4,920 research outputs found
2020 CSB/SJU Social Entrepreneur of the Year Angela Untiedt Jerabek ’90, founder and executive director of BARR Center®.
No full textThe 2020 CSB/SJU Social Entrepreneur of the Year Angela Untiedt Jerabek ’90, founder and executive director of BARR Center®
Professor Angela Shannon
No full textAngela Shannon shares her poetry with the Taylor community.
Angela Shannon is the author of Singing the Bones Together, a 2004 Minnesota Book Awards Finalist. She teaches English at Bethel University. Her work has been published in journals, textbooks, and anthologies, including TriQuarterly, Ploughshares, Where One Ends Another Begins: 150 Years of Minnesota Poetry, and Beyond the Frontier: African American Poetry for the 21st Century. Her choreopoem Root Woman premiered at the Fleetwood-Jourdain Theater in Evanston, Ill
Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition
Get PDFBackground
Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression and activity of variety of downstream targets. Resistance to TGFβ-mediated cytostasis is one of the growth transforming effects of LMP1. Of the downstream targets manipulated by LMP1, the induction of Id1 and inactivation of Foxo3a appear particularly relevant to LMP1-mediated effects. Id1, a HLH protein is implicated in cell transformation and plays a role in cell proliferation, whilst Foxo3a, a transcription factor controls cell integrity and homeostasis by regulating apoptosis. The mechanism(s) by which LMP1 induces these effects have not been fully characterised.
Results
In this study, we demonstrate that the ability of LMP1 to induce the phosphorylation and inactivation of Foxo3a is linked to the upregulation of Id1. Furthermore, we show that the induction of Id1 is essential for the transforming function of LMP1 as over-expression of Id1 increases cell proliferation, attenuates TGFβ-SMAD-mediated transcription and renders cells refractory to TGFβ-mediated cytostasis. Id1 silencing in LMP1-expressing epithelial cells abolishes the inhibitory effect of LMP1 on TGFβ-mediated cell growth arrest and reduces the ability of LMP1 to attenuate SMAD transcriptional activity. In response to TGFβ stimulation, LMP1 does not abolish SMAD phosphorylation but inhibits p21 protein expression. In addition, we found the induction of Id1 in LMP1-expressing cells upon stimulation by TGFβ. We provide evidence that LMP1 suppresses the transcriptional repressor ATF3, possibly leading to the TGFβ-induced Id1 upregulation.
Conclusion
The current data provide novel information regarding the mechanisms by which LMP1 suppresses TGFβ-induced cytostasis, highlighting the importance of Id1 in LMP1 mediated cell transformation
Angela Shanté : 2022 Irma Black Award Silver Medal Acceptance Speech
No full textAuthor Angela Shanté gives an acceptance speech for When My Cousins Come to Town, illustrated by Keisha Morris (West Margin Press)https://educate.bankstreet.edu/irma_black_awards/1004/thumbnail.jp
The Family History of Angela Ruth Weidert
Get PDFAngela Ruth Weidert authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2018 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
TESL 500: Principles of Linguistics - course syllabus
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Previous issue date: 2009-0
Materia-autore = Author-Matter
Get PDFThe etymology of the word author refers to an act of creation, an act of augmentation, from the Latin verb augere. Author instantiates creation, the expansion of the pre-existing. In 1967 Roland Barthes declared the death of the author in his famous essay to state once more that the crisis is that of the author as a single subjectivity and as a term that condenses prestige, undermined by the de-subjectivation strategies of automatism, fortuity and fragmentation of the historical avant-gardes, as well as by the machinic act and by the reproducibility of the second avant-gardes.
Fifty years after Barthes’ paradigmatic formula, this lack of authorship appears to be a successful brand. The ten- sions between the anomie of matter, the law that establishes authorship and the economy that makes the work pos- sible, invoke discordant perspectives. Artists make the self-destruction of their work the real work, and appeal is made for the demolition of architectures, whether by a recognised author or not, in order to re-design, or better still, re-claim the territory. Artificial intelligence consolidates its logics and its design by progressively shedding human ingenuity. The space of criticism becomes, finally, increasingly ephemeral. However, there is an acceptation of criti- cism that is, rather than an individual ‘signature’, an exploration and explanation of how design makes theory.
The binomial author-matter seeks to mark these tensions and contradictions: the featured term author is main- tained to underline the persistence of that prestigious subjectivity, at the very moment when the rhetoric of “mat- ter as an author” promises other forms of authorship
Giussani Sansoni, Angela
No full textLa scheda ricostruisce la vita e l'apporto della scrittrice Angela Giussani Sansoni alla letteratura per l'infanzia.The headword explains the biography and the contribution of the author Angela Giussani Sansoni to the children's literature
Deliberation and journalism
No full textThe first chapter in 'International Journalism and Democracy' re-examines current ideas about the role of journalism in promoting democracy, introducing the concept of "deliberative journalism". 'Deliberation and Journalism' lists the ways in which journalists can assist deliberation and politics in communities around the world. The chapter defines deliberation as a specific form of conversation that precedes and promotes decision-making and action by members of a community. The author recognises the difficulty of engaging in deliberation in communities that are divided by different interests, identities, backgrounds, resources and needs. She provides examples of strategies that journalists can use to encourage inclusive and productive deliberation in the face of community diversity.\ud
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The chapter introduces examples of types of deliberative journalism that have emerged around the globe. These include strategies that have been sometimes been labeled as public journalism, civic journalism, peace journalism, development journalism, citizen journalism, the street press, community journalism, environmental journalism, and social entrepreneurism. The chapter also includes models of journalism that have not yet been given any particular name. Although the book identifies problems surrounding the theory and practice of these forms of journalism, the author notes that this is to be expected. Most models of deliberative journalism are relatively new, with none being more than a few decades old. The author concludes that resolution of these problems will only occur incrementally
Il tempo perduto delle donne nei racconti di Adriana Bittel: Cum încărunţeste o blondă, Soi bun, Departe-n zare, spre Azuga
No full textIl contributo comprende la prima traduzione in italiano di tre racconti della scrittrice rumena Adriana Bittel, e un saggio sulle strategie narrative messe in atto da Bittel per descrivere lo spazio della socialità femminile nella Romania del periodo precedente al 1989The contribution consists of the translation into Italian of three short stories authored by the Romanian woman writer Adriana Bittel, entitled respectively, "How a Blond turns white", "Good Quality", “Far away in the horizon, towards Azuga”. Angela Tarantino, the author of the translation, adds to her work a presentation of Adriana Bittel and the narrative strategies used to describe the space of the women's sociality in Romania during the years previous to 198
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