (auditory vs. visual) as determined through a divided attention task (attentional preference), but not on their simple threshold detection level per sensory modality. Whereas individuals with “visual preference” showed enhanced phosphene perception irrespective of L-sound velocity, those with “auditory preference” showed differential peaks in phosphene perception whose delays after sound-offset followed the different L-sound velocity profiles. These novel findings suggest that looming signals modulate visual cortex excitability beyond sound duration possibly to support prompt identification and reaction to potentially dangerous approaching objects. The observed interindividual differences favor the idea that unlike early effects this late L-sound impact on visual cortex excitability is influenced by cross-modal attentional mechanisms rather than low-level sensory processes.</jats:p
Visual backward masking deficits are specific to female observers scoring high on cognitive disorganisation
No full textVisual backward masking (VBM) deficits are a potential endophenotype of schizophrenia. VBM deficits were found in schizophrenic patients, in their unaffected relatives, and in healthy students scoring high in "cognitive disorganisation" (CD; Cappe et al., 2012). In the latter study we found post-hoc that females seemed to be stronger affected than males. This hypothesis was tested here in a fresh sample of 29 male and 27 female students varying in their self-reported schizotypy scores. In addition, we tested performance in Wisconsin Card Sorting Task (WCST). As expected, we found significant VBM deficits in female students scoring high in CD but not in the males. We found no significant WCST deficits in individuals scoring high in CD. Our results add further evidence that VBM is a potential endophenotype of schizophrenia. Future research will investigate whether sex differences in VBM are related to hormonal differences or a sex-specific bias in the self-reports.LPS
Fatica oligociclica di cappe e rotori di turboalternatori: progetto e costruzione di attrezzatura e prime prove sperimentali
No full textDopo un’introduzione sulle principali caratteristiche delle cappe e dei rotori, sui materiali, sul ciclo di carico affaticante, viene illustrata la pianificazione sperimentale, per caratterizzare a fini progettuali due diversi tipi di acciai, tenendo conto anche della loro anisotropia. Particolare cura è dedicata al progetto concettuale e alla costruzione dell’attrezzatura di carico, appositamente studiata per ridurre al minimo i disassamenti dei provini nelle prove a trazione e compressione. La campagna sperimentale è stata divisa in due fasi. Nella prima ci si è accertati dell’effettiva corrispondenza dell’attrezzatura ai requisiti: per via estensimetrica si sono rilevate le entità dei disassamenti (dell’ordine del centesimo di mm) ed il rapporto fra contributi deformativi flessionali e dovuti a trazione e compressione (5-7%). Nella seconda si è intrapresa la caratterizzazione del materiale del rotore, determinando le curve statica e ciclica e la curva di fatica in condizioni di deformazione imposta
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