1,721,036 research outputs found

    Centromeres under pressure: Evolutionary innovation in conflict with conserved function

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    Centromeres are essential genetic elements that enable spindle microtubule attachment for chromosome segregation during mitosis and meiosis. While this function is preserved across species, centromeres display an array of dynamic features, including: (1) rapidly evolving DNA; (2) wide evolutionary diversity in size, shape and organization; (3) evidence of mutational processes to generate homogenized repetitive arrays that characterize centromeres in several species; (4) tolerance to changes in position, as in the case of neocentromeres; and (5) intrinsic fragility derived by sequence composition and secondary DNA structures. Centromere drive underlies rapid centromere DNA evolution due to the “selfish” pursuit to bias meiotic transmission and promote the propagation of stronger centromeres. Yet, the origins of other dynamic features of centromeres remain unclear. Here, we review our current understanding of centromere evolution and plasticity. We also detail the mutagenic processes proposed to shape the divergent genetic nature of centromeres. Changes to centromeres are not simply evolutionary relics, but ongoing shifts that on one side promote centromere flexibility, but on the other can undermine centromere integrity and function with potential pathological implications such as genome instability

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    La ricerca a Napoli sulle applicazioni dell'elaboratore nella didattica della fisica

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    a cura di E. Balzano ed E. Sassi; CNR Commissione per la Didattica della Fisica; CUEN Napol

    La ricerca a Napoli sulle applicazioni dell'elaboratore nella didattica della fisica

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    a cura di E. Balzano ed E. Sassi; CNR Commissione per la Didattica della Fisica; CUEN Napol

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Esperimenti didattici di fisica per studenti di ingegneria.

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    L’attività didattico-sperimentale del nuovo laboratorio LAFIDIN (Laboratorio Fisica Didattica di Ingegneria) di Napoli è continuata nell’Anno Accademico 1997-98 con acquisto di ulteriori apparecchiature capaci di eseguire alcuni classici esperimenti, capisaldi della fisica. Ad esempio sono a disposizione gli esperimenti di Frank-Hertz con interfaccia PC, quello di Millikan a goccioline di olio nonché quello di Michelson (interferometro). Molto usato nei corsi di Fisica delle Facoltà di Ingegneria e Scienze di Napoli è stata la macchina termica di Stirling della Leybold. Questo esperimento è stato messo a punto ed ha costituito una parte di una tesi didattica; nel corso di quest’ultima le tecniche di misura suggerite dalla Casa costruttrice sono state a volte modificate per apportare miglioramenti nella rilevazione delle grandezze fisiche di interesse
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