1,297 research outputs found
About twin primes and distribution of primes
No full textThis paper give us a demonstration of twin primes conjecture using approximation of function �(iupsilon) that we introduce in section 6. Section 1-5 give us introduction to terminology and a clarification on (iupsilon) terms. In particular section
5 is really important because of its Lemma. Section 7 reassume foregoing explanations and it give us two theorems and one corollary;the theorem 7.2 give us exact approximation of twin primes counting function
A post COVID lockdown pilot study on the effect of physical activity intensity on cognitive functions of children aged 6-8 years old
No full textPhysical activity practice is very important for individual’s wealth status. Moreover, it is possible to consider physical activity one of the teachers’ tool to improve the academic achievement and the cognitive functions in children. However, according to some evidences it seems that the physical activity at high intensity increase the cognitive functions compared to the low intensity physical activity. In this project, we investigate how the intensity of physical activity affects a series of cognitive functions such as Attention and Working Memory. Eleven participants of a summer camp participated at the study. Three experimental weeks with different physical intensities were involved (Standard Intensity, High intensity and Low Intensity). Participants performed the cognitive tasks at the beginning and at the end of each experimental week. Our results indicated an effect of the physical activity intensity in some kind of attention. Working Memory instead, was not affected. Thus, our results suggested that intensity could be an important factor to increase some cognitive functions, but not all of them
An integrated experimental/theoretical approach to try to unravel the complex non-linear dynamics of the inammatory pathway
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Established and Outsiders at the Same Time - Self-Images and We-Images of Palestinians in the West Bank and in Israel
No full textPalestinians frequently present a harmonizing and homogenizing we-image of their own national we-group, as a way of counteracting Israeli attempts to sow divisions among them, whether through Israeli politics or through the dominant public discourse in Israel. However, a closer look reveals the fragility of this homogenizing we-image which masks a variety of internal tensions and conflicts. By applying methods and concepts from biographical research and figurational sociology, the articles in this volume offer an analysis of the Middle East conflict that goes beyond the polar opposition between “Israelis” and “Palestinians”. On the basis of case studies from five urban regions in Palestine and Israel (Bethlehem, Ramallah, East Jerusalem, Haifa and Jaffa), the authors explore the importance of belonging, collective self-images and different forms of social differentiation within Palestinian communities. For each region this is bound up with an analysis of the relevant social and socio-political contexts, and family and life histories. The analysis of (locally) different figurations means focusing on the perspective of Palestinians as members of different religious, socio-economic, political or generational groupings and local group constellations – for instance between Christians and Muslims or between long-time residents and refugees. The following scholars have contributed to this volume: Ahmed Albaba, Johannes Becker, Hendrik Hinrichsen, Gabriele Rosenthal, Nicole Witte, Arne Worm and Rixta Wundrak. Gabriele Rosenthal is a sociologist and professor of Qualitative Methodology at the Center of Methods in Social Sciences, University of Göttingen. Her major research focus is the intergenerational impact of collective and familial history on biographical structures and actional patterns of individuals and family systems. Her current research deals with ethnicity, ethno-political conflicts and the social construction of borders. She is the author and editor of numerous books, including The Holocaust in Three Generations (2009), Interpretative Sozialforschung (2011) and, together with Artur Bogner, Ethnicity, Belonging and Biography (2009)
Investigation of the mechanisms underpinning IL-6 cytokine release in bystander phenomena: the roles of radiation dose, radiation quality and specific ROS/RNS scavengers.
No full textPurpose: To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. Materials and methods: An integrated 'systems radiation biology' approach was adopted. Experimentally the level of the secreted cytokine from human fibroblasts was detected with ELISA (Enzyme-Linked ImmunoSorbent Assay) method and subsequently the data were analyzed and coupled with a phenomenological model based on differential equations to evaluate the single-cell release mechanisms. Results: The data confirmed the important effect of radiation on the IL-6 pathway, clearly showing a crucial role of the ROS (Reactive Oxygen Species) in transducing the effect of initial radiation exposure and the subsequent long-term release of IL-6. Furthermore, a systematic investigation of radiation dose/radiation quality dependence seems to indicate an increasing efficiency of high LET (Linear Energy Transfer) irradiation in the release of the cytokine. Basic hypotheses were tested, on the correlation between direct radiobiological damage and signal release and on the radiation target for this endpoint (secretion of IL-6) Conclusions: The results demonstrate the role of reactive oxygen and nitrogen species in the signaling pathways of IL-6. Furthermore the systems radiation biology approach here adopted, allowed us to test and verify hypotheses on the behavior of the single cell in the release of cytokine, after the exposure to different doses and different qualities of ionizing radiation
The Interplay between Radioresistant Caco-2 Cells and the Immune System Increases Epithelial Layer Permeability and Alters Signaling Protein Spectrum
No full textColorectal cancer is one of the most frequent type of cancer, with a higher incidence in the developed countries. Colorectal cancer is usually managed with both surgeries, chemotherapy and radiotherapy. Radiotherapy has the well-known advantage of targeting the tumor, minimizing normal tissue exposure. Nevertheless, during radiation treatment, exposure of healthy tissues is of great concern, in particular because of the effects on the intestinal barrier functions and on cells belonging to the immune system. The functional role of intestinal barrier in avoiding paracellular trafficking and controlling bacterial spread from gut it is well known and it is due to the presence of tight junction complexes. However, intestinal barrier is fundamental in participating to the interplay with immune system, especially considering the gut-associated lymphoid tissue. Until few years ago, radiotherapy was considered to bear only a depressive action on the immune system. However, it is now recognized that the release of pro-inflammatory signals and phenotypic changes in tumoral cells due to ionizing radiation could trigger the immune system against the tumor. In this work, we address how intestinal barrier functions are perturbed by X-ray doses in the range 0-10 Gy, focusing on the interplay between tumoral cells and the immune system. To this aim, we adopted a coculture model in which Caco-2 cells can be grown in presence/absence of peripheral blood mononuclear cells (PBMC). We focused our attention on changes in the proliferation, trans-epithelial electrical resistance (TEER), cytokine release, and proteins of the junctional complexes. Our results indicate a high radioresistance of Caco-2 in the investigated dose range, and an increased permeability of the tumoral cell layer due to the presence of PBMC. This is found to be correlated with activation of PBMC, inhibiting the apoptotic pathway, with the enhancement of cytokine release and with variation of tight junction scaffold protein expression levels, assumed to be related to IFN-gamma-and TNF-alpha-mediated signaling
Gendered Adaptations: Canadian Rewritings of Classical Texts. Author-Translator Conference 2010, University of Swansea, Wales
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Quantum many-body scars : realizations and applications
No full textauthor: Gabriele Calliari, BScMasterarbeit Universität Innsbruck 202
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