703 research outputs found
A method for the direct evaluation of the fatty acid status in drop of blood from a finger tip in humans
No full textRole of plant-derived omega-3 fatty acids in human nutrition
No full textAn international workshop on the role of plant-derived omega-3 fatty acids in human nutrition took place in Milan on February 9, 2000, The meeting was sponsored by the Nutrition Foundation of Italy and was organized by its Scientific Director, Dr. Andrea Poli. It was attended by experts in polyunsaturated fatty acids and human lipid nutrition. This is the first meeting devoted to the health aspects of alpha-linolenic acid, the omega-3 fatty acid contained in plant-derived edible products, as distinct from the more widely studied long-chain omega-3 products typically present in fish and fish-derived products. This report, which is based on updated scientific evidence presented and discussed at the workshop, was prepared by the international expert panel. Copyright (C) 2000 S. Karger AG, Basel
Robotic vs laparoscopic total mesorectal excision for rectal cancers: has a paradigm change occurred? A systematic review by updated meta-analysis
No full textAim The debate about the oncological adequacy, safety and efficiency of robotic vs laparoscopic total mesorectal excision for rectal cancers continues. Therefore, an updated, traditional and cumulative meta-analysis was performed with the aim of assessing the new evidence on this topic. Method A systematic search of the literature for data pertaining to the last 25 years was performed. Fixed- and random-effects models were used to cumulatively assess the accumulation of evidence over time. Results Patients with a significantly higher body mass index (BMI), tumours located approximately 1 cm further distally and more patients undergoing neoadjuvant therapy were included in the robotic total mesorectal excision (RTME) cohort compared with those in the laparoscopic total mesorectal excision (LTME) cohort [RTME, mean difference (MD) = 0.22 (0.07, 0.36), P = 0.005; LTME, MD = -0.97 (-1.57, 0.36), P < 0.002; OR = 1.47 (1.11, 1.93), P = 0.006]. Significantly lower conversion rates to open surgery were observed in the RTME cohort than in the LTME cohort [OR = 0.33 (0.24, 0.46), P < 0.001]. Operative time in the LTME cohort was significantly reduced (by 50 min) compared with the RTME cohort. Subgroup analysis of the three randomized controlled trials (RCTs) challenged all the significant results of the main analysis and demonstrated nonsignificant differences between the RTME cohort and LTME cohort. Conclusion Although the RTME cohort included patients with a significantly higher BMI, more distal tumours and more patients undergoing neoadjuvant therapy, this cohort demonstrated lower conversion rates to open surgery when compared with the LTME cohort. However, subgroup analysis of the RCTs demonstrated nonsignificant differences between the two procedures
Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report
No full textIntroduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways involved in these tumors.
Case presentation: A 68-year-old Italian man was admitted to our unit complaining of macrohematuria, rectorrhagia, and rectal tenesmus for about 2 months. A colonoscopy showed the presence of a rectal lesion at 11cm from the anal margin; multiple biopsies were performed and a diagnosis of moderately differentiated adenocarcinoma was made. Abdominal ultrasonography and total body computed tomography performed subsequently to stage the rectal cancer showed the presence of two round nodules, interpreted as swollen lymph nodes of neoplastic origin, at the anterior aspect of the iliopsoas muscle and a budding lesion affecting the bladder. The patient underwent transurethral biopsy of the lesion in the right retrotrigonal region; the diagnosis was grade II urothelial carcinoma. The patient underwent an open anterior rectal resection with loco-regional lymphadenectomy. An enlarged appendix and a voluminous whitish soft-tissue lesion requiring an appendicectomy were detected perioperatively. Transurethral resection of the bladder lesion was also performed. The histological examination revealed that the nodular lesions in the appendix were due to a cystadenoma. For mutation analysis, genomic deoxyribonucleic acid was isolated from tumor tissue samples; for PIK3CA mutations, screening revealed that all three samples analyzed carried mutations in exon 9.
Conclusions: Appendiceal mucoceles are rare but require adequate surgical treatment, given their malignant potential and the possibility of causing peritoneal pseudomyxoma. It is essential to make a correct preoperative evaluation based on a colonoscopy rather than ultrasound and computed tomography to exclude synchronous neoplasias often associated with mucoceles and to plan the optimum surgical strategy. The association between appendiceal mucoceles and other neoplasias is relatively frequent, especially with colorectal cancer. Oncogenic activation in the PIK3CA-depending pathway may contribute substantially to the pathogenesis of the different solid tumors in the same patient
A probabilistic, hierarchical, and discriminant framework for rapid and accurate detection of deformable anatomic structure
No full textWe propose a probabilistic, hierarchical, and discriminant (PHD) framework for fast and accurate detection of deformable anatomic structures from medical images. The PHD framework has three characteristics. First, it integrates distinctive primitives of the anatomic structures at global, segmental, and landmark levels in a probabilistic manner. Second, since the configuration of the anatomic structures lies in a high-dimensional parameter space, it seeks the best configuration via a hierarchical evaluation of the detection probability that quickly prunes the search space. Finally, to separate the primitive from the background, it adopts a discriminative boosting learning implementation. We apply the PHD framework for accurately detecting various deformable anatomic structures from M- mode and Doppler echocardiograms in about a second.S. Kevin Zhou, F. Guo, J.H. Park, G. Carneiro, J. Jackson, M. Brendel, C. Simopoulos, J. Otsuki, and D. Comanici
Uso do azul de toluidina seguido Da quimioluminiscência como método euxiliar de diagnóstico clínco de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
Robotic versus laparoscopic total mesorectal excision for rectal cancers; has a paradigm change occurred? A systematic review by updated Meta-Analysis
No full textThe debate about the oncological adequacy, safety, and efficiency of robotic versus laparoscopic total mesorectal excision for rectal cancers continues. Therefore, an updated, traditional, and cumulative meta-analysis was performed to assess the current new evidence on this topic
Uso do azul de toluidina seguido da quimioluminiscência como método auxiliar de diagnóstico clínico de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Curso de Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
Bajji on the Beach: Middle-Class Food Practices in Chennai’s New Beach
No full textThis book produced by a group of interdisciplinary and international researchers working on a wide variety of cities throughout Asia, Latin America and Europe, addresses, rethinks and, in some cases, abandons the notions of formal and ..
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