1,528 research outputs found
Other title: Kansas Health Policy Authority Recommended Authorship for the Twenty Legislative Coordinating Council Requested Studies; Other title: Recommended Authorship for the Twenty Legislative Coordinating Council Requested Studies
No full textapplication/pdf; "August 14, 2008."; Author, date, and committee name taken from Kansas Department of Health and Environment website.; Information presented to the Kansas Legislature, Joint Oversight Committee on Health Policy, by Dr. Barb Langner, Director of Policy, Kansas Health Policy Authority.Document lists 20 studies recommended by the Legislative Coordinating Council, and KHPA's recommendations for which agencies should author each study
Other title: House Bill 2578 : Utilization of Unused Medications Act; Other title: Utilization of Unused Medications Act
No full textapplication/pdf; Caption title lists Marcia J. Nielsen as the author at the top of the page, but the contents indicate that the testimony was presented by Barbara Langner.; "January 31, 2008."; Testimony before the Kansas Legislature, Senate Ways and Means Committee, by Barbara Langner, Policy Director, Kansas Health Policy Authority.Testimony in support of HB 2578, the Utilization of Unused Medications Act, which will improve access to care by providing medications to citizens through Federally Qualified Health Centers - citizens who may have been without medications
Are heterogenous results of EGFR immunoreactivity in renal cell carcinoma related to non-standardised criteria for staining evaluation?
No full textAIMS:
To assess whether heterogeneity of epidermal growth factor receptor (EGFR) immunoreactivity in renal cell carcinoma (RCC) is related to non-standardised criteria for staining evaluation.
METHODS:
EGFR expression was investigated in 132 primary and 55 metastatic conventional RCCs using a tissue microarray technique.
RESULTS:
Overall, membranous and/or cytoplasmic EGFR immunostaining was present in 123 of 132 (93%) primary and 49 of 53 (92%) metastatic RCCs, with extensive immunoreactivity (> 50% of tumour cells) in 110 of 132 (83%) primary tumours and 39 of 53 (73%) metastases. Cytoplasmic staining was associated with high tumour stage and high tumour grade. In addition, strong membranous staining (score 3+) prevailed in high grade RCCs. Cytoplasmic immunostaining was associated with an unfavourable prognosis, whereas overall (cytoplasmic and membranous) immunoreactivity and intensity of membranous staining were not.
CONCLUSIONS:
Different methods of immunohistochemical evaluation led to different results, strengthening the need for standardisation, especially against a background of rapidly evolving EGFR targeted cancer treatment strategies
High quality superconducting niobium films produced by an ultra-high vacuum cathodic arc
No full textThe vacuum arc is a well-known technique for producing coatings with enhanced adhesion and film density. Many cathodic arc deposition systems are actually in use in industry and research. They all work under (high) vacuum conditions in which water vapour pressure is an important source of film contamination, especially in the pulsed arc mode of operation. Here we present a cathodic arc system working under ultra-high vacuum conditions (UHVCA). UHVCA has been used to produce ultra-pure niobium films with excellent structural and electrical properties at a deposition temperature lower than 100 degrees C. The UHVCA technique therefore opens up new perspectives for all applications requiring pure films and low deposition temperatures
Microscopic colitis: pathophysiology and clinical management
No full textMicroscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity
A combined systems and structural modeling approach repositions antibiotics for Mycoplasma genitalium
No full textBacteria are increasingly resistant to existing antibiotics, which target a narrow range of pathways. New methods are needed to identify targets, including repositioning targets among distantly related species.We developed a novel combination of systems and structural modeling and bioinformatics to repositionknown antibiotics and targets to new species. We applied this approach to Mycoplasma genitalium, acommon cause of urethritis. First, we used quantitative metabolic modeling to identify enzymes whoseexpression affects the cellular growth rate. Second, we searched the literature for inhibitors of homologsof the most fragile enzymes. Next, we used sequence alignment to assess that the binding site is shared byM. genitalium, but not by humans. Lastly, we used molecular docking to verify that the reported inhibitorspreferentially interact with M. genitalium proteins over their human homologs. Thymidylate kinase wasthe top predicted target and piperidinylthymines were the top compounds. Further work is needed toexperimentally validate piperidinylthymines. In summary, combined systems and structural modeling isa powerful tool for drug repositioning.Polish National Science Centre (UMO-2013/09/B/NZ2/00121); Wroclaw Centre for Networking and Supercomputing (255); European Cooperation in Science and Technology (BM1405); Medical University of Bialystok; European Social Fund; National Science Foundation Graduate Fellowship; James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex System
Inanspruchnahme von stationärer und ambulanter ärztlicher Versorgung bei Kindern und Jugendlichen mit Aufmerksamkeitsdefizit/Hyperaktivitätsstörung (ADHS) in Deutschland
No full textDevelopment and validation of the Material Values Scale for children (MVS-c)
No full textContains fulltext :
134938.pdf (Publisher’s version ) (Closed access)The aim of this study was to develop a scale to measure materialism among children while relying on insights from research conducted among adults. Although research among adults suggests that materialism is a second-order construct with three underlying factors (i.e., material centrality, material happiness, and material success), existing materialism scales for children include only one or two of these factors. Hence, we adapted the items of the well-established Material Values Scale (MVS) of Richins and Dawson (1992) to make them appropriate for use among children. We then administered the Material Values Scale for children (MVS-c) to 1001 8- to 11-year-olds. Structural equation modeling confirmed the presumed second-order structure of the MVS-c. Based on these findings, we created 6- and 3-item versions in addition to the full-length, 18-item MVS-c. All three versions performed well in terms of test–retest reliability and construct validity
Planning the support for cancer pharmacotherapy using vitamin C supplementation based on the new model of its homeostasis in cell
No full textWitamina C jest od lat przedmiotem dyskusji i kontrowersji spowodowanych brakiem wiedzy dotyczącej mechanizmów jej działania. W rezultacie wszelkie wskazaniaodnoszące się do suplementacji witaminą C spotykały się z dużą dozą nieufności. W przedstawionym opracowaniu pokazano aktualny stan wiedzy dotyczący metabolicznej roli witaminy C oraz mechanizmy odpowiedzialne za jej homeostazę na poziomie organizmu i komórki. W oparciu o tę wiedzę zaproponowano model opisujący homeostazę witaminy C, pozwalający na wyciągnięcie praktycznych wniosków dotyczących jej suplementacji.
Na potrzeby prezentowanego omówienia przyjmujemy, że witamina C to biologicznie aktywna postać askorbinianu (anion kwasu L-askorbinowego). Anion ten powstaje w wodzie w wyniku dysocjacji soli lub kwasu askorbinowego, a fizjologiczna aktywność witaminy C skorelowana jest z jej ilością w organizmie, którą ocenia się na podstawie stężenia w surowicy krwi. Przyjmuje się, że dwa stężenia witaminy C w surowicy są ważne z punktu widzenia diagnostycznego. Pierwsze stężenie to 50 μM. Jest to stężenie witaminy C w surowicy, powyżej której zapotrzebowanie organizmu na witaminę C jest zaspokojone. Drugie stężenie to 20 μM. Gdy stężenie witaminy C w surowicy krwi jest poniżej tego poziomu, to pojawia się zagrożenie wystąpienia szkorbutu.Vitamin C has been the subject of discussion and controversy for years due to the lack of knowledge about its mechanisms of action. As a result, all indications regarding vitamin C supplementation are met with a high degree of distrust. The presented study shows the current state of knowledge regarding the metabolic role of vitamin C and the mechanisms responsible for its homeostasis at the organism and cellular level. Based on this knowledge, a model describing vitamin C homeostasis was proposed, allowing for drawing many practical conclusions regarding its supplementatio
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