395,033 research outputs found
Perinatal outcomes of twin pregnancies affected by early twin‐twin transfusion syndrome: A systematic review and meta‐analysis
No full textIntroduction
Twin‐to‐twin transfusion syndrome (TTTS) is associated with a high risk of perinatal mortality and morbidity if not treated. However, the optimal timing and management in case of early (occurring < 18 weeks) TTTS has not been established yet.
Material and methods
This is a systematic review and meta‐analysis aiming at evaluating the outcomes of monochorionic diamniotic twin pregnancies complicated by early (ie before 18 weeks) TTTS according to different management options (expectant, laser therapy, amnioreduction or cord occlusion). The primary outcome was mortality, including single and double intrauterine, neonatal and perinatal death. Secondary outcomes were: composite morbidity, neuromorbidity, respiratory distress syndrome, admission to neonatal intensive care unit, intact survival (defined as survival free from neurological complications) and preterm birth < 32 weeks of gestation. All outcomes were reviewed according to the different management options (expectant, laser therapy, amnioreduction or cord occlusion) and reported FOR the overall population of twins, and for the donor and recipient separately. Subgroup analysis for TTTS occurring before 16 weeks of gestation was performed. Random‐effect meta‐analyses of proportions were used to analyse the data.
Results
Thirteen studies were included. Early TTTS occurred in 14.3% (95% confidence interval [CI] 11.9‐17.0) of cases. The incidence of intrauterine death was 19.0% (95% CI 2.6‐45.5) in twins managed expectantly, 32.4% (95% CI 16.5‐50.7) in those who received laser treatment and 12.5% (95% CI 4.8‐23.0) in those treated with amnioreduction. The incidence of neonatal death was 22.6% (95% CI 4.2‐49.8) in twins managed expectantly, 24.7% (95% CI 0.5‐80.3) in those who received laser and 20.2 (95% CI 5.8‐43.4) in those who had amnioreduction; it was not possible to compute the incidence of these outcomes in twins undergoing cord occlusion because of insufficient sample and lack of reporting of most of the observed outcomes. Overall, the incidence of perinatal death was 43.9% (95% CI 5.9‐87.7) in twins managed expectantly, 47.3% (95% CI 21.4‐70.0) in those treated with laser and 28.5% in those who had amnioreduction.
Conclusions
Twin pregnancies affected by early TTTS are at substantial risk of perinatal mortality and morbidity; however, the data come from very small studies with a high risk of selection bias
Hermite-Hadamard type inequalities for harmonically (?, m)-convex functions
No full textThe author introduces the concept of harmonically (?, m)-convex functions and establishes some Hermite-Hadamard type inequalities of theseclasses of functions
Perinatal outcomes of twin pregnancies complicated by late twin‐twin transfusion syndrome: A systematic review and meta‐analysis
No full textIntroduction
Untreated twin‐to‐twin transfusion syndrome (TTTS) is associated with a high risk of perinatal mortality and morbidity. Laser surgery is recommended before 26 weeks of gestation. However, the optimal management in case of late TTTS (occurring after 26 weeks of gestation) is yet to be established.
Material and methods
We conducted a systematic review and meta‐analysis to evaluate the outcomes of monochorionic‐diamniotic twin pregnancies complicated by late TTTS according to different management options (expectant, laser therapy, amnioreduction, or delivery). The primary outcome was mortality, including single and double intrauterine, neonatal, and perinatal death. Secondary outcomes were composite morbidity, neuromorbidity, respiratory distress syndrome, admission to neonatal intensive care unit, intact survival (ie, free from neurological complications), and preterm birth before <32 weeks of gestation. Outcomes were reviewed according to the management and reported for the overall population of twins and disease status (ie, donor and recipient separately). Random‐effect meta‐analyses of proportions were used to analyze the data.
Results
Nine studies including 796 twin pregnancies affected by TTTS were included. No randomized controlled trials were available for inclusion. TTTS occurred at ≥26 weeks of gestation in 8.7% (95% CI 6.9%‐10.9%; 67/769) of cases reporting TTTS at all gestations. Intrauterine death occurred in 17.7% (95% CI 4.9%‐36.2%) of pregnancies managed expectantly, 5.3% (95% CI 0.9%‐12.9%) of pregnancies treated with laser, and 0% (95% CI 0%‐9%) after amnioreduction. Neonatal death occurred in 42.5% (95% CI 17.5%‐69.7%) of pregnancies managed expectantly, in 2.8% (95% CI 0.3%‐7.7%) of cases treated with laser, and in 20.2% (95% CI 6%‐40%) after amnioreduction. Only one study (10 cases) reported data on immediate delivery after diagnosis with no perinatal deaths. Perinatal death incidence was 55.7% (95% CI 31.4%‐78.6%) in twin pregnancies managed expectantly, 5.6% (95% CI 0.5%‐15.3%) in those treated with laser, and 20.2% (95% CI 6%‐40%) in those after amnioreduction. Intact survival was reported in 44.4%, 96.4%, and 78% of fetuses managed expectantly, with laser or amnioreduction, respectively.
Conclusions
Evidence regarding perinatal mortality and morbidity in twin pregnancies complicated by late TTTS according to the different managements was of very low quality. Therefore further high‐quality research in this field is needed to elucidate the optimal management of these pregnancies
Disease in Peyami Safa’s novels
No full textYüksek Lisans TeziSanatçı bir ailenin çocuğu olan Peyami Safa, Türk edebiyatının önemli kalemlerindendir. Yazar, romanları dışında fikir eserleri, gazeteciliği, köşe yazarlığı ve polemikleriyle de ünlüdür. Peyami Safa, Batılıların otodidakt dediği, kendi kendini yetiştirmiş nadir şahsiyetlerdendir. Kırk üç yıl gibi uzun denecek bir süre boyunca yazmıştır. Edebî değeri olmayan eserlerini Server Bedi takma adı ile yayımlamıştır. Yazarın eserlerinde tahliller önemli yer tutar. Zıt kavramları eserlerinde ustalıkla işlemiştir. Peyami Safa?nın hayatı, eserleri ve sanatı daha önce çok sayıda araştırmacı tarafından incelenmiş, fakat yazarın hayatında büyük yeri olan ve eserlerinde de kendisini yoğun olarak hissettiren hastalık konusu işlenmemiştir. Bu sebeple tarafımızdan araştırma konusu olarak seçilmiştir. Küçük yaşlardan itibaren hastalıklarla boğuşan Peyami Safa, başta Dokuzuncu Hariciye Koğuşu olmak üzere bütün eserlerinde bu durumu yansıtmaya çalışmıştır. Amacımız Peyami Safa?nın romanlarını hastalıklar bakımından inceleyerek hayatının ve bu arada hastalık ve hastalıklara dair fikirlerinin eserlerine nasıl yansıdığını göstermek ve okura bu yolla anlatmak istediklerini gün ışığına çıkarmaktır.AbstractPeyami Safa, is the one of the most important writers in Turkish Literature, has an artist family. He also has worked as a journalist and columnist. Also known as intellectual works and some polemics. Peyami Safa one of the rare people himself trained. He has written articles for 43 years. The author has written works of non-literary values Server Bedi name. Analysis holds an important place in the author's works. The author skillfully opposite concepts have been committed. The author's life, works and art and has been previously studied by many researchers but author of life a great location issues that disease has not been studied. Therefore, it is selected as the subject of research by our research group. The author's life is filled with diseases since his childhood. The author particularly in the Dokuzuncu Hariciye Koğuşu, including all the works have tried to reflect this situation. Our goal; the author of the novel is the study of diseases also, the author is reflected in the works show how the ideas of the diseases and expose what they want to tell the reader in this way
Mapping the Discipline of the Olympic Games An Author-Cocitation Analysis
No full textThe authors conducted an author cocitation analysis on prominent authors writing about the Olympics during the 1990s. Author cocitation is an established bibliometric technique that can be used to measure the relative similarities of topics written about by the cited authors. This enables a visual representation of the “intellectual space” of the discipline, in this case the Olympics, to be created for the period under review. So core and peripheral research areas are identified, along with their major contributors. The representation appears as a two-dimensional cluster-enhanced map. Subject expertise was then applied to the results to place labels on the generated clusters of authors and their topics
Retrospective Analysis of 90 Patients that Underwent Retrograde Intrarenal Surgery
No full textINTRODUCTION: To evaluate the results of retrograde intrarenal surgery (RIRC) performed in our clinic in cases with renal stones. METHODS: The results of 90 patients that underwent RIRC between June 2016 and January 2019 were evaluated retrospectively. The demographic data and the preoperative and postoperative clinical characteristics of the patients were examined. RESULTS: The mean age of 90 patients that underwent RIRC (41 men/49 women) was 43.35 (21-84) years, and the mean stone size was 16.22 (10-28) mm. The operation was performed under general anesthesia in 38 patients (42.22%) and spinal anesthesia in 52 (57.78%). The mean operation duration was 61.76 (30-115) min, and the mean stone fragmentation time was 48.33 (15-95) min. In 23 patients (25.55%), a double-J stent was inserted into the ureter since the kidney could not be reached due to stenosis. In 75 patients (83.33%), a double-J stent was placed at the end of the operation. The mean hospital stay was 1.08 (1-3) days. The stone-free rate was 71.12%. Of the cases with residual stones, 21 (23.32%) underwent an additional intervention and five (5.55%) were followed up without further intervention. Complications were observed in 13 patients (14.44%) and evaluated according to the modified Clavien classification. DISCUSSION AND CONCLUSION: In the presence of adequate equipment and experience, RIRC is an effective and safe procedure with high success, low complication and minimal morbidity rates in the treatment of renal stones
jDHBenelux Author Template
No full textThis repository contains the latest official GitHub hosted versions of the LaTeX template that authors are required to use when they finalize their contribtions to the DH Benelux Journal. The repository synchronises with the corresponding easy-to-use and well-documented Overleaf Template that provides authors with a low threshold environment for writing LaTeX – but can be used with any LaTeX compiler.
About this Release: Apart from some minor changes to the .cls, v2.0 introduces a number of new files to improve open source development with git and GitHub, including a README, a CC-BY 4.0 License, and a .gitignore file. It also prepares the repository for synchronisation with Zenodo, to improve sustainability.
Full Changelog: https://github.com/DHBenelux/jDHBenelux-author-template/compare/v1.1...v2.
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
SOME GENERAL INTEGRAL INEQUALITIES FOR LIPSCHITZIAN FUNCTIONS VIA CONFORMABLE FRACTIONAL INTEGRAL
No full textIn this paper, the author establishes some Hadamard-type and
Bullen-type inequalities for Lipschitzian functions via Riemann Liouville fractional integral
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