11,346 research outputs found
Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin
No full textAbstract not availableMarcello Tiseo, Elisa Giovannetti, Carmelo Tibaldi, Andrea Camerini, Francesco Di Costanzo, Fausto Barbieri, Jacobus A. Burgers, Andrew Vincent, Godefridus J. Peters, Egbert F. Smit, Andrea Ardizzon
Giuseppe Barbieri fra Pozzo e i Bibiena
No full textGiuseppe Barbieri, originario di Termignon, in Savoia (ivi, 1647-Borgo San Donnino, 1733), benchè ancora poco noto e spesso anzi neppure correttamente identificato, ha lasciato importanti testimonianze del suo lavoro di quadraturista nei collegi d’Emilia e non solo. Durante i lavori per il collegio e la comunità gesuitica di Mondovì ove si decorava la chiesa dedicata a San Francesco Saverio, conobbe Andrea Pozzo e l’impronta dell’influenza del teorico e pittore di Trento è riconoscibile nella volta della cappella del Noviziato di Bologna con la Gloria di Sant’Ignazio (1679-1681), nei lavori per la decorazione della cupola, dei pennacchi, del presbiterio e della navata maggiore della chiesa di San Bartolomeo a Modena (1692-1698) con l’immagine divina fatta di pura luce e gli apostoli che fanno corona, nel collegio gesuitico di Fidenza (1704-1709). Vi dipinge l’Ascensione di Cristo, l’Esaltazione della Croce e Santi, l’Assunzione della Vergine con angeli concertanti, Putti col monogramma di Cristo, gli Angeli in prospettiva. Vi utilizza una tavolozza di colori morbidi che permettono alla pittura di saldarsi con efficacia all’architettura, e soprattutto di guidare il pensiero dei fedeli e degli educandi nelle questioni di fede, sollecitandoli alla meditazione. Barbieri inoltre lavora a Cotignola, Brescia, Parma, Reggio, Busseto, Imola. Si sono indagati i temi figurativi e la sua architettura dipinta. In più occasioni è stato evidenziato il significato mnemonico della ritualità esasperata, delle scenografie colorate e simboliche che accompagnarono la Compagnia, la dimensione allegorica che nel Seicento e nel Settecento riusciva a coinvolgere l’emotività dei fedeli fino a far nascere stati di esaltazione collettiva. Le metafore, in scrittura e in pittura, sono state ampiamente utilizzate, sono strumenti paradigmatici utili per meglio e più memorizzare. La critica ha acquisito da tempo il ruolo pedagogico e didattico del teatro gesuitico, l’intento di persuasione e di edificazione delle decorazioni nei collegi e nelle chiese. L’allegoria spaziale di Barbieri esaltante la gloria di Dio e dei santi, è contemporanea al magistero artistico di Andrea Pozzo e alla grande diffusione dei Bibiena in Emilia, in Italia e in Europa
One or more Higgs bosons?
No full textNow that one has been found, the search for signs of more scalars is a primary task of current and future experiments. In the motivated hypothesis that the extra Higgs bosons of the next-to-minimal supersymmetric Standard Model (NMSSM) be the lightest new particles around, we outline a possible overall strategy to search for signs of the CP-even states. This work complements Ref. arXiv:1304.3670.Now that one has been found, the search for signs of more scalars is a primary task of current and future experiments. In the motivated hypothesis that the extra Higgs bosons of the next-to-minimal supersymmetric Standard Model are the lightest new particles around, we outline a possible overall strategy to search for signs of the CP-even states. This work complements Barbieri et al. [Phys. Rev. D 87, 115018 (2013)].Now that one has been found, the search for signs of more scalars is a primary task of current and future experiments. In the motivated hypothesis that the extra Higgs bosons of the next-to-minimal supersymmetric Standard Model (NMSSM) be the lightest new particles around, we outline a possible overall strategy to search for signs of the CP-even states. This work complements Ref. arXiv:1304.3670
Depression of windup of spinal neurons in the neonatal rat spinal cord in vitro by an NK3 tachykinin receptor antagonist
No full textThe effects of the NK3 tachykinin receptor antagonist SR 142801 on synaptic transmission and spike windup induced by trains of stimuli applied to a dorsal root were investigated with intra- and extracellular recording from the neonatal rat spinal cord in vitro. SR 142801 (10 muM) reduced the depolarization (recorded from lumbar ventral roots) induced by senktide (an NK3 agonist) more strongly than the one evoked by substance P methyl ester (SPMeO; an NK1 agonist). Nevertheless, after a long (>2 h) application time, SR 142801 largely depressed the response to SPMeO as well. When NK1 or NK3 receptors were blocked by >50% in the presence of SR 142801, there was also a significant reduction in the cumulative depolarization induced by repeated stimuli to a single dorsal root. This blocking action by SR 142801 was also observed in the presence of the N-methyl-D-aspartate (NMDA) receptor antagonist D-aminophosphonovalerate (APV) and the calcium channel blocker nifedipine. Intracellular data from lumbar motoneurons showed that the spike windup was the first and most sensitive target for the SR 142801 blocking effect. Increasing stimulus strength to dorsal root fibers could partly surmount such a block. SR 142801 per se had no direct action on fast synaptic transmission, membrane potential, or input resistance. These findings indicate that SR 142801 could lead to an early, large reduction in the windup of action potential discharge by motoneurons, suggesting its ability to suppress the reflex component of central sensitization evoked by repeated dorsal root stimuli
Andrea Bacová
No full textAndrea Bacová focuses on research and teaching in the field of residential architecture. Her work includes systematic research on residential buildings and their urban context. She actively participates in promoting Slovak architecture and is the author of several publications and exhibitions
Non-home biased individuals’ investment choices: the role of the birthplace of investors
No full textThis paper investigates the determinants of non-home biased investment behaviour among individual investors, focusing on birthplace as an explanatory factor. Using microdata from the 2022 wave of the Bank of Italy’s Household Income and Wealth Survey, which distinguishes Italian citizens born in Italy from those born abroad but living in Italy, a two-stage Heckman selection model is implemented to explore both the likelihood of investing in foreign assets and
the extent of such investments. The results show that individuals born outside Italy are significantly more likely to invest in foreign securities, underscoring the role of birthplace in reducing home bias. Furthermore, non-home bias is positively associated with higher education levels, greater financial wealth, and higher risk tolerance, while age has a slight negative effect on the proportion of investment made abroad. Interestingly, the analysis reveals a negative relationship between income class and share of foreign investments, suggesting that wealthier individuals may allocate a smaller portion of their portfolios to foreign assets, despite higher participation rates.
The analysis contributes to the literature by identifying birthplace as a significant factor shaping investment decisions and extends the understanding of behavioural finance beyond traditional home bias studies. These findings have practical implications for financial advisors and regulators, helping them tailor portfolio recommendations and evaluate investor suitability based on socio-demographic and behavioural characteristics
Val d'Orcia (SI). Eleiva, oleum, olio. Un progetto multidisciplinare nell'area Val d'Orcia-Amiata per contribuire alla conoscenza delle origini del patrimonio olivicolo toscano
No full text
Nota su "Il Selvaggio" del 1535: una marca di autenticazione editoriale, un editore misterioso e una falsa indicazione di stampa
No full textIl Selvaggio is an undoubtedly minor chivalresque poem composed by one Giovambattista Cortese from Bagnacavallo in Romagna. In 1535, probably some years after the author had died, the work was published in Venice by the Nicolini da Sabbio printing firm. The privilege for the edition was requested by a certain Andrea Trevisan. The edition is interesting for a curious woodcut placed at the end of the volume, depicting a reversed view of St Mark’s Square together with the inscription “Nemo hoc signo imprimere audeat”. At the top of the woodcut the atmospheric phenomenon known as parhelia or ‘sundogs’ is shown. The upper part of the woodcut, cut away from the original woodblock, appears again in an edition published in 1536 (on the subject of an occurrence of this phenomenon) which until now has always been thought to have been printed in Rome
- …
