6 research outputs found
Subtipos macrofágicos e gotículas lipídicas na doença de Jorge Lobo e hanseníase virchowiana - análise imunoistoquímica
No full textO conjunto de dados foi gerado para estudar a atuação dos subtipos macrofágicos e gotículas lipídicas na doença de Jorge Lobo (dJL) e hanseníase virchowiana (HV), como parte de tese de doutorado. Trata-se de um estudo retrospectivo e analítico de amostras de pele, e dados clínicos, de 52 pacientes com dJL e de 16 com HV. A dJL é uma micose cutânea crônica, de patogenia pouco compreendida, em que o macrófago é a célula predominante. A hanseníase, por sua vez, é uma doença granulomatosa cutânea, milenarmente estudada. Visando compreender a atuação da população macrofágica e gotículas lipídicas na patogenia da dJL e as similaridades imunológicas com a HV, foram investigados, comparativamente, os aspectos clínicos, histológicos convencionais, o perfil do infiltrado macrofágico e a presença de gotículas lipídicas na dJL e na HV
Mucocutaneuos tumoral lesions associated with herpes simplex virus : sistematic review of the literature
No full textOrientador: Maria Letícia CintraDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Erupções muco cutâneas causadas pelo vírus herpes simples (HSV) são comuns em todo o mundo. Podem se apresentar como pápulas eritematosas dolorosas típicas, vesículas, úlceras rasas ou até lesões atípicas. A manifestação tumoral do HSV tem sido relatada em pacientes imunocomprometidos, principalmente naqueles infectados pelo vírus da imunodeficiência humana (HIV). Ela pode ser mal interpretada clinicamente como neoplasia ou afecção secundária a outros agentes infecciosos, induzindo a erros de diagnóstico e, assim, estratégia terapêutica equívoca. O objetivo foi revisar, na literatura, os trabalhos sobre lesões tumorais muco cutâneas do HSV (MCT HSV) e caracterizar o perfil clínico-epidemiológico de pacientes com MCT HSV em todo o mundo. Dois pesquisadores extraíram e revisaram, independentemente, os dados, por meio da ferramenta de busca na literatura PubMed / MEDLINE até outubro de 2018, enumerando os mais importantes aspectos clínicos, histopatológicos e terapêuticos e discutindo os possíveis mecanismos fisiopatológicos. Conclui-se que os médicos devem estar cientes das lesões tumorais MCT HSV, em pacientes imunossuprimidos, para evitar tratamentos desnecessariamente agressivosAbstract: Eruptions caused by herpes simplex virus (HSV) represents common mucocutaneous lesions worldwide. It can present with typical painful erythematous papules, vesicles, shallow ulcers, or atypical lesions. The tumoral manifestation of herpes simplex has been reported in immunocompromised patients, mainly on those infected by human immunodeficiency virus (HIV) and, could be misinterpreted clinically as neoplasms or secondary to others infectious agents, leading to misdiagnosis and equivocal therapeutic strategy. The goal was to review the reported cases of mucocutaneous tumoral HSV lesions in the literature and to characterize the clinical-epidemiological profile of patients with mucocutaneous tumoral HSV (MCT HSV) lesions across the world. Two researchers extracted and independently reviewed data from the literature search engine PubMed/MEDLINE through October, 2018. pointing out to its important clinical, histopathological and therapeutic aspects, and discussing the possible pathogenic mechanisms. Physicians should be aware of MCT HSV lesions in immunosuppressed patients to avoid unnecessarily aggressive treatmentsMestradoAnatomia PatologicaMestra em Ciências Médica
Periungual tegumentary leishmaniasis: a diagnostic challenge
No full textAbstract: Periungual and paronychia-like skin lesions can mimic various diseases, setting up a diagnostic challenge that invariably requires correlation with complementary tests. We report a case of an ulcerated tumor of the nailfold diagnosed as leishmaniasis. Although paronychia-like cutaneous leishmaniasis is a rare variant, its epidemiological relevance in Brazil should prompt dermatologists to include it as a plausible diagnosis thus leading to correct work up and treatment
Herpes simplex virus mucocutaneous tumoural lesions - systematic review
No full textThe goal was to characterize the clinical-epidemiological profile of patients with mucocutaneous tumoural herpes simplex virus (MCT HSV) lesions across the world. Two researchers extracted and independently reviewed data from the literature search engine PubMed/MEDLINE through October 2018. From 110 reported patients, the following data were available: the patients' ages ranged from 7 to 76 years; the majority was male (62.73 %-69/110) and immunosuppression was found in 97.25 % (106/109, missing 1) cases, of whom 88 were HIV- related. Lesions size varied from 0.2-13 cm, settling in the anogenital region in 76.36 % (84/110) patients; 84.13 % (53/63, missing 47) complained of pain and multiple recurrences were found in 44.94 % (40/89, missing 21) cases. On clinical basis, the initial hypothesis was neoplasia in 36/53 patients. Histopathological diagnosis was achieved in 90 % (90/100, missing 10) cases and was sample size-dependent. Type 2 HSV was detected in 86.07 % (68/79, missing 31) lesions. MCT HSV lesions recurrence after treatment was reported in 33.96 % (18/53, missing 57) patients. Pathophysiology is poorly understood. Physicians should be aware of MCT HSV lesions in immunosuppressed patients to avoid inappropriate therapeutic strategies12
