580 research outputs found
Lessons in Leadership: Patricia E. Benner
No full textLessons in Leadership: The Betty Irene Moore Speaker Series embodies Betty Irene Moore\u27s vision and hope for nurses to lead within their teams, organizations and communities, with the ultimate goal of improving the experience and outcomes of patient care. Through personal experience, Betty recognized that nurses play a critical role in providing safe, high-quality patient care and outcomes. They are caregivers, mentors, teachers and researchers; and they provide 95 percent of direct patient care in hospitals. This recognition gave rise to the Betty Irene Moore Nursing Initiative, with building leadership skills in nurses as one of its main strategies.
This video is one of a collection of 13 short videos featuring nationally-recognized nurse leaders whose leadership spans nursing, health care, government and other sectors.
This video features Patricia E. Benner, RN, PhD, FAAN: Professor Emerita, University of California, San Francisco School of Nursing Author of From novice to expert: Excellence and power in nursing practice Director of Carnegie Foundation\u27s Educating nurses: A call for radical transformation American Academy of Nursing \u27Living Legend\u27
This interview took place 19 April, 2011.
To quickly locate other leader videos in this collection, please click on the publisher link below.
To learn more about this series, or to request a copy of the video collection, please click here
Ron Benner : Trans/mission : African Vectors
No full textMcFarlane examines Benner's photo-based works and garden installations. The author points to the tenderness with which Benner "tends" to his plants, and contrasts this care with the violence embedded in agricultural history, which he views as a metaphor for systems of socio-political domination. The imperialist travels of Portuguese explorer Pedro Alvares Cabral are discussed in relation to the circulation of plant species from the Americas to Africa and Europe. Brief biographical notes on the author. 2 bibl. ref
General Pedagogy by Dietrich Benner
No full textIn the study, author marks out four tasks to realization. First, approximation the sense of existence and the
objectives and tasks of general pedagogy, developed by D. Benner in the book: General Pedagogy: a Systematic
Problem-Historical Introduction to the Basic Structure of Pedagogical Thinking and Practice (Allgemeine
Pädagogik: eine systematisch-problemgeschichtliche Einführung in die Grundstruktur pädagogischen Denkens
und Handelns). Secondly, based on the views D. Benner on the pedagogical praxis, development of
process-structure of general pedagogy and to place emphasis on praxeology and not-affirmatives. Thirdly, the
reference on the views D. Benner to general pedagogy in the development of the Polish pedagogues. And
fourth, provide some copyright proposals on general pedagogy.W pracy wyznaczono cztery zadania do realizacji. Po pierwsze, przybliżenie sensu istnienia oraz celów
i zadań pedagogiki ogólnej, opracowanych przez D. Bennera w książce: Pedagogika ogólna. Wprowadzenie
do myślenia i działania pedagogicznego w ujęciu systematycznym i historyczno-problemowym (Allgemeine
Pädagogik: eine systematisch-problemgeschichtliche Einführung in die Grundstruktur pädagogischen Denkens
und Handelns). Po drugie, oparte na poglądach D. Bennera na temat pedagogicznej praxis, opracowanie
procesualnej struktury pedagogiki ogólnej i położenie w niej nacisku na prakseologię i nieafimacyjność.
Po trzecie, odniesienie się poprzez poglądy D. Bennera, do pedagogiki ogólnej w opracowaniu polskich
pedagogów. I po czwarte, podanie kilku autorskich propozycji dotyczących pedagogiki ogólnej
General Pedagogy by Dietrich Benner (para-reviewed)
No full textW pracy wyznaczono cztery zadania do realizacji. Po pierwsze, przybliżenie sensu istnienia oraz celów i zadań pedagogiki ogólnej, opracowanych przez D. Bennera w książce: Pedagogika ogólna. Wprowadzenie do myślenia i działania pedagogicznego w ujęciu systematycznym i historyczno-problemowym (Allgemeine Pädagogik: eine systematisch-problemgeschichtliche Einführung in die Grundstruktur pädagogischen Denkens und Handelns). Po drugie, oparte na poglądach D. Bennera na temat pedagogicznej praxis, opracowanie procesualnej struktury pedagogiki ogólnej i położenie w niej nacisku na prakseologię i nieafimacyjność. Po trzecie, odniesienie się poprzez poglądy D. Bennera, do pedagogiki ogólnej w opracowaniu polskich pedagogów. I po czwarte, podanie kilku autorskich propozycji dotyczących pedagogiki ogólnej.In the study, author marks out four tasks to realization. First, approximation the sense of existence and the objectives and tasks of general pedagogy, developed by D. Benner in the book: General Pedagogy: a Systematic Problem-Historical Introduction to the Basic Structure of Pedagogical Thinking and Practice (Allgemeine Pädagogik: eine systematisch-problemgeschichtliche Einführung in die Grundstruktur pädagogischen Denkens und Handelns). Secondly, based on the views D. Benner on the pedagogical praxis, development of process structure of general pedagogy and to place emphasis on praxeology and not-affirmatives. Thirdly, the reference on the views D. Benner to general pedagogy in the development of the Polish pedagogues. And fourth, provide some copyright proposals on general pedagogy
Illumina Inifinium HumanMethylation450 array data, under the paired bisulfite (BS) and oxidative bisulfite (oxBS) treatment
No full text<p>The current data sets represent the raw methylated (M) and unmethylated (U) intensities on 38 paired samples, with cancer (non-metastatic colorectal cancer) and healthy (normal mucosa) tissue available for each single sample. The data were obtained in the context of the ongoing population-based case-control study DACHS (<em>Darmkrebs: Chancen der Verhuetung durch Screening</em>, <a href="http://dachs.dkfz.org/dachs/">http://dachs.dkfz.org/dachs/</a>), extensively described in Brenner et al. (2011). Data collecting and patient recruitment procedures as well as the processes of DNA isolation and methylation profiling using the Infinium HumanMethylation450 BeadChip array (Illumina) are similar to those described in Gündert et al. (2017).</p>
<p>In the context of our experiment, all 38 samples were handled by means of paired bisulfite (BS) and oxidative bisulfite (oxBS) procedures. The reason for such paired treatment is the fact that the BS procedure, commonly used for derivation of the M and U intensities, can only differentiate between methylated and unmethylated cytosine bases, and cannot discriminate between 5mC and 5hmC. In order to determine the level of 5hmC at a considered nucleotide position that is indispensable for our analyses of the 5hmC measures, the oxBS procedure was applied. The name of the applied procedure (BS or oxBS) as well as the name of the corresponding intensities (M or U) can be read off from the name of the corresponding file. Each file contains 77 columns. The first column provides the designation of the corresponding CpG, the remaining 76 columns provide the corresponding intensities on healthy and cancer tissue, in alternating order.</p>
<p>References:</p>
<p>Brenner H, Chang-Claude J, Seiler CM et al. Protection from colorectal cancer after colonoscopy: a population-based, case-control study. Ann Intern Med 2011; 154: 22-30.</p>
<p>Gündert M, Edelmann D, Benner A, et al. Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier). Gut 2017; 1-10.</p>
Benner's prophecies of future ups and downs in prices. What years to make money on pig-iron, hogs, corn, and provisions. By Samuel Benner ...
No full textx, 11-131 p
OPTIMIZED CALCULATION OF A QUADRATIC MODEL FOR SPEED DEPENDENT LINESHAPES
No full textAuthor Institution: Department of Physics, The College of William and Mary,; Williamsburg, VA, 23187-8795A new algorithm for computation of a speed dependent lineshape function is presented. The lineshape that is calculated is based upon a quadratic model for the Lorentz width as a function of velocity. The calculation includes both real and imaginary parts of the lineshape for applications to line mixing and Dicke narrowing. This algorithm sacrifices a small amount of memory space for a considerable gain in speed and accuracy and employs methods similar to the techniques used to calculate the Voigt Profile as described by Letchworth and Benner} In Press.}. For Lorentz widths greater than about five times the Doppler width and for points more than about five Doppler widths from the center of the spectral line, Gauss-Hermite quadrature is employed. For most other cases, a Taylor series expansion about the nearest point in a precomputed table is used. In some cases where the Doppler width is more than an order of magnitude larger than the Lorentz width, Lagrange interpolating polynomials are used with a table of precomputed points. The accuracy is one part in 10 of the value of the function itself. Optionally, derivatives with respect to certain lineshape parameters are also returned. The algorithm provides a good approximation for speed dependent lineshapes with a calculation time which is not significantly larger than the time required to calculate the Voigt Profile using the Drayson} \underline{\textbf{16}}, 611-614, 1976.}, Humlicek} \underline{\textbf{27}}, 437-444, 1982.}, and Letchworth and Benner routines. This material is based upon work supported by the National Science Foundation under Grant No. ATM-0338475
Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer
No full textMicrosatellite instability (MSI-H) is caused by DNA mismatch repair deficiency and occurs in 15% of colorectal cancers. MSI-H cancers generate highly immunogenic frameshift peptide (FSP) antigens, which elicit pronounced local immune responses. A subset of MSI-H colorectal cancers develops in frame of Lynch syndrome, which represents an ideal human model for studying the concept of immunoediting. Immunoediting describes how continuous anti-tumoral immune surveillance of the host eventually leads to the selection of tumor cells that escape immune cell recognition and destruction. Between 30 and 40% of Lynch syndrome-associated colorectal cancers display loss of HLA class I antigen expression as a result of Beta2-microglobulin (B2M) mutations. Whether B2M mutations result from immunoediting has been unknown. To address this question, we related B2M mutation status of Lynch syndrome-associated colorectal cancer specimens (n = 30) to CD3-positive, CD8-positive and FOXP3-positive T cell infiltration in both tumor and normal mucosa. No significant correlation between B2M mutations and immune cell infiltration was observed in tumor tissue. However, FOXP3-positive T cell infiltration was significantly lower in normal mucosa adjacent to B2M-mutant (mt) compared to B2M-wild type (wt) tumors (mean: 0.98% FOXP3-positive area/region of interest (ROI) in B2M-wt vs. 0.52% FOXP3-positive area/ROI in B2M-mt, p = 0.023). Our results suggest that in the absence of immune-suppressive regulatory T cells (Treg), the outgrowth of less immunogenic B2M-mt tumor cells is favored. This finding supports the immunoediting concept in human solid cancer development and indicates a critical role of the immune milieu in normal colonic mucosa for the course of disease
THE V3 SPECTRAL REGION OF : ASSIGNMENTS AND MOLECULAR CONSTANTS
No full textAuthor Institution: Physics Department, College of William and Mary; Laboratoire d'Infrarouge, Universit\'e de Paris-Sud; Department of Physics, Ohio State UniversityPositions of a few thousand spectral lines on the Fourier transform and diode laser spectrea by Malathy Devi have been measured. Numerous transitions involving and have been identified and assignments made for over 20 bands. Molecular constants have been derived for the identified bends and comparisons of these constants with the previously reported values for nine bands will be made. Comparison to theoretically predicted values will be made for all of the bands. 1V. Malathy Devi, G. Guelachvili, D.C. Benner and K. Narahari Rao, this session
A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial)
No full textBackground: Lung cancer is the leading cause of cancer deaths worldwide. Surgery, radiotherapy at conventional and high dose and chemotherapy are the mainstay for lung cancer treatment. Insufficient migration and activation of tumour specific effector T cells seem to be important reasons for inadequate host anti-tumour immune response. Ionizing radiation can induce a variety of immune responses. The goal of this randomized trial is to assess if a preoperative single fraction low dose radiation is able to improve anti-tumour immune response in operable early stage lung cancer. Methods/Design: This trial has been designed as an investigator-initiated, prospective, randomized, 2-armed phase II trial. Patients who are candidates for elective resection of early stage non-small cell lung cancer will be randomized into 2 arms. A total of 36 patients will be enrolled. The patients receive either 2 Gy or no radiation prescribed to their primary tumour. Radiation will be delivered by external beam radiotherapy using 3D radiotherapy or intensity-modulated radiation technique (IMRT) 7 days prior to surgical resection. The primary objective is to compare CD8+ T cell counts detected by immunohistochemistry in resected tumours following preoperative radiotherapy versus no radiotherapy. Secondary objectives include the association between CD8+ T cell counts and progression free survival, the correlation of CD8+ T cell counts quantified by immunohistochemistry and flow cytometry, local tumour control and recurrence patterns, survival, radiogenic treatment toxicity and postoperative morbidity and mortality. Further, frequencies of tumour reactive T cells in blood and bone marrow as well as whole blood cell transcriptomics and plasma-proteomics will be correlated with clinical outcome. Discussion: This unique intervention combining preoperative low dose radiation and surgical removal of early stage non-small cell lung cancer is designed to address the problem of inadequate host anti-tumour immune response. If successful, this study may affect the role of radiotherapy in lung cancer treatment. Trial registration: NCT02319408; Registration: December 29, 2014
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