153 research outputs found

    Business Author: Dr Ben Laker

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    Konsep dan Strategi Upaya Pelestarian Kerajinan Laker Palembang Melalui Pelatihan dan Workshop

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    This research is focused on aspects of the Process and Identification of Lkauer Crafts in Palembang, with the objectives being, 1) to support efforts to preserve the art of laker crafts in Palembang, 2) to find out the development of the design of the laker craft, 3) to find out the local cultural values contained in Palembang laker crafts, 4) to add insight and teaching materials to art and design lectures, especially DKV. The method used is descriptive qualitative method, with the method of collecting field observation data, which is to see firsthand the laker handicraft products in the craft center, and at the Bala Putra Dewa Museum in Palembang, the data collection method is also carried out by interviewing techniques and documenting the object research. The results of the data processing are the authors' analysis through the identification of problems encountered in the field. From these results the conclusions drawn by the author are summarized in the form of a draft strategy for the preservation of the laker craft. In addition to preservation efforts, the laker craft can also provide business opportunities and employment opportunities for the people of Palembang city, of course it cannot be separated from the assistance of the Regional Government in the form of training, workshops, capital assistance as well as providing a place for marketing

    Investigating the interactions between paxillin, vinculin and talin in regulating the dynamics of cell-extracellular matrix adhesions

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    Focal adhesions provide a bi-directional, highly dynamic interface between the extracellular and intracellular environments. The abundance and diversity of proteins recruited to the adhesion sites enable focal adhesions to act as highly efficient mechanosensitive signalling hubs that regulate multiple aspects of cell behaviour including cell movement. Paxillin is one of the proteins identified to localise to focal adhesions. This study explored the interaction of paxillin with the focal dhesionassociated proteins talin, vinculin and focal adhesion kinase, and how such interactions are regulated. Biochemical characterisation using a suite of assays, including fluorescence polarisation, microscale thermophoresis, nuclear magnetic resonance, size exclusion chromatography and pulldowns, identified two novel interactions: 1) the paxillin LIM domains bind talin R9-R12, and 2) multiple paxillin LD motifs cooperatively bind to the head and talin domains of vinculin. We propose a model whereby talin facilitates the localisation of paxillin in proximity of vinculin at adhesions. Once recruited, paxillin functions to control the activation state of vinculin and thus regulate adhesion dynamics, influencing a whole host of cellular activities including cell migration and apopotosis

    Leadership in the Circular Economy

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    The concept of the circular economy, introduced by Pearce and Turner (1990), envisions an economy where waste is reused as a resource to minimise the use of primary materials. It has gained traction globally, supported by entities like the Ellen MacArthur Foundation and McKinsey & Company. Unlike the linear economy, the circular economy focusses on maintaining material value through closed loops. However, its implementation faces challenges such as legislative barriers, high costs, and consumer acceptance. Despite its potential, the circular economy is not a synonym for sustainability, requiring continuous scrutiny and leadership to address its complexities and potential trade-offs
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