378 research outputs found
Convective characteristics of Fe
No full textContext. Solar convection is visible as a net blueshift of absorption lines, which becomes apparent when observing quiet Sun granulation. This blueshift exhibits variations from the disc centre to the solar limb due to differing projection angles onto the solar atmosphere.
Aims. Our goal is to investigate convective Doppler velocities based on observations from the disc centre to the solar limb. Consequently, we aim to improve our understanding of atmospheric hydrodynamics and contribute to the improvement of solar and stellar atmospheric models.
Methods. We used resolved quiet-Sun spectra to investigate the convective velocity shifts of more than 1000 Fe
Narrative Language as an Expression of Individual and Group Identity
No full textScientific Narrative Psychology integrates quantitative methodologies into the study of identity. Its methodology, Narrative Categorical Analysis, and its toolkit, NarrCat, were both originally developed by the Hungarian Narrative Psychology Group. NarrCat is for machine-made transformation of sentences in self-narratives into psychologically relevant, statistically processable narrative categories. The main body of this flexible and comprehensive system is formed by Psycho-Thematic modules, such as Agency, Evaluation, Emotion, Cognition, Spatiality, and Temporality. The Relational Modules include Social References, Semantic Role Labeling (SRL), and Negation. Certain elements can be combined into Hypermodules, such as Psychological Perspective and Spatio-Temporal Perspective, which allow for even more complex, higher level exploration of composite psychological processes. Using up-to-date developments of corpus linguistics and Natural Language Processing (NLP), a unique feature of NarrCat is its capacity of SRL. The structure of NarrCat, as well as the empirical results in group identity research, is discussed
Are There Options to Prevent Early Occurring Deaths in Acute Myocardial Infarction: Prospective Evaluation of All < 24 h In-Hospital Deaths, 2004-2006-The MONICA/KORA Augsburg Infarction Registry
No full textObjectives: To provide valid clinical data of early in-hospital deaths with presumed acute myocardial infarction (AMI) who are often not included in clinical trials or registries. Methods: From August 2004 to August 2006 all patients (age 25-84 years) dying within 24 h after hospitalization in a large tertiary care academic teaching hospital were screened regarding an underlying cardiovascular cause of death. Results: After validation, 79 out of 1,352 patients remained with a final diagnosis of AMI. Sixty-six percent of these experienced prehospital cardiac arrest or shock. In 37% no resuscitation attempts were performed in-hospital, the most common reason being multimorbidity. Only 23% could be transferred to coronary angiography for revascularisation attempts. An independent panel of clinicians judged that only in one patient would another management strategy have been promising. Of interest, 33% of the deceased patients had typical or atypical chest pain the days before the lethal event. Conclusion: A large percentage of AMI patients who died soon after hospitalization were in critical circulatory state directly before hospitalization. In 37%, in-hospital resuscitation attempts were omitted for understandable reasons. Options for improvement in acute care in the investigated setting were not found. However, in one third of the cases earlier preventive measures might have been reasonable. Copyright (C) 2010 S. Karger AG, Base
Narrative Social Psychology and the Narrative Categorical Content Analysis (NarrCat) in the Study of Social Representations of History
No full textIntrafraction motion of the prostate during an IMRT session: a fiducial-based 3D measurement with Cone-beam CT
No full textAbstract Background Image-guidance systems allow accurate interfractional repositioning of IMRT treatments, however, these may require up to 15 minutes. Therefore intrafraction motion might have an impact on treatment precision. 3D geometric data regarding intrafraction prostate motion are rare; we therefore assessed its magnitude with pre- and post-treatment fiducial-based imaging with cone-beam-CT (CBCT). Methods 39 IMRT fractions in 5 prostate cancer patients after 125I-seed implantation were evaluated. Patient position was corrected based on the 125I-seeds after pre-treatment CBCT. Immediately after treatment delivery, a second CBCT was performed. Differences in bone- and fiducial position were measured by seed-based grey-value matching. Results Fraction time was 13.6 ± 1.6 minutes. Median overall displacement vector length of 125I-seeds was 3 mm (M = 3 mm, Σ = 0.9 mm, σ = 1.7 mm; M: group systematic error, Σ: SD of systematic error, σ: SD of random error). Median displacement vector of bony structures was 1.84 mm (M = 2.9 mm, Σ = 1 mm, σ = 3.2 mm). Median displacement vector length of the prostate relative to bony structures was 1.9 mm (M = 3 mm, Σ = 1.3 mm, σ = 2.6 mm). Conclusion a) Overall displacement vector length during an IMRT session is b) Positioning devices reducing intrafraction bony displacements can further reduce overall intrafraction motion. c) Intrafraction prostate motion relative to bony structures is < 2 mm and may be further reduced by institutional protocols and reduction of IMRT duration.</p
Royal Inland Hospital School of Nursing alumnae association: A history
No full textOn March 9th 1949, in the Nurse's Home at Royal Inland Hospital, the dream of many Graduates came true. The Royal Inland Hospital School of Nursing Alunmae Association was formed.Not peer reviewedboo
Analysis of low Z elements on Si wafer surfaces with undulator radiation induced total reflection X-ray fluorescence at the PTB beamline at BESSY II
No full textLost Axillary Markers After Neoadjuvant Chemotherapy in Breast Cancer Patients-Data from the Prospective International AXSANA (EUBREAST 3) Cohort Study (NCT04373655)
No full textIntroduction: Marking metastatic lymph nodes before neoadjuvant chemotherapy (NACT) has become increasingly popular in the surgical treatment of breast cancer. A variety of devices are currently in use. However, the significance of lost markers is poorly understood, and their impact on clinical decisions is unclear. Materials and methods: Among participants enrolled in the prospective AXSANA cohort study, those planned for target lymph node biopsy (TLNB) or targeted axillary dissection (TAD) with completed post-NACT locoregional therapy (surgery and radiotherapy) by January 21, 2025, were included. Results: In 88 of 1528 patients (5.8 %), axillary markers could not successfully be removed during surgery after NACT. The lost marker rate differed depending on the marker type (metallic clip/coil 7.0 %, carbon 3.1 %, radar reflector 1.4 %, magnetic seed 0.6 %, radioactive seed 0.0 %, p < 0.001). Additional postoperative imaging was performed in 25 (28.4 %) and further surgery to remove axillary markers was performed in 6 (6.8 %) patients with lost markers. The proportion of patients undergoing axillary lymph node dissection (46.6 % versus 36.5 %, p 0.069) and axillary radiotherapy (51.1 % versus 50.2 %, p 0.748) did not differ between patients with and without lost markers. After an average follow-up of 21.8 months, axillary recurrences occurred in 3 patients (3.3 %) with and 16 patients (1.0 %) without lost markers (rate ratio 2.89, p 0.088). Conclusion: The loss of markers in TLNB/TAD is uncommon and significantly depends on the marking technique. Lost markers may lead to diagnostic uncertainties and additional imaging or surgical procedures.AGO Breast Study Group (AGO-B); Claudia von Schilling Foundation for Breast Cancer Research; Ehmann Foundation Savognin; Eugen; Irmgard Hahn Foundation; Arbeitsgemeinschaft fur asthetische, plastische und wiederherstellende Operationsverfahren in der Gynakologie e.V. (AWOgyn); EndoMag; Merit Medical; MammotomeThis work was supported by the AGO Breast Study Group (AGO-B) , the Claudia von Schilling Foundation for Breast Cancer Research, the Ehmann Foundation Savognin, Eugen and Irmgard Hahn Foundation, Arbeitsgemeinschaft fur asthetische, plastische und wiederherstellende Operationsverfahren in der Gynakologie e.V. (AWOgyn) , EndoMag, Merit Medical, and Mammotome.Science Citation Index Expande
Cancer drug development and the evolving regulatory framework for companion diagnostics in the European union
No full textThe European Union (EU) legal framework for medical device regulation is currently under revision. The European Commission has proposed a new framework to ensure that medical devices serve the needs and ensure the safety of European citizens, aiming for a framework that is fit for purpose, more transparent, and better adapted to scientific and technological progress. The proposed new framework is described as an evolution of the current regime keeping the same legal approach. An important proposed change is that companion diagnostics will no longer be considered as low risk and subject to self-certification by the manufacturer. According to the new proposal, companion diagnostics will be classified as high individual risk or moderate public health risk (category C) and require conformity assessment by a notified body. It has also been proposed that evidence of the clinical utility of the device for the intended purpose should be required for companion diagnostics. In this article, we review the EU legal framework relevant for companion diagnostics, describe the proposed changes, and summarize the available scientific guidance from the European Medicines Agency and its regulatory experience with cancer drug development including companion diagnostics. See all articles in this CCR Focus section, "The Precision Medicine Conundrum: Approaches to Companion Diagnostic Co-development.
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