102,493 research outputs found
Induction of pulmonary HLA-G expression by SARS-CoV-2 infection
No full textThe non-classical human leukocyte antigen (HLA)-G exerts immune-suppressive properties modulating both NK and T cell responses. While it is physiologically expressed at the maternal–fetal interface and in immune-privileged organs, HLA-G expression is found in tumors and in virus-infected cells. So far, there exists little information about the role of HLA-G and its interplay with immune cells in biopsies, surgical specimen or autopsy tissues of lung, kidney and/or heart muscle from SARS-CoV-2-infected patients compared to control tissues. Heterogeneous, but higher HLA-G protein expression levels were detected in lung alveolar epithelial cells of SARS-CoV-2-infected patients compared to lung epithelial cells from influenza-infected patients, but not in other organs or lung epithelia from non-viral-infected patients, which was not accompanied by high levels of SARS-CoV-2 nucleocapsid antigen and spike protein, but inversely correlated to the HLA-G-specific miRNA expression. High HLA-G expression levels not only in SARS-CoV-2-, but also in influenza-infected lung tissues were associated with a high frequency of tissue-infiltrating immune cells, but low numbers of CD8(+) cells and an altered expression of hyperactivation and exhaustion markers in the lung epithelia combined with changes in the spatial distribution of macrophages and T cells. Thus, our data provide evidence for an involvement of HLA-G and HLA-G-specific miRNAs in immune escape and as suitable therapeutic targets for the treatment of SARS-CoV-2 infections
Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development
No full textThis project provides code and data to reproduce the results, figures, and supplementary material of the paper: Joechner, A. K., Hahn, M. A., Gruber, G., Hoedlmoser, K., & Werkle-Bergner, M. (2023). Sleep spindle maturity promotes slow oscillation-spindle coupling
across child and adolescent development. eLIFE DOI: https://doi.org/10.7554/eLife.8356
Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development
No full textThis project provides code and data to reproduce the results, figures, and supplementary material of the paper: Joechner, A. K., Hahn, M. A., Gruber, G., Hoedlmoser, K., & Werkle-Bergner, M. (2023). Sleep spindle maturity promotes slow oscillation-spindle coupling
across child and adolescent development. eLIFE DOI: https://doi.org/10.7554/eLife.8356
Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development
No full textThis project provides code and data to reproduce the results, figures, and supplementary material of the paper: Joechner, A. K., Hahn, M. A., Gruber, G., Hoedlmoser, K., & Werkle-Bergner, M. (2023). Sleep spindle maturity promotes slow oscillation-spindle coupling
across child and adolescent development. eLIFE DOI: https://doi.org/10.7554/eLife.8356
Leitfadenorientierte Interviews - eine geeignete Methode zur Ergründung der Handlungsrelevanz von Therapiestandards in der kardiologischen Versorgung?
No full textSiering U, Staender J, Bergner E. Leitfadenorientierte Interviews - eine geeignete Methode zur Ergründung der Handlungsrelevanz von Therapiestandards in der kardiologischen Versorgung? In: Schaeffer D, Müller-Mundt G, eds. Qualitative Gesundheits- und Pflegeforschung. 2002: 285-304
G-Proteine und Melanomzellen
No full textMit dieser Arbeit konnten die Pertussistoxin-sensitiven heterotrimeren G-Protein- Subtypen Galphai2 und Galphai3 sowie das Pertussistoxin-insensitive Galpha16 in Melanomzellen auf RNA- und auf Proteinebene nachgewiesen werden. Die Galphai-Proteine wurden durch Pertussistoxin ADP-ribosyliert. Mit Hilfe des MTT-Tests konnte dargestellt werden, dass dadurch die Proliferation der Melanomzellen unterdrückt wurde. Zum anderen konnten auch die kleinen, monomeren G-Proteine der Rho-Familie (RhoA, RhoB, RhoG, Rac1 und Cdc42) in Melanomzellen auf Proteinebene nachgewiesen werden. Durch Clostridium difficile Toxin B wurden diese G-Proteine der Rho-Familie modifiziert. Diese Modifizierungen bewirkten bei den Melanomzellen eine Abnahme der Proliferation, die mit dem Bromodesoxyuridineinbau-Test nachgewiesen wurde
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
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