161 research outputs found
Erratum: Corrigendum to “Three dimensional multi-segmental trunk kinematics and kinetics during gait: Test-retest reliability and minimal detectable change” (Gait Posture (2016) 46 (18–25))
No full textThe authors regret that the name of the third author was wrongly spelled: Annelies Pool-Goudaazward should be Annelies L. Pool-Goudzwaard
Activity-based detection of new psychoactive substances as an alternative screening approach in forensic toxicology
No full text"¿Cómo se convierte un nuevo país en hogar?": Annelies Schwarz
No full textLibro editado por Carme Bescansa[EN] This chapter presents the female author Annelies Schwarz (1938), who belongs to the generation of displaced German children after WWII, and her work to the Spanish-speaking readership. Her childhood was strongly determined by the displacement of her family from Czech territory to Western Germany, with the consequent loss of home and search for new places to feel safe and build a new future. Her coming to terms with the vulnerability, insecurity and trauma experienced as a seven-year-old girl lead her as an adult woman to write children literature as a way of nurturing open minds that are, and will be, confronted to conflicts, interculturality and strangeness. After a section about her biography, her work and her literary approach to Heimat, selected passages of her works have been translated into Spanish
"¿Cómo se convierte un nuevo país en hogar?": Annelies Schwarz
No full textLibro editado por Carme Bescansa[EN] This chapter presents the female author Annelies Schwarz (1938), who belongs to the generation of displaced German children after WWII, and her work to the Spanish-speaking readership. Her childhood was strongly determined by the displacement of her family from Czech territory to Western Germany, with the consequent loss of home and search for new places to feel safe and build a new future. Her coming to terms with the vulnerability, insecurity and trauma experienced as a seven-year-old girl lead her as an adult woman to write children literature as a way of nurturing open minds that are, and will be, confronted to conflicts, interculturality and strangeness. After a section about her biography, her work and her literary approach to Heimat, selected passages of her works have been translated into Spanish
Annelies Umlauf-Lamatsch : mit nationalsozialistischer Propaganda zur erfolgreichen Märchenerzählerin
No full textDie Volksschullehrerin und Autorin Annelies Umlauf-Lamatsch galt als äußerst produktiv. Sie veröffentlichte zahlreiche Kinderbücher, die mehrmals überarbeitet und neu aufgelegt wurden. Dafür wurde ihr als erster österreichischen Kinder- und Jugendbuchautorin der ProfessorInnentitel verliehen. Diese Arbeit untersucht die Werke der österreichischen Autorin nach möglichen Hinweisen auf ihre Haltung im Nationalsozialismus. Analysiert wird, inwieweit ihre Texte den Anforderungen an nationalsozialistische Kinder- und Jugendliteratur entsprochen haben. Des Weiteren werden die Texte bezüglich ihrer literarischen Kontinuität vor, während und nach der nationalsozialistischen Herrschaft verglichen.Annelies Umlauf-Lamatsch worked as an elementary school teacher as well as an extremely productive author. She published a large number of childrens books, many of them have been revised and published serveral times. Being that successful she was the first Austrian child and adolescent book author to be awarded a professorship. This thesis examines the authors work for possible indications of her attitude towards National Socialism. It analyses the extend to which Umlauf-Lamatsch texts have met the requirements of National Socialist children and youth literature. Furthermore, the texts are compaired in respect of their literary continuity before, during and after the Nazi regime.eingereicht von Rebekka DiernbergerMasterarbeit Universität Linz 201
Off-target activity of NBOMes and NBOMe analogs at the mu opioid receptor
No full textNew psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are often inadequately elucidated, which contributes to the delayed characterization of their pharmacological effects. Inspired by earlier findings, this study set out to investigate the mu opioid receptor (MOR) activation potential of a large set of psychedelics, substances which typically activate the serotonin (5-HT2A) receptor as their target receptor. We observed that some substances carrying the N-benzyl phenethylamine (NBOMe) structure activated MOR, as confirmed by both the NanoBiT (R) beta arr2 recruitment assay and the G protein-based AequoScreen (R) Ca2+ release assay. The use of two orthogonal systems proved beneficial as some aspecific, receptor independent effects were found for various analogs when using the Ca2+ release assay. The specific 'off-target' effects at MOR could be blocked by the opioid antagonist naloxone, suggesting that these NBOMes occupy the same common opioid binding pocket as conventional opioids. This was corroborated by molecular docking, which revealed the plausibility of multiple interactions of 25I-NBOMe with MOR, similar to those observed for opioids. Additionally, structure-activity relationship findings seen in vitro were rationalized in silico for two 25I-NBOMe isomers. Overall, as MOR activity of these psychedelics was only noticed at high concentrations, we consider it unlikely that for the tested compounds there will be a relevant opioid toxicity in vivo at physiologically relevant concentrations. However, small modifications to the original NBOMe structure may result in a panel of more efficacious and potent MOR agonists, potentially exhibiting a dual MOR/5-HT2A activation potential
Annelies Umlauf-Lamatsch : mit nationalsozialistischer Propaganda zur erfolgreichen Märchenerzählerin
No full textDie Volksschullehrerin und Autorin Annelies Umlauf-Lamatsch galt als äußerst produktiv. Sie veröffentlichte zahlreiche Kinderbücher, die mehrmals überarbeitet und neu aufgelegt wurden. Dafür wurde ihr als erster österreichischen Kinder- und Jugendbuchautorin der ProfessorInnentitel verliehen. Diese Arbeit untersucht die Werke der österreichischen Autorin nach möglichen Hinweisen auf ihre Haltung im Nationalsozialismus. Analysiert wird, inwieweit ihre Texte den Anforderungen an nationalsozialistische Kinder- und Jugendliteratur entsprochen haben. Des Weiteren werden die Texte bezüglich ihrer literarischen Kontinuität vor, während und nach der nationalsozialistischen Herrschaft verglichen.Annelies Umlauf-Lamatsch worked as an elementary school teacher as well as an extremely productive author. She published a large number of childrens books, many of them have been revised and published serveral times. Being that successful she was the first Austrian child and adolescent book author to be awarded a professorship. This thesis examines the authors work for possible indications of her attitude towards National Socialism. It analyses the extend to which Umlauf-Lamatsch texts have met the requirements of National Socialist children and youth literature. Furthermore, the texts are compaired in respect of their literary continuity before, during and after the Nazi regime.eingereicht von Rebekka DiernbergerMasterarbeit Universität Linz 201
Quelques thèmes pour ‘pirogue’ dans les langues bantoues
No full textFrom a corpus of 255 names related to the canoe and gathered from some 200 Bantu languages, the author selected four nominal stems that she analyses in depth at the formal and semantic levels. The study reaches some interesting conclusions at the theoretical and historical levels. First of all, the data proves wrong the
hypothesis according to which nominal stems in Proto-Bantu had invariably an
initial consonantal. To the contrary, in the protolanguage, the canonical *-CV(CV) structure must have coexisted with a *-VCV structure. At the cultural history level, the comparative distribution of the four selected stems is revelatory. Alongside a very old root for ‘ canoe’, spread throughout the Bantu zone except for the extreme south, innovations emerged in the two coastal regions and along the banks of the Congo River, showing the influence that peoples specialized in navigation and/ or fishing exerted on the evolution of the lexicon.À partir d’un corpus de 255 noms relatifs à la pirogue et récoltés dans quelque
200 langues bantoues, l’auteur a sélectionné quatre thèmes nominaux qu’elle
analyse en profondeur sur le plan formel et sémantique. L’étude aboutit à certaines
conclusions intéressantes aussi bien sur le plan théorique qu’historique. Tout d’abord, les données falsifient l’ancienne hypothèse, selon laquelle, en protobantou, les thèmes nominaux avaient invariablement une initiale consonantique. Au contraire,
dans la protolangue, la structure canonique *-CV(CV) devait coexister avec une structure *-VCV. Sur le plan de l’histoire culturelle, la distribution comparée des quatre racines sélectionnées est révélatrice. À côté d’une racine très ancienne pour
'' pirogue'', répandue dans tout le domaine bantou à l’exception de l’extrême sud,
des innovations ont surgi dans les deux régions côtières et sur le cours du fleuve Congo, mettant ainsi en évidence l’influence que les populations spécialisées dans
la navigation et/ ou la pêche ont sur l’évolution du lexique.Bulkens Annelies. Quelques thèmes pour ‘pirogue’ dans les langues bantoues. In: Africana Linguistica 15, 2009. pp. 27-58
In vitro structure-activity relationship determination of 30 psychedelic new psychoactive substances by means of beta-arrestin 2 recruitment to the serotonin 2A receptor
No full textSerotonergic psychedelics, substances exerting their efects primarily through the serotonin 2A receptor (5-HT2AR), continue to comprise a substantial portion of reported new psychoactive substances (NPS). The exact mechanisms of action of psychedelics still remain to be elucidated further, and certain pathways remain largely unexplored on a molecular level for this group of compounds. A systematic comparison of substances belonging to diferent subclasses, monitoring the receptor-proximal β-arrestin 2 recruitment, is lacking. Based on a previously reported in vitro bioassay employing functional complementation of a split nanoluciferase to monitor β-arrestin 2 recruitment to the 5-HT2AR, we here report on the setup of a stable HEK 293 T cell-based bioassay. Following verifcation of the performance of this new stable cell system as compared to a system based on transient transfection, the stable expression system was deemed suitable for the pharmacological characterization of psychedelic NPS. Subsequently, it was applied for the in vitro assessment of the structure–activity relationship of a set of 30 substances, representing diferent subclasses of phenylalkylamine psychedelics, among which 12 phenethylamine derivatives (2C-X), 7 phenylisopropylamines (DOx) and 11 N-benzylderivatives (25X-NB). The resulting potency and efcacy values provide insights into the structure–activity relationship of the tested compounds, overall confrm fndings observed with other reported in vitro assays, and even show a signifcant correlation with estimated common doses. This approach, in which a large series of psychedelic NPS belonging to diferent subclasses is comparatively tested, using a same assay setup, monitoring a receptor-proximal event, not only gives pharmacological insights, but may also allow prioritization of legal
actions related to the most potent -and potentially dangerous- compounds
In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances
No full textThe landscape of new psychoactive substances (NPS) is constantly evolving, with new compounds entering the illicit drug market at a continuous pace. Of these, opioid NPS form a threat given their high potency and prevalence. Whereas previously, the use of fentanyl and fentanyl derivatives was the main point of attention, legislations have reacted accordingly, whichmay have been a driving force towards the (ab)use of alternative µ-opioid receptor (MOR) agonists. In contrast to fentanyl (analogues), details on these novel non-fentanyl opioid NPS are scarce. We investigated the biological activity of a panel of 11 ‘alternative’, newly emerging MOR agonists (2-methyl-AP-237, AP-237, bromadol, brorphine, butorphanol, isotonitazene, mitragynine, 7-OH-mitragynine, MT-45, piperidylthiambutene, and tianeptine) using two closely related in vitro MOR activation bio-assays, monitoring either G protein (mini-Gi), or β-arrestin2 (βarr2) recruitment. Activity profles were obtained for all tested compounds, with values for potency (EC50) ranging from 1.89 nM (bromadol) to>3 µM (AP-237 and tianeptine).
Bromadol, brorphine, isotonitazene, piperidylthiambutene, and tianeptine had the highest efcacy (Emax) values, exceeding that of the reference compound hydromorphone≥1.3-fold (βarr2 assay) and>2.6-fold (mini-Gi assay). Information on the recruitment of two distinct signaling molecules additionally enabled evaluation of biased agonism; none of the evaluated opioids being signifcantly biased. Taken together, this study is the frst to systematically investigate the in vitro biological activity of a diverse panel of emerging non-fentanyl opioid NPS at MOR. Given the known danger of (fatal) intoxications with many opioid NPS, it is important to continuously monitor and characterize newly emerging compounds
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