227 research outputs found
ANALISIS PENGEMBANGAN AIR TERJUN KAPAS BIRU SEBAGAI DAYA TARIK WISATA DI KABUPATEN LUMAJANG
No full textThis study aims to analyze the development of Kapas Biru Waterfall as a natural tourist attraction in Lumajang Regency using the 6A approach: Attraction, Accessibility, Amenities, Available Packages, Activities, and Ancillary Services. The method used is descriptive qualitative, with data obtained through observation, interviews, and documentation.
The results indicate that Kapas Biru has prominent natural attractions, but is hampered by difficult road access and minimal infrastructure. Available facilities are still rudimentary, tour packages are poorly organized, tourist activities are limited, and supporting services such as security and information are still minimal. Supporting factors include natural beauty, community support, and potential for digital promotion. Conversely, the main obstacles include limited
infrastructure, a lack of facilities, a suboptimal government role, and the absence of integrated management. These findings are expected to serve as a reference in designing sustainable tourism development strategies in Lumajang.
Keywords: Tourism Development, Kapas Biru Waterfall, 6A Approach, Tourist Attractions, Lumajang Regency
Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
No full textInitial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by stimulator of interferon genes (STING). Binding of c di-GMP by STING activates the Tank Binding Kinase (TBK1) mediated signaling cascades that galvanize the body's defenses for elimination of the pathogen. In addition to c di-GMP, STING has also been shown to function in innate immune responses against pathogen associated molecular patterns (PAMPs) originating from the DNA or RNA of pathogens. The pivotal role of STING in host defense is exemplified by the fact that STING(-/-) mice die upon infection by HSV-1. Thus, STING plays an essential role in innate immune responses against pathogens. This opens up an exciting possibility of targeting STING for development of adjuvant therapies to boost the immune defenses against invading microbes. Similarly, STING could be targeted for mitigating the inflammatory responses augmented by the innate immune system. This review summarizes and updates our current understanding of the role of STING in innate immune responses and discusses the future challenges in delineating the mechanism of STING-mediated responses
Pemanfaatan Sumber Daya Alam Cabai Puyang untuk Pengembangan Pariwisata Kesehatan: Studi Kasus Kampung Samin Bojonegoro
No full textPemanfaatan sumber daya alam, khususnya tanaman cabai puyang, oleh masyarakat Kampung Samin di Bojonegoro merupakan contoh nyata dari bagaimana kearifan lokal pengetahuan tradisional dapat digunakan untuk pengembangan pariwisata kesehatan demi meningkatkan kesejahteraan masyarakat dan menjaga keberlanjutan lingkungan. Melalui metode kualitatif deskriptif dengan teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi, penelitian ini mengidentifikasi bahwa cabai puyang tidak hanya berperan sebagai bahan masakan, tetapi juga sebagai pengobatan tradisional untuk berbagai penyakit. Hasil wawancara dengan ibu PKK Kampung Samin menunjukkan bahwa cabai puyang diolah menjadi herbal yang memiliki manfaat dalam pengobatan berbagai penyakit, dan pengetahuan ini turun temurun diperoleh dari para tetuah adat. Tidak hanya dijadikan sebagai herbal untuk kebutuhan rumah tangga, cabai puyang juga menjadi sumber penghasilan tambahan bagi keluarga yang memiliki tanaman tersebut di halaman rumah mereka. Melalui kegiatan jual-beli herbal cabai puyang, para ibu PKK aktif dalam memasok produk herbal ini ke pasar lokal. Praktik ini menjadi cerminan dari keinginan masyarakat Kampung Samin untuk mengembangkan sektor pariwisata Kesehatan dengan potensi sumber daya alam yang dimiliki serta mengelolanya dengan bijaksana. Dengan demikian, pengembangan pariwisata kesehatan berbasis tanaman obat seperti cabai puyang menyoroti pentingnya pemberdayaan ekonomi masyarakat, pelestarian lingkungan, dan memperkuat identitas budaya lokal. Dampak positifnya terasa dalam menjaga keberlanjutan lingkungan dan melestarikan kearifan lokal yang berharga bagi generasi mendatang
Ocular changes in Hymenoptera Sting
No full textTwo cases hereafter reported by the author demonstrated keratopathy, mydriasis and anterior lens capsule opacity and, a severe cystoid Macular oedema – a very rare complication of Bee/Hymenoptera sting to the eye. The Cystoid macular oedema induced a macular hole which led to a retinal detachment after 6 months. The first case was seen 1995 at the Hopeville Rehabilitation Centre Uturu. The second case was seen 6-months later at the General Hospital, Owerri.
KEY WORDS: Bee Sting; Ocular Changes.
Jnl of Medical Investigation and Practice Vol.1 2000: 21-2
Trial watch: STING agonists in cancer therapy
No full textInternational audienceStimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA species in the cytosol. In particular, STING ensures the production of type I interferon (IFN) in response to invading DNA viruses, bacterial pathogens, as well as DNA leaking from mitochondria or the nucleus (e.g., in cells exposed to chemotherapy or radiotherapy). As a type I IFN is critical for the initiation of anticancer immune responses, the pharmaceutical industry has generated molecules that directly activate STING for use in oncological indications. Such STING agonists are being tested in clinical trials with the rationale of activating STING in tumor cells or tumor-infiltrating immune cells (including dendritic cells) to elicit immunostimulatory effects, alone or in combination with a range of established chemotherapeutic and immunotherapeutic regimens. In this Trial Watch, we discuss preclinical evidence and accumulating clinical experience shaping the design of Phase I and Phase II trials that evaluate the safety and preliminary efficacy of STING agonists in cancer patients. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC
Honey bee sting pain index by body location
No full textThe Schmidt Sting Pain Index rates the painfulness of 78 Hymenoptera species, using the honey bee as a reference point. However, the question of how sting painfulness varies depending on body location remains unanswered. This study rated the painfulness of honey bee stings over 25 body locations in one subject (the author). Pain was rated on a 1–10 scale, relative to an internal standard, the forearm. In the single subject, pain ratings were consistent over three repetitions. Sting location was a significant predictor of the pain rating in a linear model (p < 0.0001, DF = 25, 94, F = 27.4). The three least painful locations were the skull, middle toe tip, and upper arm (all scoring a 2.3). The three most painful locations were the nostril, upper lip, and penis shaft (9.0, 8.7, and 7.3, respectively). This study provides an index of how the painfulness of a honey bee sting varies depending on body location
The Lady with the Sting
No full textThe Lady with the Sting is sequel to The Lady with a Beard. In the two novels Alobwed'Epie compares and contrasts the masculinity and femininity of the two heroines Emade, and her daughter Ntube. In the first novel, Emade shuns her sex and clinks to a false masculine mask. In spite of her achievements she fails to debunk the old system. In The Lady with the Sting, her daughter Ntube, a less charismatic heroine, allows nature take its course and in the end she seizes the opportunity the erring old system gives her and destroys it. Alobwed'Epie, author of The Death Certificate, The Lady with a Beard, The Day God Blinked, and The Bad Samaritan was born at Ngomboku in Kupe-Muanenguba Division, South-West Region, Cameroon. He studied at the Universities of Yaoundé and Leeds, and teaches Creative Writing at the University of Yaoundé 1, Cameroon
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
No full textSummarySAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I interferon (IFN) secretion. We show that the spontaneous IFN response in SAMHD1-deficient cells and mice requires the cGAS/STING cytosolic DNA-sensing pathway. We provide genetic evidence that cell-autonomous control of lentivirus infection in myeloid cells by SAMHD1 limits virus-induced production of IFNs and the induction of co-stimulatory markers. This program of myeloid cell activation required reverse transcription, cGAS and STING, and signaling through the IFN receptor. Furthermore, SAMHD1 reduced the induction of virus-specific cytotoxic T cells in vivo. Therefore, virus restriction by SAMHD1 limits the magnitude of IFN and T cell responses. This demonstrates a competition between cell-autonomous virus control and subsequent innate and adaptive immune responses, a concept with important implications for the treatment of infection
Author Correction: Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways
No full textCorrection to "Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
No full textFull author list omitted for brevity. For the full list of authors, see article.The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells. Here, Nrf2 activation decreases STING expression and responsiveness to STING agonists while increasing susceptibility to infection with DNA viruses. Mechanistically, Nrf2 regulates STING expression by decreasing STING mRNA stability. Repression of STING by Nrf2 occurs in metabolically reprogrammed cells following TLR4/7 engagement, and is inducible by a cell-permeable derivative of the TCA-cycle-derived metabolite itaconate (4-octyl-itaconate, 4-OI). Additionally, engagement of this pathway by 4-OI or the Nrf2 inducer sulforaphane is sufficient to repress STING expression and type I IFN production in cells from patients with STING-dependent interferonopathies. We propose Nrf2 inducers as a future treatment option in STING-dependent inflammatory diseases
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