7,946 research outputs found
Contro la funzionalizzazione della contrattazione collettiva. Riflessioni sul pensiero di Mario Rusciano
No full textL'autore riflette sul pensiero di Mario Rusciano in punto di funzionalizzazione della contrattazione collettiva.The author reflects on the thought of Mario Rusciano in relation to the subject of the functionalisation of collective bargaining
About twin primes and distribution of primes
No full textThis paper give us a demonstration of twin primes conjecture using approximation of function �(iupsilon) that we introduce in section 6. Section 1-5 give us introduction to terminology and a clarification on (iupsilon) terms. In particular section
5 is really important because of its Lemma. Section 7 reassume foregoing explanations and it give us two theorems and one corollary;the theorem 7.2 give us exact approximation of twin primes counting function
Gabriele D’Annunzio sotto la luce della traduzione
No full textGabriele D’Annunzio (1863 - 1938) è stato uno scrittore di tante sfaccettature, la cui produzione lo ha consacrato come una delle figure più importanti della letteratura del Novecento italiano. La sua influenza, infatti, ha superato i confini della letteratura e del territorio in cui scriveva, raggiungendo una ricezione internazionale che costituisce il fulcro di questa indagine. L’obiettivo di questo studio è comprendere quali delle sue opere siano state tradotte e in che modo la sua complessa relazione con la politica italiana abbia influito su questo processo, tanto nel numero di traduzioni quanto nelle eventuali censure. L’analisi si basa sulle opere Le traduzioni delle opere di Gabriele d’Annunzio all’estero dal dopoguerra ad oggi, di Dario D’Alessandro (1996), e Gabriele d’Annunzio in altre lingue, di Mario Cimini (2023), entrambe focalizzate sulla traduzione e circolazione dei suoi testi. Parallelamente, si metterà in evidenza anche la consapevolezza traduttiva dello stesso D’Annunzio, che considerava la traduzione uno strumento strategico per ampliare la ricezione delle sue opere. A tal fine, verrà analizzato il volume Carteggio D’Annunzio–Hérelle (1891 - 1931), che raccoglie la corrispondenza tra l’autore e il suo primo traduttore francese. Attraverso questi materiali, la riflessione è su come D’Annunzio non era solo un autore tradotto, ma un agente attivo nel processo traduttivo e nella costruzione internazionale della propria immagine letteraria. Gabriele D’Annunzio (1863 - 1938) foi um escritor multifacetado, cuja sua produção o consolidou como uma das mais importantes figuras da literatura do Novecento Italiano. Sua influência, por tal, superou os limites da literatura e do território em que escrevia, adquirindo uma recepção internacional que é foco da investigação deste artigo. Este estudo tem como objetivo compreender, então, quais de suas obras foram traduzidas e como sua relação complexa com a política italiana interferiu nesse processo, tanto no número de traduções quanto nas possíveis censuras. Para isso, a análise se baseia nas obras Le traduzioni delle opere di Gabriele d’Annunzio all’estero dal dopoguerra ad oggi, de Dario D’Alessandro, publicada em 1996, e Gabriele d’Annunzio in altre lingue, de Mario Cimini, com publicação em 2023; ambos os textos possuem foco na tradução e na circulação dos textos dannunzianos. Simultaneamente, também será destaque a consciência tradutória do próprio D’Annunzio, que via na tradução um instrumento estratégico para ampliar a recepção de suas obras. Para essa finalidade, será explorado o livro Carteggio D’Annunzio-Hérelle (1891-1631), obra que reúne a correspondência entre o autor e o seu primeiro tradutor francês. Por meio desses materiais, a reflexão proposta é como D’Annunzio não foi apenas traduzido, mas era agente ativo no processo tradutório e na construção internacional de sua figura literária. Gabriele D’Annunzio (1863 - 1938) was a multifaceted writer, whose work established him as one of the most important figures of twentieth-century Italian literature. His influence, therefore, extended beyond the boundaries of literature and the territory in which he wrote, gaining an international reception that is the focus of this article. This study aims to investigate which of his works were translated and how his complex relationship with Italian politics influenced this process, both in terms of the number of translations and potential censorship. The analysis is based on the works Le traduzioni delle opere di Gabriele d’Annunzio all’estero dal dopoguerra ad oggi by Dario D’Alessandro, published in 1996, and Gabriele d’Annunzio in altre lingue by Mario Cimini, published in 2023; both of which focus on the translation and circulation of his texts. At the same time, the article highlights D\u27Annunzio\u27 s translational awareness, as he viewed translation as a strategic instrument for expanding the reach of his works. For this, the study explores the book Carteggio D’Annunzio-Hérelle (1891 - 1931), which brings the correspondence between the author and his first French translator. Through these materials, the article reflects on how D’Annunzio was not only a translated author, but an active agent in the translational process and in shaping his international literary image
Grigore Gafencu's foreign policy viewed by the Italian Historian Mario Toscano
No full textAim of the essay is to analyze the the way the Italian Historian Mario Toscano viewed Romanian foreign policy and Italian-Romanian relations, with particular attention to the period in which Grigore Gafencu was Romanian minister of Foreign Affairs
Il diritto penale nel canone di Mario Romano
No full textThis paper deals with the extension and the extraordinary scientific value of the works written by a great Master in Criminal Law, such as Mario Romano. The Author briefly presents some of the most relevant contributions given by Professor Mario Romano to the Criminal Science, first of all his "Commentario sistematico del codice penale" (Systematic Commentary on the penal code), a unique work. Finally, the paper talks about some topics which have been developed inside the work "Studi in onore di Mario Romano" (Studies in Honour of Mario Romano)
Improving drug efficacy and specificity by innovative drug delivery approaches
No full textThe limited efficacy of current therapeutic approaches for a number of socially relevant human diseases requires the exploration of alternative and more effective therapeutic strategies. In this regard, the researchers have pursued on one hand the identification of novel and more effective therapeutic molecules and on the other the optimization of drug delivery systems.
So far, many therapeutic molecules, especially those used as anticancer drugs, are plagued by a low therapeutic index being the efficacious dose very close to the lethal one; moreover, they often lack any specificity of action. This aspect can be improved by the use of drug delivery systems composed of different drug carriers including lipids and polymers. The carriers, often in the shape of nanoparticles , can be loaded by the therapeutic molecule and directed against the target cells via the presence of targeting moieties allocated on the nanoparticle surface.
The specificity of the complex carrier/drug can be further improved by the use of therapeutic molecules preferentially/exclusively active on the target diseased cells. Molecules active against diseased-associated target (oncogenes etc) may hit the diseased cells leaving healthy cells substantially unaffected. In this regard, in the last three decades, nucleic acid based drugs (NABDs) have emerged as an attractive and novel alternative with great therapeutic potential. NABDs, which include antisense oligonucleotides, decoys, aptamers, triple helix forming oligonucleotides, DNAzymes, Ribozymes and small interfering RNAs, have been shown to be able to efficiently and specifically counteract pathological gene expression in many different experimental systems. Notably as they can be engineered to hit virtually any cell target, their potential applicability is very broad.
Despite NABD broad potential applicability, their use in the clinic is limited by the lack of optimal delivery systems. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane for which appropriate carriers are needed. Moreover, their instability in serum requires a proper protection to prevent a fast degradation which would invariably lead to the abrogation of any significant therapeutic effect.
The present special issue will be focused on the critical description of some aspects related to the optimization of drug delivery with a particular emphasis on NABD; despite this, a discussion about the possibility to use/adapt NABD developed delivery systems for more conventional drugs, is also present.
The papers of Chan et al., of Marrache et al, of Schaffert et al., Jung et al. and Grassi et al. describe different delivery approaches for NABD and other commonly used therapeutic molecules for several pathological conditions. In the paper of Chan et al. attention is given to liposome and polymeric based delivery systems with regard to DNA enzymes; the described studies offer perspectives on future methodologies for improved DNAzyme delivery and utility as novel drugs. Marrache et al. describe the use of nanoparticles (made by polymer, liposome and other delivery agents), as delivery devices which can be engineered to load multiple drugs with varied physicochemical properties, contrast agents, and cellular or intracellular component targeting moieties. Schaffert et al draw their attention on the description of delivery systems based on the polycation linear polyethylenimine, where peptide based ligands are attached to the polycation via heterobifunctional polyethylene glycol linker molecules. Conjugate synthesis, in vitro testing and in vivo cancer models in rodents are discussed. Jung et al describe the employment of the thermo sensitive pluronic-based core/shell nanoparticles, formed using various strategies such as self-assembly and temperature induced-phase transition. Particular emphasis is given to the use of the nanoparticles for tumor targeting, stimulated release of proteins, and cancer imaging capabilities. Grassi et al, beside discussing the above mentioned delivery systems, for most of the different types of NABDs, draw their attention on the complex situation of NABD delivery to the arteries describing the advantages and dis-advantages of three different administration routes i.e. systemic, perivascular and intravascular.
The papers of Lico et al, Pagliari et al and Castronovo et al report the use of “living delivery systems” and describe the influences of nano-systems on NABD. Lico et al. focus their attention on the use of a different approach for NABD delivery based on plant viruses which have a size particularly suitable for nanoscale applications and can offer several advantages being structurally uniform, robust, biodegradable and easy to produce. Pagliari et al. continue the description of “living vector” reporting the possible and very innovative use of stem cells as delivery devices for therapeutic molecules to the injured myocardium. Finally, in the paper of Castronovo et al., a completely innovative point of view about NABD complexation in nano-carriers is provided. The author show that the functionality of NABD in nano-systems is highly dependent upon the local density, molecular flexibility and network of weak interactions between adjacent molecules. The understanding of these properties can enable the development of powerful molecular tools for nano-medicine.
In conclusion, whereas the developmental process of many delivery systems is still at the beginning, other delivery strategies are closer to possible applications. Regardless of the fact that the delivery systems are used for NABD or clinically available drugs, we believe the target tissue will mainly determine the nature of the optimal strategy. Despite the delivery issue can and should be further optimized, the encouraging results displayed so far in different experimental models using NABD or clinically used drugs, fully justify further economic and scientific efforts
Established and Outsiders at the Same Time - Self-Images and We-Images of Palestinians in the West Bank and in Israel
No full textPalestinians frequently present a harmonizing and homogenizing we-image of their own national we-group, as a way of counteracting Israeli attempts to sow divisions among them, whether through Israeli politics or through the dominant public discourse in Israel. However, a closer look reveals the fragility of this homogenizing we-image which masks a variety of internal tensions and conflicts. By applying methods and concepts from biographical research and figurational sociology, the articles in this volume offer an analysis of the Middle East conflict that goes beyond the polar opposition between “Israelis” and “Palestinians”. On the basis of case studies from five urban regions in Palestine and Israel (Bethlehem, Ramallah, East Jerusalem, Haifa and Jaffa), the authors explore the importance of belonging, collective self-images and different forms of social differentiation within Palestinian communities. For each region this is bound up with an analysis of the relevant social and socio-political contexts, and family and life histories. The analysis of (locally) different figurations means focusing on the perspective of Palestinians as members of different religious, socio-economic, political or generational groupings and local group constellations – for instance between Christians and Muslims or between long-time residents and refugees. The following scholars have contributed to this volume: Ahmed Albaba, Johannes Becker, Hendrik Hinrichsen, Gabriele Rosenthal, Nicole Witte, Arne Worm and Rixta Wundrak. Gabriele Rosenthal is a sociologist and professor of Qualitative Methodology at the Center of Methods in Social Sciences, University of Göttingen. Her major research focus is the intergenerational impact of collective and familial history on biographical structures and actional patterns of individuals and family systems. Her current research deals with ethnicity, ethno-political conflicts and the social construction of borders. She is the author and editor of numerous books, including The Holocaust in Three Generations (2009), Interpretative Sozialforschung (2011) and, together with Artur Bogner, Ethnicity, Belonging and Biography (2009)
Gendered Adaptations: Canadian Rewritings of Classical Texts. Author-Translator Conference 2010, University of Swansea, Wales
No full textDisturbed flow in a patient-specific arteriovenous fistula for hemodialysis: Multidirectional and reciprocating near-wall flow patterns
No full textActual surgical creation of vascular access has high failure rates of which stenosis formation is a major cause. We have shown previously in idealized models of side-to-end arteriovenous fistula that disturbed flow, a near-wall haemodynamic condition characterized by low and oscillating fluid shear stress, develops in focal points that correspond closely to the sites of future stenosis. Our present study was aimed at investigating whether disturbed flow occurs in patient-specific fistulae, too. We performed an image-based computational fluid dynamics study within a realistic model of wrist side-to-end anastomosis fistula at six weeks post-surgery, with subject-specific blood rheology and boundary conditions. We then categorized disturbed flow by means of established haemodynamic wall parameters. The numerical analysis revealed laminar flow within the arterial limbs and a complex flow field in the swing segment, featuring turbulent eddies leading to high frequency oscillation of the wall shear stress vectors. Multidirectional disturbed flow developed on the anastomosis floor and on the whole swing segment. Reciprocating disturbed flow zones were found on the distal artery near the floor and on the inner wall of the swing segment. We have found that both multidirectional and reciprocating disturbed flow develops on the inner side of the swing segment in a patient-specific side-to-end fistula used for vascular access after six weeks post-operatively. This has obvious implications for elucidating the haemodynamic forces involved in the initiation of venous wall thickening in vascular access
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