1,720,986 research outputs found
Artificial intelligence in pediatric allergy research
Full text linkAtopic dermatitis, food allergy, allergic rhinitis, and asthma are among the most common diseases in childhood. They are heterogeneous diseases, can co-exist in their development, and manifest complex associations with other disorders and environmental and hereditary factors. Elucidating these intricacies by identifying clinically distinguishable groups and actionable risk factors will allow for better understanding of the diseases, which will enhance clinical management and benefit society and affected individuals and families. Artificial intelligence (AI) is a promising tool in this context, enabling discovery of meaningful patterns in complex data. Numerous studies within pediatric allergy have and continue to use AI, primarily to characterize disease endotypes/phenotypes and to develop models to predict future disease outcomes. However, most implementations have used relatively simplistic data from one source, such as questionnaires. In addition, methodological approaches and reporting are lacking. This review provides a practical hands-on guide for conducting AI-based studies in pediatric allergy, including (1) an introduction to essential AI concepts and techniques, (2) a blueprint for structuring analysis pipelines (from selection of variables to interpretation of results), and (3) an overview of common pitfalls and remedies. Furthermore, the state-of-the art in the implementation of AI in pediatric allergy research, as well as implications and future perspectives are discussed.AI-based solutions will undoubtedly transform pediatric allergy research, as showcased by promising findings and innovative technical solutions, but to fully harness the potential, methodologically robust implementation of more advanced techniques on richer data will be needed.• Pediatric allergies are heterogeneous and common, inflicting substantial morbidity and societal costs. • The field of artificial intelligence is undergoing rapid development, with increasing implementation in various fields of medicine and research.• Promising applications of AI in pediatric allergy have been reported, but implementation largely lags behind other fields, particularly in regard to use of advanced algorithms and non-tabular data. Furthermore, lacking reporting on computational approaches hampers evidence synthesis and critical appraisal. • Multi-center collaborations with multi-omics and rich unstructured data as well as utilization of deep learning algorithms are lacking and will likely provide the most impactful discoveries
Edgeworth Expansion and Saddle Point Approximation for Discrete Data with Application to Chance Games
No full textWe investigate mathematical tools, Edgeworth series expansion and the saddle point method, which are approximation techniques that help us to estimate the distribution function for the standardized mean of independent identical distributed random variables where we will take into consideration the lattice case. Later on we will describe one important application for these mathematical tools where game developing companies can use them to reduce the amount of time needed to satisfy their standard requests before they approve any gam
Edgeworth Expansion and Saddle Point Approximation for Discrete Data with Application to Chance Games
No full textWe investigate mathematical tools, Edgeworth series expansion and the saddle point method, which are approximation techniques that help us to estimate the distribution function for the standardized mean of independent identical distributed random variables where we will take into consideration the lattice case. Later on we will describe one important application for these mathematical tools where game developing companies can use them to reduce the amount of time needed to satisfy their standard requests before they approve any gam
Mean Field Games for Jump Non-Linear Markov Process
No full textThe mean-field game theory is the study of strategic decision making in very large populations of weakly interacting individuals. Mean-field games have been an active area of research in the last decade due to its increased significance in many scientific fields. The foundations of mean-field theory go back to the theory of statistical and quantum physics. One may describe mean-field games as a type of stochastic differential game for which the interaction between the players is of mean-field type, i.e the players are coupled via their empirical measure. It was proposed by Larsy and Lions and independently by Huang, Malhame, and Caines. Since then, the mean-field games have become a rapidly growing area of research and has been studied by many researchers. However, most of these studies were dedicated to diffusion-type games. The main purpose of this thesis is to extend the theory of mean-field games to jump case in both discrete and continuous state space. Jump processes are a very important tool in many areas of applications. Specifically, when modeling abrupt events appearing in real life. For instance, financial modeling (option pricing and risk management), networks (electricity and Banks) and statistics (for modeling and analyzing spatial data). The thesis consists of two papers and one technical report which will be submitted soon: In the first publication, we study the mean-field game in a finite state space where the dynamics of the indistinguishable agents is governed by a controlled continuous time Markov chain. We have studied the control problem for a representative agent in the linear quadratic setting. A dynamic programming approach has been used to drive the Hamilton Jacobi Bellman equation, consequently, the optimal strategy has been achieved. The main result is to show that the individual optimal strategies for the mean-field game system represent 1/N-Nash equilibrium for the approximating system of N agents. As a second article, we generalize the previous results to agents driven by a non-linear pure jump Markov processes in Euclidean space. Mathematically, this means working with linear operators in Banach spaces adapted to the integro-differential operators of jump type and with non-linear partial differential equations instead of working with linear transformations in Euclidean spaces as in the first work. As a by-product, a generalization for the Koopman operator has been presented. In this setting, we studied the control problem in a more general sense, i.e. the cost function is not necessarily of linear quadratic form. We showed that the resulting unique optimal control is of Lipschitz type. Furthermore, a fixed point argument is presented in order to construct the approximate Nash Equilibrium. In addition, we show that the rate of convergence will be of special order as a result of utilizing a non-linear pure jump Markov process. In a third paper, we develop our approach to treat a more realistic case from a modelling perspective. In this step, we assume that all players are subject to an additional common noise of Brownian type. We especially study the well-posedness and the regularity for a jump version of the stochastic kinetic equation. Finally, we show that the solution of the master equation, which is a type of second order partial differential equation in the space of probability measures, provides an approximate Nash Equilibrium. This paper, unfortunately, has not been completely finished and it is still in preprint form. Hence, we have decided not to enclose it in the thesis. However, an outlook about the paper will be included
Mean Field Games for Jump Non-Linear Markov Process
No full textThe mean-field game theory is the study of strategic decision making in very large populations of weakly interacting individuals. Mean-field games have been an active area of research in the last decade due to its increased significance in many scientific fields. The foundations of mean-field theory go back to the theory of statistical and quantum physics. One may describe mean-field games as a type of stochastic differential game for which the interaction between the players is of mean-field type, i.e the players are coupled via their empirical measure. It was proposed by Larsy and Lions and independently by Huang, Malhame, and Caines. Since then, the mean-field games have become a rapidly growing area of research and has been studied by many researchers. However, most of these studies were dedicated to diffusion-type games. The main purpose of this thesis is to extend the theory of mean-field games to jump case in both discrete and continuous state space. Jump processes are a very important tool in many areas of applications. Specifically, when modeling abrupt events appearing in real life. For instance, financial modeling (option pricing and risk management), networks (electricity and Banks) and statistics (for modeling and analyzing spatial data). The thesis consists of two papers and one technical report which will be submitted soon: In the first publication, we study the mean-field game in a finite state space where the dynamics of the indistinguishable agents is governed by a controlled continuous time Markov chain. We have studied the control problem for a representative agent in the linear quadratic setting. A dynamic programming approach has been used to drive the Hamilton Jacobi Bellman equation, consequently, the optimal strategy has been achieved. The main result is to show that the individual optimal strategies for the mean-field game system represent 1/N-Nash equilibrium for the approximating system of N agents. As a second article, we generalize the previous results to agents driven by a non-linear pure jump Markov processes in Euclidean space. Mathematically, this means working with linear operators in Banach spaces adapted to the integro-differential operators of jump type and with non-linear partial differential equations instead of working with linear transformations in Euclidean spaces as in the first work. As a by-product, a generalization for the Koopman operator has been presented. In this setting, we studied the control problem in a more general sense, i.e. the cost function is not necessarily of linear quadratic form. We showed that the resulting unique optimal control is of Lipschitz type. Furthermore, a fixed point argument is presented in order to construct the approximate Nash Equilibrium. In addition, we show that the rate of convergence will be of special order as a result of utilizing a non-linear pure jump Markov process. In a third paper, we develop our approach to treat a more realistic case from a modelling perspective. In this step, we assume that all players are subject to an additional common noise of Brownian type. We especially study the well-posedness and the regularity for a jump version of the stochastic kinetic equation. Finally, we show that the solution of the master equation, which is a type of second order partial differential equation in the space of probability measures, provides an approximate Nash Equilibrium. This paper, unfortunately, has not been completely finished and it is still in preprint form. Hence, we have decided not to enclose it in the thesis. However, an outlook about the paper will be included
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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