196,789 research outputs found

    Gad65 is recognized by t-cells, but not by antibodies from nod-mice

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    Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice, a useful model for human Type 1 diabetes, we found that these T-cells proliferate spontaneously when incubated with human GAD65, but only marginally after incubation with GAD67, both recombinated in the baculovirus system. No effect was observed with non-diabetic NOD mice or with T-cells from H-2 identical NON-NOD-H-2g7 control mice. It has been published previously that NOD mice develop autoantibodies against a 64kDa protein detected with mouse beta cells. In immunoprecipitation experiments with sera from the same NOD mice and 33S-methionine-labelled GAD, no autoantibody binding could be detected. We conclude firstly that GAD65 is an important T-cell antigen which is relevant early in the development of Type 1 diabetes and secondly that there is an antigenic epitope in the human GAD65 molecule recognized by NOD T-cells, but not by NOD autoantibodies precipitating conformational epitopes. Our results therefore provide further evidence that GAD65 is a T-cell antigen in NOD mice, being possibly also involved in very early processes leading to the development of human Type 1 diabetes

    Dr. Duane M. Jackson, Morehouse College, July 2011

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    This video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer

    "Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.

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    "Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states. By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement. To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Dr. Glendon Swarthout

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    Hosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness

    Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses

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    Following an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied

    Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy = Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing

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    Pilewska Wiesława, Matczak Paweł. Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy = Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing. Journal of Education, Health and Sport. 2015;5(11):595-605. eISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35706 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A595-605 http://pbn.nauka.gov.pl/works/684904 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive   Original Text published © The Author (s) 2015. Pilewska Wiesława, Matczak Paweł. Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy. Quality in Sport. 2015;1(1):45-54. eISSN 2450-3118.   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport (null) 2391-8306 7 © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland. Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.11.2015. Revised 20.11.2015. Accepted: 30.11.2015. Wiesława Pilewska, Paweł Matczak Instytut Kultury Fizycznej, Uniwersytet Kazimierza Wielkiego w Bydgoszczy   Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing       Streszczenie Cel pracy W niniejszej pracy podjęto próbę charakterystyki poziomu zdolności wytrzymałościowych par C-S klasowych tańca sportowego stylu standardowego w odniesieniu do aspektów sportowej działalności tanecznej. Materiał Grupę badawczą stanowiły sportowe pary taneczne, trenujące w Toruńskim Klubie Tanecznym Dance & Dance. Grupa liczyła 22 osoby tworząc 11 par. Wiek badanych mieścił się w przedziale 16-22 lata. Grupa na turniejach prezentowała grupę wiekową powyżej 15 lat. W badanej grupie dwie pary prezentowały klasę „C”,  sześć klasę „B”, dwie pary klasę „A”, jedna para klasę „S”. Metody badawcze Do pomiaru wytrzymałości wykorzystano 20-metrowy bieg wahadłowy. Test polegał na pokonywaniu 20 metrowych odcinków w określonym czasie. Sygnały określające tempo znajdowały się na nagraniu pozyskane ze strony Narodowego Centrum Badania Kondycji Fizycznej (ncbkf.pl). Niemożność utrzymania tempa lub spóźnienie się na sygnał oznaczający rozpoczęcie kolejnego cyklu, był znakiem do ukończenia testu. Wyniki i wnioski • W grupie tancerzy C-S klasowych, stylu standardowego odnotowano istotną statystycznie p≥0,01 współzależność pomiędzy uzyskiwanymi wynikami próby 20 metrowego biegu wahadłowego a ich poziomem sportowym. • We wszystkich grupach (tancerzy i tancerek) odnotowano wprost proporcjonalny charakter współzależności pomiędzy wynikiem sportowym a poziomem zdolności wytrzymałościowych (określonych wynikami 20 metrowego biegu wahadłowego). • Na przykładzie najlepszych par wnioskować można że profil pary powinien ukazywać dominację partnera w poziomie wytrzymałością a ich partnerki powinny prezentować 60-70%  poziomu partnera. Zarówno mniejsza jak i większa różnica wykazują tendencję do słabszych wyników sportowych i charakteryzowała pary o niższym poziomie sportowym.   Słowa kluczowe: taniec towarzyski, styl standardowy, 20-metrowy bieg wahadłowy, poziom sportowy.   Abstract Aim of the study In this paper, an attempt to level the characteristics of endurance capacity C-S couples sporty style dance class standard in relation to aspects of dance sport activities. Materials The research group sports were couples dancing, Training in Torun Club & Dance the Dance Dance. The group consisted of 22 people forming 11 pairs. The age of respondents ranged from 16-22 years. The group presented the age-group tournaments over 15 years. In the group of two pairs presented a class "C" six class "B", two pairs of class "A", one pair of class "S". Research Methods Used to measure the strength of a 20-meters gear swing. The test was to overcome the 20 meters sections at a given time. Signals determining the pace were on record obtained from the National Center for the Study of Physical Constitution (ncbkf.pl).Inability to keep pace or late in the signal indicating the start of the next cycle, was a sign to complete the test.   Results and conclusions • In the group of dancers C-S class, style standard p≥0,01 reported a statistically significant correlation between the results of those obtained sample of 20 meters gear swing and their level of sport. • In all groups (dancers) were recorded directly proportional nature of the correlation between the outcome and the level of sports endurance capacity (specific results of 20-meters gear swing). • For example, the best pairs can be inferred that the profile should show the dominance of a partner in the level of strength and their partners should represent 60-70% of the partner. Both smaller and larger difference tend to be weaker performance was characterized by a pair of sports and a lower level of sports.   Key words: ballroom dancing, style standard, 20-meters gear swing, sports level

    Intern experience at CH���M Hill, Inc.: an internship report

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    Includes author's vita"Submitted to the College of Engineering of Texas A&M University in partial fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc. during the period September 1975 through May 1976 is presented. During this nine month internship the author worked as an Engineer II in the Industrial Processes discipline of this large consulting engineering firm... The author's prime responsibility was as one of three lead design engineers on the design of a large wastewater treatment facility for a pulp mill in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design of individual treatment units and associated piping and pumping. The purpose of the project was to provide wastewater treatment capabilities that would satisfy the effluent limitations (standards) imposed upon the mill by the State of Washington Department of Ecology and the U.S. Environmental Protection Agency. The author's assignment also entailed necessary interaction with the project manager and other CH���M HILL design engineers and support staff members, the client's representatives, and representatives of two other consulting engineering firms working on the project. Thus, the internship position at CH���M HILL provided considerable experience coordinating the author's work with the work of other engineers, guiding the design and administrative efforts of a support staff, and interacting regularly with the client and other consulting firms. This broad exposure to a variety of engineering and organizational problems provided a valuable educational experience

    Transition to turbulence in a qblique shock-wave/boundary-layer interaction at M=15

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    Direct numerical simulations are carried out for different forcing techniques to trigger transition during the interaction between an oblique shock-wave and a laminar boundary-layer at M = 1.5. Three forcing methods are used: a) forcing of oblique unstable modes, whose shape and behaviour are determined by the local linear stability theory, b) broadband free-stream acoustic disturbances, and c) a cold plasma flow control device. While the oblique-mode breakdown is dominant for low-amplitude forcing, long streaky structures drive the transition process in a high-amplitude disturbance environment. LES are also performed on the experimental setup by the Institute of Theoretical and Applied Mechanics (ITAM) from Novosibirsk State University with cold plasma actuation. As well as the disturbance type, the effect of Reynolds number and forcing amplitude will be investigated

    Letter from Cedrick M. Shimo to the Office of Redress Administration, June 4, 1991

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    A letter from Cedrick M. Shimo to the Office of Redress Administration arguing that John Y. Udaka is entitled to a redress payment.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
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