25,552 research outputs found
Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach
No full textBackground: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s) for this phosphorylation event.Results: A combined bioinformatics approach of motif prediction and evolutionary and structural analyses identified tyrosines163 and 1856 of the skeletal muscle heavy chain as the leading candidate for the sites of insulin-mediated tyrosine phosphorylation.Conclusion: Our work is suggestive that tyrosine phosphorylation of myosin heavy chain, whether in skeletal muscle or in platelets, is a significant event that may initiate cytoskeletal reorganization of muscle cells and platelets. Our studies provide a good starting point for further functional analysis of MHC phosphor-signalling events within different cells.<br/
Espectros, diálogos y referentes polémicos: Judith Butler fuera de sí
No full textEl presente proyecto es una continuación de una línea de investigación iniciada hace mas de 10 años. En esta oportunidad nos centraremos en explorar, analizar y evaluar la importancia de la tradición filosófica en la obra de Judith Butler, aplicando las nociones de "espectros" (Derrida), "referentes polémicos " (Amoros), "diálogo" (Benhabib) como modos de recuperación del pasado filosófico.This research project is the line of previous investigations, started more than ten years ago. In this oportunity we focus on exploring, analyzing and evaluating the philosophical tradition in the works of Judith Butler, taking into account the concepts of specters (Derrida), polemic references (Amoros) and dialogue (Benhabib) as a way to preserve philosophical past.Fil: Femenías, María Luisa. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Chiacchio, Cecilia Alejandra. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina
Therapeutic uses of inorganic nitrite and nitrate - from the past to the future
No full textPotential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future
Ittijahat Abi Dhu'ayb Al-Hudhali fi Qasidatihi Ar-Ritsa’
No full textThis article aims to know Ittijahat of Abu Dhu’ayb Al-Hudhali in his poem of Ritsa’. Ittijahat in this study is a description of the poet's tendency to divide Ar-Ritsa', namely Nadb and Ta'ziyah. Ar-Ritsa 'is one of the various forms of Arabic poetry. To analyze the discussion problem, the author uses descriptive analysis method, because this method is very appropriate to find out the picture and state of a thing by describing it in as much detail as possible based on the facts found in the data in question. The results obtained are: In the beginning of the poem, he tends to mourn (Nadb) their five children. He describes in it that he does not stop crying and has trouble sleeping until he becomes weak emaciated due to the intensity of the grief, pain and worries that dominated in his pysche. As for the middle of the poem to the end, the poet turns to the consolation (Ta’ziyah) of his children’s death, as he reflects on the reality of life and death, the poet declares that death is inevitable for every human being that he must accept it and let it go, which the poet portrayed in the exciting narrative style. The story is divided into three stories: the zebra, the bull of the beast, and the two knights.</jats:p
Program “I’dad Lughowi” dalam Upaya Membekali Kemampuan Bahasa Arab Mahasiswa STIBA Ar-Raayah, Sukabumi
No full textNowdays, Arabic already has its own charm. Apart from the Al-Quran and Hadith as sources of Islamic Shari'a which are imported from the original source in Arabic, the emergence of scientific disciplines linked to Shari'a adds to the public's attraction and interest in studying Shari'a directly from its Arabic sources. Arabic language learning is starting to emerge with various strategies and methods applied. Some are successful and others need review. In this article, the author wants to examine Arabic language learning in the STIBA Ar-Raayah i'dad lughowi program which is considered successful because it has produced many regional, national and even international achievements. This article aims to examine the background of students in the STIBA Ar-Raayah i'dad lughowi program, the teaching and learning activities of the i'dad lughowi program at STIBA Ar-Raayah and the examination system implemented in the i'dad lughowi program. This article is a case study at STIBA Ar-Raayah using a descriptive qualitative approach. The results found in this research are (1) the background of students in the STIBA Ar-Raayah i'dad lughowi program who come from various regions and schools, (2) learning using the Arabiyyah book Baina Yadaik by maximizing the direct method and activities outside the classroom, (4) a unique exam system with Al-Qur'an exams, subject exams, syahri exams, nihai exams, as well as a rosib system for students who do not reach the minimum completion criteria. The results and conclusions of this research can be used as a reference for Arabic language educational institutions to make them more effective in the future
Androgens and the androgen receptor (AR)
No full textIntroduction Androgens are sex steroid hormones that are produced in both males and females, albeit in different amounts. Androgens are essential for development and maintenance of the male phenotype (1), and are also important in females, where they can either act directly via the androgen receptor (AR) or indirectly as metabolic precursors for estrogen biosynthesis (2). The majority of circulating androgens in males and females are produced by the gonads, under hypothalamic–pituitary regulation, and adrenal glands. The major circulating androgens are dehydroepiandrosterone, DHEA sulfate, androstenedione, and testosterone, which can all be metabolized to other androgens or to estrogens. Testosterone and its intracrine metabolite, 5α-dihydrotestosterone (DHT), are the most potent androgenic hormones, as they bind with high affinity to the AR. Many organs in both males and females are sensitive to androgen action and, depending on the tissue-specific context, androgens regulate multiple cellular processes, including proliferation, differentiation, apoptosis, metabolism, secretory responses, and the synthesis of lipids and fatty acids (3). Accordingly, deregulation of AR expression and/or function is associated with a diverse range of clinical conditions, including androgen insensitivity syndrome (AIS), a form of motor neuron disease known as Kennedy's disease, male and female pattern baldness, hirsutism, acne, male infertility, polycystic ovary syndrome, benign prostatic hyperplasia, and breast and prostate cancer. In particular, the AR is considered an oncogene in the prostate as it plays a critical role at all stages of prostate carcinogenesis, and consequently, inhibition or abrogation of androgen signaling is the goal of hormonal therapies for this disease. In contrast, androgens predominantly have a growth inhibitory role in the breast, consistent with an emerging view of the AR playing a tumor-suppressive role in breast tumorigenesis.Nicole L. Moore, Margaret M. Centenera, Lisa M. Butler, Theresa E. Hickey, and Wayne D. Tille
The Poetry Anthology Ar-Robi fii qalbi by Sofi Ghoniyah: A Sociology of Author Perspective
No full textThis study aims to determine the sociology of the author in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren. This research focuses on four aspects, namely (1) the social background of the author in the anthology of poetry Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (2) the author\u27s social integration in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (3) author\u27s economic sources in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (4) professionalism in the authorship of Sofi Ghoniyah\u27s anthology of poetry Ar-Robi fii Qalbi based on the perspective of Rene Wellek and Austin Warren. This type of research is qualitative research. The data source of this research uses an anthology of poetry entitled "Ar-robi fii qalbi" by Sofi Ghoniyah. While the secondary data sources of this research were obtained from reading books or journals discussing the sociological theory of the authors Rene Wellek and Austin Warren. Data collection techniques in this study used interview techniques and note-taking techniques. The data validation technique used in this study is to increase persistence, triangulate data, and discuss with colleagues and experts. Meanwhile, for the data analysis technique, this research uses the Miles and Huberman method, namely data reduction, data presentation, and drawing conclusions. The researchers produced several data, namely (1) the author of the poetry anthology Ar-Robi fii qalbi is an educated author and has close interactions with her environment. (2) The author of the poetry anthology Ar-Robi fii qalbi has a high degree of integration. He mingles with the general public. (3) The main economic source of the author in Ar-Robi\u27s poetry anthology is not through her work but in her educational activities. As a teacher, her work is often used as learning material for her students. (4) The author of the poetry anthology Ar-Robi fii qalbi has high professionalism in the authorship of her work
Pustakawan Dalam Perspektif Manajer Informasi: Studi Kasus Pada Mahasiswa Jurusan S1 Ilmu Perpustakaan Fakultas Adab dan Humaniora UIN Ar-Raniry
No full textThis study aims to find out Librarian in Perspective of Information Manager (Case Study on Library Science Undergraduate Student of Adab and Humanities Faculty of UIN Ar-Raniry, Banda Aceh). This research uses quality descriptive approach, an approach that emphasizes more on the deductive and inductive deduc- tion process and on the analysis of the dynamics of relationship between observed phenomena, using scientific logic. The students of Library Science were observed to be 54 people for three months. For this research the author will explain in detail about UIN Ar-Raniry Banda Aceh Main Library in the perspective of information managers for llibrary users especially Library Science students class of 2016 intake. The research results are; Librarians are not yet fully able to become information managers at UIN Ar-Raniry Main Library of Banda Aceh, due the small number of librarians for this size of a college library. Lack of librarian contribution to be- come information manager, in order to be able to fulfill requirement of information for their users, in this case undergraduate student of Library Science. Regarding the perspective that a library must be able to provide all forms of information required has not been done well, especially the information needs fot this such of users in this case Library Science students
Teacher Candidates' opinions about Augmented Reality(AR) as a supplemental educational tool
No full textThis poster was presented by Alam, I., Teacher Candidates' opinions about Augmented Reality(AR) as a supplemental educational tool. Presented at 10th Annual Graduate and Professional Student Conference, held at Memorial Union, Ames, IA, April 6 2022. Posted with permission.In recent years, augmented reality (AR) technology has been widely proposed as innovative technology. AR technology superimposes digitally simulated information on the physical environment, which can be a unique element for learning experiences. Despite the potential of AR, there has been relatively little integration of AR into the
classroom. The purpose of this pilot study is to examine the acceptance and intentional use of AR technology by teacher candidates and their opinions of AR as a supplemental educational tool. The study has utilized a phenomenological design that is comprised of System Usability Scale survey and interview questions. Based on the participants' answers, research data has been analyzed and discussed
La constitución del sujeto-agente: los aportes de la filosofía de Judith Butler y su influencia actual La constitución del sujeto-agente: los aportes de la filosofía de Judith Butler y su influencia actual
No full textEl presente proyecto se centra en los debates en curso respecto de la categoría de "sujeto", en su comprensión actual desde la denominada Filosofía de Género. Dentro de esta corriente, es fundamental examinar los aportes recientes de la filósofa norteamericana Judith Butler y de algunas de sus críticas y continuadoras. Si bien se examinarán sus contribuciones in toto, el Proyecto que presentamos, se centrará en, por un lado, los diversos usos del concepto de "performatividad" desarrollado y resignificado por la filósofa y, por otro, conceptos tales como "deseo" que se enraízan en la tradición filosófica y psicoanalítica, también conmocionada por los escritos de Butler. Ambos espacios semántico-conceptuales se presentan como claves hermenéuticas privilegiadas para entender la constitución de la subjetividad en términos de "agencia", punto central de nuestro análisis. Para ello, exploraremos, en diversas etapas de su obra (en curso), los alcances e implicaciones de la tradición filosófica continental y estadounidense (deconstruccionista, marxista, existencialista, nihilista, analítica, entre otras) en relación a la categoría de "sujeto", y su lúcido examen de figuras emblemáticas de la tragedia y la novela. En un segundo momento se explorarán las derivaciones y críticas a la obra de Butler; tal el caso de Beatriz Preciado, que merecerá especial atención.This project focuses on the current debates around the category of "subject" in its understanding from the Philosophy of Gender, for which it is fundamental to examine the recent contributions of the American philosopher Judith Butler and those of some of her followers and critics. Thus, we will examine, on the one hand, the different uses of the concept of "performativity" developed by Butler and, on the other hand, concepts such as "desire," rooted in the traditions of philosophy and psychology which she re-elaborates. Both semantic-conceptual spaces are hermeneutic privileged keys to understand the constitution of the subjectivity en the "agency." We also will examine its reach and implications along Butler's work as well as its displacements and connections with the philosophical heritage (deconstruction, Marxism, existentialism, nihilism, among others). In her philosophical analysis of how each one accounts for being a subject, Butler adds perceptive and enriching deconstructions of emblematic figures from tragedy, like Antigone, which is also important to revise. In short, we will trace her philosophical antecedents and polemical referents in order to situate her contributions, the originality of her thinking and the explanatory capacity of many of her conceptual inversions.Fil: Femenías, María Luisa. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Chiacchio, Cecilia Alejandra. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina
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