56 research outputs found
Cyclooxygenase-2, P53 and Glucose Transporter-1 as Predictors of Malignancy in the Development of Gallbladder Carcinomas
No full textGallbladder carcinoma is the fifth most common malignancy of the gastrointestinal tract. The absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a combination of classical standard clinico/pathological parameters (stage of the tumors, differentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). The author searched extensively for the expression and influence of 3 markers included in chronic inflammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase-2 (COX-2), p53 gene and glucose transporter-1 protein (GLUT-1). The author discusses their possible role in the development as well as fighting this disease, if specific medications targeting them were availabl
Media cognitive implications of the „Document from Aparecida”
No full textArtykuł omawia treść dokumentu końcowego V Ogólnej Konferencji Episkopatów Ameryki Łacińskiej i Karaibów zwanego „Dokumentem z Aparecidy”. Autor, podkreślając różne wskazania pastoralne, zwraca szczególną uwagę na implikacje medioznawcze dokumentu, ukazując je w kontekście nowej ewangelizacji.The article touches on the content of the final document of the 5th General Conference of the Bishops of Latin America and Caribbean known as „Document from Aparecida”. Author emphasizing various pastoral indications underlines especially the media cognitive implications of the above document presenting them in the context of the new evangelization
MEASUREMENTS OF LINE WIDTH AND SHIFT PARAMETERS FOR MICROWAVE ABSORPTION LINES
No full text R. L. Legan, J. A. Roberts, E. A. Rinehart, and C. C. Lin, J. Chem. Phys. 43, 4337 (1965).Author Institution: Jet Propulsion Laboratory, California Institute of TechnologyThe line width and shift parameters have been measured in the same experiment, with the aid of a computer controlled microwave spectrometer. The technique can be employed to rapidly and reproducibly measure these parameters for any microwave spectral line. As a test of this experimental method, the width and shift parameters were measured for the K = J self-broadened ammonia inversion lines. With a few exceptions, the width measurements are in general agreement with the work of Legan, et However, the line shift parameters generally disagree with the values obtained by previous workers. The ammonia results and some preliminary results on formaldehyde will be presented. RKK acknowledges support by an NRC Resident Research Associateship. This paper presents the results of one phase of research carried out at the Jet Propulsion Laboratory, California Institute of Technology, under Contract Number NAS 7-100, sponsored by the National Aeronautics and Space Administration
Analise facial e cefalometrica comparativa de mulheres com harmonia facial
No full textOrientador: Mario Francisco R. GabrielliTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: Foram avaliadas 2'0 mulheres leucodermas, brasileiras, com harmonia facial, modelos profissionais, que receberam análise facial conforme descrita por STELLA (1996) e PASSERI (1999). Por meio de
telerradiografias tomadas em norma lateral, as análises cefalométricas de LEGAN & BURSTONE (1980) e MCNAMARA JR (1984) foram aplicadas. Os resultados obtidos foram tabulados, analisados estatisticamente e comparados com os valores originais descritos nas análises empregadas, permitindo concluir que: 1) apesar dos diferentes aspectos faciais e oclusais da amostra, as proporções
verticais da face guardaram relação de 1/1/1, entre os três terços faciais, em média; 2) a análise facial revelou, nas mulheres estudadas, menores dimensões transversais do terço médio da face, com
diferença estatisticamente significativa, em relação à literatura; 3) as medidas cefalométricas relativas aos dois terços inferiores do terço inferior da face, na análise de LEGAN & BURSTONE (1980), que
refletem a posição do incisivo inferior e do lábio inferior apresentaram se estatisticamente diferentes dos valores descritos pelos autores; 4) para as medidas ósseas apresentadas por MCNAMARA JR (1984),
que são as comumente utilizadas no plamejamento ortodôntico cirúrgico, não houve diferenças estatisticamente significativas em relação aos valores obtidos para a amostra considerada; 5) a
variabilidade para as proporções consideradas na análise facial foi em , geral menor que para as medidas isoladas; 6) o valor médio do ângulo nasolabial para a amostra estudada foi de 107,8°; 7) a expostção
média radiográfica do incisivo central superior foi de 4,15 mm. O valor , médio obtido clinicamente foi de 0,87 mm, em repouso, e 9,05, 'fllmAbstract: Twenty white Brazillian females, professional models presenting good facial balance, were studied by means of facial analysis, as described by STELLA (1996) and PASSERI (1999). The cephalometric
analysis of LEGAN & BURSTONE (1980) and MCNAMARA JR (1984) , isolated measurements for the facial analysis; 6) the mean value for were applied to lateral cephalograms. Results were statistically
analyzed and compared with the original values as described for the considered methods, allowing the following conclusions: 1) facial proportions were 1/1/1 for the three facial thirds; 2) facial analysis
revealed smaller transverse values for the middle third horizontal measurements with statistically significant differences in relation to the literature; 3) measurements relative to the two inferior thirds of the
lower facial third, which reflected the position of the inferior incisor and lower lip, were statistically different from those described by LEGAN & BURSTONE (1980); 4) the MCNAMARA JR analysis (1984) values
presented no statistically significant differences from those described by the author; 5) facial proportions were less variable than absolut the nasolabial angle was 107,8°; 7) Mean radiographic upper incisor
exposure was 4,15 mm. The mean clinical measurement was 0,87 mm n repose and 9,05 mm in smilingDoutoradoCirurgia Buco-Maxilo-FacialDoutor em Clínica Odontológic
Christian Wagner y Robert Walser: puntos de encuentro entre el poeta y el narrador
No full textDos Außenseiter que engrosan la nómina de autores olvidados -bien que al suizo, tarde, pero se le haya rescatado-, dispares en cuanto a sus orígenes, legan una aportación, esencialmente poética el uno, fundamentalmente prosística el otro, de extraordinaria originalidad y aún no tenida suficientemente en cuenta, no ya en la consideración individual de cada uno -que quizás también- sino, a todas luces, desde enfoques propios de la investigación comparada. Las no nimias similitudes, a juicio del autor de este estudio, perceptibles en lo literario, en el mundo intelectual de Wagner y Walser, en sus concepciones de la vida..., y hasta de orden personal, invitan -y ese es, por tanto, el objetivo de este trabajo- a exponer con precisión aquello que relaciona a ambos escritores.Two Außenseiter with very different origins can be found on the inventory of forgotten authors - even if the Swiss writer has experienced a (albeit, delayed) renaissance. They have both bequeathed an extraordinarily original contribution to German language literature, a contribution which is essentially poetic in Wagner’s case and fundamentally written in prose in the case of Walser. Such notable contributions have nonetheless rarely been taken into major consideration, and while there may be some studies on the individual authors, there certainly have never been any from a comparative perspective. The significant resemblances between the two writers, which are, in the opinion of this author, not only evident in relation to literary elements, but also with regard to their intellectual world, to their conception of life or, even, to their personal lives, invite a detailed presentation of the connections between these two authors. That is precisely the objective of this article
Los delitos de disolución social: primeras experiencias (1941-1944). Antropología. Boletín Oficial del Instituto Nacional de Antropología e Historia: Vigilantes y vigilados. Seguridad, espionaje, control político y social en la historia de México. Num. 101 Nueva Época (2016) diciembre
No full textPara esta investigación se consultaron expedientes del Tribunal Superior de Justicia del Distrito Federal (AGN-TSJDF), de la policía secreta capitalina (AHDF) y de los agentes de la Secretaría de Gobernación (AGN-DIPS).Academia Mexicana de Ciencias Penales, Los delitos de disolución social, México, Botas, 1969, pp. 47-63.Acusados del delito de disolución social enviados por la Jefatura de la Policía de San Luis Potosí, junio de 1942, AGN, DIPS, caja 116, exp. 42, ff. 3-8.AGN-DIPS, caja 195, exp. 22 y caja 116, exp. 55.Agosto de 1943, agn, dips, caja 116, exp. 54.Aguayo, Sergio; 1968: los archivos de la violencia, México, Grijalbo, 1998.———; La charola: una historia de los servicios de inteligencia en México, México, Grijalbo, 2001, pp. 62 y 300.Bernal de León, José; La quinta columna en el continente americano, México, Ediciones Culturas Mexicanas, 1940.Cavazos, Israel; Diccionario biográfico de Nuevo León, Monterrey, UANL, 1987, t. I, p. 75.Coronel Aristeo de la Fuente, junio de 1943, AGN, DIPS, caja 116, exp. 54.Declaraciones del obispo de San Luis Potosí respecto de la Liga Defensora de la Libertad, CEHM-CARSO, fondo X .2.71.1 y Boletín 11. Segunda Serie: Liga Nacional Defensora de la Libertad, CEHM-CARSO, fondo X .2.69.Dickmann, Enrique; La infiltración nazi-fascista en la Argentina, Buenos Aires, Ediciones Sociales Argentinas, 1939, p. 6.El Partido Nazi en México, México, Acción Democrática Internacional, 1941.González Bustamante, Juan José; Semanario Judicial de la Federación, 6ª época, vol. LXVIII, 1961, p. 27.Hernández Galindo, Sergio; “La guerra interna contra los japoneses”, en Dimensión Antropológica, año 15, vol. 43, mayo-agosto de 2008, p. 103.———; “Orígenes del autoritarismo: la concentración de japoneses en México durante la Segunda Guerra Mundial”, en Carlos San Juan Victoria (coord.), El XX mexicano: lecturas de un siglo, México, Ítaca, 2012, p. 153.Inclán Fuentes, Carlos; “Perote y los nazis. Las políticas de control y vigilancia del Estado mexicano a los ciudadanos alemanes durante la Segunda Guerra Mundial, 1939-1946”, tesis de licenciatura, México, FFyL-UNAM, 2012.Katz, Friedrich; “Algunos rasgos esenciales de la política del imperialismo alemán en América Latina”, en Jürgen Hell, Klaus Kannapin y Úrsula Schlenter, Hitler sobre América Latina. El fascismo alemán en Latinoamérica, 1933-1943, México, Fondo de Cultura Popular, 1968, pp. 9-96.Laureano I. Michel Cobián, junio de 1943, AGN, DIPS, caja 195, exp. 22.“Ley contra el espionaje y el quintacolumnismo”; Excélsior, 9 de octubre de 1941.Lombardo Toledano, Vicente; Cómo actúan los nazis en México, México, Universidad Obrera de México, 1941.M. de la Luz Meza Cienfuegos, 3 de junio de 1942, AHDF, Fondo Cárceles: Penitenciaría, expedientes de reos, caja 662, partida 4483, ff. 2a y 2r.María de los Ángeles Berumen, 17 de junio de 1942, AHDF, Fondo Cárceles: Penitenciaría, expedientes de reos, caja 665, partida 4846, ff. 18-24.Metz, Brígida von; “Notas en torno al exilio político alemán en México (1939-1946), en Fascismo y antifascismo en Amé-rica Latina y México, México, CIESAS, 1984, pp. 48-59.Meyer, Jean; El sinarquismo: ¿un fascismo mexicano?, 1937-1947, México, Joaquín Mortiz, 1979, pp. 138-143.Olmo, Rosa del; América Latina y su criminología, México, Siglo XXI, 1981, pp. 156-158.Ortiz Garza, José Luis; La guerra de las ondas, México, Planeta, 1992, pp. 23-30.“Paul Ernest Strobelt, alemán acusado del delito de disolución social”, 1942, AGN, DIPS, caja 125, exp. 5, ff. 11-12.Paz Salinas, María E.; Strategy, Security and Spies: Mexico and the U.S. as Allies in World War II, State College, The Pennsylvania State University, 1997, pp. 61-73.“Proyecto de Dickmann”, diputado nacional, 18 de mayo de 1938, pp. 7-36.Radkau, Verena; “El Tercer Reich en América Latina”, en Brígida von Metz, Ricardo Pérez Montfort y Verena Radkau, Fascismo y antifascismo en América Latina y México (apuntes históricos), México, CIESAS, 1984, pp. 5-28.Rankin, Mónica A.; ¡México, la patria! Propaganda and Production during World War I, Lincoln/University of Nebraska Press, 2009.Ross, Colin; Der Balkan Amerikas: mit Kind und Kegel durch Mexiko zum Pana-makanal (7ª ed.), Leipzig, F.A. Brockhaus, 1938.Salazar Anaya, Delia y Begoña Hernández y Lazo; “Introducción”, en Guía del fondo de la Secretaría de Gobernación, sección: Dirección de Investigaciones Políticas y Sociales, 1920- 1950, México, INAH, 2006.Schuler, Friedrich; “Alemania, México y los Estados Unidos durante la Segunda Guerra Mundial”, en Secuencia, núm. 7, enero-abril de 1987, p. 186.Servín, Elisa; La oposición política. Otra cara del siglo XX, México, FCE/CIDE, 2006, p. 44.Speckman, Elisa; “Reforma legal y opinión pública: los códigos penales de 1871, 1929 y 1931”, en Arturo Alvarado (ed.), La reforma de la justicia en México, México, El Colegio de México, 2008, pp. 575-613.Tschuppik, Walter; Los caballos de Troya de Hitler. Técnica de la quinta columna, México, Minerva, 1941Valdovinos, Carlos y Luis Cousiño; “Segundo Congreso Latinoamericano de Criminología”, en Cuadernos Criminalia, México, 1941, p. 59.Yankelevich, Pablo; “Extranjeros indeseables en México, 1911- 1940: una aproximación cuantitativa a la aplicación del artículo 33 constitucional”, en Historia Mexicana, vol. 53, núm. 3, enero-marzo de 2004, pp. 693-744.Este trabajo estudia la aplicación temprana del artículo referente a delitos de disolución social en México. Su objetivo es entender la etapa seminal de una ley reputada por ser empleada para desactivar y reprimir movimientos sociales en periodos posteriores. Para ello se dimensionan las prácticas de un Estado que supuestamente prevenía el espionaje y quintacolumnismo en territorio mexicano durante la Segunda Guerra Mundial, detallando los mecanismos coercitivos, ambigüedades y límites que experimentó la administración judicial en dicha materia, con el sesgo que invariablemente legan los archivos.This paper analyzes the early implementation of social dissolution laws in Mexico. Its aim is to understand the application of a juridical instrument which later was used to punish a diversity of social movements. In doing so, this article shows the practices of a State allegedly called to prevent espionage and Fifth Column in Mexico during World War II. Thus this text details the enforcement mechanisms, ambiguities and limits experienced by the judicial administration in this matter, with biases that the official files invariably leave
Free serum cortisol during the postoperative acute phase response determined by equilibrium dialysis liquid chromatography-tandem mass spectrometry
No full textIn severely ill patients low concentrations of the corticosteroid binding globulin are typically found; the aim of this study was to quantify directly free bioactive cortisol concentrations in the sera of postoperative cardiosurgical patients. Serum samples of 12 consecutive patients undergoing aortocoronary bypass surgery taken preoperatively and on the postoperative days 1 to 4 were analyzed. Total serum cortisol was quantified using liquid chromatographytandem mass spectrometry with an online sample extraction system and trideuterated cortisol as the internal standard, and free serum cortisol was measured after overnight equilibrium dialysis. Whereas on the first postoperative day, the median total serum cortisol concentration was approximately twofold increased compared to preoperative samples (preoperatively, 245 nmol/l (interquartile range (IQR) 203293 nmol/l); first postoperative day, 512 nmol/l (IQR 410611 nmol/l)), median dialyzable free cortisol concentration was almost sevenfold increased (preoperatively, 14.2 nmol/l (IQR 10.920.7 nmol/l); first postoperative day, 98.3 nmol/l (IQR 81.3134 nmol/l)). On the fourth postoperative day, median free cortisol was still significantly increased compared to baseline sampling (p < 0.05), whereas median total cortisol was not. A median of 5.7% (IQR 5.47.0%) of total cortisol was found as free cortisol on the preoperative day, 21.2% (IQR 18.9 23.5%) on the first postoperative day and 10.5% (IQR 9.814.0%) on the fourth postoperative day. It is concluded that during the postoperative period the freeto bound ratio of cortisol is highly variable and that during the acute phase response direct quantification of free bioactive cortisol concentrations seems to be biologically more appropriate than the measurement of total cortisol concentrations
Material characterisation of a painted beehive panel by advanced spectroscopic and chromatographic techniques in combination with hyperspectral imaging
No full text© 2020, The Author(s). In this study, a painted beehive panel from the collection of the Slovene Ethnographic Museum was examined with respect to its material composition with the aim to reveal the painting technique. Due to the state of degradation due to outdoor weathering (UV irradiation, rainfall, extreme temperature and humidity fluctuations), as well as past conservation interventions, the object represented a complex analytical challenge. We aimed for non-invasive techniques (FTIR in reflection mode, Raman spectroscopy and hyperspectral imaging in the range of 400–2500 nm); however, in order to explore paint layers, cross-sections were also analysed using Raman spectroscopy. FTIR spectroscopy in transmission mode and gas chromatography coupled to mass spectrometry were also used on sample fragments. Various original materials were identified such as pigments and binders. The surface coating applied during conservation interventions was also characterised. Additionally, organic compounds were found (oxalate, carboxylate), representing transformation products. The potential use of Prussian blue as a background paint layer is discussed.[Figure not available: see fulltext.]
Molecular biology of hearing
No full textThe inner ear is our most sensitive sensory organ and can be subdivided into three functional units: organ of Corti, stria vascularis and spiral ganglion. The appropriate stimulus for the organ of hearing is sound, which travels through the external auditory canal to the middle ear where it is transmitted to the inner ear. The inner ear houses the hair cells, the sensory cells of hearing. The inner hair cells are capable of mechanotransduction, the transformation of mechanical force into an electrical signal, which is the basic principle of hearing. The stria vascularis generates the endocochlear potential and maintains the ionic homeostasis of the endolymph. The dendrites of the spiral ganglion form synaptic contacts with the hair cells. The spiral ganglion is composed of neurons that transmit the electrical signals from the cochlea to the central nervous system. In recent years there has been significant progress in research on the molecular basis of hearing. An increasing number of genes and proteins related to hearing are being identified and characterized. The growing knowledge of these genes contributes not only to greater appreciation of the mechanism of hearing but also to a deeper understanding of the molecular basis of hereditary hearing loss. This basic research is a prerequisite for the development of molecular diagnostics and novel therapies for hearing loss
Christian views of euthanasia: a comparison of Russian and western perspectives
No full textThe following research aims at unfolding an authentic Christian attitude to euthanasia by means of a comparative analysis of Christian bioethical thinking and practice in Russia and in the West. It seeks to establish what is euthanasia, whether it is incompatible with Christianity and, if so, what is the alternative. The first chapter explores the meaning of 'euthanasia', comparing and rethinking a number of definitions from the existing multitude. Through the psychological thicket of slogans such as "mercy killing", "personal autonomy" and "death with dignity" the core characteristic of euthanasia - deadly intention - is hardly ever seen. With some notable exceptions with regard to self-defence, just war, or capital punishment, in Christianity intending to kill has always been regarded as a grave sin of breaking the sixth commandment. The second chapter shows how Western Christian bioethics has gone from the ethics of Paul Ramsey to the ethics of Tristram Engelhardt, from balancing between justifying certain forms of intentional killing while condemning others to purifying one's heart and cultivating one's soul in order to prevent the formation of an intention to kill. The third chapter is dedicated to the development of Christian bioethics in Russia. In a country with over a millennium of Orthodox tradition there is an exceptional opportunity for the bioethical framework of Engelhardt to settle in naturally. The fourth chapter presents a number of well-publicized medical situations in Britain where choices between life and death were exercised. The analysis based on the material of the previous chapters shows most of them to be clear cases of euthanasia, while others have a recognizable potential to be described as such. The history and an ongoing story of the modem hospice movement - a living alternative to euthanasia - are the focus of the fifth and last chapter of this dissertation. Its core ability - to live with suffering - sustains the opposition to euthanasia and is essentially a Christian virtue
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