3,558 research outputs found
A imagem de Alessandro Baricco no Brasil
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2013.Com a intenção de delinear o modo pelo qual o escritor italiano Alessandro Baricco se inseriu no sistema literário brasileiro e os caminhos percorridos pelos seus livros traduzidos, esta dissertação dá voz às experiências tradutórias de seus tradutores. A inserção de Bariccono Brasil tem seu início em 1997, através de uma proposição da Profa. Dra. Roberta Barni à editora Iluminuras da tradução de Oceano Mare. A partir daí, outras sete obras foram publicadas no Brasil, sendo três delas traduzidas por Roberta Barni e as outras quatro por quatro tradutores diferentes. De um lado, considera-se o tradutor como figura principal namediação entre culturas, e, de outro, se analisa a realidade desta figuradentro do sistema literário, sua invisibilidade, seus limites e o exercíciode sua profissão. A pesquisa conta, ainda, com críticas e resenhas referentes ao autor italiano publicadas em jornais consagrados no Brasil, considerando estas como parte constituinte da imagem de Baricco refletida em território nacional. Abstract : Intending to delineate the way the Italian writer Alessandro Baricco has been inserted in the Brazilian literary system and the paths his translated books have followed, this thesis gives voice to the translating experiences of his translators. Baricco's insertion in Brazil began in 1997, through a personal project of Dr. Roberta Barni, with her translation of Oceano Mare. Since then, seven other of his works have been published in Brazil, three of which were translated by Roberta Barni and the other four by four different translators. On the one hand,the translator is considered as the main figure in mediation betweencultures and, on the other, this figure's reality is analyzed within theliterary system: its invisibility, its limits and its professional practice. Criticisms and reviews of this Italian author published in well established Brazilian newspapers are also considered, with the understanding that they are part of Baricco's image reflected here
Formation of black holes in the pair-instability mass gap: evolution of a post-collision star
No full textABSTRACT
The detection of GW190521 by the LIGO–Virgo collaboration has revealed the existence of black holes (BHs) in the pair-instability (PI) mass gap. Here, we investigate the formation of BHs in the PI mass gap via star–star collisions in young stellar clusters. To avoid PI, the stellar-collision product must have a relatively small core and a massive envelope. We generate our initial conditions from the outputs of a hydrodynamical simulation of the collision between a core helium burning star (∼58 M⊙) and a main-sequence star (∼42 M⊙). The hydrodynamical simulation allows us to take into account the mass lost during the collision (∼12 M⊙) and to build the chemical composition profile of the post-collision star. We then evolve the collision product with the stellar evolution codes parsec and mesa. We find that the post-collision star evolves through all the stellar burning phases until core collapse, avoiding PI. At the onset of core collapse, the post-collision product is a blue supergiant star. We estimate a total mass-loss of about 1 M⊙ during the post-collision evolution, due to stellar winds and shocks induced by neutrino emission in a failed supernova. The final BH mass is ≈87 M⊙. Therefore, we confirm that the collision scenario is a suitable formation channel to populate the PI mass gap.</jats:p
THE INSIDIOUS BOOSTING OF THERMALLY PULSING ASYMPTOTIC GIANT BRANCH STARS IN INTERMEDIATE-AGE MAGELLANIC CLOUD CLUSTERS
No full textIn the recent controversy about the role of thermally pulsing asymptotic giant branch (TP-AGB) stars in evolutionary population synthesis (EPS) models of galaxies, one particular aspect is puzzling: TP-AGB models aimed at reproducing the lifetimes and integrated fluxes of the TP-AGB phase in Magellanic Cloud (MC) clusters, when incorporated into EPS models, are found to overestimate, to various extents, the TP-AGB contribution in resolved star counts and integrated spectra of galaxies. In this paper, we call attention to a particular evolutionary aspect, linked to the physics of stellar interiors, that in all probability is the main cause of this conundrum. As soon as stellar populations intercept the ages at which red giant branch stars first appear, a sudden and abrupt change in the lifetime of the core He-burning phase causes a temporary "boost" in the production rate of subsequent evolutionary phases, including the TP-AGB. For a timespan of about 0.1 Gyr, triple TP-AGB branches develop at slightly different initial masses, causing their frequency and contribution to the integrated luminosity of the stellar population to increase by a factor of ~2. The boost occurs for turn-off masses of ~1.75 M ☉, just in the proximity of the expected peak in the TP-AGB lifetimes (for MC metallicities), and for ages of ~1.6 Gyr. Coincidently, this relatively narrow age interval happens to contain the few very massive MC clusters that host most of the TP-AGB stars used to constrain stellar evolution and EPS models. This concomitance makes the AGB-boosting particularly insidious in the context of present EPS models. As we discuss in this paper, the identification of this evolutionary effect brings about three main consequences. First, we claim that present estimates of the TP-AGB contribution to the integrated light of galaxies derived from MC clusters are biased toward too large values. Second, the relative TP-AGB contribution of single-burst populations falling in this critical age range cannot be accurately derived by approximations such as the fuel consumption theorem, which ignore, by construction, the above evolutionary effect. Third, a careful revision of AGB star populations in intermediate-age MC clusters is urgently demanded, promisingly with the aid of detailed sets of stellar isochrones
The impact of metallicity-dependent mass-loss versus dynamical heating on the early evolution of star clusters
No full textWe have run direct N-body simulations to investigate the impact of stellar evolution and dynamics on the structural properties of young massive (~3×104M⊙) star clusters (SCs) with different metallicities (Z = 1, 0.1, 0.01 Z⊙). Metallicity drives the mass-loss by stellar winds and supernovae (SNe), with SCs losingmoremass at highmetallicity. We have simulated three sets of initial conditions, with different initial relaxation time-scale. We find that the evolution of the half-mass radius of SCs depends on how fast two-body relaxation is with respect to the lifetime of massive stars. If core collapse is slow in comparison with stellar evolution, then mass-loss by stellar winds and SNe is the dominant mechanism driving SC evolution, and metal-rich SCs expand more than metal-poor ones. In contrast, if core collapse occurs on a comparable time-scale with respect to the lifetime of massive stars, then SC evolution depends on the interplay between mass-loss and three-body encounters: dynamical heating by three-body encounters (mass-loss by stellar winds and SNe) is the dominant process driving the expansion of the core in metal-poor (metal-rich) SCs. As a consequence, the half-mass radius of metal-poor SCs expands more than that of metal-rich ones. We also find core radius oscillations, which grow in number and amplitude as metallicity decreases. © 2014 The Authors
La maturità di Alessandro Fei del Barbiere, in bilico tra Maniera e Riforma
No full textThis article studies the mature career of the Florentine painter Alessandro Fei del Barbiere (1537-1592), beginning with the rediscovery of the 'Ascension' altarpiece formerly in the Albizi Chapel in the destroyed church of San Pier Maggiore, Florence. Studying this painting and others recorded in 1584 by the biographer Raffaello Borghini, such as the two altarpieces for Santa Maria delle Grazie and the Madonna dell'Umiltà in Pistoia, the author reconstructs a body of works showing how in the 1580s Fei gradually went beyond the archaic style of his apprenticeship - he had been trained by Ridolfo del Ghirlandaio and Pierfrancesco Foschi, but was also marked by the Maniera of Vasari - evolving towards naturalism in both mimesis and pictorial handling. In Florence, his development partly parallels that of Santi di Tito and his circle, but Fei was also influenced by a probable sojourn during the early part of that decade in Rome, where he could have been inspired by Girolamo Muziano and the painters working for Pope Gregory XIII. Among other proposals, the author suggests that the artist was responsible for decorating the chancel of Fiesole Cathedral (c. 1584-1589), which consisted of an altarpiece, only rarely discussed by scholars, and a cycle of frescoes hitherto attributed to Nicodemo Ferrucci
Cardiovascular risk assessment and diagnostic work-up in rare diseases: focus on hyperaldosteronism and primary antibody deficiency
No full textIntroduction: Unilateral form of primary aldosteronism (PA) is the main curable cause of endocrine hypertension cause of PA and it is in up to 66% of all cases investigated with adrenal vein sampling (AVS). Mutations in the KCNJ5 potassium channel involve up to 70% of unilateral PA. The in vitro evidences of macrolide antibiotics specifically inhibit the altered function of mutated KCNJ5 channels has opened new horizons for the diagnosis and treatment of unilateral PA with KCNJ5 mutations in that it can allow identification and target treatment of PA patients harbouring a mutated unilateral PA.
Aim: To test the effect of roxithromycin on aldosterone secretion and blood pressure in vivo in patients without PA, and in those with PA subtyped by AVS and examined according to the presence or absence of KCNJ5 mutation.
Methods: We enrolled consecutive hypertensive patients undergoing screening for secondary hypertension, from January 2018 to June 2022. Each patient received a single oral dose of roxithromycin and, after the diagnostic work-up, baseline values of plasma aldosterone concentration (PAC) and blood pressure were compared with post-roxithromycin values. Next- generation sequencing (NGS) was used to identify KCNJ5 mutated from wild-type forms of unilateral PA. Response to roxithromycin was compared between non-PA, non-unilateral PA and unilateral PA. In unilateral PA we focused on KCNJ5 mutated vs wild-type patients.
Results: After roxithromycin administration, patients with unilateral PA carring KCNJ5 mutation showed a decrease in PAC (p=0.030) that did not occur in unilateral PA KCNJ5 wild-type. In these groups systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not change in response to roxithromycin. However, in non-PA group a decrease in PAC was observed (p<0.001) with a decrease in plasma cortisol concentration (PCC) (p<0.001) and systolic (p<0.001) but not diastolic blood pressure. After adrenalectomy, roxithromycin did not induce any change in PAC in KCNJ5 mutated unilateral PA.
Conclusion: Roxithromycin administration induces a decrease in aldosterone production in patients with KCNJ5 mutation but not in wild-type, confirming its ability in vivo to blunt aldosterone production by blocking the mutated Kir3.4 sodium channel without affecting wild-type forms. As the decrease in PAC in the same patients did not occur after adrenalectomy, the roxithromycin effect is unequivocally attributable to the KCNJ5 mutated unilateral PA.Introduction: Although the immune system is involved in vascular disorders, the actual role of B cells in atherosclerotic cardiovascular disease (ASCVD) remains unclear. Inflammatory conditions like Rheumatoid Arthritis and Systemic Lupus Erythematosus present an accelerated atherosclerotic process, that is somehow limited by appropriate treatment, including B cell depleting therapies. Common Variable Immunodeficiency (CVID) is a rare primary immunodeficiency of adulthood and represents a pathological condition suitable for studying the role of B cells in ASCVD. The cardiovascular risk profile of patients affected by this rare disease is unexplored and it is unclear whether CVID patients are protected towards atherogenesis.
Aim: We investigated the prevalence of cardiovascular risk factors and the presence of subclinical ASCVD in CVID patients.
Methods: We collected anamnestic clinical and biochemical data related to CVID and to ASCVD in a single center cohort of CVID patients, grouped according to clinical and immunological phenotype. At follow-up visit vascular structural and functional investigation was performed by SphygmoCor(R) XCEL instrument while droplet digital PCR analysis was used to assess gene expression.
Results: 127 CVID patients were enrolled in the study. Patients with complicated phenotype presented significantly lower levels of cholesterol and blood glucose, despite a significantly higher use of corticosteroids (p=0.014) due to higher frequency of GLILD (p<0.001) and autoimmunity(p=0.007), particularly ITP (p<0.001). Patients with Chapel phenotype 2 and 3 presented the lowest cholesterol and HbA1c levels. No significant difference was found in terms of metabolic syndrome, hypertension, diabetes, anti-hypertensive, anti diabetic and lipid lowering ongoing treatment, as well as acute cardiovascular events between complicated and uncomplicated phenotype. Lower IgA, IgM IgG levels at diagnosis, SmB cells % as well as higher T-LGL % (CD3+CD8+CD57+) and monthly dosage of IgRT in the complicated group were the main between groups significantly different immunologic parameters. In vivo measurement by SphygmoCor(R) XCEL instrument in a subgroup of 55 patients showed significant difference pulse pressure and augmentation pressure, with a tendence towards higher arterial thickness in patients with only infections. In the same subgroup, B lymphocytes isolated from pheripheral blood of patients with complicated phenotype presented a borderline-significantly higher expression of LDL receptor gene at droplet digital PCR analysis (p=0.053). Conclusion: Our data suggest that clinical phenotypes of CVID may be associated with different cardiovascular risk profiles, possibly based on the different underlying immunological alterations. Preliminary data suggests that B cell defects in CVID patients might influence the development of cardiovascular disease leading to different cardiovascular risk profile. The role of IgRT also needs to be explored. Follow-up studies will unravel the significance of our subclinical findings in terms of development of overt disease, with possible implications in terms of new therapeutic strategies for ASCVD
Tra socialdemocrazie e Perestrojka. Le relazioni internazionali del Pci attraverso le carte di Alessandro Natta
No full textThis essay reconstructs the foreign policy of the Italian Communist Party during the four
years of Alessandro Natta’s secretariat (1984-1988) through largely original archival documentation,
from the Alessandro Natta Fonds of the Historical Archive of the Chamber of
Deputies. Natta’s papers are also cross-referenced with those kept in the PCI Archive at the
Gramsci Foundation. The author analyses the relationship that the PCI establishes with
Gorbachev’s Perestroika, Deng’s China, and European social democracies during the last
years of the Cold War
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