4 research outputs found
Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia
No full textVulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers
No full textA stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traits underlying the development of depressive disorders in adult animals. Four weeks after a priming stressful event, serum corticosterone concentration returned to control values in all animals, whereas the other biological parameters returned to basal level in only 58% of animals (called nonvulnerable). In contrast, 42% of animals displayed persistent decreased serum and hippocampus BDNF concentrations, reduced hippocampal volume and neurogenesis, CA3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. In this group, called vulnerable, a subsequent mild stress evoked a rise of serum corticosterone levels and a “depressive” phenotype, in contrast to nonvulnerable animals. Intracerebroventricular administration of 7,8-dihydroxyflavone, a selective TrkB receptor agonist, dampened the development of the “depressive” phenotype. Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression.</jats:p
Planck 2013 results. IV. Low Frequency Instrument beams and window functions
No full textThis paper presents the characterization of the in-flight beams, the beam window functions and the associated errors for the Planck Low Frequency Instrument (LFI). Knowledge of the beam profiles is the key to determining their imprint on the transfer function from the observed to the actual sky anisotropy power spectrum. The main beam distortions affect the beam window function, complicating the reconstruction of the anisotropy power spectrum at high multipoles, whereas the sidelobes affect the low and intermediate multipoles. The in-flight assessment of the LFI main beams relied on the measurements performed during Jupiter observations. By stacking the data from Jupiter transits, the main beam profiles are measured down to -20 dB at 30 and 44 GHz, and down to -25 dB at 70 GHz. The main beam solid angles are determined to better than 0.2% at each LFI frequency band. To ensure a characterization of the main beam free from the radiometer noise, a dedicated tuning on the Planck pre-launch optical model is performed. This approach provides an optical model whose beams fully reproduce the measurements in the main beam region, but also allow us to describe the beams at power levels lower than can be reached by the Jupiter measurements themselves. The agreement between the simulated beams and the scanning beams is better than 1% at each LFI frequency band. The simulated beams are used for the computation of the window functions for the effective beams. The error budget in the window functions was estimated considering both main beam and sidelobe contributions, as well as taking into account the radiometer bandshapes. The total uncertainties in the effective beam window functions are: (at ell = 600) 2% and 1.2% at 30 and 44 GHz, respectively; and at ell = 1000, 0.7% at 70 GHz
Planck 2013 results. I. Overview of products and scientific results
No full textThe European Space Agency’s Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. In March 2013, ESA and the Planck Collaboration released the initial cosmology products based on the first 15.5 months of Planck data, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the cosmic microwave background (CMB) and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the Sunyaev-Zeldovich effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter ΛCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25σ. Planck finds no evidence for non-Gaussianity in the CMB. Planck’s results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations (σ8) derived from CMB data and that derived from Sunyaev-Zeldovich data. The Planck and WMAP power spectra are offset from each other by an average level of about 2% around the first acoustic peak. Analysis of Planck polarization data is not yet mature, therefore polarization results are not released, although the robust detection of E-mode polarization around CMB hot and cold spots is shown graphically.
Reproduced with permission from Astronomy & Astrophysics, © ESO 201
