5 research outputs found
Evaluación de los niveles de referencia mediante descriptores en tomografía computarizada en pacientes adultos y pediátricos: Evaluación de los niveles de referencia mediante descriptores en tomografía computarizada
No full textObjetivo: Los inexactos parámetros técnicos y dosimétricos considerados en la tomografía computarizada (TC) han generado un incumplimiento en los niveles de referencia de dosis (NRD) por lo que es importante evaluar los descriptores dosimétricos CTDIvol y DLP de las TC en las áreas craneales, torácicas y abdominales en pacientes adultos y pediátricos y contribuir con los NRD actuales.
Método: Se aplicó un estudio de enfoque cuantitativo, observacional y analítico. Se analizaron los parámetros CTDIvol y DLP obtenidos por el programa DICOM del sistema PACS del equipo CT03S del TC Canon Medical Systems.
Resultados: En adultos, los valores de CTDIvol y DLP superaron los valores referenciales de TC en cabeza en 47.92 % y 90.07 %. En TC torácico, el CTDIvol fue un 18.02 % menor que su valor referencial, mientras que el DLP superó a su similar en 19.46 %. En TC abdominal, el CTDIvol superó al valor referencial en 111.55 %; mientras que el DLP obtuvo un valor inferior en 9.66 %. En menores, los valores de CTDIvol en TC torácica y abdominal y DLP en TC abdominal mostraron estar dentro de los valores referenciales, el DLP en la región torácica obtuvo un valor mayor en 99.21 % en comparación con la referencia. En TC en cabeza, el CTDIvol y DLP registraron un 96.12 % y 207.76 % por encima del promedio.
Conclusiones: Los valores de CTDIvol y DLP no cumplieron con los niveles de referencia, mostrando una discordancia en la entrega de la dosis nominal y la dosis recibida por los pacientes
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
No full textThe SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article
Bank capital regulation, the lending channel and business cycles
No full textThis paper develops a Dynamic Stochastic General Equilibrium (DSGE) model to study how the instability of the banking sector can amplify and propagate business cycles. The model builds on Bernanke, Gertler and Gilchrist (BGG) (1999), who consider credit demand friction due to agency cost, but it deviates from BGG in that financial intermediaries have to share aggregate risk with entrepreneurs, and therefore bear uncertainty in their loan portfolios. Unexpected aggregate shocks will drive loan default rate away from expected, and have an impact on both firm and bank's balance sheet via the financial contract. Low bank capital position can create strong credit supply contraction, and have a significant effect on business cycle dynamics. --Bank capital regulation,banking instability,financial friction,business cycle
Das memórias às veredas: Revista USP - letras, cenas e sons
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-graduação em LiteraturaEsta tese tenta configurar o espaço ocupado pela literatura na Revista USP, partindo da reflexão que ali se realiza sobre a arte produzida nos anos 80 e 90. As criações recentes da música popular, do teatro e do cinema são submetidas a um balanço enquanto a literatura não recebe o mesmo tipo de abordagem crítica. Investigar as motivações e desdobramentos de tal postura por parte da revista é a principal proposição desta pesquisa, que busca desenvolver a seguinte hipótese: um vasto conjunto de ensaios publicados na Revista USP compõe um mosaico, no qual a reflexão acerca da literatura brasileira se configura através da constituição de um eixo monumental, formado por Memórias póstumas de Brás Cubas, de Machado de Assis e Grande sertão: veredas, de João Guimarães Rosa. Estas duas obras sustentam e demarcam os limites do cânone proposto pela revista, que posiciona a obra de Guimarães Rosa como última baliza do ciclo criativo da literatura brasileira. Entretanto, é possível perceber algumas sombras que conturbam o desenho nítido do referido eixo. A primeira delas é Grande sertão: veredas enquanto texto neobarroco e a segunda é uma antologia de poesia brasileira publicada na revista Universidad de México. This thesis tries to configure the space occupied by literature in Revista USP magazine, starting from the reflection about the art produced in the 80's and 90's. The popular music, the theater and the movies are submitted to an evaluation of their recent creations while the literature does not receive the same kind of critical approach. Investigating motivations and consequences of this attitude is the main proposition of this research, which intends to develop the following hypothesis: a great amount of texts published in Revista USP composes a mosaic, in which the reflection about Brazilian literature configures itself through the constitution of a monumental axle, formed by Memórias póstumas de Brás Cubas, written by Machado de Assis and Grande sertão: veredas, by João Guimarães Rosa. These books mark and support the limits of the canon proposed by the magazine, which considers Guimarães Rosa's narrative as the last sign of creativity in Brazilian literature. Although, it's possible to perceive some shadows that disturb the clearness of this axle. The first one is Grande sertão: veredas seen as a "neobarroco" text, and the second is an anthology of Brazilian poetry published at Universidad de México magazine
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
No full textBackground: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0-4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2-6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society
