1,721,273 research outputs found
Thematic Study of Aziz ur Rehman Aziz’s poetry
Full text linkProfessor Aziz ur Rehman Aziz was born in Agra India in 1948 .Basically he belong to the tribe of Hashim Khel of Swat but they were migrate to Hazara after coming from India.He got his early education in gajborai Middle School and Metric from Batagram High school. After matriculation he went to Karachi, where he work as a laboure.During performing his duty in a factory he continue his education too as private candidate. As will as he also takes part in literary activities. He passed F.A, B.A and M.A during his private job in Karachi. Then he came back to batagram and started service as Scholl teacher. After some time he Appointed as 1st Pashto lecture in Hazara region. He also performed his duties as secretory with several ministers and section officer.
In his literary contributions two books of poetry are publish, one is “Tandar” and other is” Khawre umeedona”.we will discuss the thematic study of his poetry. His poetry mainly contains religious thoughts, Nationalism, Realism and progressive approach
CCDC 689446: Experimental Crystal Structure Determination
No full textAn entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.,Related Article: M.Hussain, M.Hanif, S.Ali, R.Butcher, T.Mirza, D.VanDerveer, Aziz-ur-Rehman|2010|Drug.Dev.Ind.Pharm.|36|1079|doi:10.3109/0363904100365728
CCDC 689445: Experimental Crystal Structure Determination
No full textAn entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.,Related Article: M.Hussain, M.Hanif, S.Ali, R.Butcher, T.Mirza, D.VanDerveer, Aziz-ur-Rehman|2010|Drug.Dev.Ind.Pharm.|36|1079|doi:10.3109/0363904100365728
Integrated Systems Modeling for Assessing the Water–Energy Nexus in Pakistan: Lessons Learned From Coupling LEAP–WEAP Planning Approaches
Full text linkSystems thinking is crucial in developing strategies for managing and allocating resources in complex scenarios. In the Global South, Pakistan faces challenges such as water scarcity and energy crises, which require integrated approaches. This study combines long-range energy alternatives planning (LEAP) with a water evaluation and planning system (WEAP) to explore potential strategies for managing interconnected water and energy resources in Pakistan. The aim of this work is to identify policy flaws and assess the consequences of water–energy decisions in Pakistan. The findings suggest that maintaining the current status quo will hinder Pakistan’s goal of reducing its water consumption by 30% by 2027 and its energy usage by 50% by 2030. Innovative modeling scenarios suggest that energy and water consumption reductions in the agricultural, domestic, industrial, and transport sectors could save up to 15% energy usage by 2050. However, water-saving strategies can inadvertently lead to increased energy consumption, particularly in the agricultural and industrial sectors, with projections reaching an additional 2.8 million tonnes of oil equivalent (MTOE) by 2050. Realizing Pakistan’s policy goals and meeting its targets present considerable challenges for the government, especially against the backdrop of severe economic conditions. Current policies necessitate significant investments of 145 billion PKR (∼500 million EUR or USD) for water conservation and an additional 10 billion PKR for energy-conservation measures by 2030. Despite international financial aid, the success of these initiatives is at risk due to political instability, administrative weaknesses, and institutional shortcomings
Mediterranean Sea Struggle between Turkey and Greece and its Implications for the Existence of NATO and the Way Forward
No full textThe Mediterranean Sea has been a vital passage since time immemorial. It was the cultural and ideological fault line between empires in eastern and western countries. Contrary to its previous past, the last century saw the peaceful sea. However, Greece and Turkey’s recent standstill ruins this ideal time. Turkey’s assertive policies to explore gas and oil in the Mediterranean Sea, known as the Blue Homeland approach, have been a significant disruption in the region’s status quo. The presence of France, Egypt, and the UAE in the dispute has exacerbated this rivalry. The negotiated conflict settlement is essential; otherwise, NATO’s very existence and regional stability are in danger. The author explains the conflict actors’ their interests and introduces the potential solution to this conflict and NATO alliance revitalization that could end Russian aggression in the region
Homozygous HOXC13 variant causes pure hair and nail ectodermal dysplasia via reduction in protein stability
No full textPure hair and nail ectodermal dysplasia (PHNED) is a congenital disorder characterized by reduced or absent hair and dystrophic nails. PHNED is caused by pathogenic variants in genes involved in hair and nail development, including HOXC13. Previously reported biallelic HOXC13 pathogenic variants led to PHNED by either disrupting protein expression through nonsense-mediated decay or altering the DNA-binding affinity of the homeobox domain of HOXC13. Here, we report a case of HOXC13-related PHNED with a rare homozygous variant, c.931C>T, p.Arg311Trp. Similarly to previously reported missense variants, p.Arg311Trp resides in the homeobox domain of HOXC13 and was assumed to lead to the decreased transcriptional activity of target genes. However, in contrast with previously reported variants, in vitro overexpression assays revealed that the p.Arg311Trp variant decreases HOXC13 protein stability, which is corroborated by a series of in silico predictions. Computational models further suggest that p.Arg311Trp results in a structural rearrangement with loss of interhelical connection between Arg311 in α-helix 3 and Glu276 in α-helix 1. Altogether, our results suggest a novel molecular mechanism causative of PHNED, whereby biallelic pathogenic variants in HOXC13 may result in decreased protein stability and consequently decreased transcriptional activity of target genes essential for hair and nail development
الأسلوب الأدبي في رحلات العلامة أبي الحسن علي الندوي
No full textAbul Hassan Ali Al-Nadawi (1999) is an indian scholar, author, preacher, Islamic thinker, Arabic and Urdu writer and author of several books in different fields.
He traveled to many Islamic and Western countries, and wrote his impressions and observations of his travels, in his various books, the most important of which are;
The journey of life (three volumes), Two weeks in the Far Morocco, From the River Kabul to the River Yarmouk, The notes of a tourist in the East and West, Journeys of Nadwi.
In this article, I will introduce Allama Nadwi and literary aspects of his travel literature. I will explain the concept of literary style, the artistic construction of the journeys of the Allama Nadwi, with examples from his travels
سرائیکی لُغت نویسی: آغاز و ارتقا
No full textReligious texts of Saraiki are the preliminary samples of dictionary writing in Saraiki. Besides orientalists like Edward O'Brien, Andrew Jukes, James Wilson, the local language experts Akhtar Waheed Ansari, Jamshed Kamtar Rasoolpuri, Dilshad Kalanchvi, Fida-e-Athar, Aslam Qureshi, Bashir Ahmad Zami, Maulana Aziz ur Rehman Aziz, Maulana Noor Ahmad Fareedi, Dr. Mahar Abdul Haq, Qais Fareedi, Shaukat Mughal, Saadullah Khetran etc. contributed a lot in the development of Saraiki dictionary. Though remarkable work on Saraiki lexicography has been done yet a lot more attention is required to produce Saraiki dictionary in light of international standard of lexicography
India, TRIPS-plus free trade agreements and the future of access to essential medicines
No full textThe issue of TRIPS-plus standards and its implications of access to essential medicines are discussed in this article in the Indian context. As a leading country in the manufacture and supply of generic drugs, the case of India is crucial when considere
Pharmacological studies on bradykinin and other inflammaory mediators in rat neural preparations
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