1,721,145 research outputs found
Cocrystallization as a tool to stabilize liquid active ingredients
No full textCocrystallization is an extensively used method in Crystal Engineering for tuning the properties of target compounds by pairing them with ad-hoc selected molecular partners (i.e. coformers) in a stoichiometric ratio within the same crystal structure. The formation of a new intermolecular network significantly alters the physical–chemical properties of the final material, becoming crucial for target applications such as pharmaceutical, agrochemical and nuctraceutical where cocrystals are largely investigated. Although, the majority of the cocrystals reported in the literature so far are generally made of coformers which are solid at room temperature, there is no restriction in using liquid or low melting compounds as a coformer. This contribution aims at reviewing some significant cases and applications where cocrystallization is used to stabilize liquid ingredients, that are generally poorly stable and their manufacturing, transportation, and storage conditions present considerable environmental, logistical, and cost-related challenges
Synthesis of E/Z 3-(1H-benzotriazol-1-yl)-3-(pyridin-4-yl)acrilonitriles and E/Z 2-(3-imino-2-benzofuran-1(3H)-ylidene)acetonitriles. An unusual case of displacement of the benzotriazole ring
No full textSynthesis of 3-(1H-benzotriazol-1-yl)-3-(pyridin-4-yl)acrylonitriles (E/Z 6) and 2-(3-imino-2-benzofuran-1(3H)-ylidene)acetonitriles (E/Z 20), by an unusual case of displacement of the benzotriazole ring, has been described. The X-Ray structure analysis of Z 20 and antimycobacterial activity of both E/Z 6 and E/Z 20 were also reported
Bernini
No full textLa mostra che ha presentato trenta marmi, varie terrecotte e bronzi, quindici dipinti, ha rappresentato la più vasta iniziativa espositiva dedicata a Gian Lorenzo Bernin
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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