186,380 research outputs found
Adesmus calca Galileo & Martins 2005
No full text1. <i>Adesmus calca</i> Galileo & Martins, 2005 <p>Type locality— Peru, Cuzci: Calca (80 km N). (USNM). Distribution — Peru.</p> <p> <i>Adesmus calca</i> Galileo & Martins, 2005b: 278, fig. 16.</p>Published as part of <i>MONNÉ, MIGUEL A., 2006, Catalogue of the Cerambycidae (Coleoptera) of the Neotropical Region. Part III. Subfamilies Parandrinae, Prioninae, Anoplodermatinae, Aseminae Spondylidinae, Lepturinae, Oxypeltinae, and addenda to the Cerambycinae and Lamiinae,, pp. 1-244 in Zootaxa 1212 (1)</i> on page 181, DOI: 10.11646/zootaxa.1212.1.1, <a href="http://zenodo.org/record/5064972">http://zenodo.org/record/5064972</a>
Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice
No full textOsteoarthritis represents a chronic degenerative joint disease with exceptional clinical relevance.Polymorphisms of the CALCA gene, giving rise to either a procalcitonin/calcitonin (PCT/CT) or acalcitonin gene-related peptide alpha (αCGRP) transcript by alternative splicing, were reported to beassociated with the development of osteoarthritis. The objective of this study was to investigate therole of both PCT/CT and αCGRP transcripts in a mouse model of post-traumatic osteoarthritis (ptOA).WT, αCGRP−/− and CALCA−/− mice were subjected to anterior cruciate ligament transection (ACLT) toinduce ptOA of the knee. Mice were sacrificed 4 and 8 weeks post-surgery, followed by micro-CT andhistological evaluation. Here we show that the expression of both PCT/CT and αCGRP transcripts isinduced in ptOA knees. CALCA−/− mice show increased cartilage degeneration and subchondral boneloss with elevated osteoclast numbers compared to αCGRP−/− and WT mice. Osteophyte formation isreduced to the same extent in CALCA−/− and αCGRP−/− mice compared to WT controls, while areduced synovitis score is noticed exclusively in mice lacking CALCA. Our data show that expressionof the PCT/CT transcript protects from the progression of ptOA, while αCGRP promotes osteophyteformation, suggesting that CALCA-encoded peptides may represent novel targets for the treatmentof ptOA.Osteoarthritis represents a chronic degenerative joint disease with exceptional clinical relevance. Polymorphisms of the CALCA gene, giving rise to either a procalcitonin/calcitonin (PCT/CT) or a calcitonin gene-related peptide alpha (αCGRP) transcript by alternative splicing, were reported to be associated with the development of osteoarthritis. The objective of this study was to investigate the role of both PCT/CT and αCGRP transcripts in a mouse model of post-traumatic osteoarthritis (ptOA). WT, αCGRP−/− and CALCA−/− mice were subjected to anterior cruciate ligament transection (ACLT) to induce ptOA of the knee. Mice were sacrificed 4 and 8 weeks post-surgery, followed by micro-CT and histological evaluation. Here we show that the expression of both PCT/CT and αCGRP transcripts is induced in ptOA knees. CALCA−/− mice show increased cartilage degeneration and subchondral bone loss with elevated osteoclast numbers compared to αCGRP−/− and WT mice. Osteophyte formation is reduced to the same extent in CALCA−/− and αCGRP−/− mice compared to WT controls, while a reduced synovitis score is noticed exclusively in mice lacking CALCA. Our data show that expression of the PCT/CT transcript protects from the progression of ptOA, while αCGRP promotes osteophyte formation, suggesting that CALCA-encoded peptides may represent novel targets for the treatment of ptOA.</p
Association study of the calcitonin gene-related polypeptide-alpha (CALCA) and the receptor activity modifying 1 (RAMP1) genes with migraine
No full textMigraine is a common neurovascular brain disorder characterised by recurrent attacks of severe headache that may be accompanied by various neurological symptoms. Migraine is thought to result from activation of the trigeminovascular system followed by vasodilation of pain-producing intracranial blood vessels and activation of second-order sensory neurons in the trigeminal nucleus caudalis. Calcitonin gene-related peptide (CGRP) is a mediator of neurogenic inflammation and the most powerful vasodilating neuropeptide, and has been implicated in migraine pathophysiology. Consequently, genes involved in CGRP synthesis or CGRP receptor genes may play a role in migraine and/or increase susceptibility. This study investigates whether variants in the gene that encodes CGRP, calcitonin-related polypeptide alpha (CALCA) or in the gene that encodes a component of its receptor, receptor activity modifying protein 1 (RAMP1), are associated with migraine pathogenesis and susceptibility. The single nucleotide polymorphisms (SNPs) rs3781719 and rs145837941 in the CALCA gene, and rs3754701 and rs7590387 at the RAMP1 locus, were analysed in an Australian Caucasian population of migraineurs and matched controls. Although we find no significant association of any of the SNPs tested with migraine overall, we detected a nominally significant association (p = 0.031) of the RAMP1 rs3754701 variant in male migraine subjects, although this is non-significant after Bonferroni correction for multiple testing.Griffith Health, School of Medical ScienceNo Full Tex
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Condiciones turísticas que presenta el distrito de Calca para la práctica del turismo de aventura 2019
No full textLa presente indagación, hace un estudio acerca de la relación entre las Condiciones
turísticas que caracterizan al distrito de Calca y la práctica del turismo de aventura
del año 2019. Esta población está conformada por 39,210 turistas nacionales y extranjeros de
los cuales se eligió a los que visitaron el distrito de Calca en el mes de noviembre de 2019 por lo
cual la muestra está conformada por 90 turistas nacionales y extranjeros. El tipo de investigación
es descriptivo explicativo y tiene un diseño no experimental, transversal y correlacional. Para su
recolección de datos se encuestó cerca de veinte ítems perteneciendo a una escala de
interpretación de cinco niveles contrastados con el Alfa de Crombach siendo su valía de 0.974
respecto de los ítems estimados para la variable “Condiciones turísticas” y 0.953 hacia
los ítems para la variable “Prácticas del turismo de aventura”. La interpretación de los
resultados generales fueron así “Como = 0.000 < 0.05, en la prueba Chi – cuadrado, se
puede manifestar existen condiciones turísticas que presenta el distrito de Calca para la
práctica del turismo de aventura, 2019, siendo el porcentaje de relación mediante la
correlación de Spearman un 53.3%, con una confiabilidad al 95%”; siendo así, podría
aceptarse la Hipótesis Alterna «Existen condiciones turísticas que presenta el distrito de
Calca para la práctica del turismo de aventura, 2019» y se rechaza la Hipótesis nula.The research study studies the relationship between the tourist conditions presented
by Calca district and practice of adventure tourism 2019. The population is made up of
39,210 national and foreign tourists from which those who visited the district of Calca
were chosen in the month of November 2019, so the sample is made up of 90 national
and foreign tourists. The investigation is descriptive and explanatory and its design is not
experimental, transversal and correlational. For the data collection, a twenty-item survey
was used with a five-level interpretation scale contrasted with the Cronbach's Alpha that
has a value of 0.974 for the items considered in the Tourist Conditions variable and 0.953
for the items in the Practices variable of adventure tourism. The interpretation of the
general results were thus “As p = 0.000 <0.05, in the Chi - square test, it can be affirmed
that there are tourist conditions presented by the district of Calca for the practice of
adventure tourism, 2019, where the degree of relationship through Spearman's correlation
it is 53.3%, at 95% reliability ”, therefore, the Alternate Hypothesis is accepted« There
are tourist conditions presented by the district of Calca for the practice of adventure
tourism, 2019 »and the Hypothesis is rejected null
La gestión municipal y su incidencia en la recaudación tributaria de la municipalidad de Calca - Cusco, periodo 2022
No full textEl presente trabajo de investigación titulado “La gestión municipal y su incidencia en la recaudación tributaria de la municipalidad de Calca - Cusco, periodo 2022” tuvo como objetivo el de determinar la incidencia que tiene la Gestión Municipal en la Recaudación Tributaria de la Municipalidad de Calca - Cusco, periodo 2022, teniendo como problema ¿Cuál es la incidencia que tiene la Gestión Municipal en la Recaudación Tributaria de la Municipalidad de Calca - Cusco, periodo 2022? Considerando que la Gestión Municipal incide significativamente en la Recaudación Tributaria de la Municipalidad de Calca - Cusco, periodo 2022. Esta investigación es considerada como una Investigación Aplicada de Nivel Explicativo de Investigación mixta, con un diseño No experimental de corte transversal. La población y muestra fue en base a 14 trabajadores de la Oficina de Administración Tributaria de la Municipalidad de Calca – Cusco. Se aplicó una prueba de Kolmogórov-Smirnov exhibe un nivel de significancia inferior a 0,05 lo cual conlleva al rechazo de la hipótesis nula (H0) de acuerdo con las reglas de decisión, al cumplirse el criterio de p < 0,05. En consecuencia, se acepta la hipótesis alternativa, que sugiere que la distribución de los datos de la muestra no es normal. Por lo tanto, se utilizará el estadístico no paramétrico, específicamente la herramienta del coeficiente de correlación de Rho Spearman, para llevar a cabo los análisis estadísticos necesarios para probar la hipótesis de investigación
Fiscalización tributaria y la recaudación del impuesto predial de la Municipalidad Provincial de Calca 2023
No full textEl presente estudio se centró en determinar como la Fiscalización Tributaria
se relaciona con la Recaudación de Impuesto predial en la Municipalidad provincial
de Calca en el año 2023. Metodológicamente se optó por un enfoque correlacional,
de tipo aplicada, con un diseño no experimental de corte transversal, teniendo como
muestra a 50 empleados seleccionados mediante muestreo no probabilístico con
los respectivos datos, extraídos de la Municipalidad Provincial de Calca. Como
técnica de la investigación, la recolección de datos se llevó a cabo mediante
encuestas, utilizando cuestionarios como herramienta principal para la recolección
de información e instrumento para cada una de las variables de estudio, por
consiguiente, se sometieron a pruebas de validez y confiabilidad mediante el
procesamiento de los datos en el programa estadístico SPSS. Por su parte, los
resultados de la investigación determinaron la relación de significancia, positiva y
moderada entre la fiscalización tributaria y la recaudación de impuesto predial en la
Municipalidad Provincial de Calca obteniendo un valor Rho=0.431 (p=0.002). Por
último, se concluye que, a mayor fiscalización, mayor será la recaudación de
impuesto predial, demostrando así que la fiscalización incide de forma directa y
positiva en la recaudación de impuesto predial de la Municipalidad Provincial de
Calca
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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