3,205 research outputs found
TUTELA DEL LAVORO E LIBERTA' D'IMPRESA NEI PROCESSI DI ESTERNALIZZAZIONE
No full textL’elaborato analizza le conseguenze lavoristiche della successione fra imprenditori, muovendo da una ricognizione delle varie tipologie di esternalizzazione con le relative esigenze e principali criticità.
L’indagine si concentra in primo luogo sul trasferimento d’azienda, esaminando la normativa e la giurisprudenza europee per passare poi alla disciplina di diritto interno, alle procedure sindacali e a uno specifico focus sul trasferimento delle aziende in crisi.
Successivamente l’autore si sofferma sull’appalto, prendendone in particolare considerazione gli indici di genuinità, i criteri di distinzione dalla somministrazione illecita di manodopera e la tutela delle maestranze in caso di avvicendamento fra imprese.
Da ultimo, la ricerca approfondisce le c.d. “clausole sociali”, sia di prima che di seconda generazione, valutandone la compatibilità con il diritto eurounitario e con la costituzione nonché riflettendo sui possibili rimedi in caso di loro violazione.The author analyzes the labour consequences of the succession between entrepreneurs, starting from a recognition of the various types of outsourcing with the related needs and main critical issues.
The survey focuses primarily on the transfer of businesses, examining European legislation and case-law and then moving on to internal legislation, trade union procedures and a specific focus on the transfer of companies in crisis.
The author then dwells on the contract, taking into account in particular the indications of authenticity, the criteria of distinction from the illicit administration of labour and the protection of workers in the event of turnover between companies.
Finally, the research deepens the "social clauses", both first and second generation, assessing their compatibility with European law and with the constitution and reflecting on possible remedies in case of their violation
Duloxetine in panic disorder with somatic gastric pain
No full textMatteo Preve,1 Cristiana Nisita,1 Massimo Bellini,2 Liliana Dell'Osso1 1Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, 2Department of Gastroenterology, Gastrointestinal Unit, University of Pisa, Pisa, Italy Abstract: Panic disorder is the most common type of anxiety disorder, and its most common expression is panic attacks characterized with sudden attacks of anxiety with numerous symptoms, including palpitations, tachycardia, tachypnea, nausea, and vertigo: ie, cardiovascular, gastroenterologic, respiratory, and neuro-otologic symptoms. In clinical practice, panic disorder manifests with isolated gastroenteric or cardiovascular symptoms, requiring additional clinical visits after psychiatric intervention. The first-line treatment for anxiety disorders, and in particular for panic disorder, is the selective serotonin reuptake inhibitors. However, these drugs can have adverse effects, including sexual dysfunction, increased bodyweight, and abnormal bleeding, that may be problematic for some patients. Here we report the case of a 29-year-old Caucasian woman affected by panic disorder with agoraphobia who was referred to our clinic for recurrent gastroenteric panic symptoms. The patient reported improvement in her anxiety symptoms and panic attacks while on a selective serotonin reuptake inhibitor, but not in her gastric somatic problems, so the decision was taken to start her on duloxetine, a serotonin-norepinephrine reuptake inhibitor. After 6 months of treatment, the patient achieved complete remission of her gastric and panic-related symptoms, and was able to stop triple gastric therapy. Other authors have hypothesized and confirmed that duloxetine has greater initial noradrenergic effects than venlafaxine and is effective in patients with panic disorder. This case report underscores the possibility of tailoring therapeutic strategies for the gastroenteric expression of panic disorder. Keywords: anxiety disorder, panic attacks, palpitations, tachycardia, tachypnea, nausea, vertig
Artificial Intelligence for Personalized Perioperative Medicine
No full text: The development of artificial intelligence (AI) is disruptive and unstoppable, also in medicine. Because of the enormous quantity of data recorded during continuous monitoring and the peculiarity of our specialty where stratification and mitigation risk are some of the core aspects, anesthesiology and postoperative intensive care are fertile fields where new technologies find ample room for expansion. Recently, research efforts have focused on the development of a holistic technology that globally embraces the entire perioperative period rather than a fragmented approach where AI is developed to carry out specific tasks. This could potentially revolutionize the perioperative medicine we know today. In fact, AI will be able to expand clinician's ability to interpret, adapt, and ultimately act in a complex reality with facets that are too complex to be managed all at the same time and in a holistic manner. With the support of new tools, as healthcare professionals we have the moral obligation to govern this transition, allowing an ethical and sustainable development of these technologies and avoiding being overwhelmed by them. We should welcome this transhumanist tension which does not aim at the replacement of human capabilities or even at the integration of these but rather at the expansion of a "single intelligence"
A survey on machine learning applied to symmetric cryptanalysis
No full textIn this work we give a short review of the recent progresses of machine learning techniques applied to cryptanalysis of symmetric ciphers, with particular focus on artificial neural networks. We start with some terminology and basics of neural networks, to then classify the recent works in two categories: "black-box cryptanalysis", techniques that not require previous information about the cipher, and "neuro-aided cryptanalysis", techniques used to improve existing methods in cryptanalysis
Modeling and simulation of the blood coagulation cascade
No full textIn the last years, the use of Graphical Processing Units (GPUs) has witnessed ever growing applications for different computational analyses in the field of Life Sciences. In this work we present a CUDA-powered computational tool for the simulation of biological models defined as systems of mixed ordinary differential equations, based on both mass-action kinetics and Hill functions. The tool, named coagSODA, was purposely developed and applied for the analysis of a large model of the blood coagulation cascade. We present the biological results of a parameter sweep analysis of this model, and show that GPU can boost the computational performances up to 177× speedup
Massive exploration of perturbed conditions of the blood coagulation cascade through GPU parallelization
No full textThe introduction of general-purpose Graphics Processing Units (GPUs) is boosting scientific applications in Bioinformatics, Systems Biology, and Computational Biology. In these fields, the use of high-performance computing solutions is motivated by the need of performing large numbers of in silico analysis to study the behavior of biological systems in different conditions, which necessitate a computing power that usually overtakes the capability of standard desktop computers. In this work we present coagSODA, a CUDA-powered computational tool that was purposely developed for the analysis of a large mechanistic model of the blood coagulation cascade (BCC), defined according to both mass-action kinetics and Hill functions. coagSODA allows the execution of parallel simulations of the dynamics of the BCC by automatically deriving the system of ordinary differential equations and then exploiting the numerical integration algorithm LSODA. We present the biological results achieved with a massive exploration of perturbed conditions of the BCC, carried out with one-dimensional and bi-dimensional parameter sweep analysis, and show that GPU-accelerated parallel simulations of this model can increase the computational performances up to a 181× speedup compared to the corresponding sequential simulations
Back-and-forth endoscopic septoplasty: analysis of the technique and outcomes
No full textBackground: To describe our clinical experience in 218 consecutive
patients undergoing endoscopic back-and-forth
septoplasty (EBFS), examining surgical indications, technique,
and follow-up.
Methods: From January 2005 to November 2008, 218
patients underwent EBFS at the Department of Otorhinolaryngology,
San Raffaele Hospital, Milan, Italy. The
indication for EBFS in this series was nasal airway obstruction
(NAO). Patients were studied with nasal rigid endoscopy
and in some cases computed tomography (CT)was
used to exclude rhinosinusitis. The most common concomitant
diagnoses included allergic rhinitis and turbinate hypertrophy.
EBFS facilitates the interruption of perichondrial
and periosteal bridges, which are more represented
in the anterior portion of the septum between the caudal
quadrangular cartilage and the vomeropremaxillary
crest. Septal splints were positioned. No nasal packing was
required.
Results:No cases required conversion to a traditional headlight
approach, and no intraoperative complications were
encountered. Intraoperative mucosal microlacerations occurred
in 77.98% of cases; suturing was required in only
8.25%of cases.Of 218 patients, 74.77% experienced resolution
of NAO, while 16.06% experienced only improvement;
9.17% noted the persistence of symptoms. Complications
included transient dental pain/hypesthesia (6.88%), septal
hematoma (5.04%), synechiae formation (2.29%), epistaxis
(1.83%), septal perforation (1.83%), cheek swelling (0.45%),
and septal abscess (0.45%).
Conclusion: EBFS as a variation of endoscopic septoplasty
(ES) represents a viable procedure with good outcomes
and a low rate of complications. The technique allows lysis
of tissue fibers while preserving the integrity of mucosa
at the critical area using less force and reduces the probability
of mucosal tears, based on embryologic knowledge of
anatomical dissection
Ultra Low Carbon Vehicles: New Parameters for Automotive Design
No full textAs the influence of vehicle emissions on our environment has become better understood, the UK government has recently placed urgent emphasis on the implementation of low carbon
technologies in the automotive industry through: the UK Low Carbon Industrial Strategy. The overall objective is to offer big incentives to consumers and support for the development of infrastructure and engineering solutions. This scheme however does not consider how the development of functional and experiential user value might drive consumer demand, contributing to the adoption of low carbon vehicles (LCVs) in the mass market.
With the emergence of the North East of England as the UK’s first specialised region for the development of ultra-low carbon vehicles (ULCVs), ONE North East, as a development agency for the region's economic and business development, and Northumbria University Ideas-lab have supported a project to facilitate innovation through the collaboration of technology, research and development (R&D) and business. The High Value Low Carbon (HVLC) project aims to envisage
new user value made possible by the integration of low carbon vehicle platforms with new process and network technologies. The HVLC consortium represents vehicle manufacturers and their suppliers as well as technology based companies and through an ongoing process of design concept generation the project offers a hub for innovation led enterprise.
Whilst new technological developments in areas such as power generation, nano materials, hydrogen fuel cells, printed electronics and networked communications will all impact on future automotive design, the mass adoption of low carbon technologies represents a paradigm shift for the motorist. This paper aims to describe how the mapping of new parameters will lead to new transport scenarios that will create the space for new collaborative research on user experiences supported by innovative technologies and related services
sj-docx-1-jic-10.1177_08850666231199050 - Supplemental material for Difficult Intravascular Access in Pediatric Emergency Department: The Ultrasound-Assisted Strategy (DIAPEDUS Study)
No full textSupplemental material, sj-docx-1-jic-10.1177_08850666231199050 for Difficult Intravascular Access in Pediatric Emergency Department: The
Ultrasound-Assisted Strategy
(DIAPEDUS Study) by Matteo D’Alessandro, Margherita Ricci, Tommaso Bellini, Benedetta Chianucci, Maria Grazia Calevo, Emanuela Piccotti and Andrea Moscatelli in Journal of Intensive Care Medicine</p
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