254 research outputs found
Author response
No full textEmerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes independently of Tel1/ATM and Mec1/ATR. Since the DSB ends undergo nucleolytic degradation (resection) of their 5′-ending strands, we investigated the contribution of resection in this DSB-induced transcriptional inhibition. We discovered that resection-defective mutants fail to stop transcription around a DSB, and the extent of this failure correlates with the severity of the resection defect. Furthermore, Rad9 and generation of γH2A reduce this DSB-induced transcriptional inhibition by counteracting DSB resection. Therefore, the conversion of the DSB ends from double-stranded to single-stranded DNA, which is necessary to initiate DSB repair by homologous recombination, is responsible for loss of transcription around a DSB in S. cerevisiae
Computing in matrix groups without memory
No full textFunding: UK Engineering and Physical Sciences Research Council award EP/K033956/1Memoryless computation is a novel means of computing any function of a set of registers by updating one register at a time while using no memory. We aim to emulate how computations are performed on modern cores, since they typically involve updates of single registers. The computation model of memoryless computation can be fully expressed in terms of transformation semigroups, or in the case of bijective functions, permutation groups. In this paper, we view registers as elements of a finite field and we compute linear permutations without memory. We first determine the maximum complexity of a linear function when only linear instructions are allowed. We also determine which linear functions are hardest to compute when the field in question is the binary field and the number of registers is even. Secondly, we investigate some matrix groups, thus showing that the special linear group is internally computable but not fast. Thirdly, we determine the smallest set of instructions required to generate the special and general linear groups. These results are important for memoryless computation, for they show that linear functions can be computed very fast or that very few instructions are needed to compute any linear function. They thus indicate new advantages of using memoryless computation.Peer reviewe
Computing in permutation groups without memory
No full textFunding: UK Engineering and Physical Sciences Research Council (EP/K033956/1)Memoryless computation is a new technique to compute any function of a set of registers by updating one register at a time while using no memory. Its aim is to emulate how computations are performed in modern cores, since they typically involve updates of single registers. The memoryless computation model can be fully expressed in terms of transformation semigroups, or in the case of bijective functions, permutation groups. In this paper, we consider how efficiently permutations can be computed without memory. We determine the minimum number of basic updates required to compute any permutation, or any even permutation. The small number of required instructions shows that very small instruction sets could be encoded on cores to perform memoryless computation. We then start looking at a possible compromise between the size of the instruction set and the length of the resulting programs. We consider updates only involving a limited number of registers. In particular, we show that binary instructions are not enough to compute all permutations without memory when the alphabet size is even. These results, though expressed as properties of special generating sets of the symmetric or alternating groups, provide guidelines on the implementation of memoryless computation.Peer reviewe
Neural Entrainment to Auditory Rhythms: Automatic or Top-Down Driven?
No full textReview of and commentary on: Pesnot Lerousseau J, Trébuchon A, Morillon B, Schön D (2021) Frequency selectivity of persistent cortical oscillatory responses to auditory rhythmic stimulation. J Neurosci 41:7991–8006
BAND STRENGTH MEASUREMENT OF THE BAND OF
No full textAuthor Institution: Jet Propulsion LaboratoryThe band strength of the band of has been determine by measuring the 9 moderately isolated Q-branches, The curves of growth for these Q-branches were calculated using the molecular rotation constants given by Morillon-Chapey and Graner. A. Voigt profile was assumed for the line shape as the measurements were made in the 1.0 to 5.0 Torr pressure range. An approximate method was derived to account for blending of the Q-branches with P branch lines. As is expected, there is no evidence of a vibration rotation interaction effect on the intensities of the Q-branches
Reactivity effect breakdown calculations with deterministic and stochastic perturbations analysis – JEFF-3.1.1 to JEFF3.2T1 (BRC-2009) actinides application
No full textJEFF-3.1.1 is the reference nuclear data library in CEA for the design calculations of the next nuclear power plants. The validation of the new neutronics code systems is based on this library and changes in nuclear data should be looked at closely. Some new actinides evaluation files at high energies have been proposed by CEA/Bruyères-le-Chatel in 2009 and have been integrated in JEFF3.2T1 test release. For the new release JEFF-3.2, CEA will build new evaluation files for the actinides, which should be a combination of the new evaluated data coming from BRC-2009 in the high energy range and improvements or new evaluations in the resolved and unresolved resonance range from CEA-Cadarache. To prepare the building of these new files, benchmarking the BRC-2009 library in comparison with the JEFF-3.1.1 library was very important. The crucial points to evaluate were the improvements in the continuum range and the discrepancies in the resonance range. The present work presents for a selected set of benchmarks the discrepancies in the effective multiplication factor obtained while using the JEFF-3.1.1 or JEFF-3.2T1 library with the deterministic code package ERANOS/PARIS and the stochastic code TRIPOLI-4. They have both been used to calculate cross section perturbations or other nuclear data perturbations when possible. This has permittted to identify the origin of the discrepancies in reactivity calculations. In addition, this work also shows the importance of cross section processing validation. Actually, some fast neutron spectrum calculations have led to opposite tendancies between the deterministic code package and the stochastic code. Some particular nuclear data (MT=5 in ENDF terminology) seem to be incompatible with the current MERGE or GECCO processing codes
Une installation expérimentale pour l'étude du traitement par combustion des fumées industrielles An Experimental Plant for Processing Industrial Fumes by Combustion
No full textLe rejet à l'atmosphère d'effluents gazeux d'origine industrielle entraîne un accroissement sensible de la pollution atmosphérique ; en outre, il s'accompagne souvent d'une perte d'énergie lorsque l'élément polluant est un hydrocarbure. Dans ce cas, l'utilisation du gaz naturel pour le traitement par combustion des fumées industrielles apporte une solution élégante et souvent peu coûteuse grâce à la récupération d'énergie qu'il est possible de faire. La première partie de l'article rappelle les aspects théoriques de ce traitement ; en particulier, l'influence des divers éléments sur son efficacité y est discutée (composition de l'atmosphère polluée, température, temps de séjour, etc.). II apparaît ainsi que diverses conditions doivent être remplies simultanément pour obtenir une efficacité satisfaisante. Afin de disposer d'éléments d'ingénierie permettant de construire les unités de traitement les plus efficaces et les plus sûres possible, au coût le plus bas possible, la Direction des études et techniques nouvelles du Gaz de France a réalisé une installation expérimentale qui est présentée dans la deuxième partie de l'article. Enfin, quelques examples d'utilisation de cette installation expérimentale, qui constitue un nouvel outil de travail mis à la disposition des utisitateurs et des constructeurs, sont décrits dans la troisième partie de l'article. The discharge into the atmosphere of industrial waste gases causes substantially increased air pollution. Moreover, it is often accompanied by loss of energy when the polluting element is a hydrocarbon. In such cases, the use of natural gas for processing industrial fumes by combustion provides an elegant solution, which moy often prove economical too becouse of the recovery of energy it makes possible. The first part of this article reviews the theoretical aspects of such processing. The way in which its effectiveness is affected by various parameters (composition of the polluted atmosphere, temperature, résidence time, etc.) is discussed in particular, and it is show that various conditions must be met simultaneously ta ensure satisfactory efficiency. In order ta gather engineering data to enable the most efficient and reliable processing units to be built at the lowest possible cost, Gaz de France's Research and Development Directerate has built an experimental plant which is described in the second part of the article. The final section describes some examples of utilization of this experimental plant, which constitutes a new working tool available to usera and manufacturera alike
Biblia. A.T. Salmos. Latín
No full textExiste una variante cuya última p. es 964 [i.e. 1008]Colofón (en recto de 3Y\b7\s) en el que consta "ex typographia ..."Marca tip. de Cardon en portEl impresor consta en el colofón (r. de 3Y\b7\s)Marca de ed. en portSign.: a-h\p8\s, A-3X\p8\s, 3Y\p8\sError tip. de pag. en la última numeradaPort. con grab calc. y a dos tintas; parte del texto de la primera parte a dos tintasError de pag. en última pPort. y parte del texto de la primera parte a dos tintas, con grab. calc"In Psalmos Dauidis vulgata editione commentariorum ... pars secunda", comienza con port. propia en p. [417]In Psalmos Dauidis vulgata editione commentariorum ... pars secunda ..., p. [417]-964 [i.e. 1008], con port. propi
L'expression clinique traumatique chez les enfants et les adolescents : évaluation du retentissement psychologique
No full textAutrice : linguistiquement correct
No full textInternational audienceThis article aims to rethink the mechanisms of legitimization of the word autrice, drawing on contemporary commentaries on the word autrice. Between 2020 and 2024, the word autrice experienced a considerable boom in the press, one year after its use was made official by the Académie française. Comments in the French and French-language press, as well as remarks by women writers, enrich the semantic approach and raise questions about the word’s contemporary meaning. What does it mean to be an author today? Does the morphological derivation of the word carry an additional meaning to that of the simple feminization of a professional name? Beyond the question of usage or morphological regularity, the meaning of the word questions linguistic sentiment and the way in which women writers intend to situate themselves in the exercise of their art.Cet article vise à renouveler la réflexion sur les mécanismes de légitimation du mot autrice en s’appuyant sur les commentaires contemporains sur le mot autrice diffusés dans la presse. Entre 2020 et 2024, le mot autrice connaît un essor considérable, un an après l’officialisation de son usage par l’Académie française. Les commentaires dans la presse française et la presse francophone, ainsi que les remarques de femmes de lettres enrichissent l’approche sémantique et amènent à s’interroger sur le sens contemporain de ce mot. Que signifie être autrice aujourd’hui ? La dérivation morphologique du mot est-elle porteuse d’un sens supplémentaire à celui de la simple féminisation d’un nom de métier ? Au-delà de la question de l’usage ou de la régularité morphologique, la signification du mot interroge le sentiment linguistique et la manière dont les femmes qui écrivent entendent se situer dans l’exercice de leur art
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