13 research outputs found
Chinese literary works translated into Baba Malay: a bibliographical study
No full textAnalyses 68 unique titles of Baba translated works published between 1889 and 1950. The titles are held in the libraries of the University of Malaya (UM), Science University Malaysia (USM), National University of Malaysia (UKM), the Dewan Bahasa dan Pustaka (DBP), National University of Singapore (NUS), National Library of Singapore (NLS) and the British Library (BL). The results reveal three periods of active publication of Baba translated works. A total of 18 works were translated before World War I, followed by 10 just after the war, 39 titles were published before the break of the World War II and 1 was identified in 1950. There were 103 persons involved in the 68 translated works, some of whom are responsible for more than one title. The most prominent translators were Chan Kim Boon, Wan Boon Seng, Seow Chin San and Lee Seng Poh. Some of the translators were also be editors, illustrators or editors. There were 31 publishers and 21 printing presses involved, all were located in Singapore. The most active publishers were Wan Boon Seng, Kim Seck Chy Press and Nanyang Romanised Malay Book Co. The translated works mainly cover historical classical Chinese stories, chivalrous stories, romances, folklore and legends. The titles were priced between 10 cents to 2 dollars in Straits currency. The University of Malaya Library held the largest number of unique title (62) out of which 15 were unique titles
EFFECTS OF NANOPARTICLES IN SURFACTANT ON FOAM STABILITY FOR GAS MOBILITY CONTROL
No full textGas mobility is a common issue in petroleum reservoir due to significant viscosity
difference between the injected gas and residual oil, as well as permeability contrast
Adsorption and Squeeze Performance of PAMAM-PGLU Inhibitors for Silicate Scale Mitigation Due to Asp Flooding
No full textSilica and silicate scale deposition in the production systems resulted in reduced production rates and equipment damages. Chemical scale inhibition using squeeze method is advantageous for petroleum reservoir conditions. This paper aims to assess the adsorption and squeeze performance of developed scale inhibitors that consist of polyamidoamine (PAMAM) dendrimers and pteroyl-L-glutamic acid (PGLU). Commercial inhibitor, diethylenetriamine penta(methylene phosphonic acid), also known as DETPMP, was also used to benchmark the laboratory findings. Static adsorption test and core flooding were performed to investigate the adsorption characteristics and retention of the inhibitors in Berea sandstone cores. Simulation was also conducted to estimate the squeeze performance of the inhibitors. Results revealed that PAMAM-2-PGLU scale inhibitor exhibited the highest adsorption and retention in the sandstone core. The treatment of PAMAM-2-PGLU and PAMAM-1-PGLU inhibitors increased the core permeabilities. SQUEEZE IV model predicted that both PAMAM-PGLU inhibitors yielded longer squeeze lifetime than DETPMP inhibitor. Both experimental and simulation results showed good fit in terms of adsorption and squeeze lifetime. In this paper, the tested PAMAM-PGLU scale inhibitors have demonstrated better adsorption, retention, and squeeze lifetime in sandstone formation. They could offer effective and low-toxicity alternatives to commercial inhibitors due to raising environmental concerns
A case study : using choice experiment in an open distance learning
No full textThere are approximately 62 private higher education providers in Malaysia as on May 2014. Among them, there are
several institutions offer the open and distance (ODL) mode of teaching and learning pedagogy. Due to the ODL flexibility
mode, there has been quite a stir of competition in the education industry. Learners of ODL tend to be more challenging to
fulfill their needs as they have other commitments in life, hence the ODL mode to be chosen. Therefore, the ODL education
institution need to able to read and provide the necessary needs to these learners. The aim of this study is to investigate the
attributes that contributes to choosing an ODL private higher education institution in Malaysia and to explore the
consumer behavior in the area of student choice, and consumers’ willingness-to-pay price. Although there are studies on
the attributes that influence student choice of a university, but has failed to use the choice experiment theory to examine the
attributes that influence choice of course particularly an ODL mode. The sample population was 320 using face-to-face
interview. The results would be able to introduce the right marketing strategy for the institution in Malaysia. (Abstract by author
Recent Advances in Enhanced Polyamidoamine Inhibitors for Silicate Scales in the Petroleum Upstream
No full textChemical flooding is regarded as a promising enhanced oil recovery technique to recover more hydrocarbon from reservoirs. However, the dissolution of quartz minerals in a highly alkaline environment poses the risk of silicate scaling near the production well region from the mixing of two different waters. Commercial scale inhibitors are effective, but they are also harmful to the environment. This paper aims to provide insights into current advances in environment-friendly or “green” scale inhibitors for petroleum upstream. Previous research works have demonstrated that green chemicals are effective in mitigating silicate, carbonate, and sulfide scales. Polyamidoamine or amide-based inhibitors have been widely investigated in recent literature due to several advantages. The addition of anionic compounds in these inhibitors enhanced scale inhibition efficiency by roughly 10%. Nevertheless, the reported findings were deliberated for industrial wastewater treatment. Meanwhile, understanding the performance of polyamidoamine or amide-based scale inhibitors in petroleum upstream is inadequate to a certain extent. The formation process of silicate scales inside a reservoir is rather complicated by looking at the influence of water salinity, composition of brine, temperature, pressure, and rock type. Hence, it is essential to study and develop green scale inhibitors that are effective and environmentally friendly to meet increasingly stringent disposal regulations in the petroleum industry.
ABSTRAK: Pembanjiran kimia merupakan teknik pemulihan minyak. Ia berpotensi dalam memperoleh lebih banyak hidrokarbon dari takungan. Namun, pelarut mineral kuarza dalam persekitaran beralkali tinggi memberi risiko penumpukan silikat berhampiran kawasan takungan pengeluaran. Ia disebabkan oleh pencampuran dua jenis cecair berbeza. Perencat penumpukan silikat komersial adalah berkesan, tetapi sangat berbahaya pada alam sekitar. Kajian ini bertujuan bagi menambahbaik kemajuan perencat silikat mesra alam terkini atau perencat silikat hijau bagi bidang saliran petroleum. Kajian terdahulu telah membuktikan bahawa bahan kimia mesra alam adalah berkesan dalam pengurangan penumpukan silikat, karbonat dan sulfida. Perencat poliamidoamina atau perencat bersumber amida telah dikaji secara meluas dalam beberapa kajian sejak kebelakangan ini kerana kelebihannya yang banyak. Penambahan sebatian anionik dalam perencat ini mampu meningkatkan keberkesanan perencat silikat sebanyak 10%. Namun, laporan kajian terdahulu adalah khusus bagi rawatan sisa air industri. Sementara itu, pemahaman tentang prestasi perencat silikat bersumberkan poliamidoamina atau perencat bersumber amida dalam saliran petroleum masih tidak mencukupi. Proses pembentukan penumpukan silikat dalam takungan adalah agak rumit berdasarkan faktor saliniti air, komposisi air garam, suhu, tekanan dan jenis batuan. Oleh itu, kajian dan pembangunan berkesan tentang perencat silikat mesra alam adalah penting bagi memenuhi peraturan pelupusan sisa yang semakin ketat dalam industri petroleum
Факторы, влияющие на потребление алкоголя в России
No full textThe main purpose of the study is to determine the differences in factors influencing alcohol consumption in Russia (among urban and rural residents).The first part of the article provides the author's assessment of studies in which place of residence is considered as a specific factor influencing alcohol consumption. Attention is paid to works that focus on differences in factors affecting alcohol consumption depending on the place of residence.The main section of the article contains a description of the empirical testing of the hypotheses based on statistical data for 2012–2021 from the Russian Longitudinal Monitoring Survey (RLMS) NRU HSE. The author used panel logistic regression with random individual effects for the probability of alcohol consumption and a panel Tobin model for the volume of alcohol consumption. The study revealed differences in the degree of influence of the level of education and religiosity, marital status and the presence of children on the level of alcohol consumption among urban and rural residents. Thus, a higher level of religiosity reduces the likelihood of alcohol consumption by rural residents; the volume of alcohol consumption decreases with a rise in the level of religiosity in the city. It is also shown that the presence of children in families reduces per capita alcohol consumption only in villages.According to the author, the findings help make more effective and targeted recommendations for implementing state alcohol policy.Основная цель исследования, результаты которого изложены в статье, – определить различия в факторах, оказывающих влияние на потребление алкоголя в России (городским и сельским населением).В первой части статьи даются авторские оценки исследований, в которых место проживания рассматривается в качестве специфического фактора, влияющего на потребление алкоголя. Внимание уделяется работам, в которых не только используется место проживания в качестве бинарной переменной в регрессионном анализе, но и делается акцент именно на различиях в факторах, влияющих на человека в зависимости от его места проживания.В основном разделе статьи описывается эмпирическая проверка выдвигаемых гипотез на основе статистических данных за 2012–2021 гг., которыми располагает Российский мониторинг экономического положения и здоровья населения (РМЭЗ) НИУ ВШЭ. Применены панельная логистическая регрессия со случайным индивидуальным эффектом для вероятности потребления алкоголя и панельная модель Тобина для объема потребления алкоголя. Выявлены различия в степени влияния уровня образования и религиозности, семейного положения и наличия детей на уровень потребления алкоголя у горожан и сельских жителей. Так, чем выше уровень религиозности у человека из сельской местности, тем с меньшей вероятностью он будет потреблять алкогольную продукцию; в городе с ростом уровня религиозности происходит снижение объемов потребления алкоголя. Также показано, что наличие в семьях детей снижает среднедушевое потребление алкоголя только в сельских поселениях. Полученные результаты исследования, по мнению автора, позволяют сделать рекомендации по реализации государственной алкогольной политики более конкретными и адресными
0006
No full textDAILY PALO ALTO Y1MES THl'RSDAY. DEC. 16, 1915.
PACE SEVEN
NOTICE OF TIME SET FOR
PROBATE OF WILL
la lh* Knpr-rlor Cnun of Lhe Conntj
ol snntn tiara. tMale ot ("sllfor-
90%,
la U** Mailer ot the Katate ot ANNIE I (iHUIKItT. ttee*taa*mCu
A document purporting lo be tha
laat Will and Testament of Annie L.
Corb«rt, deceased, hsvlng on tba
lOtb dar of December. A. D. 1»1S.
com-- into tbe possession ot uld Superior Court, and a petition for the
Probate tber«of and for the Itta-
ance of letters testamentary to B
P. Oliver. Sadie I. Jackson and
AciU I. Drxbee baring been filed
by Uld petitioners with me. tbe
Clerk of uld Court, notice U hereby
Etven thst l-*Tld*y. tbe *Mth day of
December. A. D. 1»15. st 10 o'clock
am of uld dsy In De-pare meat 1
at tbe Courtroom of ssld Court, st
tbr Courthouse, ln tbe City of Ssn
Joae. ln lhe County of SsnU Clsrs.
ba* been ul ss thp tlmt- and plsce
tor proving tbe will of uld Annie L
Corbert. deceased, sad for hearing
tbe sppllcstlon of Uld petitioner*
tor (he Issusnce lo them of Leltcn
1>»tsn.enlsry when and where sny
person Interested msy appear ind
contest tbe ume
Former Stanford Man
Honored by Governor
Chosen Delegate to National
Marketing and Credit
Conference
William It Csmp, pro'esso** ot
economics st West Raleigh. N. C,
Stsnford graduate l*»o». ws* chosen
by tbe governor of bis state as delegate to tbe nstloosl conference of
marketing and credit beld »t Chicago Ibe flrst week In December A
ostlonsl sssoctstlon wss organised
ss a permsnent working force. Professor Camp wss chosen ss secretary
Pimmion.
['ensnili-sii. (be staple food of arctic
explorers, la msde from the Bash and
fsi 01 btso-ns.
(liven under my band nnd the
Seal of uld Superior Court thla
10th day of December. 1911.
(SEAL)
HENRY A rnSTER. Clerk
Bl W DKNKEIt. Deputy Clerk
NORMAN K MALCOLM. Attoroe)
for Petitioner*.
1.5-1 3-1 Ol—AdTt
Wideman fk Son
GIFT CKNTEU FOB MKN
Jom s few of ihr taany In-j-jnful. utw-ful
we hsve lo offer—
SHIRTS AU guaranteed
NECKWEAR- Hundred* to ehuose from
J-1 OS K Holeproof or hoik nil pa It
JKWKI.ItY Sluds. Link* Pin* and Set.
PAJAMAS The new Middy
TIES Pine Imported silk
HUSK I'h .-Mi .silk all shade-.
Sl'ITCABES—All leather
SHIKTS Army Plsunel
I NDKRWEAH Wool or cott-'ii
HAT oHDKH Crofu( snd Knspp raskv
SrSI'ENDERS -Silk and Halm
I'.AIlTKItS Silk a»d lisle
BATHROBES Some beauties
MACKINAW COATS Norroik ityte
DENT HI.OVKS Tan or grsv
I MHHKLLAS
sad d-*-(»cndsl.lr glfU
a 1 (mi. ai.no. »■-.(>(>
BOe
sav
QaOr up
•t.fiO stad 'J.(>»
VIOO
50r, :.v. »i.oo
•fC..(M) lit fKKXl
• i no. ,«: mi, 9&.M*
ma. ntiicnw
*M..V> and * I tm
fiO<. 7fW. »l.O0
3iW- ami HOr
M .Ml to SHI.IMI
•7 ..no
* I no and fcoo
mi. u> VB.0Q
IF |\ IWll UT OlVt, HIM \ MKttf'tl WDISK OfUHttt
Wideman & Son
PALO ALTO
TWO STORES
Mexican Relief Funds {Excellent Number of
Relieve Much Distress Manzanita Bark Out
Converted Into 4,000 Mexican Best Edition Ever Published by
Money—Letter of Thanks Students at Popular
Received School
Funds rslsed ir Palo Alto by tbe;
recent Mexican fiesta have arrived
lu Mexico and are being used In tti«- ■
relief work among the destitute of,
Mexico City, according to a letter |
received bv Mrs Will tan Wallace,
who sided In the fiesta It cotnesi
front W 11 make, a noted old-book 1
specialist who Is taking a leadlag
part In the relief work
Owing (o (he depreciation of Mas-
lean currency the draft of 1565 In
I'nlted States money netted IMffil
In Mexican currency. The approach
of winter finds Mexico City tn a das-
olste stele. srcordlng to Blake'*
letter, a copy of whlcb follow*'
l-*((«**r Ktprp-w.fr* TTianVx.
"Mexlro City. Dec 4. 1915. '
"My Dear Uns. Wallace Yoar
letter of November ITth hu Ju»*
reached me Being registered It
wss probably delayed a few daya en
route tt knocked rne clean off the
perch ' Thai the good people of
Palo Alto should so bountifully
come in our asslstsnce certainly demands and receives our deepea(
gratitude Do vou know how,
much H*M In failed States money
I means here* Well 1 sold the draft
for I4.00P Mexican r«rreocy. snd
ithe rati-, wsa IF. to 1. equal to |3.-'
i»?6 but I made the bank give me'
||3.'> more, an I could uy ll waa an
even 14.000 Un't tbat splendid*
And now )■■■( hnw |o spend tl
I Mrs Blake to full of plans In fact
' -.he cried Tor Joy when she read the
I lelter The al-chlt* we see on the
atreeta constantly are very diatrees-
itig -a* vmi wbo hsve lived bere'
I --an well reallie Tell tout people
ihn**- very, verv grateful we s-s for
t-Ma timet v sMixtnnce. snd that I
I «11! keep s careful record of sll ei-
ll>enditure* and send you s detailed
report.
"A great d*-ai uf it wltl prohahly
g" for corn AKhough I have
lived Ihtrt* tlir**.- veers In Mexlro. 1
did nol realise until Mil year bow
KhsOlUtel t imcMii rom w ss to a
Mexican Then next in imp-i-runce'
im beans i arm *)* probably have
(O pur.liaae some chea-i blanket*
and shoes a* (ht* nlgh(s now are'
■ fry cold 1'osslMr I mi) have to
lliveet Iti ntedlrines snd sanlt-tr*-
measures as tha typhus i* raging ns
richer before
Y'.u see I hava. my hand* fall. |
The Christmss number of tbe
Mnnianlti. Itsrk. published by the
students of Mantanlla Hall, bas Just
come off Ihe press and Is ready for
distribution
The editors and managers of the
Hark have performed their service"
unusuallv well this year, snd th*
(>•.-*( number whlcb hss yet appeared
(• tbe result E P Larrabee was
ediior In chief, and Trls D Connelly business mansger Iloib were
supported by sn able «orpe of as-
slstsnts
Rlon Kl> c snd Owen Churchill
■ (ar In the sa depsrtment. of which
Churchill was editor Rice's mas-
:,■■-, ...,,- tm (ho cover design, whlrh
I* undoubtedly the beal the nark
hs* ever had. Churchill's clever
'.••■ii is In evidence throughout the
edition
The editorials are from tlie pen*
of I. 11 l-evi and Milton F. Samls,
• hlle •tblettce i* done In excellent
»(>1e by W R laugenour Kenneth
D*.er wrote 'Society." while Rlre Is
res[ton*lb|e for the Jokes H. Fl.
Whiteside and K A O'Neill asslited
Connell) In the business affairs [1.
Ij
Sf(*d as faculty adviser
Anniiny Trsr-sforn-adWi.
One may be a speckled trout In tbe
country and s codfisb In tbe city, sc
curdUig to an obeerver. wbo beiWree
that many cuuuto U>ya would du *-*-«n
to aia j i-l lii'inc
"A farmer. " he ssld. "once caught
a Hne speckled. (Mill, which lie decided
(o present te li'-s suti( in the city Ac-
cor-dlugly. be wrapped It In green
leave. dimI pU<-r-J ll lu s basket lu tb*
iHtdy of the watguo As ha stopped for
rerrc-tbuMMil nt * rusdslde tavern aouie
uiUehlc-uus it.ij* took s codfish frum
a nearby gnx-rrv sutl aud sul»tltu(ed
K for tbe diiuy beauty
"An-lvlni* In tbe city, be (-resented
the (Ish Ut his sunt 'Whst do you
mesiiT' abe cried. "This Isn't a iroul;
Ita s codfiab'
**l*j»(ln*r crestfallen. In- l — 'k K back,
hut i>n (be toad the t-ujs again made
a sut-slltudon. and when he showed
(lie fish to his wife U was s s-*eckle<l
iroUL She l.sd-iied to his tnlo With sn
auiuaed stulle 'Yes.' she nnil finsll).
-It's like you -s ei-eckled trout In (be
f-outury and a codflsli lu (own.' "— Ex
cliange
FIRST IN SAFETY
Holiday
Excursion
Fares
For
CHRISTMAS
and NEW YEAR'S
Salt Dates
CHRISTMAS-Dec. 23, 2-4, 25
Kniirn Limit Jaa. 1
NEW YEAR'S-Dec. 50, 31. Jin. 1
rUlum Limit Jss. 3
For Tickets and Train Service
Ask Southern Pacific Aficnt
WE WANT MEN WHO "KICK"
sl-OUt the wsy their clolhes are cleaned pressed snd
repaired to let ua care for their spparel - - then
KICKING slop*
Our methods of doing (his work are »o modern snd
up (o tbe minute (hat we are certain nf pleasing all
• Im trust ua with their work
, KNIGHT—-MANLEY
Phone PALO ALTO 470
IHO rMVKIWITY AVE.
PLANT 700 KMEIIHON 8T.
I-1U---WB -Uesni --leeno-1, 7fic pr.
Stanford Laundry
Tlte I.ai--i-lry of Quality
Family wish—wet, dry or
rouch-dry
PHONE njriK.
IF VOI* WANT GOOD JX%-
HRrAIRING l»ONE leave your
shoes at the
Campus Shoe Shop
E. DF.I.YON
Hack uf SUnford l*o*tomce.
I'In me 4B6K
I 1 prop
isl ami
rise equal (o
:he moaai -te
the
as far as pO-Mlfa|rt. A-jalu thanking1
vou and (lie l'nlf> Allans for your |
noble gentfroalty Aa ever.
-w ii ni-AKE-
llmne P. A. SIM.
J. I.1VI\ l.i I.Its—40.00U Jus( receded from
orted hyacinths, tulips, daffodils etc Plant In Oi'ober
Dealer In tubher. metal, ta
rope, stoves, tools. Junk of and November Our prlres low»r
r-v-T) description (han Ssn Jos* or city
ca Hon- m«mmr. ,au> alto PALO ALTO NUkSEHY
BREAD
'.'
24 Loaves for 4.50
SOAP BOXES
Is r-.ur.d oMnng anil r.val r. „2C ir. nl any
.sits
25c to 50c
TRINKET BOXES
fo, luildina .inm. |>iaa an.l i,»rlr, Plain ...
plush hard
3.50
BONNET BRUSHES
Willi hanrll,. l'-T liriMhing a plusli vrl.ci
..f like malr-ial
2.00
HAIR BRUSHES
In rjiassn. ol ,iyl,a Olil*«r hsfks an-l i-lain
75c to 1.25
MIRRORS
Kinu or .traiRl't h»n«*l-l and l-.n." handl, b-»n-
nn nylp,
75c to 2.50
MANICURE SETS
In h.d.icr iramr-s Ol ivory l.osr. lncliidr ihr
menu essential iniplrmsnt,
3.50
NAIL BUFFERS
Ilj.iifr in n/r [r-.in lhc .nullrH In llir h.ng
,.,.|„„.„,al
50c to 1.00 to 1.50
TALCUM BOXES
Come in round and oval ihapei. Both -ith
Sl'lrrtep.
50c to 2.50
CLOTH BRUSHES
In tire-a and style* lo match yuir set.
3.00
MILITARY BRUSHES
Ur rsery tlir best and m.m durahlr bristle-
l.ru.he,
5.00 a Pair
PICTURE FRAMES
In round, oval or square, and doxent o( dif
Irrrtit [iSttcrni
50c to 2.00
SHOE HORNS
Wllh r.ra) and plain hamiln Made r.tra
25c to 75c
NAIL BRUSHES
Will not crsrk or spill am! lite bristle, arc
.haeilutel) .cure
50c to $1.75
Tha GoossbeTy.
GooeebeiT-r busb.-s were -.rlicl.-ially
called Kt-CaM-l^-tTy l.ust>es from tbe
plants li.iilii,: iiricklcs *lmllsr to tbose
of the gnrse ahruti
Weingartner and Co.
PALO ALT
Characterizing determinants of BK Polyomavirus-specific immune response
No full textBK polyomavirus (BKPyV) is one of now 13 human polyomavirus (HPyV) species detected in humans. BKPyV is only known to infect humans and seroprevalence rates of more than 90% have been reported in adult populations around the world. Following primary infection, BKPyV persists in the renourinary tract without causing any disease as evidenced by urinary shedding in 5% - 10% of healthy immunocompetent blood donors.
In immunocompromised persons, however, BKPyV can cause significant diseases whereby uncontrolled high-level replication may lead to organ invasive pathologies in kidneys, bladder, lungs, vasculature, and the central nervous system. The most consistently found diseases are BKPyV-associated hemorrhagic cystitis (BKPyVHC) in 5%-20% allogeneic hematopoietic stem cells transplant patients, and BKPyV-associated nephropathy (BKPyVAN) in 1%-15% of kidney transplant patients. BKPyVHC is highly symptomatic with pain, anemic bleeding, and increased mortality. BKPyVAN is asymptomatic except for progressive renal failure and premature return to dialysis. Both entities are characterized by high-level viral replication i.e. with urine BKPyV loads of 8-10 log10 Geq/mL, plasma BKPyV loads often above 4 log10 Geq/mL, and an allogeneic constellation between the virus-infected host cell and the available T-cell effectors. Despite these similarities, the clinical manifestations are strikingly different suggesting relevant, but experimentally undefined differences in pathogenesis. Thus, BKPyVHC typically occurs within 4 weeks after allogeneic HSCT and is confined to the bladder, and typically without kidney involvement. By contrast, BKPyVAN is diagnosed around 3-6 months after kidney transplantation and confined to the kidney allograft without causing cystitis. Although high-level BKPyV replication should be formally amenable to antiviral drug treatment, no effective and BKPyV-specific antiviral therapy is currently available. Therefore, a better understanding of the immune alteration in both diseases has been deemed essential to identify patients at risk and to develop prophylactic, preemptive and therapeutic strategies.
The currently recommended strategy for BKPyVAN is to screen kidney transplant patients for BKPyV replication and to promptly reduce immunosuppressive therapy in those with significant replication to facilitate mounting of BKPyV-specific T cell responses and thereby preventing progression to disease. This manoeuver has been linked to expanding BKPyV-specific T cell responses in the peripheral blood of kidney transplant patients. However, this approach may place patients at risk for acute rejection episodes that predispose equally well to premature kidney transplant failure. Although the clinical feasibility of reducing immunosuppression and curtailing BKPyV replication has been shown to be effective in prospective cohort studies for many, but not all of kidney transplant patients, this approach has not been possible in allogeneic HSCT patients because of concurrent or imminent graft-versus host disease. Thus, there are significant gaps in the current understanding of the BKPyV– host interaction in the normal host and in the allogeneic setting, which need to be investigated for a more effective and safer management of these significant viral complications.
In this thesis, the interaction of BKPyV and the immune response has been approached from two different angles. In the first project, potential mechanisms of BKPyV immune evasion were studied. Here, we focused on a small accessory protein called agnoprotein encoded as a leader protein in the late viral early region (LVGR). Although HPyV genomes overall show a very similar genome organization, agnoproteins are only found in the genomes of BKPyV and JCPyV that have a kidney tropisms, but not in any of the other 11 presumably non-renotropic HPyVs. We hypothesized that agnoprotein could play a role in immune evasion by downregulating HLA expression. The effects of agnoprotein were studied on HLA class I and II expression in vitro by flow cytometry following transfection of primary human renal tubular epithelial cells, which are the viral target of BKPyV-associated nephropathy. In addition, transfected human UTA-6 cells were studied as well as UTA-6 cells bearing a tetracycline-regulated agnoprotein. As control, the effects were compared with the ICP47 protein of Herpes simplex virus-1, which has been previously reported to effectively down-regulate HLA class I. Although both viral proteins share some similarities at the protein level, our results showed that BKPyV agnoprotein did not down-regulate HLA class I or class II molecules. Also, there was not inhibitory effect on the increase of HLA-class I or class-II surface expression following exposure to interferon-. By contrast, ICP47 reduced HLA class I surface expression, but not class II. We also evaluated effects of agnoprotein on virus epitope-specific T-cell killing by 51Chromium release assay, however no interference could be observed. We concluded that agnoprotein did not contribute to these types of HLA-dependent immune evasion processes. However, further investigations are needed to understand if agnoprotein could contribute to viral immune escape by other mechanisms.
In the second project, we aimed at better characterizing BKPyV-specific CD8 T cell immunity targeting epitopes encoded in the early viral gene region (EVGR). Selected coding sequences of the BKPyV EVGR were submitted to two web-based computer algorithms (SYFPEITHI, IEDB) in order to predict immunodominant 9mer epitopes presented by 14 frequent HLA-class I molecules. For an experimental confirmation, 97 different 9mer epitopes were chemically synthesized and tested in 42 healthy individuals. A total of 39 epitopes could be confirmed by interferon- ELISpot assay in at least 30% of healthy individuals. Interestingly, most of the 9mer epitopes appeared to cluster in short amino acid stretches, and some 9mer could be presented by more than one HLA class I allele as expected for immunodominant domains. HLA-specific presentation was demonstrated by 9mer- MHC-I streptamers for 21/39 (54%) epitopes. The 9mer dependent T-cell killing by 51Chromium release assay and the CD107a surface detection indicated that the 9mer epitopes could be recognized by cytotoxic T-cells. Moving to a clinically relevant situation, 13 9mer epitopes could be validated in 19 kidney transplant patients protected from, or recovering from, BKPyV viremia. The results suggest that, pending further corroboration in larger patient populations, novel 9mer epitopes can be identified, which are associated with CD8 T cell control of BKPyV replication. Thus the identified immunodominant 9mer T-cell epitopes could be further developed for clinical assays to better predict the risk and the recovery of BKPyV diseases, help guiding immunosuppression reduction, and to develop specific adoptive T-cell therapy or vaccine responses to prevent or treat BKPyV-associated disease
0000
No full textlaito iJalii Alto SfottM*
TWENTY-FOURTH YEAR.
EIGHT PAGES.
PALO ALTO, CAL, MONQAY, JULY 17. 1916.
EIGHT PAGES.
NO. tjt.
KEEP COOL
With a'
POLAR CUB
Electric Fan
PRICB 99 RACH
OooU about 9 ceatt per day to operate. Knjoy tiitirrnsii wttboat
going to tbe eoaabosw.
He haea away otber bo_-we*th<T comforts—White Mountain
_-*r*_-__er», Aato Vara am P_W_a_. IU_rtgcrmtr_, etc.
Palo Alto Hardware Co.
BUY
(DESTRUCl
BAOOACE^
CHICAGO, July IT.
Lioa wired *" thla morning tbat he
thovght we were rtagy. Wovidal
that spoil yoar breakfaat! He read
Thnreday _ ad attest oar IM-wan
Hay. he's aeveral
away, aad he left aa wllh a mighty
aaaall halaace la tbe lU*nk. Were
■or*. Anyway, we oold a lot of aalta
aad we will keep the •17-00 price
for »_ft.no units going thla weak. If
UNO MOVEMENT
TO OE OISGOSSEO
William Smythe. Founder of Little Land Movement, to Speak
Here Tomorrow
Runnymcde Is to Be Made Capita, of Little Landers of
thc State
William Smythe. founder ot the
M«nyFdoAii.jLOC'LGUARBSMEN
S_T ON OUTPOST DOTY
BOY SCOUTS
The comfortable,
durable shoe for
hiking and vacation
wear.
We sell the original Boy ScoutShoes
with the medal attached.
Tan, Grey and
Black Eikskin.
Registration to Date Ia Par
Below That of Two
Years Ago
The total registration of volera tn
Palo Alto up to July -> is ahown lo
the following table
Republicans -OO
Progressives *;*
!>emocrata it*
ProhiblUonlttt tt
Socialists 19
Declined to *tat.
ins
Total !*ۥ
The total registration up to the
j November election two veer* ago
Company L Takes tu Turn at
Guarding Camp at Nogalca,
Ariaona
Jay Risling and Leverett Taff
Develop Reputations as Rip
Van Winkles
By RAY I/IVKTT
NOC.AU-8. Arlt , July H -Today
la Company I.t (Inn day at outpoet
duty All day long Ihe Palo Alto
private* guarded the camp, and tonight their vigil will cootlnoa. with
a little more "watchfulness." Bach
Little landers movement, will gl«e,
yoo haroa't. well come In tomorrow.jan mu,trfttwi iwm.e tomorrow ev«n-|
Ing ln Itamona Hall on "The New(
Ufa of the land" Mr Smythe i»|
(Wi.vi Straw Hate. I1.0O « ot tht world'a leading students;
of tbe Lend problem, sa well aa
I.80 Caps d*"! finished Iscturer and writer "A Ut-Uraa 2.2'.0. which without making -"ompany In the regiment takea Its
{tie land and liberty and a living Is allowance for any growth In popu- -urn *• -*■■■* duty, and we wlll aat
hla motto. 'latlon would Indicate that there are ->• <*slled upon again for about else-
' Tbe Llltle lender movement has. In Palo Alto approximately to.'*" <1*T«
really become worldwide In IU I voters who have nol yet registered Sergeant Irwin Tslboy Is la
scope Here in California llr.] But two weeks remsln before the -*harge of the outpoet. whlcb U a
Smythe haa already eatabllahed ihraaj registration wlll cloaa Ior tbe prl- ™>™ ■•rlous undertaking than tha
colonics People trom every walkjroary election on August jr. Interior guard He I. accompanied
of life have turned to him for ad. The Progieaalvea nnd those who *>? »h«* "Quads of Corporal Charlea
vice and help People want to go1 have declined to ttaie their party Zollinger and Archie Watson. Outback to thc null, if they can find ajsmilatlon will be barred rrom vol-1 »*o«" *ark '" *>°nc only at nlgbt la
Smythe hat the toltillon ' »«Ut at the August primary olectton ****** **mp, and tha hoyt will not
mind In a little land and Tor the nomination of I'nlted Slate* ,'av* 9*9eb time for reat Coffee
Smythe senator, member of the house of -**■*■ •*••« sandw|chea are furnlahed
The Regent
FIIKK >._I.IV______
TAXI?
PHONE
15
AMUU'R TAXI BKHVICK
Special Trips to
BIG BASIN
YOSEMITE
S4NTACRLZ
LA HONDA
■ ■'.:■
Mtt If
way Mr
and it i*
Intensive
la now
fourth
colon i h
i ital of th.
tba world i
; Hunnin.edc
| part of Paio
I vat Ion M
. in Mtnbll
1 . . :-_._-.-t cob
ilng
-ill
I in;.- l.nn.l
bit representative* mem be
This atoembly and member*
ie the cap- *>' central committee
■r* throughout »o deelre may chang
be located Sl
■ virtually a
Ku
. to pro
I elogan
I The cl
I famed
ti advantage
Mr Smythe*
md .i living
the
210
lormal vote
Stanford p
voter-, are
In I
... Hi
reg
alo Al
I So
stere-l
1 about
and In
Pnlo Alio Is
half
ford No
the vote
ii
on 11
lhr
i:'-
altar
or oae-
ireclnrt
BUICK
l950F.O.B.PaloAl.o
'When better cars are built
Buick will build them."
Stanford Auto Co.
Phone P. A. 76 511 Alma Street
STANFORD SHOE SHOP »•*'-*• ■*»«" th
n round nnd If
Old
Made
New
i.r i rosso
erll Of
0 land
right
ii California
SVatUtaai ol temperature -sarin
enough hut not too warm, cool bul
not too 'I'.-l the iiinrket I* Ihe \.r- i
In California - flrat of all a homo
homes all
Snn Prun
rkeley are not 5e#|e cuthbertson. Mrs. Coburn
Hays and Townley Compose
Mrs. Coburn Receives
Biggest School Vote
the nearne-t* '
and the unli
ioi C ire It
■ far nwwv. and 'lien
; good public school*
sity
In conjunction wtih thl* new cot-
Ion) of Ituoa.rnedo many new fea-
' lutes are In lie Introduced The
mnel Interesting I* lindoilbtedli lhe
.pert that iwiiH'i production Is to
pla> Poultry I* lo be the source nf
{much of the caah returns Charlie
Week* who is actively interested in
(he new colon- of Ituuinmede so
Good Templars' Home
Children on Outing
Pass Through Palo Alto on Way
to Sanu Cruz to Spend a.
Week
(hn
alo
Is nfie
ill.-.I the
Chnrl.'i
Week* poultry
inch all tin. colo-
iilii. laying hen*
8 net He abi
on one acre of
each hen pay »
10 buy direct all the egga
try produced paving San
greei
ii ! ;■ .Ill
MOTOR TRUCKS
niiMTini: MOTlUG
Unit: and Short Hauls.
Prompt and tpecit.. attantlon
given to baggage ordara.
I'HONK 90
Palo Alto Transfer and
Storage Company
ill <_Itci_E
'I
FIREWOOD
Mill Cl TT INGS
lilt, 1X.AI. FOR .1
; e
Dudfield Lumber Co.
Y_r,l -tmma 21. MUI phono _23
THOMSONS
138 25*
ALCO TAXIS
3 and 7 pa at eager open n
BIG IllMN
*>..!. Siogr
Fare »_..V> round trip.
Atk It AhM.1 II
I'l... or 1SS
_
Klfl) of the i-hlldien from the
',..'.'. Templar* home for orphan*
;.j.--i.| through I'nlo Allo today en
route to Santa Crut. where tho> will
tie lbe guest* of the Santa Cruz Klk*
ror one week The V a Ik-Jo Klk*
.-.tit ni. ii.t Uie management In the
ex.M-nse of getting the children to
and from Snnta Crui Mrt F W
Sherman of this city Is vice-prealdent.
of the hoard of dim-tor* of the
(_:>od Templars' home.
initiation* Mo
:ry ram h of 0
in actual dall
ho» he xiorrn It
I.ilthei Ilurbar.k
Is so deeply Inlen
I-if.de
ier his own poul
1.000 chlck.-nn i-
demonstration of
plant alta"!
in Ihe 1.lllle
emeril Hint lit
laid
Ilurbank ■
deinonxtrn
-j ii
r or the famous
i Un nn* mede to
Uttl.- I-ander
«Mli plants and
if (he stale '•' 'll"" "■■'•Ii'IkIiI meal Plenty of
' tlm i-iiuD- smmunltlon Is carried for thjilr own
Those who Protection if the need ahouid arise.
lhelr parti Pb.st._i examinations are being
deaignatlon before Jfllf 29 carried on continuously. and tha"
These two classes and those not ****** mr* looking forwanl lo Ihe fln-
leglatered repreaent :b par rent of"'■hln* " •hol« of the typhoid and
I)Phut Inoculation We wonder If
ihe tainting bee will start again
at ihe next proceeding It takes
three different ■-•tun. In j r-. I Ion* to
complete the ••■» ration 8ome*of
the Palo Alto boyt have already ra>
net-red iho treatment from Health
Officer (Hay and have* their .erilfl*
catea to prove It. but ths regular
army men -* 111 nol rc-rognlie, them
even though the stale of California
autboriied the tre-itment.
The regimental hesdouarter orderlies from Company I, were Private* (lakes Htchardton and Brit-
ter It la Quite an honor for a prl-
vale to get thit appointment at tbo
i'i-*! appearing and equipped men
are ghen the preference
The weather hat changed from the
storming and roaring tlege. aa date rl bed in lbe latt writing, and Is
I now beginning to gel s little warm-
I er with a beautiful clear aky this
, evening The few men left ln camp
iare i.t..',!,- gating at the ecllpte of
the moon which showa up plainly.
Iln- mall 'orderly aeys that
Cum pan l I. get* more mall than any
order t«0 companies combined,
win. h L> quite a record and a pleas-
ani tiaie of affairs, for we certainly
nre glad to heat Sergeant McCol-
.a-'b ■ now famous "mallo" yell The
outgoing mall nils our roallboi to
It* caper it; and we feer Artificer
(olHer win hate lo enlarge It
The sanitary conditions are not
yet perfected ln the camp, but they
are fast becoming ao Captain
Hairs to. s matter of -.n-. mitlnn has
ordered ail Comiteny \, drinking
an!." io ha sterlMied
\" .mm it complete »Ithoul Ite
grub klrkert and there are tome
'Continued on Paat Fuur )
Board
.Ifred Seale was electe.1 to the
nioii high school lioard of truateet
Ith It.? vote* for lhe one (ear Inm
the election latt Saturday
\frs a ii Coburn with is*, votes
id ** M CuthberteoO «Hh 171
■tie*, were elected for Ihe teo-yea
■rm* and lbe Rev Waller Hi)
itii I7'i vole, nnd Ptofeaaor « l>
OWUlc) wllh 17*. volet mrtv rhoacn
ir the ihrea-yaai terms
**lr« Coburn rim ahead of
i-kc. receiving the large-i n.
I ...I.- of .mi nandldate
The folluwlng eaa lbe ...'■- .„
her
f-'rank Cramer
Alfred Seale
W l har|.-.
Mr* A VI
ruthhertson
: nl
P'a.*kln>on 1 I p
if I K J Klnghan
ear lertn Walter
Townle) 102 Pathi
t,ti-et,,i larruih I
P
I 'I r
Snn in Itoaa
(irsi time in
ntlnned .... |,ege i
BKK U8 ABOUT
rofonnr hopkins- lots
THK IMVKRHITV RBAI/TT
OOMPANT
Palo Alta Han Praaclaco
KILLAM FURNITURE CO.
Successors to Russ.ll Furniture Exchange
Have your Mattress Repaired
UPHOLSTERINO
Carpets, Rugs etc. Cleaned
FtM_M SfUl. A. F. KII.UOI. t-rop-tetor. loo-ir.l High fk.
>,
L.
"Alta" Brand Certified
>
and
o
■J
__
Inspected^
Milk you will eventually want
>
u
V
tii
-*A
c.
•o
E
c
CS
Place your crder before it is too late
c
L.
-_
Palo Alto Stock Farm
Phone Palo Alto 636
{__.
HAVE Till-: ItAII.V FWA)
ALTO TIMKM MCIVT To VOC
Wlflf.P. OM VOIR V tr .TION
PHOKB P A. IIS.
****** ************
Miss Harkcr's School *
«
Telephone .50 a
MI drpartmrnti 1
Montessori) open
d->ily from 9 to 1
ncluding a
o visitors
I* Special .tudrntt received in *
I « Mutic. Arts snd Crsfts Work, *•*■
* ind Domettic Science. *
. s e
oommmmmmm-fmmmmemmmm
MARQUEE
THEATER
Ideal Ventilatioi.
Only tirade A Pictures Shown
TRIANGLE PROGRAM
Billy BurKe In
11
PEGGY"
TtM- greeie«t and tntmt pwpalar |__dncti«n of tbe cnrreaC year.
LATEST "PATHE WEEKLY"
Al»t*LT_| |Or—Mt.HIM. 7: IA. MA TIN'Kit BUM—'III I.IHtKN _c.
TOMOItROW — ULUAM OlHH |\ --rtOLH Ftm HAHMAtlK."
IKMM.I.I. Pl.iM.lt I
3
No full textOUR
eR E- a r>
G. W. La Peire & Son
Tbe Grocers
IH* Max. Baatasreant
«. PBTRICB. ....
WitllfM BIk Hi*
LETTEH FROM MANILA.
Cbsvluusfsl from pciur /,
OIL STOVES .
G. H. ALLEN OIL COMPANY
raio Alto
Billiard Parlor
Ms w*-*»
t'tsiri * au.DC wama.
■St *AT(Q COUMTT
BUILDING A LOAN ASSOCIATION
at-am-wisfo. m. torn. Sat.
It. K. Msilrrtimn
Palo Alto Transfer Co.
J. E. Teague
I'l.t -MhlM.. STEAM AND
GAS FITTING
Osasral Contracting Tiaalag
Kl rniirt.lt)' Av-nnu
S. HARRIS st SOH T*-**
Express and Transfer Co.
210 Unirenity Annum
lava ftslr m**- BAXERV
lilt, UH .,,.«„„„,
210 HOMCH AVENUE
Renters Loan S Trust Co.
eanTtu, ai.eae.eee
tan Franciaco - Cal.
era-, *m* .m . w. n n «.<ltr
-a - A**-. '• Lis
OtTIco 131 University Ave.
j. e. ruxiiui :.r."4o^
F—.PuMtrMr-tBa BCs—
OsSjUssS h—intdl*
THE BANK OF PALO ALIO
I. t. l-.rt...
House a Decorative Painter
Callahan HacCftrthj>
PAl-O At.TO, CAL.
Tinting, r*ia*rh*o--io|-. ('tiding,
Craiaing, Marbling
WliRRY & SON
miNiri. aa* E trtal SB I
• I .... csf 1'a.i.ll... Ijiicltir. al
LUvn't.l^lfc.i tlll.iilta.e .',lilll,h -I
time of the cboUra ootbreak ta March
last tbare was iota uf green .lull
brought from Chin*. Soom I* gro*n
about Manila. Native fruit* are ua-
ually abundant Amerlt-au Qt-aagu*.
batooa, etc., an, of oour**, blgb la
price. O-Jt-nso* aad wild Urds are
pleotlfal la tbe marfc*as. Average
pi-sCeo oa *o*s* fruits *nd fowl, are:
Baaaaas, SO to 30 cents a doien; co-
t-eaaata, 7 to B coat* serb; plaeepptee,
1& to ti cent*, amall chlckeu*. CO
coots; lor**, gl.H*; wild ******* Bl;
•alp*. SO osots; saaatl quail, Th oeuta
a doxso: doves. Hi) to M c*ots socb.
Etwt-ybody wsora white of course.
Ia*** suits oost from IC to BIO *e-
cordtng to tbe cloth. Wool eaa be
wum In tbe talny mouth* but tt b aot
nec*r***ry. Good abt** at* eit-usli-e
and difficult te Had. The native mad*
bote, eiiber of grass or Lamboo, ar*
light aad null* equal to Panama*.
Sturt-. are operated by nil aatltat,
tbe Chlneee aoally do tb* most bo*.-
ne** and will tiring most anything to
-four room. Tnere b a sprinkling of
Spanish, Indian and Amet-to*a store
keepers. Tin rr are *everal American
book otoree wherw toast of tbe new
III.vrti are ^iild.
t'l.niilnu la a almple and Inexpvn-
slvs proposition; transportatioa b
simple, ohcap and unsatisfactory;
rooms and chaw are ousellafactory at|d
ratbsr expensive. Of eutertalumeuta
tbare are uoue. It ts difficult to visit
your friend* If you bars mi, and tbe
magazines, aud Ann-Mean papera are a
month old *h*u they get b*r*. We
bate three morning papers, one evening ami one weekly. Tbe Utter b tba
style uf Tuwu Topics*. Her* are two
it,ii- ■ from tbe editorial page: "A
Mau.cr la tbe hand b worth a hundred Isvlrs.ne. la tb* baeqoe." ■
" rutty Mora* were killed at e wadding. Who says thai msrri*** b a
"Tb* clltaate^irtl^l'liTli|>i.iii--ts i«
much lietter than generally l--llev.il.
Tin- Isn't falifc.rnla, but if Manila
i't a better ellmat* tban New York
Cltr, then my memory for *un*truk*e
and snow storm* b pour. Home of
tbe -seldbrs bod ■ bard Urns, aodouU.
but comtdag would nut las pleasant In
tbs rainy ss*BBS.aayuber*. I'r-.l*!|y
Yolo, or tome uf lb* cuuuti-* along
Ibcre t-.mll p-v-iuo* lend es pls*a*uat
for ■■hike.' wint rk* poddy. Aa
I naaarkwd, tbb ba't Csllforola, nor
yet tba Kant* Cbua valley. ,*jX • •*•*"
not found M *o lisferaal s* many bsve
made It. I bare aot 'got mixed up
- it (• fever yet and * ill |vrubaUy -"bang*
my tone s-ma**** or.later. 1 will tall
you about at tbeo. t-«r>r*rely.
KIClUKI) C. MHIRMKIK.
Manila, Aagast 3&, 1 :■■■-'.
to; loiversity Aienue
SHREWSBURY & SMITH
Dedrical and M«haniaf Enginem
st-srtrw UtSI wsnu. ruU* aa* T «*..*....
SBerti-ai sue** lartaJtsU. I'.aaaat
ll.itaaaii riiaaisl Be-aBat—**,
A rt as*— WaU IwsBsu
M.UB aal Sir, Bateo
S. C. GIBSON
V. W. C A. WORK.
The phslant hrui-le deiartmeul af
tbe Y. W. C. A. b dotug active work.
A committee of twenty young women
b canvassing the cani]iu* snd * l**-g*
part of Palo Atlo for outgrowu or cost
off clothing, Ist-uka, etc., to 1* -mi
whs-re tb**— Is need In Msn I jam l-v..
Neil Salui.lay. November It. will st*
the Orat Millectlfiu of three article*.
'■■ Tii"— wim inn '|'i i-l Hi.-tu are
het*eby |-ealiie«ta*d to bste tbr 1 . i ■ ■ ■ I - -
reedy. So tbat the i*ollt-cttiig conimit-
tse will not be delayed.
If tilers- sre huntc* which hare not
been t. .t.-li-I by tbe t-umtnttten, lu
wblch tbare are ann-l.-* to glee away,
a -Ht-tal sent to Miss K. It- Kip, lm
virslty P. O', oefre Wetlnaeday,
! will insure a crU next tmlurdey.
K. R. KIP.
■ NEW MACHINERY AT UNIVERSITY I
A Sis.ijI.cj- tnductur gene-rat or. ca- j
' [-city 120 K. W., arranged fur 00, or
; 120 cycl*. and ^adapted foi IS. CO,]
00, or 11.0 cycles, bas Ju.t t-***n re-:
ceive.1 .t tbs eeglii-vriiig building. \'
tally M-uipped marble switch board
ect-t-m-*niea tbe machine. A *i- ■! .1
tleoeraj Rtactric Company motor I*
.i--r.-te.i.e-.ii. Tbb mecblnery will,
be st-K-t*d uadsr tbe dirt-etiuu of Pro- >
ftat it F. U. Beam, by tb* ia-*r-trlt-sj
■tusleuts a* a part of their tatso-sli-y
******
*k* N**m*m
PtAUMI*
BOOTS AND ShOES
Gtamrml **§t*d*$ a sp.oiolTy
**** mtwumrr tttamt
United Caa and Elnctrlc Co.
THE NEW DIRECTORY.
Tb* I>i-*t-tory uf OfBcers and Hta-
.i'uu .if tbe University baowoosal*.
It ******** tbe CDa-M* t'olvevsity
-reeord of all und.-t-gi-»dtialew *xe*pt,
frsihiaiB. aad abowa a d-*-kled ia-1
i iias* la all parUcolar* over laat yeer.
Id gr*.dust> ******** tnor* ar* Bl
against 73 cf **»3. L'lidergrBdostm. I
UM ******* MS. S-i-cUl .toda-ul*.
1*.» ss-sli**t 125. and a total nuatsr
of 13S0, against 11 TO.
ts-sui-gs W. Utter ta spsudlng tbta
TACDMA MILL'Q3.
rtEDsfDOD Crrv ' PALO AI.TO
LUMBER. SHINGLES. POSTS, ETC
mtSIH B. eOX. MANASE* OBt.: stWK earns Co.. oitpd.,,,
UMPHREY'S
FOR ICE CREAM AND
CANDIES
This Means You
K**bl-« ta as
MgoogtMBbbi^alVags* bWirlM* v
aa uailmely grave, t-iib lUt, II K).
psamplly cuesd, ofia* i-s*ali la oasti
aaUd I****** Ledbeand gtailsmso.
auwbeareaesker In UoubU, eoasult
Tho World's Famous
Horb Spcolallst
(MBihttsl tamale c-nmplalnbt. Man-
at.rual tesaale eomplatel* postUvsly
c-urad. Tb***o*t ******* *** Uasted.
1 Bymp*ibl** wtlh lb* tick. I waat te
***** avery clirouic Invalid wslL I
want lo prove lo jou what my Iruat-
ateai wttl Jo. 1 waat atory tick pot-
•oa la lata country te call or write to
*xe ptismaally. T«tl m tbo Isadlag
ay mpttoroa ot your d|a-a*n and 1 will at
si no* outline lb* method of treatataat
foe you, wbleb will pualhlvcly euro you.
Tatlmeiaooeadeaoe fully aad freely
Mrs. M. Van
1IEKB sl-KflAI.IST '
Ilooaw-l aad Ii Madama-TTsoltB Bid.
Pais. Alto ID 11 lm
ON ALMA STREET
RE-iOLVED, tbat lb* otrwat week
nsrvlo described b r-qsirsd by tba
panUo iatarmie ead ooav**ls*os, and
tea l-j*rd ot iruttee* ot lb* Tewa af
Pale Alto, Oouaty of Santa Clara,
6iat* ot Calltor-uU. ordet-s lb* aoaas te
be duo* aocurdlng to tae spselSestloae
adopted by told Board for sold work,
now on file la tae offl-s of tb* Clerk
of tb* Town of Palo Alto, and to tb*
-Mtt-dactloa of tb* E-u-artnteodeut of
tJlreet* of sold towu, te wit:
Th* oiuitrtiction of oeme&t sidewalks Are feet wide and tbta* lucbe*
dstep, arid wooosn carl* tbta* locihes
by twelve laebes, wltb posts tbi**
Incbet fay four .luehe* every six test,
and s?ont-T*te curb* at tb* oomers of
■treota. atteudsd as far as tbs property line oa either side. npoB and
along tbe t-et-tbeost slds of Alma
strset In aald Town, from tbe aoulb*
eaet eurb line of University Aveaoe
t» th* nortbweat curb line of Addtaoa
Avenue, ezoept *hns sama era already laid: aald work to b* done la
accurilaoc* with tbe plans' sad »p*ciB-
eatluna adopted by tb* Board of Trua-
teea of tb* Towa of Palo Alto for ce-
sidewalks, wooden cart* aad
EUREKA
. ***** m *it ea** aam* at*4s l****.
Baldy's Candy Store
208 University Avenue
PALO ALTO
NOTICE.
Annual aaeetlog of at* >rk holders of
Palo Alto I tat. ri.itj Hall (a i-uri-.r
.1 ii ti} will I* bold Wednesday. Norma
bar II, lBOt, at B p. m. la tbe room*
«** Ibe Pale Alto Roeid of Trade. A
llaard of ini*-*Hs.ra for tbe ensuing
year will b* .1,-1.-1
MAICHIUIX BLACK. Bes-rstary.
% Kills I
1 Pain
% tl sewetrsm* «aaa>ty •**• Ua. a**- '
k **ta********* •****>*** *** ***■ i
*•** ataeaarss. ********. liOaili
*W ai* atl* a** awilm Jatats-
^ ***m-h*****c ********* I
*•*. ■■*■■ so* ****** ***** *"*?„?? !
W u mm imimi*n«aB s»*s i iiwiig '
-J 1S1 a U*lavtasi BB-aaa. -rt a* rsSarw I
tn>| r-f-BB-t rr-.*-***** j
c-mc-rwU -rttrfaa et the eocaaea eg
strset*. now oo SU In tb* offlc* of tb*
Clerk of tb* Towa of Palo Alt*.
Tbs "Palo Alto TT-aos," S daily
B***pap**r pubibbed aad -*t-r«lat--d
ia sap- Towa. ta faottby dmlgnalod a*
tb* a****->sper la wbleb tbb rswolotloo
end r>otk-* cf aald work, Invitla*
t-rofwa-ata. shall to puUtatod
isnasr aad form and by Uha
laqetrad by taw.
Tbe Towa Clwrk «f said Town ta
bereby dlnt-ted to poet rxmeptr-isously
for Bee d*y* «* or aaar tbs doer ef
tb* room In wUeb tb* ■**«*-*•* of .
tbta femrd an bald In said Town. In
tbe manure aad form reqit-lnd by is*,
* aotb**. wttb -tpst-afk*tiuBs. IntiUng
saalwt profiosota or bals for doto* said
work; and aaid Clerk b fat-ret. di-
rvx-tt-j to puUlab for two-day*, la tb* •
■Banner and form r-suaired try lew, a
ootlc-B--f sold work, loviUug t*al*d
profsoaala or tods , for doing
said work aad rsfstrrtng to
tbe B-.i-i flea Hun. posted or on file. In
sold ne**|*p*r hereby designated fur
tbat purpose es afninselil Held aotle* shall require a oertlfled cbeok dr
bond, cither, a* pi--*t>t-ril**d by law,
and for an amount not lr*. tban toe
per cent of the aggrrsrate of the pro-
pusal. Held Clorit b alao torsby dl-
i-erted tu publbb tbb i*aaolot|oti for
two .lay. to tbe manner i-**qalred try
lew, lo said t-s-wapaper. dralguatesj for
tbat ptirpc-ee a* aforeeald.
I heri-by i-etlify that tbe foi-egulnc
r*-.u|nd..ii was ***ssd by tb* Board
of Trusts** of tb* Town of Palo Alto
at a meeting beld oo tb* l*t day of
.\o-remtor, A. D.( IBo2, by tbe following rote:
.\ji*s ~llurk* Cocbst. 0. A. Carry.
' Chea. D. Marx, 0. W. Mosber.
t Hose—If oo*.
I Atwrnl l>. I.. Klottn.
B. W.'SIMKINH,
(*l-rk of tbs Towa of Palo Alto.
f. UeSCHo. Carriage
Painter
i Saw Tsark a*.**
T W. ROLUft
*** • U*eat*u*sker *s*d Embalm*-
jB^jj.j-sr^'ys---.**!
Chas. A. Stevens
Sir. B IWtah-iaal, 171 Lrtlas A...
Pal. Alfca. U B«w stvpsrarl Va rto. omr
loll Ubb s! IbH aijlaa la cSoska asd eata
BBS Will SB*— }CB BBT 1.CM— BTBSS.
Palo Alto Homo Bakory
Hrit-Clsu
BREAD, PIES,
CAKE, ETC.
—**>«*. C. £ BeiHehme
