2,488 research outputs found
Biosintesi della vitamina B3: studi strutturali e funzionali di isoenzimi nicotinamide mononucleotide adenililtrasferasi coinvolti nella protezione dalla neurodegenerazione
No full textLa Nicotinamide MonoNucleotide AdenililTrasferasi (NMNAT) è l’enzima chiave per la biosintesi del NAD+, sia nella via de novo che in quelle di recupero (salvage pathways). Nelle vie di recupero, l’NMNAT consente alla cellula di rigenerare il coenzima dalla vitamina B3 (niacina) o PP (Pellagra Preventing) assunta attraverso fonti esogene o ottenuta metabolicamente dalla degradazione intracellulare del dinucleotide stesso. Catalizzando il trasferimento dell’adenilato dall’ATP all’NMN, la forma mononucleotidica della vitamina B3, l’enzima porta alla formazione di PPi e NAD+. Il NAD+ è coinvolto nella cellula in vitali funzioni redox e non redox e la sua carenza è associata ad una vasta gamma di patologie nell’uomo, tra cui malattie neurodenegerative. È stato scoperto che la proteina chimerica WldS, proveniente da una mutazione spontanea sul cromosoma 4 nel ceppo murino C57BL/6J, è in grado di ritardare la degenerazione assonale. La porzione enzimaticamente attiva della proteina chimerica è l’omologo murino dell’enzima umano NMNAT1, una delle 3 isoforme note di NMNAT nei mammiferi che catalizzano la biosintesi del NAD+ in diversi distretti cellulari. Diversi lavori pubblicati hanno mostrato la capacità delle 3 isoforme di conferire protezione in varia misura, anche se non concordano su quale sia l’isoforma responsabile della protezione dalla neurodegenerazione. Per chiarire i meccanismi molecolari alla base del fenomeno sono state studiate proprietà cinetiche e molecolari delle 3 isoforme NMNAT note da mammifero. Tale studio ha permesso di mettere a punto un saggio di determinazione individuale della loro attività applicabile direttamente a estratti tissutali grezzi. Tale saggio consente di rilevare in maniera diretta le alterazioni a carico delle singole isoforme, già osservate in varie patologie cronico-degenerative riguardanti il sistema nervoso, nella pellagra e in stati patologici cellulari definiti “pellagra-like”, strettamente connessi alla carenza nutrizionale della vitamina PP
Structural and functional characterization of pathogenic protein effectors belonging to the PcF Toxin Family by mutagenesis and homology modeling
No full textEducation and Training in St.Lucia: A Partially Annotated Bibliography
No full textThis bibliography on “Education and Training in St. Lucia” has been specifically prepared for the UWI School of Continuing Studies’ St. Lucia Country Conference. An attempt has been made to be as comprehensive as possible, but because of the weak bibliographical coverage of the literature of the region, important items may have been omitted. This is especially true for policy documents emanating from official sources. It covers all aspects of education and training in St.Lucia including distance education, educational finance,health and family life education and educational reform
Columbus Square, St. Lucia
No full textLandscape, black & white, 4 x 6 in.No. 18.
Columbus Square, St. Lucia.
Columbus Square, St. Lucia, located in the heart of the capital city, Castries was formerly the site of the Place D’Armes, which was renamed Promenade Square before being renamed the Columbus Square. The Square is currently named after a St. Lucian author Derek Walcott. This spot also pays respect to residents who lost their lives in battle.
On the Postcard; “Columbus Square, St. Lucia.” people can be seen congregating in the Square under the trees.
Information at the back of the Post Card:
Union Postale Universelle
Sarah Cameron, 2013. Footprint Focus. St Lucia & Dominica with Fort-de-France
The language of the cataloguer (part 1). The author
No full textThe paper analyses the evolution of the language of cataloguing, focusing on the concept of authorship. It evaluates cataloguing principles, rules and theory, from Cutter to ICP 2016, in order to study the modification of the idea of author in cataloguing and the emerging importance of non-authorial responsibilities as access points for the organization of catalogues
The causes and the effects of the deficiency in the Pre-Legislative and Legislative scrutiny processes in St. Lucia
No full textThis dissertation argues that there is a significant deficiency in the pre-legislative and legislative scrutiny processes in St. Lucia, caused by the failure of Parliament to utilize the Standing Orders in the manner in which they were intended and develop and follow a more systematic scrutiny process. The author explains how this has hindered St. Lucia’s ability to gain more benefit from the legislative process and improve the quality of legislation produced with less likelihood of amendments
Export Processing in the Caribbean: Lessons from Four Case Studies
No full textThe author reviews case studies of four Caribbean countries-the Dominican Republic, Jamaica, Saint Lucia and Trinidad-and briefly discusses an African country, Mauritius. He compares labour legislation, nationality of investors, technology transfer, and linkages with the rest of the economy. Of these five cases, only Trinidad failed to develop a significant export processing sector. Explanations rooted in government policy are suggested for this result. United Nations ECLAC Working Paper No. 42 (September 1996).export processing zones, export promotion, Dominincan Republic, Saint Lucia, Jamaica, Trinidad and Tobago, Mauritius, transnational corporations
Séquence 3, La rencontre entre Ivaldo et Lucia, raconté par Ivaldo
No full textCette séquence fait partie du corpus vidéo de Langue des Signes Emergentes utilisé lors de la thèse d'Ivani Fusellier-Souza : le locuteur Ivaldo raconte avec Lucia leur première rencontre.00:00:00>00:00:14 Lucia demande à Ivaldo de raconter leur rencontre, ou du moins la première fois qu'il l'a vu dans la rue. 00:00:14>00:00:18 Ivaldo raconte que Lucia passait dans la rue et qu'il l'a regardé marcher. 00:00:18>00:00:20 Lucia lui rappelle qu'elle marchait dans la rue et avait un air hautain. 00:00:20>00:00:24 Ivaldo raconte qu'il lui a offert une glace qu'elle a mangée. 00:00:24>00:00:26 Lucia lui dit qu'il la regardait de loin. 00:00:26>00:00:31 Ivaldo raconte qu'il l'a vu passée et qu'il lui a offert une glace qu'elle a accepté. 00:00:31> 00:00:42 Lucia se rappelle qu'il lui a offert une glace. 00:00:42>00:00:52 Ivaldo demande à son fils de ne pas passer devant la caméra. 00:00:52>00:00:58 Lucia lui rappelle comment elle était belle avec ses cheveux longs. 00:00:58>00:01:20 Ivaldo raconte qu'il n'aimait pas ses cheveux longs, qu'il préfère Lucia avec des cheveux courts, et qu'elle a bien fait de les couper. 00:01:20>00:01:23 Lucia raconte qu'après ils se sont mariés. 00:01:23>00:01:32 Ivaldo dit qu'ils se sont mariés à Fortaleza
Literary translations in a sample of anarchist periodicals of the Atlantic space (1890-1910)
No full textDataset of the Anarchist Translation Flows and World Literature Project (ARGOT)
Marie Skłodowska-Curie Grant Agreement No. 101065157, 2023-2025 (Main researcher: Lucia Campanella).
This dataset, consisting of various collections of structured data in diverse formats, presents the results of the ARGOT project.
Below, there is a list and brief description of the four interconnected subdatasets, each representing a distinct phase in the data processing pipeline. Information on each subdataset is to be found in a Readme document included in each collection.
Subdataset I contains metadata on the selected periodicals used as the primary data sources.
Subdataset II consists of the digitized and transcribed content from these periodicals.
Subdataset III includes all extracted text lines in which author entities have been identified using Named Entity Recognition (NER) and cross-referenced with VIAF (Virtual International Authority File) identifiers.
Subdataset IV contains manually validated literary translations, with enriched metadata providing additional contextual and bibliographic information
Introducition : Veritas in dicto, veritas in re
No full textThe present Introduction is the joint work of two authors: Paolo Di Lucia is the author of §§ 1., 2., and 5.; Lorenzo
Passerini Glazel is the author of §§ 3. and 4. The authors of the Introduction are grateful to the Editorial Board of
“Phenomenology and Mind”, especially to the Editors in chief Roberta De Monticelli and Francesca De Vecchi, as well
as to Francesca Forlé and Sarah Songhorian, for the invitation to edit this special issue, as well as for their precious
assistance in the publication process. We also thank the Faculty of Philosophy and the PhD School in Philosophy of
the University Vita-Salute San Raffaele, as well as the research centre PERSONA, the centre of studies CeSEP, and the
centre for interdisciplinary studies CISEPS, for their contribution to the organization of the 2022 San Raffaele School
of Philosophy
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