758 research outputs found
Produção/reprodução e transformação do comportamento alcoolista nos contextos culturais da família e do trabalho /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.A presente dissertação de mestrado trata de uma investigação realizada a partir dos resultados obtidos na Prática Assistencial, quando foi oferecida, a três famílias de servidores alcoolistas, uma modalidade de assistência de enfermagem pautada na Teoria Sistêmica de Família e na Teoria de Leininger. Buscando ampliar e complementar os dados obtidos, foi elaborado um projeto que deu origem a este estudo, o qual tem por objetivos: analisar as influências do contexto do trabalho na produção/reprodução e transformação do comportamento alcoolista; analisar os nexos entre a produção/reprodução e transformação do comportamento alcoolista no contexto do trabalho e da família e propor alternativas para a transformação do comportamento alcoolista no trabalho, mediante as potencialidades identificadas na família e no trabalho. Este é um estudo exploratório, qualitativo, realizado com três funcionários alcoolistas da UFSM (Universidade Federal de Santa Maria) vinculados às famílias anteriormente pesquisadas. A metodologia constitui-se na análise de fichas funcionais, observação participante no ambiente de trabalho e entrevista com chefias, quando necessário. Após a etapa de coleta de dados, foi possível analisar os nexos entre o comportamento alcoolista na família e o comportamento alcoolista no trabalho. Identificar a produção/reprodução do comportamento alcoolista no contexto do trabalho viabilizou a sinalização de uma proposta de transformação, para a qual aponto indicadores de mudanças; e também reconheço a necessidade de espaços para desenvolver um trabalho integrado entre os serviços que tratam o alcoolismo, principalmente ao nível institucional, no qual me incluo, na tentativa de buscar outras maneiras de investir em mudanças gradativas do comportamento alcoolista
Picasso and the war. From Guernica to Massacre in Korea
No full textreservedA. Note identificative
Laureando: Rossato Giovanni
Titolo tesi: Picasso e la guerra: da Guernica a Massacro in Corea
Corso di laurea: Storia
Relatore: professore Bianchi Giovanni
B. Elementi di contenuto
Come caso di studio ho preso in esame il percorso evolutivo della guerra nell'arte e nello specifico la figura di Pablo Picasso.
Per eseguire questo lavoro ho consultato vari testi storici: manuali di storia contemporanea, testi monografici riguardo i singoli eventi storici presi in considerazione ( Guerra civile spagnola, Seconda Guerra Mondiale, Guerra di Corea); manuali di storia dell'arte per l' argomento riguardante l'evoluzione del rapporto tra arte e guerra; libri biografici sulla figura e le opere di Picasso
IL-10 and miRNAs as modulators of gene expression in lipopolysaccharide-activated neutropils and monocytes
No full textIl processo infiammatorio è costituito dalla successione temporale di eventi coordinati dalla presenza di distinte citochine pro- e antinfiammatorie. Il mancato controllo temporale e/o dell'entità della risposta infiammatoria può svolgere un ruolo importante nello sviluppo di patologie infiammatorie croniche e autoimmuni. In questo contesto, è noto che il corretto equilibrio nella produzione di citochine pro- e anti-infiammatorie è essenziale per il corretto sviluppo dell’infiammazione mirata ad eliminare gli agenti patogeni senza danno ai tessuti. Di conseguenza, è evidente che la caratterizzazione delle vie di trasduzione del segnale che regolano l’espressione dei geni codificanti per citochine durante l’infiammazione è di particolare importanza, dal momento che permette di chiarire quali siano gli eventi fondamentali nel determinare l’insorgenza di patologie nelle quali il processo infiammatorio risulta deregolato. L’entità e la durata della risposta infiammatoria sono finemente regolate dall’ Interleuchina (IL)-10, una potente citochina antinfiammatoria, in grado di limitare l’espressione e la produzione di citochine e chemochine pro-infiammatorie e promuovere il rilascio di molecole antinfiammatorie da monociti, macrofagi e neutrofili attivati in seguito a stimolazione dei recettori Toll-like (TLRs), come il lipopolisaccaride (LPS) batterico. Nonostante l’IL-10 sia una citochina molto studiata per le sue attività antinfiammatorie ed immunomodulatorie, il meccanismo molecolare attraverso cui esercita le sue azioni biologiche è ancora controverso. Lo scopo di questa tesi è quello di caratterizzare i meccanismi molecolari attraverso i quali l’IL-10 modula l’espressione di geni codificanti per citochine in neutrofili e monociti umani attivati dall’LPS. In particolare, lo studio si è articolato in modo da perseguire due obiettivi principali:
(A) caratterizzare i meccanismi attraverso i quali l’IL-10 modula l’espressione di geni codificanti per citochine a livello trascrizionale;
(B) analizzare la capacità dell’IL-10 di regolare l’espressione genica in neutrofili e monociti a livello post-trascrizionale, in particolare attraverso la modulazione dei miRNA.
(A) I risultati ottenuti attraverso l’ analisi quantitativa dei trascritti primari di diverse citochine dimostrano che l’IL-10 esercita la sua attività antinfiammatoria
principalmente inibendo la trascrizione dei geni indotti dall’LPS. Inoltre, i nostri dati dimostrano che l’azione inibitoria dell’IL-10 sull’espressione dei geni codificanti per TNF-α e CXCL8 procede attraverso una prima fase diretta ed una successiva fase dipendente da sintesi proteica.
(B) Nella seconda parte dello studio abbiamo analizzato se l’IL-10 potesse regolare l’espressione di citochine indotte dalla stimolazione con LPS anche mediate meccanismi post-trascrizionali, in particolare attraverso l’azione dei miRNA. Mediante un’analisi su larga scala, abbiamo inizialmente caratterizzato il profilo di espressione dei miRNA indotti in risposta all’LPS. Quindi abbiamo studiato gli effetti dell’IL-10 sull’espressione dei miRNA identificati. Questo studio ci ha permesso di dimostrare per la prima volta che l’IL-10 è in grado di modulare l’espressione di miRNA indotti dall’LPS. Abbiamo quindi condotto uno studio più approfondito sui meccanismi che regolano l’espressione e le funzioni biologiche del miR-9 e del miR-187, gli unici due miRNA modulati dall’IL-10 sia nei neutrofili che nei monociti. Infine, abbiamo identificato il fattore di trascrizione NFKB1/p105/p50 come target di miR-9.
Complessivamente questo studio ha dimostrato che l’IL-10 è in grado di regolare l’espressione genica sia di citochine che di miRNA agendo principalmente a livello trascrizionale. D’altra parte i miRNA regolati dall’IL-10 possono influenzare l’espressione genica dei loro target attraverso meccanismi post-trascrizionali. I risultati di questo studio suggeriscono che l’IL-10 modula l’espressione genica di neutrofili e monociti attraverso circuiti distinti, intervenendo direttamente a livello della trascrizione ed indirettamente, attraverso i miRNA, a livello post-trascrizionale.The inflammatory process consists of a coordinated, sequential and self-limiting release of different mediators that orchestrate and control the chronological phases of leukocytes recruitment, activation, and clearance. In this contest, it is well known that the appropriate balance between pro- and anti-inflammatory cytokines production and action is essential for successful innate immune response that clears infectious pathogens but limits tissue damage and autoimmunity. Based on these knowledges, it is evident that the characterization of the pathways and checkpoints that regulate cytokine gene expression during physiologic inflammation is of particular importance, since it will yield insights into fundamental events occurring in disorders characterized by deregulated inflammation. The amplitude and the duration of the inflammatory response are fine-tuned by Interleukin (IL)-10, a potent antinflammatory cytokine produced, among others, by myeloid cells in response to Toll-like receptor (TLR) activation and, in turn, very effective at suppressing TLR-induced gene expression and inflammatory cytokine production. Although IL-10 antinflammatory properties have been thoroughly described, the molecular mechanisms governing IL-10 production and actions on cells of the innate immune system have not been fully elucidated yet. The purpose of the thesis is to provide a comprehensive characterization of the molecular mechanisms through which IL-10 modulates cytokine gene expression in human neutrophils and monocytes exposed to lipopolysaccharide (LPS). In particular, the study is focused on two main goals:
(A) characterization of the mechanisms through which IL-10 modulates cytokine gene expression at the transcriptional level;
(B) analysis of the role of IL-10 on post-transcriptional regulation of neutrophils and monocytes gene expression, via modulation of miRNAs.
(A) Our results demonstrate that, in neutrophils and monocytes stimulated with LPS, IL-10 primarily targets the transcription of TNF-α, CXCL8 and IL-1ra genes, as revealed by Primary Transcript (PT) real-time RT-PCR. In addition, we show that the transcriptional repression of TNF-α and CXCL8 gene expression induced by IL-10
consists of two distinct phases: an early one, occurring rapidly and in a protein synthesis-independent manner, followed by a second phase, more delayed and dependent on protein synthesis.
(B) In the second part of the thesis we addressed the question whether IL-10 could regulate LPS-induced cytokine expression also by using post-transcriptional mechanisms, in particular through the action of miRNAs. We initially characterized the profile of miRNAs induced in response to LPS. Subsequently, the effect of IL-10 on LPS-induced miRNA expression was characterized. This analysis, performed on a large scale, revealed a previously unrecognized ability of IL-10 to modulate the expression of miRNA induced in response to LPS. We specifically characterized the induction and the regulatory functions of LPS-induced miR-9 and miR-187, being the only miRNAs respectively down- or up-regulated by IL-10 in both cell types. Finally, NFKB1/p105/p50 was identified in silico and experimentally as a miR-9 target.
In summary, the present work demonstrated that IL-10 can modulate the expression of both cytokines and miRNAs at the transcriptional level. In turn, , IL-10-regulated miRNAs could post-transcriptionally influence the expression of specific target genes involved in the regulation of transcription. Collectively these results suggest that IL-10 is able to influence the final output of neutrophils and monocytes gene expression by acting directly at the level of transcription and indirectly, via miRNA, at a post-transcriptional level
An Example of Innovative University Teaching and Learning: the Fashion-Tech Model of Integration
No full text[EN] The aim of the paper is to investigate the relationship between higher education institutions and companies in the field of Fashion-Tech educational system, in order to test the effectiveness of the integration of heterogeneous skills and disciplines. The paper firstly analyses how design, pervaded by the results of technological progress, has become over time an increasingly complex and multidisciplinary field, determining the need and development of new professional figures. Secondly, it focuses on the fashion-tech sector, the resulting area obtained from the intersection of fashion design and digital technologies, highlighting the need for a reviewed educational approach to form hybrid professional figures. To this aim the paper examines data obtained through interviews and desk research conducted within the framework of XXX European project, outlining the state of the art in fashion-tech and investigating the transversal dynamics between the academic world and companies. Next, a case study is reported: an international and multidisciplinary workshop carried out in the field of academic training with the collaboration of a company. What emerged from the experience is that in the Fashion-Tech, the close and continuous relationship with companies acquires a fundamental role.Rossato, B.; Tenuta, L.; Testa, S. (2021). An Example of Innovative University Teaching and Learning: the Fashion-Tech Model of Integration. En 7th International Conference on Higher Education Advances (HEAd'21). Editorial Universitat Politècnica de València. 817-825. https://doi.org/10.4995/HEAd21.2021.13113OCS81782
Risultati a distanza della Collis-Nissen toraco-laparoscopica per il trattamento della MRGe severa con brachiesofago acquisito.
No full textRisultati a distanza della Collis-Nissen toraco-laparoscopica per il trattamento della MRGe severa con brachiesofago acquisito
Food Television Discourse: A cross-cultural diachronic approach
No full textThis study initially arose from the general interest of the author in food, perceived as a deeply-rooted culture-bound aspect of society and hence a potential ‘culture bump’ in cross-cultural communication and translation practices. Modern society is undergoing dramatic changes in the field of nutrition and culinary discourse, as mirrored in the extensive coverage of food topics in the media. Driven by stark economic and social changes that have occurred in European society from the 1950s on-wards, the role of food and food-related practices have gradually freed themselves from their function of mere sustenance, and have taken on many new dimensions, so much so that food consumption has acquired the proportion of a cultural movement and a fashion trend. This is even more strikingly so in a country like Britain, where the average citizen used to have little interest in food and healthy eating, but is now apparently a nation of food experts (Chiaro 2008; 2012). Chefs have achieved the popularity of superstars, as perhaps only pop singers and actors had done in the past. This can be easily explained if we accept that in the new millennium food has become a lifestyle and today Britain is still one of the largest exporters of television celebrity chefs. Moreover, thanks to major technological advances, today’s television consumers have unprecedented choice in terms of television content they can access. Audiences can decide when where and with which translation mode they can watch their preferred TV content. TV viewers can use social media platforms to comment upon, share or even produce media content.
This book investigates food television looking at the intersections between language, culture and television over time and from a cross-cultural perspective. By addressing the diachronic evolution of mainly British and Italian television cookery programmes, from the early days of television to the so-called ‘noughties’ (the 2000s) and up to present day, this book seeks to demonstrate that it is not by chance that Britain has long been one of the strongest exporters of food television discourse and that Italy has absorbed and integrated into its television system many of the programmes and formats of Anglophone cookery culture and tradition.
This volume provides a guide to the features, language and cultural issues involved in televised food-related programmes and looks at their diachronic evolution in connection to the technological and industrial evolution of the medium. The suggestions provided in this book will hopefully appeal to a wide cross-section of scholars and postgraduates in the fields of linguistics, media and food studies as well as screen translation and allow them to look at what are considered unpretentious products, but which are in fact, complex, multi-layered, multifaceted “cultural gateways”
Ibrido moderno: l’istituto B. M. di Gautam Sarabhai ad Ahmedabad, India
No full textDopo le due Guerre Mondiali un approccio ha lentamente e deliberatamente rotto i legami con il passato: le smembrate colonie europee e nuove identità nazionali
hanno ibridato le diverse influenze architettoniche globalmente emerse. Questo edificio progettato da Gautam Sarabhai e costruito nel 1976 è un mirabile (e poco conosciuto internazionalmente) esempio all’interno di questa dirompente contaminazione culturale.After the two World Wars an approach has slowly and deliberately broke the ties with the past: the dismembered European colonies and new national
identities have hybridized the different architectural influences globally emerged at that time. This building designed by Gautam Sarabhai and
built in 1976 is a fine (and almost internationally unknown) example in this astonishing cultural contamination
A Jewelry-Tech Experience: Teaching and Learning Model for Academic Training
No full textThe paper aims to describe an innovative teaching and learning process in jewelry-Tech design. First of all, the paper analyzes the contemporary and multidisciplinary context, underlining the growing presence of a close connection between digital technologies and the world of accessory design, particularly jewelry. The need to define learning models that aim to integrate different skills to train new professional figures successfully is outlined in this context. Secondly, the paper presents and examines the case study "Living Jewellery" held at the School of Design of the Politecnico di Milano, an international workshop conducted in academic training in collaboration with the Italian jewelry company Roberto Coin. The results obtained during this experience are presented and underline effective methodologies and critical issues in conducting the workshop
Il ruolo delle comunità nella documentazione digitale e preservazione dello scenario urbano storico: una proposta di approccio inclusivo
No full textThe essay describes an approach developed by the author in different international realities in order to make communities aware of the importance of digital documentation and preservation of historical agglomerations, constituted prevalently by vernacular architectures of very high sociocultural value.
With this purpose in mind, the concept of historic urban landscape is introduced, which identifies the whole territorial context it is set in, thus going well beyond the simple definition of historic centre and leading to the determination of an ensemble composed of characteristic features such as patterns, spatial organisation, visual relations.
Interventions of contemporary architecture at world level, have undermined the urban scenario of many historic sites, marring them with projects out of scale and of dubious quality, for the last two decades.
The text deals with the suggestions arisen from years of educational research conducted in extremely lively and mutable environments such as the historic centres of some Asian Countries, with an in-depth study on the case of the Kathmandu Valley in Nepal. In order to treat this topic the paper presents the feedback results of awareness raising projects developed in different historic centres, including academic cooperation, involvement of professors, researchers, local authorities, professionals and young intellectuals.
The research stressed the importance of different visions on the documentation and representation of cultural heritage, which acquires different meanings based on local culture and traditions, in order to define future directions, low cost methodologies and working tools in the field of education for the conservation and enhancement of the historic fabric.
The digitalisation techniques, also shared with a less specialised audience, were essential tools for setting up a methodology capable of meeting the main requirements of knowledge and comprehension.
The activities and experimentations carried out have identified functional methods for the analysis, representation and diagnostics of vernacular contexts, demonstrating the potential of interdisciplinary activities implemented in fragile but at the same time extremely stimulating environments.
The involvement of local communities showed to be a conditio sine qua non to achieve the objective of a shared and more aware preservation of the historic urban landscape
Future Management Challenges
No full textThe business world has changed in the few years that separate us from the last century. Eight principal factors are worthy of special note.These factors all raise special challenges for management which is called upon to reinvent its role where growing complexity demands that each business is a “good business” (Mihaly, 2003), or perhaps a “harmonious business” (Baccarani, 2005), ensuring wellbeing for all the stakeholders and in this way be creative, innovative and competitive.With a view to assessing the business’s own perception of this need for change, starting with the model put forward by Gary Hamel and HBR (Hamel, 2009), we sketched out thirty action vectors aimed at reinterpreting the managerial role in transforming business into a dynamic and harmonious relationship with all stakeholders within and without the organisation itself.The objective of this work is to communicate the results of this explorative study carried out on a sample of sixteen enterprises located in north east Italy, one of Italy’s and indeed the world’s most industrialised areas, each of which was interviewed in depth using questionnaires that mustered together all the aforementioned vectors.The aims were: a) to see the priority challenges as perceived in the minds of management; b) to see how much of a gap there was between the felt need for change and the actual effort being committed to change; c) to measure the convergence, or otherwise, of management perceptions and theoretical projections of future change and trends
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