1,355,025 research outputs found

    Investigating Long-Run Demand for Broad Money in the Gulf Arab Countries

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    We estimate the long-run demand for broad money for the six Gulf Cooperation Council countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates) over the 1980–2012 period. Applying time series and panel econometric tests, we first document the existence of long-run equilibrium relationship for money demand – both nationally and regionally. The estimated income elasticities are generally lower than those reported in the literature, while the interest elasticities are more in line with the standard money demand literature. We discuss how the movements in income velocity can reconcile the varying income and interest elasticities documented across the six countries. A discussion on the homogeneity (poolability) of the long-run money demand parameters and the error correction model of money demand is also provided

    Interaction of Pyrrolobenzodiazepine conjugates with DNA

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    Pyrrolobenzodiazepines (PBD) are a group of naturally occurring antitumor antibiotics that consist of a tricyclic system containing anthranilate, diazepine and pyrrolidine ring. The compounds bind preferentially to 5’-Pu-G-Pu-3’ sequences in the minor groove of double stranded DNA by covalently linking the diazepine ring with the 2-amino group of guanine. The PBD binding sites can be extended by conjugating the C8 position of the anthranilate ring with heterocyclic moieties such as pyrrole, imidazole and thiazole. Alternatively, benzofused rings such as benzothiophene, benzofuran and indole can be used for conjugate formation; some natural compounds containing these benzofused heterocycles have been found to show anticancer activities.We have examined the sequence selectivity of PBD-conjugates using DNase I footprinting with substrates that contain every tetranucleotide (MS1 and MS2) and every symmetrical hexanucleotide (HexA and HexB). Conjugates with pyrrole, imidazole and thiazole were found to bind adjacent to AT-rich sequences; their binding preferences towards AT-rich sequences were confirmed with synthetic DNA fragments in which the compounds bound at ATATAT with a guanine at either the 5’- or 3’-end. Conjugation with benzothiophene and benzofuran benzofused rings produced similar binding profiles, though indole conjugates did not appear to bind. The benzofusedconjugates bound at lower concentrations than the polyamide conjugates. These binding sites indicate that the conjugated component plays a vital role in determining the sequence selectivity, while the PBD unit forms the covalent linkage with guanine. PBD-conjugates were also studied by fluorescence melting to evaluate their effect on melting profiles of different oligonucleotide duplexes; the compounds produced biphasic melting curves with large increases in melting temperature.We also describe a simple ligation assay for determining the sequence selectivity of PBD-dimers. The assay involves chemically joining two DNA duplexes by a PBD-dimer when a binding site is generated by overhanging single-stranded ‘sticky ends’. Oligonucleotides containing GATC or GTAC or GAATC overhangs were used to demonstrate that SJG-136 has strongest affinity for GATC; it also produces cross-links with GTAC, but not with GAATC.The final chapter uses DNase I footprinting to examine the sequence specificity of two pyrrole/imidazole hairpin polyamides that were expected to bind to the sequences (A/T)GG(A/T)G(A/T) and (A/T)GG(A/T)C(A/T). We confirm the expected selectivity, but demonstrate that they can also form strong interactions with some secondary sites

    A study in panel cointegration and poolability: Long-run money demand equations for Gulf Cooperation Council countries

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    We model demand for money in the Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) and test poolability (a key policy question in view of a planned monetary union) through a new bootstrap test. The results suggest that the welfare cost of inflation is different across GCC countries

    The long-run relationship between savings and investment in oil-exporting developing countries: a case study of the Gulf Arab states

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    The relationship between national saving and investment over the long termis examined for six GulfArab oil-exporting developing countries—Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and theUnited Arab Emirates.We show that, provided some large outliers are properly accounted for, longrunequilibrium relationships between saving and investment (both total and fixed) exist in thesecountries. Because these countries have typically large current account surpluses, such relationshipscannot be explained by standard arguments. Our hypothesis is that the response of investment tosaving largely depends on domestic absorptive capacity

    A TRANSLATION ANALYSIS OF GEOLOGICAL TERMS IN CHILDREN’S SCIENCE BOOK ENTITLED BASHER SCIENCE: ROCKS AND MINERALS

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    This study aims at finding out the ways of the translator translated the geological terms in the Basher Science: Rocks and Minerals and the quality of translation in terms of accuracy and acceptability. This study is descriptive qualitative research. The source of data are Children’s Science Book entitled Basher Science: Rocks and Minerals and informants. The data are in the form of geological terms found in the book and the information about the translation quality gained from informants. The techniques of data collection are content analysis and focus group discussion. The findings show that there are 7 translation techniques used by the translator in translating 167 data of geological terms in children’s science book entitled Basher Science: Rocks and Minerals, which are established equivalent (104 data or 62.28%), naturalized borrowing (46 data or 27.54%), pure borrowing (6 data or 3.59%), amplification (5 data or 2.99%), particularization (3 data or 1.80%), reduction (2 data or 1.20%), and generalization (1 data or 0.60%). The most frequent translation technique is established equivalent technique and the least frequent translation technique is generalization. The analysis of translation quality shows that from total 167 data, there are 160 data or 95.81% data categorized as accurate translation, 4 data or 2.39% data categorized as less accurate translation, and 3 data or 1.80% data categorized as inaccurate translation and there are 158 data or 94.61% data categorized as acceptable translation and 9 data or 5.39% data categorized as less acceptable translation. Dealing with accuracy and acceptability, the use of established equivalent technique contributes most on the producing of accurate translation with 101 data or 60.48% data and acceptable translation with 103 data or 61.68% data. Since almost all of the translation of geological terms are accurate and acceptable, the translation of geological terms in children’s science book entitled Basher Science: Rocks and Minerals is categorized as high quality translation. Keywords: translation techniques, translation quality, geological term

    Extreme physics: take a quantum leap... to the edge of science

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    In Basher's totally hip and quirky style, readers are introduced to the amazing research that is revolutionizing physics! From the pioneering experiments taking place in the Hadron Collider to NASAs deep-space exploration, "Basher Science: Extreme Physics "highlights the realm of miniscule things that was discovered in the early 1900s by scientists who were on the hunt for teeny-tiny parts of matter, the bits from which all larger things are made. This wild, uncertain world is bursting with crazy characters you're about to meet-youre gonna love them

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Regional income dynamics in Bangladesh

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    Bangladesh’s remarkable achievements in economic and social progress have placed the country in a position that was unimaginable just 20 years ago. However, has such improvement in development outcomes been equal across all areas within the country? We aim to address this question by analyzing district-level income per capita derived from the 2000 and 2016 rounds of the Household Income and Expenditure Survey. Using models based on standard neoclassical economic convergence theory, which may also account for natural disasters, we find little evidence of convergence. This suggests that income differentials among Bangladesh’s 64 districts persist. We also examined the possibility of multiple steady states by estimating models with a threeclub structure based on income percentiles as registered in 2000. However, we found no evidence of conditional convergence. Additionally, we explored the potential for endogenous club formation using regression trees and machine learning algorithms. Yet, once again, the results did not support convergence. Overall, our findings reveal no evidence of conditional convergence in income among Bangladesh’s districts. This implies that policy implications might vary, with targeted interventions possibly necessary to address the specific factors hindering convergence among similar region
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