30 research outputs found
Endometriosis of the Perineum: a rare diagnosis usually associated with episiotomy
No full textEndometriosis of the perineum is rare, and is usually associated with prior episiotomy.Peer reviewe
Development of a multifunctional dressing for epidermal wound monitoring and on-site drug delivery
No full textThe treatment of epidermal wounds, particularly chronic wounds, is one of the most ubiquitous medical challenges and has imposed a considerable financial burden on the global health care system. Several factors in epidermal wounds lead to severe medical conditions among which infection comprises a large number of mortalities. To tackle this issue, great efforts have been made in the last decades to incorporate antimicrobial agents into wound dressings in order to inhibit microorganism colonization. Additionally, various wound monitoring systems have been developed to detect and track infections using different indicators such as bacterial by-products. However, the integration of these infection sensors with wound dressings – most of which have benefited from electrochemical detectors – has been a major bottleneck due to the electrode failure in the wound environment and the need for electrical power supply. Other approaches have focused on the development of point-of-care devices that simplify the detection of infection. This study aims to address the aforementioned challenge by developing a multifunctional hydrogel-based wound dressing – made of alginate 1.5% (w/v) – for on-site infection monitoring via colourimetric and image processing methods. Taking advantage of wound acidity as an indicator of bacterial infection, the developed wound dressing was composed of an array of pH sensors, fabricated by 3-dimensional (3D) bioprinting. Brilliant Yellow and cabbage juice as two pH-responsive dyes were immobilized in the pH sensors to facilitate a wireless wound monitoring. In this system, Brilliant Yellow afforded a higher accuracy in image processing while cabbage juice provided a better visual observation of the wound condition. The functionality of the developed dressing in detecting bacterial infection was evaluated via an ex-vivo test on pig skin samples, infected by Pseudomonas aeruginosa, and the presence of bacteria was detected within 30 minutes after the placement of the dressings on the skin samples. Moreover, the inclusion of gentamicin-loaded components into the wound dressing facilitated the inhibition of bacterial growth, which was evaluated in vitro on the same strain of bacteria. In this experiment, 2 mg/ml of gentamicin in the hydrogel led to the eradication of P. aeruginosa. This incorporation of antibiotic delivery along with the simple colourimetric infection detection holds a great promise for managing acute and chronic wounds by inhibition of bacterial growth and monitoring infection in real-time without a need for dressing removal.Graduate2018-08-1
Out-of-the-box soft tissue tumor: pediatric synovial sarcoma of larynx
No full textSynovial sarcoma (SS) is a very rare, aggressive, mesenchymal neoplasm that displays both spindle cell and epithelial histologic characteristics. To our knowledge, there are only 20 documented cases of primary laryngeal SS in the English language literature among all age groups and only three case reports among the pediatric population. Due to its rarity, recognition of this laryngeal neoplasm is often very difficult, and diagnosis relies heavily on immunohistochemistry and its unique translocation between chromosome X and 18 [t(X; 18) (p11.2; q11.2)]. The treatment of SS typically involves a multimodal approach with surgery, chemotherapy, and radiation but despite these options the prognosis remains poor. Here we report the fourth laryngeal SS pediatric patient along with a review of all SS published cases in children. The current report is not only presenting the youngest patient with laryngeal SS but also the pediatric patient with the longest survival
Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future
No full textAt the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend directly within organs and tissues. These sophisticated devices are mediators, recorders, and stimula-tors of electricity with the capacity to monitor important electrophysiological events, replace disabled body parts, or even stimulate tissues to overcome their current limitations. They are therefore capable of leading humanity forward into the age of cyborgs, a time in which human biology can be hacked at will to yield beings with abilities beyond their natural capabilities. The resulting advances have been made possible by the emergence of conformal and soft electronic materials that can readily integrate with the curvilinear, dynamic, delicate, and flexible human body. This article discusses the recent rapid pace of development in the field of cybernetics with special emphasis on the important role that flexible and electrically active materials have played therei
Early Clinical and Subclinical Visual Evoked Potential and Humphrey's Visual Field Defects in Cryptococcal Meningitis.
No full textCryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwent Humphrey's visual field (HVF) testing. Decreased best corrected visual acuity (BCVA) was detected in 46.5% of patients. VEP was abnormal in 51/74 (68.9%) right eyes and 50/74 (67.6%) left eyes. VEP P100 latency was the main abnormality with mean latency values of 118.9 (±16.5) ms and 119.8 (±15.7) ms for the right and left eyes respectively, mildly prolonged when compared to our laboratory references of 104 (±10) ms (p<0.001). Subclinical VEP abnormality was detected in 56.5% of normal eyes and constituted mostly latency abnormality. VEP amplitude was also significantly reduced in this cohort but minimally so in the visually unimpaired. HVF was abnormal in 36/47 (76.6%) right eyes and 32/45 (71.1%) left eyes. The predominant field defect was peripheral constriction with an enlarged blind spot suggesting the greater impact by raised intracranial pressure over that of optic neuritis. Whether this was due to papilloedema or a compartment syndrome is open to further investigation. Subclinical HVF abnormalities were minimal and therefore a poor screening test for early optic nerve dysfunction. However, early optic nerve dysfunction can be detected by testing of VEP P100 latency, which may precede the onset of visual loss in CM
Heart valve tissue engineering: technological success of biomaterials and biofabrication strategies
No full textHeart valve replacement is often the only treatment option for severe valvular heart disease. Current valve replacements, primarily mechanical and bioprosthetic valves, suffer from thrombogenicity or poor durability and do not provide growth, regeneration, and repair, features essential, especially, for pediatric and young patients. As an alternative to the currently clinically available valve substitutes, tissue-engineered heart valves hold the promise of realizing these features using bioresorbable materials that can host endogenous cells and are replaced by cell-secreted matrices in vivo over time, yielding a living valve in the patient’s heart. During nearly three decades, a variety of biomaterials and biofabrication techniques have been utilized to develop tissue-engineered heart valves. However, the quest for an ideal combination of biomaterial and biofabrication strategy to achieve longevity in these heart valve substitutes continues. Attempting to overcome various obstacles to this goal, the approach to heart valve tissue engineering has continuously evolved. Most notable examples are the application of biomechanical conditioning via dynamic cultures instead of growing valves in static condition to generate robust tissues that are capable of enduring hemodynamic loads upon implantation and more recently, implantation of acellular instead of cell-laden valves to avoid adverse in-vivo tissue remodelling. Additionally, more complex biomaterials and biofabrication technologies are currently being employed in efforts to recapitulate some of the crucial characteristics of the native valve tissue such as its microarchitecture and mechanical properties. With an emphasis on biomaterials and biofabrication technologies, this review first outlines various biomaterials used in heart valve tissue engineering and the role that material properties, such as degradation and mechanical behaviours, play in the success of the final valve product. Next, the strategies used in various steps in the development of tissue-engineered heart valves including scaffolding, origami-folding, biomechanical conditioning, and decellularization are explored. Lastly, the state of the art in the progress of tissue-engineered heart valves toward clinical translation is highlighted
Dissociative Identity Disorder Of Main Character In Sybil Novel By Flora R. S Based On Psychological Perspective
No full textSybil novel tells about woman that has sixteen personalities. This novel is very interesting because there is a psychology aspect in this novel. The writer intends to find out the characterization of the sixteen personalities and psychological problems in that novel, in this case, dissociative identity disorder. The writer wants to know about the symptom, the causes, and the treatment of dissociative identity disorder that found in Sybil novel. In finding the analysis of this paper the writer uses descriptive method and library research. The writer found that the author of the novel, Flora, uses both direct and indirect characterization to reveal the characterization of each character in the novel. The characterization can be seen from the character's word, character's thought, and the author's narration. Sybil as the main character suffers from dissociative identity disorder because she got physical and sexual abuse from his mother and she has no one to share and solve her problems. It forces her to get another solution by making other personalities to share her problems. Suffering dissociative identity disorder makes her losing her time. She does not know what she has done and what she told about until she meet with Dr. Wilbur, the psychiatrist who give her psychotherapy to bend all her personalities
Orbital cellulitis, sinusitis and intracranial abnormality in two adolescents with COVID-19
No full textRetrospective review of two adolescent cases suggests bacterial orbital cellulitis with sinusitis and COVID-19 may have radiographic signal consistent with hemorrhagic or thrombotic phenomena, retro-maxillary antral fat changes, or meningeal extension, thereby mimicking fungal infection.This article is free through Taylor-Francis as part of the ongoing effort against COVID-19
Perancangan sistem informasi akuntansi penyaluran BSU di PT Bank Tabungan Negara menggunakan Micrsoft Visual Studio 2010
No full textBSU is assistance given to workers or laborers during the COVID-19 pandemic. The purpose of this study was to find out the information system for channeling BSU funds at PT. State Savings Bank to BSU beneficiary customers. Information is collected using qualitative methods with a descriptive approach by means of observation and literature study. The results of research that has been done by the author at the PT. State Savings Bank (BTN) Bandung Branch With the BSU distribution accounting information system, it can be easier for officers to input, process, generate data, and check the accuracy of customer data for those who receive Wage Subsidy Assistance (BSU). At the time of data input, the officer has successfully entered data into the system, which can be processed for data checking and then processed for the storage process. The output of this system is that it displays customer data that receives wage subsidy assistance, which is then sent to customer service so that customer service no longer manually checks customer data. In addition, this BSU distribution information system has become more integrated into improving the quality of the bank
Farmer participation
No full textPresented at Ground water and surface water under stress: competition, interaction, solutions: a USCID water management conference on October 25-28, 2006 in Boise, Idaho.The Indus Basin Irrigation System (IBIS), commanding an area of 15.08 million hectares (ha), is Pakistan's century old and largest contiguous irrigation system in the world. The main problem facing the system is lack of equitable and reliable delivery of water in the tails of the channels to almost 1.4 million small farmers (landowners of less than 2 hectares). Its mismanagement occurs due to pressure of influential big land owners and head reach farmers and rent seeking by the irrigation officials. Consequently, small farmers and tail enders of the irrigation system are unable to cultivate their lands and suffer from extreme poverty. To address this issue, institutional reforms have been introduced aiming to improve the water management. Through these reforms, irrigation management has been transferred to farmers groups called Farmer's Organizations (FOs) initially introduced by the Nara canal area water board (AWB) in Sindh . The paper describes the involvement of empowered and organized members of 3,217 watercourse associations (WCAs) and 166 farmer organizations (FOs) at Nara canal system for the social and economic justice to the suffering farming community. About 55% is water equitably distributed trough FO managed chancels and 15% of irrigation water is saved to irrigate land to combat the poverty. In all 762 issues relevant to water distribution have been resolved through the conflict resolution committees in their respective distributaries. Interestingly, 30% new chairmen of FOs have been inducted in the organizations through democratic process of election after the completion of first tenure of the elected board of management of Farmers Organizations. This has been possible as 16,557 pertinent members of these organizations have been imparted relevant trainings. In addition the crop assessment and water charges recovery has been increased sufficiently to operate and maintain the farmer managed irrigation system to support institutional reforms process. In order to create effective linkages and coordination among organizations and with other line agencies and national and international organizations, farmer organizations council (FOC) has been established by these organizations. This paper also suggests policymakers to support institutional reforms on other canals to replicate the model of Nara Canal area water board
