6 research outputs found
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
No full textMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
VIBRONIC INTERACTIONS IN AND THE PERTURBED. (000) STATE
No full text1. D. Gauyacq, M. Horani, S. Leach, and J. Rostas, Can. J. Phys. 53, 2040-2059 (1975). . J. Rostas and R. P. Tuckett, J. Mol. Spectrosc. 96, 77-86 (1982). . M. A. Johnson, R. N. Zare, J. Rostas, and S. Leach, J. Chem. Phys. 80, 2407-2428 (1984).Author Institution: Laboratoire de Photophysique Moleculaire du CNRS, Batiment 213, Universite de Paris-Sud; Department of Chemistry, St. Francis Xavier, University; Herzberg Institute of Astrophysics, National Research Council of CanadaIt has been known for many that the (000) level of the state of the ion is severely perturbed at low values of and laser excitation with low rotational temperatures have given low. J rotational term values for the e and f components of the state and of two perturbing states. The present work is concerned with rotational analyses of new emission spectra at rotational temperatures of about 40 K and 200 K from the perturbed state to high levels (up to of the ground state. These bands, whose intensity is due to the perturbing states, are shown to be parallel bands to and vibronic levels with odd values of the vibrational quanturm numbers and in the ground g electronic state. The states perturbing the state, which must therefore be one state and one state, are assigned to the vibronic levels and of the electronic state. Improved vibronic parameters for the and electronic states are obtained
Institute celebrates 80 years
No full textNewspaper Article - 'Institute celebrates 80 years' - The Camrose Canadian, June 24, 1998AWI CollectionInstitute celebrates 80 vears • - THE CAMROSE CANADIAN June 24, 1998
On June 7, 1998 a crowd
gathered in the Round Hill
Community Hall to celebrate
the 80th Anniversary
of Round Hill Women's
Institute.
A short program was
enjoyed with President
Dianne Campbell as
emcee.
History of the 80 years of
the Institute, which began
with the first meeting in a
tent August 6, 1918 was
given by Marion Burnstad,
Annie Banack, Jeanne
Campbell, Edith Blades,
Doreen Haugen and Doris
Powell, each of which was
dressed in the period
depicted.
Louisa Undin, Dena
Storms and Ethel Rude did
a humorous skit ordering
eggs to make angel food
cakes and egg salad sandwiches
for a W. I. meeting
lunch.
Presentation of Service
Awards was
Alberta Vice
Mildred Luz.
Doris Powell received her
Branch Life Membership.
Years of Service
Certificates were presented
by Dianne Campbell and
Doris Powell.
Greetings were received
from M. L. A. LeRoy
made by
President,
Johnson, M. L. A. Albert
Klapstein, Prime Minister
Jean Chretien, Premier
Ralph Klein, M. P. Jack
Ramsay, Vern Peterson on
behalf of Camrose County,
Jim Prost on behalf of the
Elks, Bernie vonTettenborn
from Trondhjem Lutheran
Church, Round Hill Ag.
Society, Lougheed,
Heather Brae, Ohaton,
Women's Institutes as well
as local greetings from
individuals in the community.
Members were presented
with corsages from the
Round Hill Elks. Bouquets
from Transfiguration of our
Lord Ukrainian
Catholic Church
and the R. H. Ag.
Society.
Special guests on
hand to enjoy the
celebration were
A. W. I. President,
Doris Northy;
Maxine Brigley,
President Elect;
Mildred Luz
Alberta Vice
President; Marcella
Bacso, District # 3
Director; Kay
Sastard, District # 1
Director; and new
E x e c u t i v e
Secretary of
A. W. I., Mae
Deams. A number
of former W. I.
members were welcomed
from B. C.
and various parts of
Alberta.
Life members
Irene Campbell
and Marion
Burnstad cut the
Anniversary cake
which was made
and decorated by
Doris Powell.
The afternoon
concluded with a
buffet supper
which was made
" he Round Hill Women's Institute manufactured this symbolic and served by our
ignpost containing the name of every current member. It rep- Round Hill W. I.
esents 475 years of dedication to the group. members.
Women's Institute members in the back row; from left to right, are: ( 28 years);
Dianne Campbell - President; ( 2) Lynne Erickson; ( 14) Linda Chrystian; ( 10)
Doreen O'Brien; ( 15) Alice Kushnerick; ( 13) Doris Pasynyck; ( 21) Dena Storms; ( 4)
Carol Haugen - Secretary; ( 30) Annie Banack; ( 3) Esther Pack; ( 19) Louisa Undin;
( 14) Ethel Rude; ( 20) Doris Powell; and ( 3) Rose Campbell. In the front row, left to
right, are: ( 32) Laurelee Blades; ( 34) Doreen Haugen; ( 33) Edith Blades; ( 45)
Marion Burnstad; ( 41) Jeanne Campbell - Treasurer; and ( 24) Lucie Owen.
Members missing from picture are: ( 12) Shirley Bawden; ( 11) Cathi Naherniak; ( 45)
Irene Campbell; and ( 1) Elaine Zeniuk
Montana Wildlife and Transportation Planning Tool
No full textThe Montana Wildlife & Transportation Planning Tool (MWTPT) combines wildlife and transportation information to identify areas of greatest need for wildlife/transportation accommodations along Montana highways. Development of this tool was a key objective of the Wildlife Transportation Summit in 2018. The Wildlife and Transportation Steering Committee, which formed after the summit, assigned this task to the Data and Information Working Group (DIWG). The DIWG is a collaboration of staff from the Montana Department of Transportation, Montana Fish Wildlife and Parks, and representatives from the Montanans For Safe Wildlife Passage coalition. Data layers were collected to evaluate wildlife-vehicle conflict and important areas for wildlife movement and conservation along Montana Department of Transportation maintained roads. Data layers considered for the analyses were at the continental, national, regional (i.e., Northern Great Plains, Pacific Northwest, etc.) and, statewide scale, along with ecological systems within Montana. Those data were then compiled, categorized, weighted, and ranked to identify large areas (i.e., not specific locations) of greatest need for wildlife and transportation accommodations. This information has now been visualized as an ArcGIS StoryMap consisting of a series of interactive maps and includes a summary report as well as a comprehensive user guide. This presentation will introduce this exciting new product to the audience and provide information on the data and analysis features available, as well as how to use the tool to support work to reduce wildlife-vehicle conflict across the state
COMPARISON OF NUMERICAL AND ANALYTICAL APPROACHES FOR REDUCTION OF ROTATIONAL AND VIBRATION-ROTATIONAL SPECTRA OF DIATOMIC MOLECULES TO PARAMETERS OF RADIAL FUNCTIONS
No full textJ. A. Coxon and M. Molski, Phys. Chem. Comm. 2001, 21 1; J. A. Coxon and M. Molski, Spectrochim. Acta A 2002, submitted for publication. J. A. Coxon and P. G. Hajigeorgiou, J. Mol. Spectrosc., 1991, 150, 1; J. A. Coxon, J. Mol. Spectrosc., 1992, 152, 274. J. M. Campbell, M. Dulick, D. Klapstein, J. B. White and P. F. Bernath, J. Chem. Phys., 1993, 99, 8379; H. G. Hedderich, M. Dulick and P. F. Bernath, J. Chem. Phys., 1993, 99, 8363; M. Dulick, K. Q. Zhang, B. Guo and P. F. Bernath, J. Mol. Spectrosc., 1998, 188, 14. J. Y. Seto, R. J. Le Roy, J. Verges and C. Amiot, J. Chem. Phys., 2000, 113, 3067. J. F. Ogilvie, J. Phys. B, 1994, 27, 47; J. F. Ogilvie, The Vibrational and Rotational Spectrometry of Diatomic Molecules, Academic Press, London, 1998. M. Molski, J. Phys. Chem., 1999, 103, 5269; M. Molski, Chem. Phys. Lett., 1999, 306, 88. M. Molski, Chem. Phys. Lett. 2001, 342, 293.Author Institution: Department of Chemistry, Dalhousie University; Theoretical Chemistry Department, A. Mickiewicz UniversityThe talk presents a numerical of the three most popular methods used for direct inversion of the highly resolved IR and MW spectra of diatomic systems: (A) the numerical techniques such as those described by , , Le and their co-workers, (B) the analytical approach of , implemented in the computer program Radiatom, and (C) its improved version, called deformational self-consistent procedure (DS-cP), proposed by . The test calculations show that the Ogilvie's Radiatom program does not produce sufficiently accurate radial parameters and energy term values for their export to other utilities employed in the spectral analysis of diatomic systems
Avaliação do potencial efeito protetor do probucol em modelos experimentais da doença de Huntington
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA doença de Huntington (DH) é uma patologia neurodegenerativa, autossômica dominante caracterizada por sintomas atribuídos à morte de neurônios estriatais e corticais no cérebro. O mecanismo de neurodegeneração na DH parece estar relacionado com excitotoxicidade, disfunção mitocondrial e estresse oxidativo. O probucol (PB) é um composto fenólico antilipêmico, que apresenta propriedades anti-inflamatória e antioxidante em diferentes modelos experimentais de toxicidade/patologia. O objetivo deste estudo foi investigar o possível efeito protetor do PB sobre a neurotoxicidade e estresse oxidativo em modelos experimentais de DH in vitro e in vivo. Inicialmente, foi avaliada a relação entre prejuízo no metabolismo energético, excitotoxicidade e estresse oxidativo em fatias de estriado de ratos expostas ao ácido quinolínico (AQ), ácido 3-nitropropiônico (3-NP) e ao modelo combinado (AQ + 3-NP). Os dados sugerem que os modelos utilizados podem gerar um padrão complexo de dano, que envolve comprometimento metabólico, formação de espécies reativas de oxigênio (ERO) e estresse oxidativo. O PB preveniu o estresse oxidativo nas três condições experimentais e foi capaz de proteger contra disfunção mitocondrial induzida pelo AQ e AQ + 3-NP. Além disso, o potencial efeito protetor do probucol foi avaliado sobre a neurotoxicidade do 3-NP em ratos. O pré-tratamento com probucol (por 60 dias) aumentou a atividade da glutationa peroxidase (GPx) no estriado e no córtex e preveniu o prejuízo motor e o estresse oxidativo induzido pelo 3-NP em ratos. O efeito do PB sobre a GPx e suas propriedades antioxidantes estão provavelmente associados ao seu efeito benéfico neste modelo. Também foi verificado o possível efeito protetor do succinobucol, um análogo do PB, sobre a toxicidade induzida pelo 3-NP em preparações mitocondriais de cérebro de ratos in vitro. O probucol e o succinobucol preveniram o estresse oxidativo induzido pelo 3-NP, mas apenas o succinobucol foi capaz de prevenir a disfunção mitocondrial induzida pela toxina. Juntos este resultados sugerem um novo papel para o probucol e seu análogo succinobucol como potenciais agentes neuroprotetores em modelos de DH
